Genetics Of Influenza Viruses

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Genetics Of Influenza Viruses

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Author : P. Palese
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Genetics Of Influenza Viruses written by P. Palese and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

With the advent of genetic engineering methods and improved biochemical tech niques, much has been learned about the replication of influenza viruses, their structure and their epidemiology. It appears that the time is ripe to review these efforts and to provide a molecular perspective of influenza virology. It is hoped that this book will stimulate our thinking, help us in designing new experiments, and possibly show avenues leading to the control of the diseases associated with influenza viruses. Peter Palese, New York, N. Y. August 1983 David W. Kingsbury, Memphis, Tenn. Contents List of Contributors. . . . . . . . . . . . . . . . . XV 1. The Evolution of Influenza Viral Genetics - A Perspective. By E. D. Kilbourne. . . . . . . . . . . . . . . . 1 I. Introduction. . . . . . . . . . . . . . . . . 1 II. The Development of Modern Influenza Viral Genetics 2 A. Early Evidence of Genetic Variation in the Laboratory 2 B. Application of Formal Genetic Techniques to Studies of Influenza Virus . . . . . . . 3 C. Genetic Markers. . . . . . . . . 3 D. Development of Plaquing Systems. . . 4 E. The Use of Conditional Lethal Mutants 5 F. New Approaches in Influenza Virus Genetics. 6 1. The Biochemical Identification of Viral Gene Products in the Unambiguous Definition of Viral Inheritance . . . 6 2. Mapping of the Influenza Virus Genome by Correlative Physico-Chemical and Biological Techniques. . . . . . 7 3. The Application of Molecular Biological Techniques to the Study of Viral Genetic Variation. . . . . . . . . 8 4. Oligonucleotide Mapping of Viral RNA's . . . . . . . 8 5. Contribution of Protein and RNA Sequencing to Influenza Viral Genetics-Intragenic Mapping . . . . . . . 8 III. Viral Genetics and the Understanding of Viral Virulence and Pathogenicity . . . . . . . . . . . . . . . . . . .

Genetic Variation Among Influenza Viruses

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Author : Debi P. Nayak
language : en
Publisher: Academic Press
Release Date : 2013-09-24

Genetic Variation Among Influenza Viruses written by Debi P. Nayak and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-09-24 with Medical categories.

Genetic Variation Among Influenza Viruses documents the proceedings of ICN-UCLA symposium held in Salt Lake City, Utah, 8-13 March 1981. The symposium brought together people from different disciplines working with the common objective of reducing the ravages of influenza and to expose them to the totality of the problem of influenza. The papers presented at the meeting included nearly all major aspects of influenza in which important advances are being made. Because of recombinant DNA technology and rapid DNA sequencing, a number of genes of influenza virus from a number of strains have been either completely or partially sequenced. Among these, the gene coding for hemagglutinin (HA) has been most intensively studied and the HA of one or more strains from each subtype (H1, H2, H3) has been completely sequenced. Other topics discussed include the question of drift and shift at the genomic level; the role of the capped host mRNA is the process of initiation of transcription; and the regulation of viral transcription. This volume also includes papers presented by the speakers of the plenary sessions and that of keynote speaker, Sir Charles Stuart-Harris as well as the selected papers presented in the poster sessions.

Textbook Of Influenza

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Author : Robert G. Webster
language : en
Publisher: John Wiley & Sons
Release Date : 2014-01-06

Textbook Of Influenza written by Robert G. Webster and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-06 with Medical categories.

