Guidelines For The Clinical Management Of Thalassaemia
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Guidelines For The Clinical Management Of Thalassaemia
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Author :
language : en
Publisher:
Release Date : 2000
Guidelines For The Clinical Management Of Thalassaemia written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Thalassemia categories.
Guidelines For The Clinical Management Of Thalassaemia
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Author : Maria-Domenica Cappellini
language : en
Publisher:
Release Date : 2008
Guidelines For The Clinical Management Of Thalassaemia written by Maria-Domenica Cappellini and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.
Guidelines For The Management Of Non Transfusion Dependent Thalassaemia Ntdt
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Author : Ali Taher
language : en
Publisher:
Release Date : 2017
Guidelines For The Management Of Non Transfusion Dependent Thalassaemia Ntdt written by Ali Taher and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Iron deficiency anemia categories.
Emergency Management Of Thalassaemia
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Author : John Porter (Hematologist)
language : en
Publisher:
Release Date : 2012
Emergency Management Of Thalassaemia written by John Porter (Hematologist) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.
The multi-organ pathology of the thalassaemias means that the most successful patient treatment programmes involve a number of medical staff, led by paediatricians and haematologists, but including other specialists in a multidisciplinary approach. However, this means that medical professionals not involved in such multidisciplinary groups, including primary care physicians and the staff of Accident and Emergency departments, rarely treat patients with thalassaemia. As a result, their knowledge of how to address acute complications in such patients is extremely limited. This handbook aims to provide a brief evaluation of the situations in which a thalassaemia patient may seek help beyond the specialized environment he/she is used to. The layout of the handbook is intended to enable the medical professional in a busy clinical setting to draw essential information at a glance, supporting rapid, accurate as possible, decisions on how to proceed.
The Obstetric Hematology Manual
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Author : Sue Pavord
language : en
Publisher: Cambridge University Press
Release Date : 2010-04-15
The Obstetric Hematology Manual written by Sue Pavord and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-04-15 with Medical categories.
Obstetric hematology is a fast-growing area of medicine covering the diagnosis and management of hematological problems of pregnancy. Comprehensive in approach, The Obstetric Hematology Manual addresses the many hematological conditions that can cause serious problems in pregnancy, delivery and the post-partum period for both mother and baby. Written by a team of international authorities, this text provides up-to-date, evidence-based guidelines on best care, as well as sound advice based on the experience and opinion of experts. Where appropriate, basic principles are discussed to clarify the rationale for management, and systems and procedures for disease prevention are highlighted. Many conditions and cases are discussed, including venous thromboembolism, pre-eclampsia, anemia, thrombocytopenia and inherited disorders. This book will appeal to both trainees and practitioners in obstetrics, obstetric medicine, obstetric anesthesia and hematology. It is also an accessible text for midwives, nurses, and laboratory staff.
Iron Chelation Therapy
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Author : Chaim Hershko
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Iron Chelation Therapy written by Chaim Hershko and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Within the last few years, iron research has yielded exciting new insights into the under standing of normal iron homeostasis. However, normal iron physiology offers little protec tion from the toxic effects of pathological iron accumulation, because nature did not equip us with effective mechanisms of iron excretion. Excess iron may be effectively removed by phlebotomy in hereditary hemochromatosis, but this method cannot be applied to chronic anemias associated with iron overload. In these diseases, iron chelating therapy is the only method available for preventing early death caused mainly by myocardial and hepatic iron toxicity. Iron chelating therapy has changed the quality of life and life expectancy of thalassemic patients. However, the high cost and rigorous requirements of deferoxamine therapy, and the significant toxicity of deferiprone underline the need for the continued development of new and improved orally effective iron chelators. Such development, and the evolution of improved strategies of iron chelating therapy require better understanding of the pathophysiology of iron toxicity and the mechanism of action of iron chelating drugs. The timeliness of the present volume is underlined by several significant develop ments in recent years. New insights have been gained into the molecular basis of aberrant iron handling in hereditary disorders and the pathophysiology of iron overload (Chapters 1-5).
