Heat Shock Proteins And The Cardiovascular System
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Heat Shock Proteins And The Cardiovascular System
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Author : A.A. Knowlton
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Heat Shock Proteins And The Cardiovascular System written by A.A. Knowlton and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Heat shock proteins (HSP) were originally described in heat-shocked drosophila by Ritossa in the early 1960's. In the last 5 years it has become apparent that these heat shock proteins have important functions both in the normal cell and in the stressed cell. These proteins constitute an endogenous protective system; mutations in the heat shock proteins can be lethal, and there are no known organisms without heat shock proteins. The first observations on heat shock proteins and the heart were made in the 1980's and interest in these proteins increased over the decade. In the last few years there has been an exponential growth in number of papers published on heat shock proteins and the heart. Heat shock proteins have been implicated in a number of cardiovascular research areas including ischemia, hypertrophy, aging, and atherosclerosis, and this list is growmg. The purpose of this volume is to give an overview of our current understanding of the heat shock proteins in the cardiovascular system, and to summarize the approaches to the study of heat shock proteins in the heart. This volume assembles results from a number of different cardiovascular fields. and provides a comprehensive review of heat shock proteins in the cardiovascular system.
Heat Shock Proteins In Cardiovascular Diseases
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Author : Satoru Takeuchi
language : en
Publisher: Nova Biomedical Books
Release Date : 2012
Heat Shock Proteins In Cardiovascular Diseases written by Satoru Takeuchi and has been published by Nova Biomedical Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Cardiovascular system categories.
Heat shock proteins (HSPs) are of historical importance and interest since their discovery in Drosophila chromosomes during elevated temperatures. HSP expression is transcriptionally regulated and is highly specialised in eukaryotes where their induction is based on heat shock mRNA lacking in introns and is thus instantaneous in response to stress. HSPs are implicated in a variety of physiological imbalances. The precise roles of these chaperones in cardiovascular system are an interesting arena but not yet fully understood. This book is a dedicated effort in a concerted approach to describe the various HSPs that are elicited in cardiovascular diseases and to provide an interface between clinicians and biochemists in a concise platform.
Heat Shock Protein 60 In Human Diseases And Disorders
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Author : Alexzander A. A. Asea
language : en
Publisher: Springer Nature
Release Date : 2019-10-31
Heat Shock Protein 60 In Human Diseases And Disorders written by Alexzander A. A. Asea and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-31 with Science categories.
The book Heat Shock Protein 60 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP60 in human diseases and disorders. Using an integrative approach, the contributors provide a synopsis of novel mechanisms and signal transduction pathways. To enhance the ease of reading and comprehension the book has further been subdivided into various section including; Section I: Biomolecular Aspects of HSP60; Section II: HSP60 and Cancer; Section III: HSP60 and Inflammatory Diseases and Disorders; Section IV: HSP60 and Cardiovascular Diseases and Disorders; Section V: HSP60 and Neurological and Neurosciences; Section VI: Biomolecular Aspects of HSP60; Section VII: HSP60 and Skeletal Muscle Diseases and Disorders; and Section VIII: HSP60 in Human Health. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Neurology & Neuroscience, Oncology, Cardiovascular Disease, Skeletal Muscle Diseases and Disorders, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
Heat Shock Proteins In Myocardial Protection
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Author : Rakesh C. Kukreja
language : en
Publisher: CRC Press
Release Date : 2000-08-01
Heat Shock Proteins In Myocardial Protection written by Rakesh C. Kukreja and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-08-01 with Science categories.
Myocardial ischemic syndromes pose a major medical problem and a significant economic health care concern. Reperfusion, although used in the clinical arena as essential to the survival of acutely ischemic heart muscle carries with it the risk of "reperfusion injury". Therefore the salvage of additional myocardium is highly desirable. Over a decade ago, it was shown that whole body heat shock activated a powerful endogenous protective mechanism that significantly improved myocardial salvage following prolonged ischemia and reperfusion injury in the heart. A characteristic feature of this heat shock response was the expression of a family of proteins known as heat shock proteins. Many of these proteins function as molecular chaperones, helping to refold proteins denatured as a consequence of lethal injuries and facilitating the synthesis of new proteins to replace those irreparably damaged. Altered expression of these proteins has been extensively documented in association with a diverse array of diseases such as ischemia and perfusion injury, cardiac hypertrophy, fever, inflammation, metabolic diseases, infection, cell and tissue trauma, aging, and cancer. Interestingly, some studies have now shown a direct correlation of the heat shock proteins produced and the degree of myocardial protection. This book is a thorough description of the current state of knowledge of the mechanisms of heat shock proteins induced cardiac protection at the cellular and molecular level, the controversies in this growing field and the potential of treating ischemic heart disease with overexpression of heat shock proteins in patients. The book will be especially useful for investigators interested in studying tissue injury and its protection with the overexpression of heat shock proteins.
