Genomics In Regulatory Ecotoxicology
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Genomics In Regulatory Ecotoxicology
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Author : Gerald Ankley
language : en
Publisher: CRC Press
Release Date : 2007-11-27
Genomics In Regulatory Ecotoxicology written by Gerald Ankley and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-27 with Science categories.
Fueled partially by large, well-publicized efforts such as the Human Genome Project, genomic research is a rapidly growing area in multiple biological disciplines, including toxicology. Much of this potential, however, has been discussed in the literature and at technical meetings only in relatively broad terms, making it difficult to assess exactl
Genomics In Regulatory Toxicology
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Author : Gerald T. Ankley
language : en
Publisher:
Release Date : 2007-12
Genomics In Regulatory Toxicology written by Gerald T. Ankley and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12 with categories.
Genetics And Ecotoxicology
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Author : Valery E. Forbes
language : en
Publisher: CRC Press
Release Date : 2022-01-27
Genetics And Ecotoxicology written by Valery E. Forbes and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-27 with Science categories.
This first volume in the series provides a detailed treatment in ecotoxicology and stresses why genetics is important in understanding if and how chemical contaminants affect populations. Written by an array of international contributors from various fields covering mammals, invertebrates, fish, plants, as well as molecular ecotoxicology, this book considers both ecological/evolutionary consequences and practical implications of the interplay between chemical toxicants and the genetic population. In broadening the understanding of ecological response, this resource ranges from molecular to classical genetics, from plant to animal, from asexual to sexual, touching on some fundamental issues of evolutionary biology. In addition, gaps in our present understanding of genetic and ecotoxicological processes and future research directions have been identified.
Genomics And Environmental Regulation
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Author : Richard R. Sharp
language : en
Publisher: JHU Press
Release Date : 2008-10-14
Genomics And Environmental Regulation written by Richard R. Sharp and has been published by JHU Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-10-14 with Law categories.
To reduce the deleterious effects of environmental contamination, governments across the world have enacted regulations broadly conceived for entire populations. Information arising out of the Human Genome Project and other cutting-edge genetic research is shifting the policymaking process. This fascinating volume draws on experts from academia, government, industry, and nongovernmental organizations to examine the science of genomic research as applied to environmental policy. The first section explores environmental policy applications, including subpopulation genetic profiling, industrial regulations, and standardizing governmental evaluation of genomic data. The second section assesses from multiple angles the legal framework involved in applying genomics to environmental regulation. In the third section, the contributors review closely the implications of genomic research for occupational health, from disease prevention and genetic susceptibility to toxicants, to workers' rights and potential employment discrimination. A fourth section explores the bioethical and philosophical complications of bringing genetic data and research into nonclinical regulatory frameworks. Genomics and Environmental Regulation points to ways in which information on toxicology and genetics can be used to craft more precise and efficient regulations. -- Wendy Wagner, University of Texas
Molecular Ecotoxicology Of Plants
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Author : Heinrich Sandermann
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Molecular Ecotoxicology Of Plants written by Heinrich Sandermann and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.
A well-structured and comprehensive summary of the strategies and several case studies for applying molecular plant genomics in the fields of plant ecotoxicology and plant ecology. With an increasing number of plant genome projects now being completed, there arises the need to develop plant functional genomics. The book concentrates on ecological functions and relates molecular stress responses and signalling pathways to environmental interactions. This paves the way for uncovering new mechanisms of plant fitness, population dynamics and evolution, and new possibilities for plant breeding and sustainable agriculture. Topics covered include: definition and up-scaling of molecular ecotoxicology; signalling substances, enzymes and genes involved in defence against pathogens, xenobiotics, ozone, UV-B and further environmental stressors; and manipulation of plant signal transduction by soil bacteria.
Emerging Bioinformatic Tools In Toxicogenomics
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Author : Danyel Jennen
language : en
Publisher: Frontiers Media SA
Release Date : 2020-02-27
Emerging Bioinformatic Tools In Toxicogenomics written by Danyel Jennen and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-27 with categories.
Toxicogenomics was established as a merger of toxicology with genomics approaches and methodologies more than 15 years ago, and considered of major value for studying toxic mechanisms-of-action in greater depth and for classification of toxic agents for predicting adverse human health risks. While the original focus was on technological validation of in particular microarray-based whole genome expression analysis (transcriptomics), mainly through cross-comparing different platforms for data generation (MAQC-I), it was soon appreciated that actually the wide variety of data analysis approaches represents the major source of inter-study variation. This led to early attempts towards harmonizing data analysis protocols focusing on microarray-based models for predicting toxicological and clinical end-points and on different methods for GWAS data (MAQC-II). Simultaneously, further technological developments, geared by increasing insights into the complexity of cellular regulation, enabled analyzing molecular perturbations across multiple genomics scales (epigenomics and microRNAs, metabolomics). While these were initially still based on microarray technology, this is currently being phased out and replaced by a variety of next generation sequencing-based methods enabling exploration of genomic responses to toxicants at even greater depth (SEQC-I). This raises the demand for reliable and robust data analysis approaches, ranging from harmonized bioinformatics concepts for preprocessing raw data to non-supervised and supervised methods for capturing and integrating the dynamic perturbations of cell function across dose and time, and thus retrieving mechanistic insights across multiple regulation scales. Traditional toxicology focused on dose-dependently determining apical endpoints of toxicity. With the advent of toxicogenomics, efforts towards better understanding underlying molecular mechanisms has led to the development of the concept of Adverse Outcome Pathways, which are basically presented as a structural network of linearly related gene-gene interactions regulating key events for inducing apical toxic endpoints of interest. Impulse challenges from exposure of biological systems to toxic agents will however induce a cascade-type of events, presenting both adverse and adaptive processes, thus requiring bioinformatics approaches and methods for complex dynamic data, generated not only across dose, but clearly also across time. Currently, time-resolved toxicogenomics data sets are increasingly being assembled in the course of large-scaled research projects, for instance devoted towards developing toxicogenomics-based predictive assays for evaluating chemical safety which are no longer animal-based.
