Genomics Proteomics And The Nervous System
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Genomics Proteomics And The Nervous System
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Author : James D Clelland
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-12-03
Genomics Proteomics And The Nervous System written by James D Clelland and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-03 with Medical categories.
This newest volume of Advances in Neurobiology discusses the utilization of genomic and proteomic technologies, to address facets of neurobiology including development and epigenetic regulation, functions in learning and memory, and changes associated with neurological and psychiatric disorders.
Genomics Proteomics And The Nervous System
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Author :
language : en
Publisher:
Release Date : 2011-04-11
Genomics Proteomics And The Nervous System written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-11 with categories.
Handbook Of Neurochemistry And Molecular Neurobiology
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Author : James Clelland
language : en
Publisher:
Release Date : 2009-12
Handbook Of Neurochemistry And Molecular Neurobiology written by James Clelland and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12 with categories.
Functional Genomics And Proteomics In The Clinical Neurosciences
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Author : Scott E. Hemby
language : en
Publisher: Elsevier
Release Date : 2006-10-09
Functional Genomics And Proteomics In The Clinical Neurosciences written by Scott E. Hemby and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-10-09 with Science categories.
The purpose of this work is to familiarize neuroscientists with the available tools for proteome research and their relative abilities and limitations. To know the identities of the thousands of different proteins in a cell, and the modifications to these proteins, along with how the amounts of both of these change in different conditions would revolutionize biology and medicine. While important strides are being made towards achieving the goal of global mRNA analysis, mRNA is not the functional endpoint of gene expression and mRNA expression may not directly equate with protein expression. There are many potential applications for proteomics in neuroscience: determination of the neuro-proteome, comparative protein expression profiling, post-translational protein modification profiling and mapping protein-protein interactions, to name but a few. Functional Genomics and Proteomics in Clinical Neuroscience will comment on all of these applications, but with an emphasis on protein expression profiling. This book combines the basic methodology of genomics and proteomics with the current applications of such technologies in understanding psychiatric illnesses. * Introduction of basic methodologies in genomics and proteomics and their integration in psychiatry* Development of the text in sections related to methods, application and future directions of these rapidly advancing technologies* Use of actual data to illustrate many principles of functional genomics and proteomics. * Introduction to bioinformatics and database management techniques
Neural Degeneration And Repair
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Author : Hans Werner Müller
language : en
Publisher: John Wiley & Sons
Release Date : 2008-09-08
Neural Degeneration And Repair written by Hans Werner Müller and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-08 with Medical categories.
With contributions from leading scientists around the world, this is the first book focussing on the analysis of nerve cell damage and repair using genomics, transcriptomics, proteomics and systems biology in order to develop novel therapeutic and diagnostic approaches for neural diseases. Following an introduction into the microarray technology in translational neuroscience, the book goes on to look at the use of '-omics' technologies to analyse molecular changes in traumatic injury, neuron degeneration and regeneration, oxidative stress response, neuropathic pain manifestation etc. The work covers central nervous system as well as peripheral nervous system pathologies. This novel approach makes the book an indispensable companion for neurobiologists, neurologists, cell and molecular biologists, geneticists, and analytical chemists.
Neuroproteomics
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Author : Oscar Alzate
language : en
Publisher: CRC Press
Release Date : 2009-10-26
Neuroproteomics written by Oscar Alzate and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-10-26 with Science categories.
