Handbook Of Multiple Comparisons
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Handbook Of Multiple Comparisons
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Author : Xinping Cui
language : en
Publisher: CRC Press
Release Date : 2021-11-17
Handbook Of Multiple Comparisons written by Xinping Cui and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-17 with Mathematics categories.
Written by experts that include originators of some key ideas, chapters in the Handbook of Multiple Testing cover multiple comparison problems big and small, with guidance toward error rate control and insights on how principles developed earlier can be applied to current and emerging problems. Some highlights of the coverages are as follows. Error rate control is useful for controlling the incorrect decision rate. Chapter 1 introduces Tukey's original multiple comparison error rates and point to how they have been applied and adapted to modern multiple comparison problems as discussed in the later chapters. Principles endure. While the closed testing principle is more familiar, Chapter 4 shows the partitioning principle can derive confidence sets for multiple tests, which may become important as the profession goes beyond making decisions based on p-values. Multiple comparisons of treatment efficacy often involve multiple doses and endpoints. Chapter 12 on multiple endpoints explains how different choices of endpoint types lead to different multiplicity adjustment strategies, while Chapter 11 on the MCP-Mod approach is particularly useful for dose-finding. To assess efficacy in clinical trials with multiple doses and multiple endpoints, the reader can see the traditional approach in Chapter 2, the Graphical approach in Chapter 5, and the multivariate approach in Chapter 3. Personalized/precision medicine based on targeted therapies, already a reality, naturally leads to analysis of efficacy in subgroups. Chapter 13 draws attention to subtle logical issues in inferences on subgroups and their mixtures, with a principled solution that resolves these issues. This chapter has implication toward meeting the ICHE9R1 Estimands requirement. Besides the mere multiple testing methodology itself, the handbook also covers related topics like the statistical task of model selection in Chapter 7 or the estimation of the proportion of true null hypotheses (or, in other words, the signal prevalence) in Chapter 8. It also contains decision-theoretic considerations regarding the admissibility of multiple tests in Chapter 6. The issue of selected inference is addressed in Chapter 9. Comparison of responses can involve millions of voxels in medical imaging or SNPs in genome-wide association studies (GWAS). Chapter 14 and Chapter 15 provide state of the art methods for large scale simultaneous inference in these settings.
Handbook Of Generalized Pairwise Comparisons
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Author : Marc Buyse
language : en
Publisher: CRC Press
Release Date : 2025-03-31
Handbook Of Generalized Pairwise Comparisons written by Marc Buyse and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-31 with Mathematics categories.
In today's healthcare landscape, there is a pressing need for quantitative methodologies that include the patients' perspective in any treatment decision. Handbook of Generalized Pairwise Comparisons: Methods for Patient-Centric Analysis provides a comprehensive overview of an innovative and powerful statistical methodology that generalizes the traditional Wilcoxon-Mann-Whitney test by extending it to any number of outcomes of any type and including thresholds of clinical relevance into a single, multidimensional evaluation. The book covers the statistical foundations of generalized pairwise comparisons (GPC), applications in various disease areas, implications for regulatory approvals and benefit-risk analyses, and considerations for patient-centricity in clinical research. With contributions from leading experts in the field, this book stands as an essential resource for a more holistic and patient-centric assessment of treatment effects.
Multiple Comparisons
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Author : Jason Hsu
language : en
Publisher: CRC Press
Release Date : 1996-02-01
Multiple Comparisons written by Jason Hsu and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-02-01 with Mathematics categories.
Multiple Comparisons introduces simultaneous statistical inference and covers the theory and techniques for all-pairwise comparisons, multiple comparisons with the best, and multiple comparisons with a control. The author describes confidence intervals methods and stepwise exposes abuses and misconceptions, and guides readers to the correct method for each problem. Discussions also include the connections with bioequivalence, drug stability, and toxicity studies Real data sets analyzed by computer software packages illustrate the applications presented.
Handbook Of Simulation
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Author : Jerry Banks
language : en
Publisher: John Wiley & Sons
Release Date : 1998-09-14
Handbook Of Simulation written by Jerry Banks and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-09-14 with Technology & Engineering categories.
The only complete guide to all aspects and uses of simulation-from the international leaders in the field There has never been a single definitive source of key information on all facets of discrete-event simulation and its applications to major industries. The Handbook of Simulation brings together the contributions of leading academics, practitioners, and software developers to offer authoritative coverage of the principles, techniques, and uses of discrete-event simulation. Comprehensive in scope and thorough in approach, the Handbook is the one reference on discrete-event simulation that every industrial engineer, management scientist, computer scientist, operations manager, or operations researcher involved in problem-solving should own, with an in-depth examination of: * Simulation methodology, from experimental design to data analysis and more * Recent advances, such as object-oriented simulation, on-line simulation, and parallel and distributed simulation * Applications across a full range of manufacturing and service industries * Guidelines for successful simulations and sound simulation project management * Simulation software and simulation industry vendors
Oxford Handbook Of Medical Statistics
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Author : Janet L. Peacock
language : en
Publisher: Oxford University Press
Release Date : 2020-06-11
Oxford Handbook Of Medical Statistics written by Janet L. Peacock and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-11 with Medical categories.
