Glutamate Related Biomarkers For Neuropsychiatric Disorders
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Glutamate Related Biomarkers For Neuropsychiatric Disorders
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Author : Hsien-Yuan Lane
language : en
Publisher: Frontiers Media SA
Release Date : 2020-01-15
Glutamate Related Biomarkers For Neuropsychiatric Disorders written by Hsien-Yuan Lane and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-15 with categories.
Glutamate Related Biomarkers In Drug Development For Disorders Of The Nervous System
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2011-08-05
Glutamate Related Biomarkers In Drug Development For Disorders Of The Nervous System written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-05 with Medical categories.
Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System: Workshop Summary investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop.
Glutamate And Neuropsychiatric Disorders
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Author : Zoran M. Pavlovic
language : en
Publisher: Springer Nature
Release Date : 2022-04-10
Glutamate And Neuropsychiatric Disorders written by Zoran M. Pavlovic and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-10 with Medical categories.
This volume provides a comprehensive overview of recent advances in targeting glutamate signaling for the treatment of major psychiatric and neurological disorders. It draws on the latest findings in glutamate neurobiology and offers valuable insights into the application of translational principles in neuroscience drug discovery and development. In each chapter, glutamate as a neurotransmitter, its receptors and transporters, and their interplay with other neurotransmitters and neurotrophic factors, are discussed in the context of a specific, highly prevalent and disabling CNS disease. Most recent and detailed information is provided on Ischemic Stroke, Chronic Stress, Major Depressive Disorder, Bipolar Disorder, Autism Spectrum Disorders (ASD), Posttraumatic Stress Disorder (PTSD), Alzheimer’s Dementia, Schizophrenia, Impulsive Aggression, Substance Use Disorders (SUD), Amyotrophic Lateral Sclerosis (ALS), Chronic Pain, Multiple Sclerosis, Parkinson’s Disease, Attention Deficit Hyperactivity Disorder (ADHD), Migraine, Epilepsy and Anxiety disorders. Moreover, the book includes an extensive overview of glutamatergic treatments already available on the market, and those which are currently in pharmaceutical drug development pipelines. The primary beneficiaries will be neurology and psychiatry specialists and residents, neuroscientists, neuropharmacologists, pharmaceutical industry and clinical research organization professionals, academics, and clinicians working with psychiatric and neurological patients with comorbidities such as cardiologists, pulmonologists, and endocrinologists. This book will also appeal to psychiatry and neurology subspecialists and clinicians working in neuroscience labs seeking an easy-to-understand yet comprehensive overview of contemporary evidence-based clinical insights backed by basic science (preclinical) research evidence. Given its scope, the book is also a unique and indispensable resource for both preclinical and clinical neuroscientists, medical advisors, and clinical research specialists in the pharmaceutical industry. In addition, it will appeal to neuroscience and neuropsychopharmacology students and guide them through the complexities of glutamate involvement in the pathophysiology of the most common debilitating brain diseases with high unmet medical needs.
Neurophysiologic Biomarkers In Neuropsychiatric Disorders
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Author : Daniel C. Javitt
language : en
Publisher: Springer Nature
Release Date : 2024-11-19
Neurophysiologic Biomarkers In Neuropsychiatric Disorders written by Daniel C. Javitt and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-19 with Medical categories.
This book reviews neurophysiological biomarkers in neuropsychiatric disorders from the viewpoint of the 21st Century Cures Act, which encourages the use of biomarkers for a variety of purposes during drug development. It covers both traditional etiologic uses of biomarkers and the more recent Biomarkers, EndpointS, and other Tools (BEST) classification scheme used by the FDA, which permits biomarkers for purposes of susceptibility, diagnosis, monitoring, prognosis, pharmacodynamics/response, and safety. The first section of the book describes potential uses of neurophysiologic biomarkers. Subsequent sections focus on a wide range of conditions, including schizophrenia, autism spectrum disorder, Parkinson’s disease, and depression, as well as cross-diagnostic and translational uses, including monkey and rodent analogs. The purpose of the book is to help clinicians understand how neurophysiological biomarkers may be used to understand and manage clinical conditions; to help researchers to understand how biomarkers may be used translationally to test specific theories; and to help pharma investigators to understand how biomarkers can be used to accelerate treatment development.
Modulation Of Nmda Receptors From Bench Side To Clinical Applications In Psychiatry
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Author : Natasa Petronijevic
language : en
Publisher: Frontiers Media SA
Release Date : 2022-05-04
Modulation Of Nmda Receptors From Bench Side To Clinical Applications In Psychiatry written by Natasa Petronijevic and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-04 with Medical categories.
The Handbook Of Neuropsychiatric Biomarkers Endophenotypes And Genes
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Author : Michael Ritsner
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-04-21
The Handbook Of Neuropsychiatric Biomarkers Endophenotypes And Genes written by Michael Ritsner and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-04-21 with Science categories.
