Ghrelin Function Mechanism Of Action And Role In Health And Disease
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Ghrelin Function Mechanism Of Action And Role In Health And Disease
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Author : Dennis Hertz
language : en
Publisher:
Release Date : 2020-03-30
Ghrelin Function Mechanism Of Action And Role In Health And Disease written by Dennis Hertz and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-30 with categories.
Ghrelin is a 28-amino acid peptide mainly secreted by the stomach. To better understand the role of ghrelin signaling, Ghrelin: Function, Mechanism of Action and Role in Health and Disease first explores the regulation of age-associated adipose tissue inflammation. Following this, the authors discuss the influence of different variables on the response of short-term appetite regulation induced by exercise. External factors such as temperature and environment exert effects on hormonal responses, including hunger sensation and energy intake. The effects of gender differences and aging on psychological stress-dependent eating disorders are assessed, and the involvement of endogenous ghrelin, the serotonin 2c receptor and the estrogen alpha receptor is discussed. The penultimate chapter reviews the relationship between sleep and eating behavior, focusing in the influences of circadian changes on appetite related responses such as plasma concentration of ghrelin. The concluding study highlights the ghrelin system as a promising candidate for cardiovascular drug discovery, a new therapeutic approach for the treatment of endothelial impairment, and a possible contribution to the prevention of atherosclerosis.
Ghrelin In Health And Disease
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Author : Roy G. Smith
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-10-19
Ghrelin In Health And Disease written by Roy G. Smith and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-19 with Medical categories.
Ghrelin, the endogenous ligand for the growth hormone secretagogue (GHS) receptor, is critical in the control of food intake and energy balance. The ghrelin receptors are now known to have important physiological properties as modulators of growth hormone release, appetite, glucose homeostasis, metabolism, immune function, neurotransmitter activity, cognitive function and neurodegeneration. Bringing all of this information together in the first comprehensive text on the topic, Ghrelin in Health and Disease provides a state-of-the-art synthesis of the latest work in this area for physicians and physician-scientists. This volume addresses the unique property of ghrelin as a modulator of function. Such a property provides potential utility for safe intervention in a wide variety of disease states. Indeed as we learn more about the basic physiology of ghrelin, the potential for treating new disease targets emerge requiring validation in the clinic. Each chapter in this volume is authored by a leading investigator in the field. The introductory chapter sets the background for the book and provides a superb overview of the relevance of ghrelin to physiology, describing how the discovery of ghrelin has prompted us to completely rethink traditional physiology. The authors conclude their chapters by critically addressing the future translational aspects of ghrelin biology and outlining what key basic research and clinical questions remain to be addressed. An invaluable resource, Ghrelin in Health and Disease distinguishes itself as the first comprehensive title covering all of the molecular and clinical issues relating to ghrelin and advancing our clinical understanding of obesity, growth, and reproductive pathogenesis.
The Ghrelin System
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Author : A. Benso
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2013-04-22
The Ghrelin System written by A. Benso and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-22 with Medical categories.
The ghrelin story started more than 30 years ago with the discovery of synthetic GH secretagogues. Only in 1999 was ghrelin a natural GH-releasing peptide, discovered. Ghrelin, however, is much more than simply a natural GH secretagogue. In fact, this hormone is one of the most important factors known for regulating appetite and energy expenditure. Furthermore, ghrelin is the trigger for other neuroendocrine, metabolic and nonendocrine actions.This book, written by researchers who provided the major contributions to our current knowledge of this complex system, gives a comprehensive overview of the recent advances in ghrelin research. The hormone's influence on the cardiovascular, metabolic and gastroenteropancreatic system, hypothalamus-pituitary-adrenal axis, prolactin secretion, thyroid axis, gonadal axis as well as on behavior is discussed in detail. Furthermore, the clinical perspectives for ghrelin-derived therapeutic products are presented.Illustrating the tight inter-relationship between endocrinology, metabolism, cardiovascular disease and internal medicine, this book is essential reading for all scientists interested in appetite control, body weight and energy expenditure, as well as diabetes mellitus and neuroendocrinology.
Gut Hormones
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Author : Stephen Robert Bloom
language : en
Publisher:
Release Date : 1981
Gut Hormones written by Stephen Robert Bloom and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1981 with Gastrointestinal hormones categories.