The Thalassemias
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Author : D. J. Weatherall
language : en
Publisher:
Release Date : 1983
The Thalassemias written by D. J. Weatherall and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1983 with Medical categories.
Prevention Of Thalassaemias And Other Haemoglobin Disorders
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Author : Galanello Renzo
language : en
Publisher:
Release Date : 2003
Prevention Of Thalassaemias And Other Haemoglobin Disorders written by Galanello Renzo and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with categories.
Volume 1 of the Prevention Book presents the principles of a programme for the prevention of the thalassaemia and other haemoglobin disorders, including a description of the various types of disorders requiring prenatal diagnosis, the strategies used for carrier screening, and a number of annexes listing upto date epidemiological and mutation data on thalassaemia. This book was written for use in combination with Volume 2, which describes many of the laboratory protocols in great detail.
Guidelines For The Management Of Non Transfusion Dependent Thalassaemia Ntdt
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Author : Ali Taher
language : en
Publisher:
Release Date : 2013
Guidelines For The Management Of Non Transfusion Dependent Thalassaemia Ntdt written by Ali Taher and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.
The term thalassaemia intermedia describes a form of thalassaemia of intermediate severity between the major, transfusion-dependent forms of the disease and the symptomless carrier states. The term includes many different varieties of thalassaemia including the compound heterozygous state for mild and severe beta thalassaemia mutations or forms of homozygous beta thalassaemia in which genetic modifiers have reduced the severity of the disease, diseases like haemoglobin E beta thalassaemia due to the co-inheritance of a structural haemoglobin variant with beta thalassaemia, the compound heterozygous states for other structural variants such as haemoglobins S or C and beta thalassaemia and a heterogeneous group of forms of alpha thalassaemia that produce haemoglobin H disease of varying severity. The wide clinical variability of these conditions leads to major difficulties in their management. These problems have been magnified over recent years by the discovery that in many forms of thalassaemia intermedia there are a wide range of complications which tend to occur later in the lives of affected patients.
Gene And Cell Therapies For Beta Globinopathies
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Author : Punam Malik
language : en
Publisher: Springer
Release Date : 2017-11-09
Gene And Cell Therapies For Beta Globinopathies written by Punam Malik and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-09 with Medical categories.
Hemoglobin defects, specifically sickle cell disease & thalassemia, combined, constitute the most common monogenic disorders in the world. In fact, nearly 2% of the world’s population carries a globin gene mutation. The transfer of the corrective globin gene through the HSC compartment by allogeneic HSC transplantation (HSCT) has already proven curative in both SCD and thalassemia patients, and provides the proof of concept that genetic manipulation of the defective organ might be equally therapeutic. However, procedural toxicities and the requirement of an HLA-matched sibling donor limit this approach to a fraction of affected individuals. The editors review the progress & the state of the field in HSCT for hemoglobinopathies & shed light on the major changes expected in the next decade. Although allogeneic HSCT is a curative option, it is limited by the availability of matched donors, which are often available only to 15-20% of patients. An alternative to allogeneic HS CT is genetic correction of autologous HSCs, to overcome donor availability & immune side effects. This Book reviews the progress made on additive gene therapy approaches & the current state of the field. Finally, targeted genetic correction is emerging as a novel therapeutic strategy in the hemoglobinopathies. Although ideal, the inefficiency of targeted correction was rate limiting for translation of this technology to the clinic. With advancements in zinc finger nucleases and TALE endonuclease mediated targeted correction, correction frequencies in hematopoietic stem cells is now reaching levels that may become clinically relevant. Furthermore, the ability to generate autologous embryonic stem cell like cells from primary somatic cells (skin fibroblasts or hematopoietic cells) of the affected individual has allowed for the potential application of genetic correction strategies.This Book reviews upcoming genetic strategies to reactivate fetal hemoglobin production and research advances.