Genotoxicity And Dna Repair
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Genotoxicity And Dna Repair
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Author : L. María Sierra
language : en
Publisher: Humana
Release Date : 2016-09-17
Genotoxicity And Dna Repair written by L. María Sierra and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-17 with Medical categories.
Genotoxicity and DNA Repair: A Practical Approach provides a key reference for determining how to analyze the genotoxic activity of molecules or materials and, at the same time, serves as a useful tool for researchers in the Environmental Mutagenesis and DNA Repair fields. Focused on genotoxicity assays recommended by the “OECD guidelines for the testing of chemicals”, this volume also covers other useful assays, such as some gene mutation assays, the comet assay in different species and applications, and the SMART assays of Drosophila. For all the assays, the book presents brief theoretical introductions to the topics and updated standard and modified step-by-step protocols to perform them. Special emphasis is placed on the analysis of nanoparticles, including an integrative approach analysis. The DNA Repair section includes several assays that provide information on repair activity in vitro and in vivo, as well as recent applications to study DNA repair in humans, cell cultures, and animal models. As a volume in the Methods in Pharmacology and Toxicology series, the chapters contain the kind of detail and key implementation advice that ensures reproducible results in the lab. Authoritative and invaluable, Genotoxicity and DNA Repair: A Practical Approach aims to aid scientists in their pursuit of forwarding this vital field of study.
Genotoxicity And Mutagenicity
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Author : Sonia Soloneski
language : en
Publisher: BoD – Books on Demand
Release Date : 2021
Genotoxicity And Mutagenicity written by Sonia Soloneski and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with categories.
This edited book, "Genotoxicity and Mutagenicity - Mechanisms and Test Methods", aims to present the latest developments from different fields, highlighting the detrimental influence that mutagenic and genotoxic agents inflict on DNA and how antimutagenic and anticarcinogenic modulators are able to reduce the negative impact of such toxic agents on living species.
Induced Effects Of Genotoxic Agents In Eukaryotic Cells
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Author : Toby G Rossman
language : en
Publisher: CRC Press
Release Date : 2020-07-26
Induced Effects Of Genotoxic Agents In Eukaryotic Cells written by Toby G Rossman and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-26 with Science categories.
This book provides an understanding of the consequences of induced proteins in the toxicological response of cells to chemical and radiation damage to DNA and will be helpful in creating proper mathematical models for extrapolation to low doses and assessing human exposure or cellular injury.
Insight On Genotoxicity
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Author : Shiv Shankar Shukla
language : en
Publisher: CRC Press
Release Date : 2020-10-14
Insight On Genotoxicity written by Shiv Shankar Shukla and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-14 with Science categories.
Genetic toxicology is considered to be an important assessment tool as there is genetic impact of artificial chemicals. Insight on Genotoxicity discusses testing, mechanism, prediction, and bioindicator of genotoxicity taking into consideration recent advances in nano-engineered particles. Corollary of DNA dent is also discussed in detail taking into consideration the impact of ICH guidelines on genotoxicity testing, which is important for drug discovery innovation and development. Perspective review of genotoxicity evaluation in phytopharmaceuticals has been mentioned along with the prevention of genotoxicity in brief viewpoint. Salient Features Presents methods, standard protocols, and guidelines for genotoxicity testing Examines the impact of ICH Guidelines on genetic toxicity testing which is a regulatory requirement for drug discovery and development Defines appropriate strategies about advances in in vivo genotoxicity testing which have been listed along with progress and prospects Discusses advancement in the high-throughput approaches for genotoxicity testing Details computational prediction of genotoxicity with consideration of mutagenicity, chromosomal damage caused and strategies for computational prediction in drug development
The Cellular Response To The Genotoxic Insult
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Author : Helmut Greim
language : en
Publisher: Royal Society of Chemistry
Release Date : 2015-11-09
The Cellular Response To The Genotoxic Insult written by Helmut Greim and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-09 with Science categories.
Genotoxic carcinogens can lead to DNA mutations with the potential to cause cancer. Typically, a series of mutation events are needed before malignancy occurs so a single, small exposure may not result in disease. Also, cells have an armoury of defence mechanisms which, to a degree, counter the effects of mutagens. Distinguishing the point at which exposure to a carcinogen increases mutation rates beyond the background level is challenging. In fact, there is now general agreement that, for genotoxic carcinogens, no specific threshold can be identified. However, NOAELs (No Observed Adverse Effect Levels) may be used in the process of establishing a dose-response relationship. These denote the level of exposure at which there is no significant increase in adverse effects in the exposed population when compared to an appropriate control. Such a scientifically defendable threshold allows us to propose health based exposure limits for genotoxic carcinogens. This book describes the various cellular defence mechanisms individually and explains how they are regulated. The processes covered include metabolic inactivation, epigenetic regulation, scavenging mechanisms, DNA-repair and apoptosis. It also considers dose-dependent threshold mechanisms of carcinogenesis and the rate limiting parameters. Aimed at graduate level and above, the book discusses the consequences of genotoxic evaluation and urges readers to question the idea that even low exposures present a cancer risk.