Toxicogenomics
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Author : Tohru Inoue
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09
Toxicogenomics written by Tohru Inoue and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Medical categories.
The meteoric rate at which the human genome is being sequenced has presented to the research community a vast array of newly discovered genes, which in tum has catalyzed an even more dramatic effort to decipher this voluminous data set into understanding how genes function both individually and in complex pathways that regulate the biochemistry of life. A compendium of gene expression data, enhanced by complete proteomic analysis, will enable investigators to probe into the complexities of the mechanisms of normal genetic and metabolic pathways and, subsequently, how disease occurs when they malfunction. The new science of toxicogenomics combines genomic, proteomic, and informatics technologies, and biological research can now foresee a time when there will be a full comprehension of the complex dynamic mechanisms of genetics, biochemistry, and physiology. The inherent power of toxicogenomics derives from an amalgamation of multiple scientific disciplines that were originally drawn together to facilitate sequencing the three billion bases that comprise the human genome. Traditionally, the science of toxicology has been founded upon empirical codification of dose-related effects. It has evolved to studies that are directed towards understanding the mechanisms by which individual agents cause their effects in humans. Due to technical limitations, this process has been relatively slow, since it has accomplished one chemical or one effect at a time.
Genomic Approaches For Cross Species Extrapolation In Toxicology
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Author : William H. Benson
language : en
Publisher: CRC Press
Release Date : 2006-12-13
Genomic Approaches For Cross Species Extrapolation In Toxicology written by William H. Benson and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-12-13 with Mathematics categories.
The latest tools for investigating stress response in organisms, genomic technologies provide great insight into how different organisms respond to environmental conditions. However, their usefulness needs to be tested, verified, and codified. Genomic Approaches for Cross-Species Extrapolation in Toxicology provides a balanced discussion drawn from
Environmental Toxicology
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Author : Edward A. Laws
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-12
Environmental Toxicology written by Edward A. Laws and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-12 with Science categories.
Environmental Toxicology provides a detailed, comprehensive introduction to this key area of sustainability and public health research. The broad coverage includes sections on ecological risk assessment, monitoring, mechanisms, fate and transport, prevention, and correctives, as well as treatment of the health effects of solar radiation and toxicology in the ocean. The 23 state-of-the-art chapters provide a multi-disciplinary perspective on this vital area, which encompasses environmental science, biology, chemistry, and public health.
A Framework To Guide Selection Of Chemical Alternatives
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2014-10-29
A Framework To Guide Selection Of Chemical Alternatives written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-29 with Science categories.
Historically, regulations governing chemical use have often focused on widely used chemicals and acute human health effects of exposure to them, as well as their potential to cause cancer and other adverse health effects. As scientific knowledge has expanded there has been an increased awareness of the mechanisms through which chemicals may exert harmful effects on human health, as well as their effects on other species and ecosystems. Identification of high-priority chemicals and other chemicals of concern has prompted a growing number of state and local governments, as well as major companies, to take steps beyond existing hazardous chemical federal legislation. Interest in approaches and policies that ensure that any new substances substituted for chemicals of concern are assessed as carefully and thoroughly as possible has also burgeoned. The overarching goal of these approaches is to avoid regrettable substitutions, which occur when a toxic chemical is replaced by another chemical that later proved unsuitable because of persistence, bioaccumulation, toxicity, or other concerns. Chemical alternative assessments are tools designed to facilitate consideration of these factors to assist stakeholders in identifying chemicals that may have the greatest likelihood of harm to human and ecological health, and to provide guidance on how the industry may develop and adopt safer alternatives. A Framework to Guide Selection of Chemical Alternatives develops and demonstrates a decision framework for evaluating potentially safer substitute chemicals as primarily determined by human health and ecological risks. This new framework is informed by previous efforts by regulatory agencies, academic institutions, and others to develop alternative assessment frameworks that could be operationalized. In addition to hazard assessments, the framework incorporates steps for life-cycle thinking - which considers possible impacts of a chemical at all stages including production, use, and disposal - as well as steps for performance and economic assessments. The report also highlights how modern information sources such as computational modeling can supplement traditional toxicology data in the assessment process. This new framework allows the evaluation of the full range of benefits and shortcomings of substitutes, and examination of tradeoffs between these risks and factors such as product functionality, product efficacy, process safety, and resource use. Through case studies, this report demonstrates how different users in contrasting decision contexts with diverse priorities can apply the framework. This report will be an essential resource to the chemical industry, environmentalists, ecologists, and state and local governments.