Genotype Phenotype Coupling
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Genotype Phenotype Coupling
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Author : Stefan Zielonka
language : en
Publisher: Springer Nature
Release Date : 2023-07-05
Genotype Phenotype Coupling written by Stefan Zielonka and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-05 with Science categories.
This detailed new edition broadens the scope of the first edition by moving beyond classical display technologies. This book explores methodologies for the generation of natively paired antibody libraries, single cell technologies, alternative scaffolds, and in silico antibody sequence assessments are described. The application of these methods may allow for a generation of improved therapeutics and diagnostic reagents in a shorter time frame. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Genotype Phenotype Coupling: Methods and Protocols, Second Edition serves as an ideal guide for researchers seeking to expand their knowledge of antibody-based therapeutics.
Genotype Phenotype Coupling
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Author : Stefan Zielonka
language : en
Publisher:
Release Date : 2020
Genotype Phenotype Coupling written by Stefan Zielonka and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with Human genetics categories.
This volume aims at providing state-of-the-art protocols detailing ribosome display, cDNA display, phage display, yeast surface display, and mammalian display. Chapters guide readers through methods and protocols on in vitro methods over prokaryotic display systems, lower eukaryotes, and mammalian cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of all necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Genotype Phenotype Coupling aims to provide an overview of current technologies in this exciting and continuously evolving field.
Molecular Theory Of The Living Cell
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Author : Sungchul Ji
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-04-05
Molecular Theory Of The Living Cell written by Sungchul Ji and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-05 with Science categories.
The book presents the first comprehensive molecular theory of the living cell ever published since the cell doctrine was formulated in 1838-1839. It introduces into cell biology over thirty key concepts, principles and laws imported from physics, chemistry, computer science, linguistics, semiotics and philosophy. The author formulates physically, chemically and enzymologically realistic molecular mechanisms to account for basic living processes such as ligand-receptor interactions, enzymic catalysis, force-generating mechanisms in molecular motors, chromatin remodelling, and signal transduction. Possible solutions to basic and practical problems facing contemporary biology and biomedical sciences have been suggested, including pharmacotherapeutics and personalized medicine.
Protein Engineering Handbook
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Author : Stefan Lutz
language : en
Publisher: John Wiley & Sons
Release Date : 2012-07-31
Protein Engineering Handbook written by Stefan Lutz and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-31 with Science categories.
Unparalleled in size and scope, this new major reference integrates academic and industrial knowledge into a single resource, allowing for a unique overview of the entire field. Adopting a systematic and practice-oriented approach, and including a wide range of technical and methodological information, this highly accessible handbook is an invaluable 'toolbox' for any bioengineer. In two massive volumes, it covers the full spectrum of current concepts, methods and application areas.
Recent Advances In Artificial Life
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Author : Hussein A Abbass
language : en
Publisher: World Scientific
Release Date : 2005-11-04
Recent Advances In Artificial Life written by Hussein A Abbass and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-11-04 with Science categories.
Artificial life is now a recognized discipline of research with many important applications and software tools. However, many theoretical issues remain unresolved. This book brings together a cross-section of key developments in artificial life, which in turn gives us new insight into the theory of complex systems.The central ideas of the book surround genetics and evolution in an artificial life framework. Topics covered include maintenance of genetic diversity, hierarchical structures and stability of ecosystems. Underpinning these topics are key theoretical developments surrounding network complexity, the development of pattern languages for complex networks and a deeper understanding of the edge of chaos where complex systems live. Practical applications include optimization, gene regulatory networks, modeling the spread of disease and the evolution of ageing.The reader will gain an insight into the mathematical techniques at the core of artificial life and encounter a sufficient diversity of applications to stimulate new directions in their own field.
Theoretical Information Studies Information In The World
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Author : Mark Burgin
language : en
Publisher: World Scientific
Release Date : 2020-03-24
Theoretical Information Studies Information In The World written by Mark Burgin and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-24 with Computers categories.
This is the first attempt to delineate the synthetic field of the theoretical study of information, treating information as the basic phenomenon on the fundamental level of the world, encompassing nature, technology, individuals and society. The exploration of information is done within Info-computational approaches, to natural and social phenomena such as Bioinformatics, Information Physics, Informational Chemistry, Computational Physics, Cognitive and Social sciences, with special emphasis on interdisciplinary, crossdisciplinary and transdisciplinary knowledge.The book presents results of collaboration across research fields within info-computational and info-structural frameworks, in attempt to better theoretically and conceptually capture the phenomenon of information and its dynamics (such as computation and communication), as they appear on different levels of organization, on different scales and in different contexts.
Introduction To Antibody Engineering
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Author : Florian Rüker
language : en
Publisher: Springer Nature
Release Date : 2021-01-04
Introduction To Antibody Engineering written by Florian Rüker and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-04 with Medical categories.
This highly readable textbook serves as a concise and engaging primer to the emerging field of antibody engineering and its various applications. It introduces readers to the basic science and molecular structure of antibodies, and explores how to characterize and engineer them. Readers will find an overview of the latest methods in antibody identification, improvement and biochemical engineering. Furthermore, alternative antibody formats and bispecific antibodies are discussed. The book’s content is based on lectures for the specializations “Protein Engineering” and “Medical Biotechnology” within the Master’s curriculum in “Biotechnology.” The lectures have been held at the University of Natural Resources and Life Sciences, Vienna, in cooperation with the Medical University of Vienna, since 2012 and are continuously adapted to reflect the latest developments in the field. The book addresses Master’s and PhD students in biotechnology, molecular biology and immunology, and all those who are interested in antibody engineering.
Protein Targeting Compounds
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Author : Thomas Böldicke
language : en
Publisher: Springer
Release Date : 2016-05-28
Protein Targeting Compounds written by Thomas Böldicke and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-05-28 with Medical categories.
This book presents an overview of the most relevant protein knockdown techniques. Readers will find a description of the generation and use of recombinant human antibodies, ER intrabodies and peptides as well as a description of the working mechanism and potential of the inhibitory action of each of these molecules. The book will also describe the selection and activity of a number of phosphatases, aptamers and allosteric modulators, focusing on A G protein coupled receptors. The book starts with a chapter on the in silico prediction of target-inhibitor interactions. Key aspects of this book are: - Selection strategies for monoclonal and recombinant human antibodies - Selection strategies for ER intrabodies, peptides and aptamers - Examples of the most efficient inhibitors and their applications in protein biochemistry and cell biology - Antibodies for cancer therapy and inhibitors of angiogenesis. The book will be of great interest to scientists and students working in the life sciences on all areas related to protein biology. The variety of methods to modulate the activities of specific proteins which are introduced here will be of great benefit to the reader who is interested in general protein research or to readers who have very specific protein related questions.
Principles And Procedures Of Plant Breeding
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Author : G. S. Chahal
language : en
Publisher: CRC Press
Release Date : 2002
Principles And Procedures Of Plant Breeding written by G. S. Chahal and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Crop improvement categories.
Covering traditional and emerging breeding procedures, this book explores the scientific bases and details of breeding plants. It puts a special emphasis on the further refinements possible in the light of the latest developments in molecular biology. Specific breeding methods in self and cross-pollinated crops, their genetic basis and scope of further refinements, concepts and techniques of tissue culture, molecular biology and production of transgenic plants, commonly used experimental designs in plant breeding, seed production, and implications of plant breeder's rights are other highlights.
Principles And Methods Of Plant Breeding
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Author : Slavko Borojević
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 1990-12-31
Principles And Methods Of Plant Breeding written by Slavko Borojević and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990-12-31 with Technology & Engineering categories.
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