The Textbook of Influenza is a comprehensive resource covering all aspects of influenza, from the genetic and molecular biology of the virus through to clinical aspects of the disease and the latest drug developments and treatments. This new edition has been completely revised and reflects the integration of disciplines concerning the emergence, evolution, pathogenesis and control of influenza viruses in the field of human and veterinary public health. Textbook of Influenza examines the lessons learnt from the latest pandemic and provides the current state of knowledge for many yet unresolved issues related to virus origin, spread, pathogenesis and disease severity to better prepare for future pandemics. It covers the background to recent advances in influenza genomics and reverse genetics which have allowed the identification of virus virulence factors and the analysis and reconstruction of influenza viruses such as the 1918 Spanish flu strain. This new edition is divided into eight key sections, containing chapters co-written by international experts from both the clinical and scientific communities, covering: • Influenza Perspectives • Structure and Replication • Evolution and Ecology • Epidemiology and Surveillance • Immunology • Vaccines and Vaccine Development • Clinical Aspects and Antivirals • Public Health Textbook of Influenza is for all those working in the area of influenza including clinical and basic scientists, immunologists, molecular and structural virologists, public health officials and global pandemic control planners.

Influenza Viruses

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Author : Michael F. Schmidt
language : en
Publisher:
Release Date : 2007

Influenza Viruses written by Michael F. Schmidt and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with categories.

This book includes most of the lectures held at the Berlin Influenza Conference, written by some of the leading virologists in the world. The articles are top class and up-to-date.Contents:Scholtissek?s 75th Birthday, Aspects of Protein Structures of Borna Disease Virus, The Looming Danger: Avian influenza in wild birds, The sialic acid binding activity of the porcine transmissible gastroenteritis coronavirus (TGEV), Stability of the HA-Ectodomain, Reverse Genetics with Influenza Viruses, Rapid generation of influenza virus vaccines, 100 years of influenza history, Influenza Pandemic Preparedness, Proteolytic cleavage of the influenzavirus haemagglutinin and other viral glycoproteins, The risk for a wirld-wide influenza pandemic is a national and international challenge, Influenza viruses and MAP kinase cascades ? Novel targets for an antiviral intervention?, Lipid rafts in immune cell signalling and viral infection, Receptor specificity, host range and cellular tropism of influenza viruses, Influenza virus budding: the role of host and virus components, Membrane accumulation and lipid-raft-association of influenza A virus haemagglutinin triggers signalling and nuclear export of the viral genome, Glycosylation ? lessons from viruses and protozoa, Dissecting the influenza virus genome, Molecular biology of the pathogenesis of Sendai virus host range mutant, F1-R, Recent structural studies of influenza haemmagglutinin, A new approach of a live virus vaccine by modification of the cleavage site of the Influenza virus haemagglutinin by reverse genetics, Cell entry of Influenza virus by membrane fusion, The outbreak of H5N1 highly pathogenic avian Influenza in asia and pandemic preparedness, Influenza ? The role of migrating birds in past and future influenza pandemics

Genetic Diversity Of Rna Viruses

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Author : John J. Holland
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Genetic Diversity Of Rna Viruses written by John J. Holland and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

Many RNA viruses have been known for decades to be genetically and biologically quite variable. Some well-known examples are influenza viruses, foot and mouth disease viruses, and Newcastle disease virus. During the past decade, it has become clear that most, it not all. , RNA viruses (riboviruses and retroviruses) are much more mutable than was recognized previously, and that this great mutability generates extremely complex populations consisting of indeterminate mixtures of related variants (Le. , "mutant swarms" or "quasispecies" populations). This is also true of DNA viruses (such as hepatitis DNA genomes via RNA transcripts B virus) which replicate their that are reverse-transcribed back to DNA. This hypermutability of RNA replicons provides great biological adaptability for RNA virus genomes. It also allows (but does not necessitate) RNA viruses, so that they can extremely rapid evolution of evolve over a million times more quickly than their eukaryotic DNA-based hosts. The genetics of RNA replicons is so unusual (and often counterintuitive) that it has many important biological conse quences which are neither readily apparent nor widely under stood. Failure to understand the distinctive aspects of RNA genetics frequently generates confusion and controversy and can adversely impact vaccine and antiviral drug programs and other applications of medical virology. The 14 chapters in this volume describe advances in a number of significant areas of RNA virus genetics and evolution.