In this, the post-genomic age, our knowledge of biological systems continues to expand and progress. As the research becomes more focused, so too does the data. Genomic research progresses to proteomics and brings us to a deeper understanding of the behavior and function of protein clusters. And now proteomics gives way to neuroproteomics as we begin to unravel the complex mysteries of neurological diseases that less than a generation ago seemed opaque to our inquiries, if not altogether intractable. Edited by Dr. Oscar Alzate, Neuroproteomics is the newest volume in the CRC Press Frontiers of Neuroscience Series. With an extensive background in mathematics and physics, Dr. Alzate exemplifies the newest generation of biological systems researchers. He organizes research and data contributed from all across the world to present an overview of neuroproteomics that is practical and progressive. Bolstered by each new discovery, researchers employing multiple methods of inquiry gain a deeper understanding of the key biological problems related to brain function, brain structure, and the complexity of the nervous system. This in turn is leading to new understanding about diseases of neurological deficit such as Parkinson’s and Alzheimer’s. Approaches discussed in the book include mass spectrometry, electrophoresis, chromatography, surface plasmon resonance, protein arrays, immunoblotting, computational proteomics, and molecular imaging. Writing about their own work, leading researchers detail the principles, approaches, and difficulties of the various techniques, demonstrating the questions that neuroproteomics can answer and those it raises. New challenges wait, not the least of which is the identification of potential methods to regulate the structures and functions of key protein interaction networks. Ultimately, those building on the foundation presented here will advance our understanding of the brain and show us ways to abate the suffering caused by neurological and mental diseases.
Biomedical Applications Of Proteomics
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Author : Jean-Charles Sanchez
language : en
Publisher: John Wiley & Sons
Release Date : 2006-03-06
Biomedical Applications Of Proteomics written by Jean-Charles Sanchez and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-06 with Science categories.
In this first book to provide an overview of applications of proteomics in the discovery of new diagnostic, prognostic and therapeutic targets, a team of international specialists from research institutions, hospitals and companies contribute with their specific expertise. They cover a wide range of example applications for the most important diseases, such as heart and cardiovascular disorders, cancer, pharmatoxicology, infectious diseases and diseases of the nervous system. Denis Hochstrasser is an eminent scientist in the field of bioinformatics and proteomics and one of the founders of the Swiss Prot Databank as well as of the Swiss biotech company Genebio.
Functional Genomics And Proteomics In The Clinical Neurosciences
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Author : S. E. Hemby
language : en
Publisher:
Release Date : 2006
Functional Genomics And Proteomics In The Clinical Neurosciences written by S. E. Hemby and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Genomics categories.
Neuroproteomics
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Author : Andrew K. Ottens
language : en
Publisher: Humana Press
Release Date : 2012-07-12
Neuroproteomics written by Andrew K. Ottens and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-12 with Medical categories.
Neuroproteomics: Methods and Protocols presents experimental details for applying proteomics to the study of the central nervous system (CNS) and its dysfunction through trauma and disease. The target audience includes clinical or basic scientists who look to apply proteomics to the neurosciences. Often researchers hear of proteomics without an adequate explanation of the methodology and inherent limitations. This volume conveys where proteomic methodology is in its application to CNS research and what results can be expected. We also address clinical translation of neuroproteomics, specifically in the area of biomarker research. The inception of neuroproteomics capitalized on rapid progress in large-molecule mass spectrometry over the last decade. Two seminal advances have spurred research – development of reliable polypeptide ionization processes and bioinformatics to rapidly process tandem mass spectra for peptide identification and quantification. What has followed is the exponential application of mass spectrometry to proteome characteri- tion across biological and biomedical disciplines. Arguably, the most elaborate proteomic implementation is in studying the CNS, the most enigmatic and complex animal system. Neuroscience is characterized by grandiose questions – what is consciousness, how does thought or memory work. Neuroproteomics researchers, however, have pri- rily involved themselves dysfunction, based on a pressing need (and invariably funding), in answering questions on CNS dysfunction, based on a pressing need (and invariably funding), and because such questions hold more accessible answers. Dysfunction is readily contrasted against normal function and presumably produces a lasting differential protein signature.
Methods In Genomic Neuroscience
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Author : Hemin R. Chin
language : en
Publisher: CRC Press
Release Date : 2001-09-26
Methods In Genomic Neuroscience written by Hemin R. Chin and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-09-26 with Science categories.
The past few years have witnessed extraordinary advances in molecular genetic techniques and the accumulation of structural genomics information and resources in both human and model organisms. With the development of new technologies and the availability of resources like the sequence of eukaryotic genomes, problems of a previously unthinkable sco