Introduction To Antibody Engineering
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Introduction To Antibody Engineering
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Author : Florian Rüker
language : en
Publisher: Springer Nature
Release Date : 2020-11-30
Introduction To Antibody Engineering written by Florian Rüker and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-30 with Medical categories.
This highly readable textbook serves as a concise and engaging primer to the emerging field of antibody engineering and its various applications. It introduces readers to the basic science and molecular structure of antibodies, and explores how to characterize and engineer them. Readers will find an overview of the latest methods in antibody identification, improvement and biochemical engineering. Furthermore, alternative antibody formats and bispecific antibodies are discussed. The book’s content is based on lectures for the specializations “Protein Engineering” and “Medical Biotechnology” within the Master’s curriculum in “Biotechnology.” The lectures have been held at the University of Natural Resources and Life Sciences, Vienna, in cooperation with the Medical University of Vienna, since 2012 and are continuously adapted to reflect the latest developments in the field. The book addresses Master- and PhD students in biotechnology, molecular biology and immunology, and all those who are interested in antibody engineering.
Therapeutic Antibody Engineering
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Author : William R Strohl
language : en
Publisher: Elsevier
Release Date : 2012-10-16
Therapeutic Antibody Engineering written by William R Strohl and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-16 with Medical categories.
The field of antibody engineering has become a vital and integral part of making new, improved next generation therapeutic monoclonal antibodies, of which there are currently more than 300 in clinical trials across several therapeutic areas. Therapeutic antibody engineering examines all aspects of engineering monoclonal antibodies and analyses the effect that various genetic engineering approaches will have on future candidates. Chapters in the first part of the book provide an introduction to monoclonal antibodies, their discovery and development and the fundamental technologies used in their production. Following chapters cover a number of specific issues relating to different aspects of antibody engineering, including variable chain engineering, targets and mechanisms of action, classes of antibody and the use of antibody fragments, among many other topics. The last part of the book examines development issues, the interaction of human IgGs with non-human systems, and cell line development, before a conclusion looking at future issues affecting the field of therapeutic antibody engineering. - Goes beyond the standard engineering issues covered by most books and delves into structure-function relationships - Integration of knowledge across all areas of antibody engineering, development, and marketing - Discusses how current and future genetic engineering of cell lines will pave the way for much higher productivity
Antibody Engineering
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Author : Carl A. K. Borrebaeck
language : en
Publisher: Breakthroughs in Molecular Biology
Release Date : 1995
Antibody Engineering written by Carl A. K. Borrebaeck and has been published by Breakthroughs in Molecular Biology this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Medical categories.
In presenting a practical overview of the engineering of recombinant human or mouse monoclonal antibodies, the book incisively addresses essential topics such as antibody structure relevant to engineering, recombinatorial cDNA libraries, phage display, synthetic and humanized antibodies, engineering of affinity and biological effector functions, and plant, mammalian, and bacterial expression vectors and hosts. Antibody Engineering, Second Edition - written by leading experts and now thoroughly updated - is a unique resource for current information on the subject.
Antibody Engineering
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Author : Damien Nevoltris
language : en
Publisher: Humana
Release Date : 2019-12-10
Antibody Engineering written by Damien Nevoltris and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-10 with Medical categories.
This detailed new edition provides complete and easy access to a variety of antibody engineering techniques. The volume explores topics such as the generation of native, synthetic, or immune antibody libraries, the selection of lead candidates via the different powerful and innovative display technologies, Fc engineering, as well as their production, characterization, and optimization of antibodies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Antibody Engineering: Methods and Protocols, Third Edition presents the reader with an extensive toolbox to create the powerful molecules of tomorrow.
Antibody Engineering
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Author : J. Donald Capra
language : en
Publisher: Karger Publishers
Release Date : 1997
Antibody Engineering written by J. Donald Capra and has been published by Karger Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Medical categories.
The last decade has witnessed remarkable developments in antibody research and its therapeutic applications. With the methods of molecular biology it is now possible to manipulate the specificities and activities of antibody molecules to generate an almost limitless array of structures for both basic investigations and the clinical setting. The contributions to this volume cover all three domains of the antibody: the variable regions, the relatively neglected but crucial hinge, and the constant region. These studies provide critical structural and functional information about antibodies, while also pointing the way to the construction of molecules with enhanced or even novel properties. Bringing together major experts on antibody engineering, this book is highly recommended to faculty, postdoctoral fellows and graduate students in molecular biology, microbiology, immunology, cancer research and genetics.
Approaches To The Purification Analysis And Characterization Of Antibody Based Therapeutics
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Author : Allan Matte
language : en
Publisher: Elsevier
Release Date : 2020-08-24
Approaches To The Purification Analysis And Characterization Of Antibody Based Therapeutics written by Allan Matte and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-24 with Medical categories.
Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics provides the interested and informed reader with an overview of current approaches, strategies and considerations relating to the purification, analytics and characterization of therapeutic antibodies and related molecules. While there are obviously other books published in and around this subject area, they seem to be either older (c.a. year 2000 publication date) or are more limited in scope. The book will include an extensive bibliography of the published literature in the respective areas covered. It is not, however, intended to be a how-to methods book.
Antibody Drug Discovery
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Author : Clive R. Wood
language : en
Publisher: World Scientific
Release Date : 2012
Antibody Drug Discovery written by Clive R. Wood and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Medical categories.
Antibody-based therapeutics are a central driver of the success of biopharmaceuticals. The discovery technology of this field is isolated to a limited number of centers of excellence in industry and academia. The objective of this volume is to provide a series of guides to those evaluating and preparing to enter particular areas within the field. Each chapter is written with a historical perspective that sets into context the significance of the key developments, and with the provision of “points to consider” for the reader as a value-added feature of the volume. All contributors are experts in their fields and have played pivotal roles in the creation of the technology.
Structural Biology In Immunology
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Author : Chaim Putterman
language : en
Publisher: Academic Press
Release Date : 2018-05-15
Structural Biology In Immunology written by Chaim Putterman and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-15 with Medical categories.
Structural Biology in Immunology, Structure/Function of Novel Molecules of Immunologic Importance delivers important information on the structure and functional relationships in novel molecules of immunologic interest. Due to an increasingly sophisticated understanding of the immune system, the approach to the treatment of many immune-mediated diseases, including multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, and inflammatory bowel disease has been dramatically altered. Furthermore, there is an increasing awareness of the critical role of the immune system in cancer biology. The improved central structure function relationships presented in this book will further enhance our ability to understand what defects in normal individuals can lead to disease.
Developability Of Biotherapeutics
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Author : Sandeep Kumar
language : en
Publisher: CRC Press
Release Date : 2015-11-18
Developability Of Biotherapeutics written by Sandeep Kumar and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-18 with Medical categories.
Biopharmaceuticals are emerging as frontline medicines to combat several life-threatening and chronic diseases. However, such medicines are expensive to develop and produce on a commercial scale, contributing to rising healthcare costs. Developability of Biotherapeutics: Computational Approaches describes applications of computational and molecular
Monoclonal Antibodies
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Author : Maher Albitar
language : en
Publisher: Humana Press
Release Date : 2010-10-28
Monoclonal Antibodies written by Maher Albitar and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-28 with Medical categories.
This book examines a collection of state-of-the-art methods that employ monoclonal antibodies in a clinical setting. The chapters offer in-depth description for generating mouse and recombinant humanized antibodies, and a comprehensive review of how antibodies are being used in bead-based methods for measuring proteins. This field will continue to expand and provide new and innovative techniques in the laboratory and as a basis that complements targeted therapy.