Influenza Vaccines For The Future

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Author : Rino Rappuoli
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-10-28

Influenza Vaccines For The Future written by Rino Rappuoli and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-28 with Medical categories.

The emergence of H5N1 avian influenza in 1997 and of the influenza A H1N1 of swine origin in 2009 calls for new, rapid and sustainable solutions for both seasonal and pandemic influenza viruses. During the last ten years, science and technology have made enormous progress, and we are now able to monitor in real time the genetics of viruses while they spread globally, to make more powerful vaccines using novel adjuvants, and to generate viruses in the laboratory using reverse genetics. This volume not only provides state-of-the-art information on the biology of influenza viruses and on influenza vaccines, but is also designed to be a resource to face the present H1N1 pandemic and to plan for long-term global and sustainable solutions.

Insight Into Influenza Viruses Of Animals And Humans

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Author : Sanjay Kapoor
language : en
Publisher: Springer Science & Business Media
Release Date : 2014-03-31

Insight Into Influenza Viruses Of Animals And Humans written by Sanjay Kapoor and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-03-31 with Medical categories.

This book provides salient information on all aspects of influenza/flu viruses affecting animals and humans. It specifically reviews the properties and replication of influenza viruses; their evolution and emergence; epidemiology; role of migratory birds in disease transmission; clinical signs in humans, animals and poultry; pathogenesis and pathogenicity; public health importance and potential threats; diagnosis; prevention and control measures; and pandemic preparedness. Influenza/flu viruses evolve continuously and jump species causing epidemics as well as pandemics in both human and animals. During the past 150 years, various strains of influenza virus like the Spanish flu, Asian flu, Hong Kong flu, bird flu and swine flu were responsible for high mortality in humans as well as birds. High mutation rates, antigenic shifts, drifts, reassortment phenomena, and the development of antiviral drug resistance all contribute to ineffective chemotherapy and vaccines against influenza viruses. Due to their devastating nature, high zoonotic implications and high mortality in humans and poultry, they have a severe impact on the socioeconomic status of countries. Disease awareness, rapid and accurate diagnosis, surveillance, strict biosecurity, timely adoption of appropriate preventive and control measures and pandemic preparedness are crucial to help reduce virus transmission, thus reducing clinical cases, deaths and pandemic threats.

The Influenza Viruses

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Author : Robert M Krug
language : en
Publisher:
Release Date : 1989-09-01

The Influenza Viruses written by Robert M Krug and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989-09-01 with categories.

Current Issues In Molecular Virology

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Author : Victor Romanowski
language : en
Publisher: BoD – Books on Demand
Release Date : 2013-11-20

Current Issues In Molecular Virology written by Victor Romanowski and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-20 with Science categories.

This book is a collection of chapters dealing with examples of RNA and DNA viruses, and issues such as how these gene packages have learnt to take advantage of their hosts, molecular recognition events that hosts may use to counterattack the viruses, and how researchers have developed strategies to use viruses or their parts as tools for different purposes.

Influenza Pathogenesis And Control Volume I

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Author : Richard W. Compans
language : en
Publisher: Springer
Release Date : 2014-10-08

Influenza Pathogenesis And Control Volume I written by Richard W. Compans and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-08 with Medical categories.

This two-volume work covers the molecular and cell biology, genetics and evolution of influenza viruses, the pathogenesis of infection, resultant host innate and adaptive immune response, prevention of infection through vaccination and approaches to the therapeutic control of infection.. Experts at the forefront of these areas provide critical assessments with regard to influenza virology, immunology, cell and molecular biology, and pathogenesis. Volume I provides overviews of the latest findings on molecular determinants of viral pathogenicity, virus entry and cell tropism, pandemic risk assessment, transmission and pathogenesis in animal species, viral evolution, ecology and antigenic variation, while Volume II focuses on the role of innate and adaptive immunity in pathogenesis, development of vaccines and antivirals.