Neuropsychiatric disorders such as schizophrenia, mood disorders, Alzheimer's disease, epilepsy, alcoholism, substance abuse and others are some of the most debilitating illnesses worldwide characterized by the complexity of causes, and lacking the laboratory tests that may promote diagnostic and prognostic procedures. Recent advances in neuroscience, genomic, genetic, proteomic and metabolomic knowledge and technologies have opened the way to searching biomarkers and endophenotypes, which may offer powerful and exciting opportunities to understand the etiology and the underlying pathophysiological mechanisms of neuropsychiatric disorders. The challenge now is to translate these advances into meaningful diagnostic and therapeutic advances. This book offers a broad synthesis of the current knowledge about diverse topics of the biomarker and endophenotype strategies in neuropsychiatry. The book is organized into four interconnected volumes: “Neuropsychological Endophenotypes and Biomarkers” (with overview of methodological issues of the biomarker and endophenotype approaches in neuropsychiatry and some technological advances), “Neuroanatomical and Neuroimaging Endophenotypes and Biomarkers”, “Metabolic and Peripheral Biomarkers” and “Molecular Genetic and Genomic Markers”. The contributors are internationally and nationally recognized researchers and experts from 16 countries. This four-volume handbook is intended for a broad spectrum of readers including neuroscientists, psychiatrists, neurologists, endocrinologists, pharmacologists, clinical psychologists, general practitioners, geriatricians, health care providers in the field of neurology and mental health interested in trends that have crystallized in the last decade, and trends that can be expected to further evolve in the coming years. It is hoped that this book will also be a useful resource for the teaching of psychiatry, neurology, psychology and mental health.
Biomarkers Of Brain Injury And Neurological Disorders
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Author : Kevin K. W. Wang
language : en
Publisher: CRC Press
Release Date : 2014-10-28
Biomarkers Of Brain Injury And Neurological Disorders written by Kevin K. W. Wang and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-28 with Medical categories.
This book explores the recent advances in the techniques and platforms used in biomarker research that have revolutionized the way we study, diagnose, and treat brain injury conditions. The contributors describe different biomarker studies pertaining to brain injury and other neurological disorders and analyze the different models and technologies
Neurocognitive Behavioral Disorders
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Author : Maureen Nash
language : en
Publisher: Springer
Release Date : 2019-03-27
Neurocognitive Behavioral Disorders written by Maureen Nash and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-27 with Medical categories.
Dementia, now known as major neurocognitive disorder, is not one monolithic disease. Nor is behavior disturbance driven by one particular neurocognitive dysfunction. In fact if we are able to understand it, behavior is an excellent form of nonverbal communication. There are many different causes of dementia. A major challenge with both researching and implementing interventions is viewing dementia and related behaviors as single entities. This approach leaves room for critical errors in the treatment of dementia patients, beginning with misdiagnosis. This book approaches dementia by reviewing cognitive and functional assessments to provide a more accurate diagnosis, which then allows physicians to design specific interventions that are tailored to the person and their challenges. Because person centered care is vital to quality of life and longevity to an aging patient, this understanding of individual needs is vital. Written by experts in the field,this book incorporates the latest evidence-based behavioral interventions matched to specific deficits. Behavioral management focuses not on controlling behavior, but using it to teach staff and caregivers how to interpret common actions and maximize function for people with major neurocognitive disorders. Quality of life and individualized care planning will be the theme and the book will provide practical case examples. The book begins by introducing dementia and other neurocognitive illnesses, contextualizing them both historically and contemporarily. Next, the text focuses on the comprehensive assessment of a person with neurocognitive challenges in order to identify strengths and understand what the person is trying to communicate with their behavior. This process allows individualized care planning and behavioral (non-pharmacologic) management to meet the cognitive challenges and maximize individual strengths and thereby improve outcomes, makingthis a cutting edge resource.
The Development Of Biomarkers In Psychiatry
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Author : Takashi Nakano
language : en
Publisher: Frontiers Media SA
Release Date : 2023-01-03
The Development Of Biomarkers In Psychiatry written by Takashi Nakano and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-03 with Medical categories.
Biomarkers For Huntington S Disease
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Author : Elizabeth A. Thomas
language : en
Publisher: Springer Nature
Release Date : 2023-10-12
Biomarkers For Huntington S Disease written by Elizabeth A. Thomas and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-12 with Medical categories.
Huntington’s disease (HD) is a fatal, inherited, neurodegenerative disorder, characterized by chorea, motor instabilities, psychiatric manifestations and cognitive decline. Early genetic testing provides an opportunity for clinical interventions aimed at delaying onset and/or slowing progression of disease; however, current treatments for HD are limited, with only two FDA-approved drugs available to manage chorea. Encouragingly, however, several disease-modifying treatment approaches are in the therapeutic pipeline, with more than 200 clinical studies, and many more preclinical studies, in the works. Robust and reliable biomarkers are needed to predict disease onset, monitor disease progression and assess treatment responses. More specifically, biomarkers to stratify patients for clinical trials and biomarkers to track drug efficacy will certainly lead to improved clinical trial design and success. This book represents the first book focused solely on biomarkers for HD and represents a distinct resource that will be informative, not only for clinicians and those involved in clinical trial design, but also for a wide range of neurodegenerative disease researchers. This edited volume is written by top leaders in the field, and takes a cross-disciplinary approach to cover a broad spectrum of biomarker types, in order to provide the latest advances in the development of biochemical, molecular, imaging and digital biomarkers that have been investigated for HD. With the ultimate goal of treating patients, the development of disease-associated biomarkers has never been more important.