Genotoxicity
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Author : Andor Kocsis
language : en
Publisher: Nova Science Publishers
Release Date : 2009
Genotoxicity written by Andor Kocsis and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with DNA adducts categories.
This book looks at genotoxicity which is a deleterious action on cell genetic material affecting its integrity. Genotoxic substances are known to be potentially mutagenic or carcinogenic, specifically those capable of causing genetic mutation and of contributing to the development of tumours. In humans, DNA damage or genotoxicity may be caused by exposure to outside agents like radiation, pesticides, combustion of hydrocarbon products as well as antineoplastic drugs. DNA damage could also come from inside of the body, determined mainly by excessive free radical production generated by some disease process. The importance then, is to identify the genotoxity and try to protect the body, which may be as simple as removing the source of exposure or providing protection against such agents. This new important book gathers the latest research from around the globe in this dynamic field of study.
Methods To Assess Dna Damage And Repair
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Author : Robert G. Tardiff
language : en
Publisher:
Release Date : 1994-08-16
Methods To Assess Dna Damage And Repair written by Robert G. Tardiff and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-08-16 with Science categories.
Integrates data obtained from a variety of disciplines to evaluate the current state of knowledge regarding defense mechanisms and applies this information to estimate health risks to humans exposed to substances that alter genetic material. Recognized experts document, to a large extent, which carcinogens can cause injury to human beings and their surroundings, providing guidance for the structured acquisition of key information to reduce cancer risks throughout the environment.
Principles Of Genetic Toxicology
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Author : D. Brusick
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Principles Of Genetic Toxicology written by D. Brusick and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Medical categories.
The field of genetic toxicology has gone through remarkable development in the seven years since the appearance of the first edition of Principles of Genetic Toxicology. One branch of toxicology research, chemical mutagenesis, has been elucidated and expanded as a result of increased effort, testing, and the sharing of data. This expansion has occurred not only in the industrialized countries, but also in countries that are comparatively less advanced in scientific implementation. These developing countries have taken advan tage of the basic practical methods that were so well described in the first edition of this work. It is significant to note how many centers have been established throughout the world and are now studying the basic concepts and applying them to practical problems such as the detection of genetic effects caused by exposure to chemicals. In fact, there are now toxicology training centers in twelve countries. Genetic toxicology, in addition to being investigated as a science unto itself, has been taught to people in the applied fields so that these techniques may be put to use in solving other biological problems. For these reasons, it is most useful to have an update of the basic methods and their development. Dr. Brusick should be congratulated for doing such an excellent job of assembling a text that will be worthwhile to any researcher who is interested in the principles of genetic toxicology. Alexander Hollaender Council for Research Planning in Biological Sciences, Inc. Washington, D. C.
Thresholds Of Genotoxic Carcinogens
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Author : Takehiko Nohmi
language : en
Publisher: Academic Press
Release Date : 2016-05-20
Thresholds Of Genotoxic Carcinogens written by Takehiko Nohmi and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-05-20 with Medical categories.
Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation brings together current opinion and research activities from Japan, the US, and Europe on the subject of genotoxic thresholds. In regulation, it is an adage that genotoxic carcinogens have no thresholds for action, and that they impose cancer risk on humans even at very low levels. This policy is frequently called into question as humans possess a number of defense mechanisms including detoxication, DNA repair, and apoptosis, meaning there is a threshold at which these genotoxic carcinogens take action. The book examines these potential thresholds, describing the potential cancer risks of daily low-level exposure, the mechanisms involved (such as DNA repair, detoxication, translesion DNA synthesis), chemical and statistical methods of analysis, and the ways in which these may be utilized to inform policy. Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation is an essential reference for any professional researchers in genetic toxicology and those involved in toxicological regulation. Unites an international team of experts to provide a balanced overview of the current opinion on thresholds of genotoxic carcinogens Provides all the information readers need to determine a safe threshold for potential genotoxic carcinogens Includes information on the mechanisms of genotoxic carcinogens and how these can inform regulation Serves as an essential reference for any professional researchers in genetic toxicology and those involved in toxicological regulation
The Chemical Biology Of Dna Damage
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Author : Nicholas E. Geacintov
language : en
Publisher: John Wiley & Sons
Release Date : 2011-08-04
The Chemical Biology Of Dna Damage written by Nicholas E. Geacintov and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-04 with Science categories.
Bringing the power of biochemical analysis to toxicology, this modern reference explains genotoxicity at the molecular level, showing the links between a DNA lesion and the resulting cellular or organismic response. Clearly divided into two main sections, Part 1 focuses on selected examples of important DNA lesions and their biological impact, while the second part covers current advances in assessing and predicting the genotoxic effects of chemicals, taking into account the biological responses mediated by the DNA repair, replication and transcription machineries. A ready reference for biochemists, toxicologists, molecular and cell biologists, and geneticists seeking a better understanding of the impact of chemicals on human health.