A good understanding of medical statistics is essential to evaluate medical research and to choose appropriate ways of implementing findings in clinical practice. The Oxford Handbook of Medical Statistics has been written to provide doctors and medical students with a comprehensive yet concise account of this often difficult subject. Described by readers as a 'statistical Bible', this new edition maintains the accessibility and thoroughness of the original, and includes comprehensive updates including new sections on transitional medicine, cluster designs, and modern statistical packages. The Handbook promotes understanding and interpretation of statistical methods across a wide range of topics, from study design and sample size considerations, through t- and chi-squared tests, to complex multifactorial analyses, all using examples from published research. References and further reading are included, to allow deeper understanding on specific topics. Featuring a new chapter on how to use this book in different medical contexts, the Oxford Handbook of Medical Statistics helps readers to conduct their own research and critically appraise others' work.
Handbook Of Research Methods In Experimental Psychology
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Author : Stephen F. Davis
language : en
Publisher: John Wiley & Sons
Release Date : 2008-04-15
Handbook Of Research Methods In Experimental Psychology written by Stephen F. Davis and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-15 with Psychology categories.
The Handbook of Research Methods in Experimental Psychology presents a comprehensive and contemporary treatment of research methodologies used in experimental psychology. Places experimental psychology in historical context, investigates the changing nature of research methodology, experimental design, and analytic procedures, and features research in selected content areas. Provides an excellent source of potential research ideas for advanced undergraduate and beginning graduate students. Illustrates the range of research methodologies used in experimental psychology. Contains contributions written by leading researchers. Now available in full text online via xreferplus, the award-winning reference library on the web from xrefer. For more information, visit www.xreferplus.com
Multiple Comparisons
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Author : Alan J. Klockars
language : en
Publisher: SAGE
Release Date : 1986-09
Multiple Comparisons written by Alan J. Klockars and has been published by SAGE this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986-09 with Mathematics categories.
Describes the most important methods used to investigate differences between levels of an independent variable within an experimental design. Readers will learn not only how to conduct multiple comparisons in experimental designs but also how to better understand and evaluate published research. "A highly readable introduction to multiple comparison methods, which demands little from its reader in the way of background other than some familiarity with analysis of variance." --The Statistician
A Handbook Of Neuropsychological Assessment
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Author : John R. Crawford
language : en
Publisher: Routledge
Release Date : 2018-09-03
A Handbook Of Neuropsychological Assessment written by John R. Crawford and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-03 with Psychology categories.
Originally published in 1992, this is a wide-ranging text concerned with the principles and practice of neuropsychological assessment in adults. It combines a flexible hypothesis testing approach to assessment with information on specialised test batteries. The book covers the major areas of memory, language, perception, attention, and executive dysfunctions, and includes chapters on dementia, alcohol, drug and toxic conditions, stroke and closed head injury. Assessment of dysfunction in cases involving claims for compensation and chapters on specialised assessment techniques, including automated test procedures, are provided. The book presents a sound introduction to this complex area and gives guidelines for the clinician who may need concise information on a specialised topic.
Toxicological Testing Handbook
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Author : David Jacobson-Kram
language : en
Publisher: CRC Press
Release Date : 2016-04-19
Toxicological Testing Handbook written by David Jacobson-Kram and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Medical categories.
Furnishing essential data on all areas of toxicity testing, this Second Edition provides guidance on the design and evaluation of product safety studies to help ensure regulatory acceptance. Every chapter highlights regulatory requirements specific to the United States, Europe, and Japan, and in addition to expanded information on da
Handbook Of Ethics In Quantitative Methodology
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Author : A. T. Panter
language : en
Publisher: Taylor & Francis
Release Date : 2011-03-01
Handbook Of Ethics In Quantitative Methodology written by A. T. Panter and has been published by Taylor & Francis this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-03-01 with Psychology categories.
This comprehensive Handbook is the first to provide a practical, interdisciplinary review of ethical issues as they relate to quantitative methodology including how to present evidence for reliability and validity, what comprises an adequate tested population, and what constitutes scientific knowledge for eliminating biases. The book uses an ethical framework that emphasizes the human cost of quantitative decision making to help researchers understand the specific implications of their choices. The order of the Handbook chapters parallels the chronology of the research process: determining the research design and data collection; data analysis; and communicating findings. Each chapter: Explores the ethics of a particular topic Identifies prevailing methodological issues Reviews strategies and approaches for handling such issues and their ethical implications Provides one or more case examples Outlines plausible approaches to the issue including best-practice solutions. Part 1 presents ethical frameworks that cross-cut design, analysis, and modeling in the behavioral sciences. Part 2 focuses on ideas for disseminating ethical training in statistics courses. Part 3 considers the ethical aspects of selecting measurement instruments and sample size planning and explores issues related to high stakes testing, the defensibility of experimental vs. quasi-experimental research designs, and ethics in program evaluation. Decision points that shape a researchers’ approach to data analysis are examined in Part 4 – when and why analysts need to account for how the sample was selected, how to evaluate tradeoffs of hypothesis-testing vs. estimation, and how to handle missing data. Ethical issues that arise when using techniques such as factor analysis or multilevel modeling and when making causal inferences are also explored. The book concludes with ethical aspects of reporting meta-analyses, of cross-disciplinary statistical reform, and of the publication process. This Handbook appeals to researchers and practitioners in psychology, human development, family studies, health, education, sociology, social work, political science, and business/marketing. This book is also a valuable supplement for quantitative methods courses required of all graduate students in these fields.