Handbook Of Biologically Active Peptides
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Author : Abba Kastin
language : en
Publisher: Elsevier
Release Date : 2011-04-28
Handbook Of Biologically Active Peptides written by Abba Kastin and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-28 with Science categories.
Peptides play a crucial role in many physiological processes including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience, immunology, pharmacology, and cell biology. The Handbook of Biologically Active Peptides presents, for the first time, this tremendous body of knowledge in the field of biologically active peptides in one single reference. The section editors and contributors represent some of the most sophisticated and distinguished scientists working in basic sciences and clinical medicine. The Handbook of Biologically Active Peptides is a definitive, all-encompassing reference that will be indispensable for individuals ranging from peptide researchers, to biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and to endocrinologists. Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas with which they would not ordinarily be familiar. *Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas that they would not ordinarily be familiar.*Fascinating relationships described in the book include the presence of some peptides originally found in frog skin that persist in the human human and brain where they can affect food intake and obesity.
Global Perspectives On Childhood Obesity
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Author : Debasis Bagchi
language : en
Publisher: Academic Press
Release Date : 2010-10-12
Global Perspectives On Childhood Obesity written by Debasis Bagchi and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-12 with Medical categories.
Understanding the complex factors contributing to the growing childhood obesity epidemic is vital not only for the improved health of the world's future generations, but for the healthcare system. The impact of childhood obesity reaches beyond the individual family and into the public arenas of social systems and government policy and programs. Global Perspectives on Childhood Obesity explores these with an approach that considers the current state of childhood obesity around the world as well as future projections, the most highly cited factors contributing to childhood obesity, what it means for the future both for children and society, and suggestions for steps to address and potentially prevent childhood obesity. This book will cover the multi-faceted factors contributing to the rapidly growing childhood obesity epidemic The underlying causes and current status of rapidly growing obesity epidemic in children in the global scenario will be discussed The strategies for childhood obesity prevention and treatment such as physical activity and exercise, personalized nutrition plans and school and community involvement will be presented
Mechanisms Of Insulin Action
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Author : Alan R. Saltiel
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-10-05
Mechanisms Of Insulin Action written by Alan R. Saltiel and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-10-05 with Medical categories.
More than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. This book attempts to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. It explores insulin action at the most basic levels, through complex systems.
Clinical Neuroendocrinology
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Author : Michael Wilkinson
language : en
Publisher: Cambridge University Press
Release Date : 2019-01-03
Clinical Neuroendocrinology written by Michael Wilkinson and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-03 with Medical categories.
A concise and innovative account of clinical neuroendocrine disorders and the key principles underlying their diagnosis and management.
Free Fatty Acid Receptors
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Author : Graeme Milligan
language : en
Publisher: Springer
Release Date : 2017-02-08
Free Fatty Acid Receptors written by Graeme Milligan and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-08 with Medical categories.
This book highlights the important role free fatty acids (FFA) play as potential drug targets. While FFA have long been considered byproducts of cell metabolism, they are now recognized as ligands that regulate cell and tissue function via G-protein-coupled receptors. At least three receptors have been identified for which FFA appear to be the endogenous ligands.
Growth Hormone In Adults
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Author : Anders Juul
language : en
Publisher: Cambridge University Press
Release Date : 2000-04-27
Growth Hormone In Adults written by Anders Juul and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-04-27 with Medical categories.
This revised new edition reviews the substantial advances in our understanding of the vital role of growth hormone (GH) in maintaining adult health, and the resulting disorders from GH deficiency. The first edition, published in 1996, provided a pioneering overview of the subject; this new edition provides an even more comprehensive account, fully updated with the latest research, clinical applications, and references. The therapeutic benefits of GH treatment in GH deficiency are thoroughly evaluated, including effects on metabolism, cardiac function, exercise performance, psychosocial aspects, and aging and gender-specific effects. This compilation by the world's leading experts covers clinical investigation, diagnosis and treatment issues, and encompasses new knowledge of the control and action of GH secretion. This volume is the most authoritative, comprehensive, and detailed account available and will be an essential source of reference for all endocrinologists.