Heat Shock Proteins In Human Diseases
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Author : Alexzander A. A. Asea
language : en
Publisher: Springer Nature
Release Date : 2021-03-23
Heat Shock Proteins In Human Diseases written by Alexzander A. A. Asea and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-23 with Science categories.
The book Heat Shock Proteins in Cancer Therapeutics provides the most comprehensive review on contemporary knowledge on the role of HSP in various types of cancer therapeutics. Using an integrative approach, the contributors provide a synopsis of the most current updates on the state of HSP in cancer therapeutics. The heat shock response pathway is a highly conserved cellular process. Heat shock factors are a master transcriptional regulator responsible for expression of several important heat shock proteins, which can effectively protect critical client proteins from misfolding and degradation, thus maintaining intracellular integrity under stressed conditions. Recent studies have demonstrated the direct connections between heat shock response players and tumor cell survival, validating heat shock response players as novel molecular targets in anticancer treatment. Although many hurdles in clinical application still need to be effectively addressed, such as undesirable drug toxicity and off target effects; narrow therapeutic window; poor PK/PD profiles, etc. Recent reports on synergistic drug combination, advanced prodrug design, smart nanoparticle packaging, and RNA aptamer selection offer promising solutions to overcome these challenges. Future advancements in this fast-growing area can potentially lead to the next generation of cancer therapeutics. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Cancer Biology, Oncology, Translational Medicine, Clinical Research, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
Cardiac Small Heat Shock Proteins And Their Roles In Maintaining The Integrity Of The Cytoskeletal System
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Author : Zihao Wang
language : en
Publisher:
Release Date : 2021
Cardiac Small Heat Shock Proteins And Their Roles In Maintaining The Integrity Of The Cytoskeletal System written by Zihao Wang and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with categories.
The Role Of Inhibitor 1 And Heat Shock Protein 20 In Cardiac Pathophysiology
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Author : Persoulla Nicolaou
language : en
Publisher:
Release Date : 2008
The Role Of Inhibitor 1 And Heat Shock Protein 20 In Cardiac Pathophysiology written by Persoulla Nicolaou and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.
Cardiovascular disease, which remains the leading cause of mortality in the Western world, is manifested in contractile dysfunction, myocardial infarction and arrhythmias. These detrimental effects are partially attributed to impaired Ca cycling and cell death. Since calsequestrin (CSQ) and inhibitor-1 (I-1) are key regulators of Ca cycling and the anti-apoptotic small heat shock protein 20 (Hsp20) is an important mediator of cardioprotection, this dissertation sought to gain further insights into the role of these proteins in cardiac pathophysiology. CSQ is a crucial regulator of Ca load in the sarcoplasmic reticulum and the Ca-release channel, the ryanodine receptor. Interestingly, human CSQ null mutations have been associated with catecholaminergic polymorphic ventricular tachycardia (CPVT). To further address the significance of CSQ and CSQ null mutations, this dissertation attempted to generate a mouse model with ablation of CSQ. I-1 and its phosphorylation at Thr35 are important mediators of the heart's beta-adrenergic responses. To address any potential beneficial effects of enhanced I-1 activity in the adult heart, a mouse model with inducible expression of active I-1 (T35D) was generated. Active I-1 expression significantly enhanced contractility, associated with preferential phospholamban (PLN) and myosin light chain 2a phosphorylation. Upon ischemia/reperfusion (I/R), active I-1 augmented contractile function, associated with increased pThr17-PLN phosphorylation. Further examination revealed that the infarct region and apoptotic as well as necrotic injury were significantly attenuated by enhanced I-1 activity, associated with suppression of the endoplasmic reticulum stress response. These findings indicate that active I-1 may represent a potential therapeutic strategy in myocardial infarction. Hsp20 and its phosphorylation at Ser16 protect cardiomyocytes against apoptosis. To determine whether genetic variants exist in human Hsp20, which may modify these beneficial effects, the Hsp20 gene was sequenced in dilated cardiomyopathic patients and individuals with no heart disease. A C59T substitution was identified in Hsp20 in one patient and three individuals without heart disease. This mutation changes a conserved proline residue into leucine at position 20 (P20L), resulting in secondary structural alterations. The significance of this variant was assessed by subjecting cardiomyocytes, infected with Ad. GFP, Ad. WT-Hsp20 and Ad. P20L-Hsp20, to simulated ischemia/reperfusion. Expression of WT-Hsp20 significantly attenuated apoptotic injury, while the P20L-Hsp20 mutant showed no protection. This was associated with the mutant's diminished phosphorylation at Ser16. Furthermore, stimulation of cardiomyocytes with isoproterenol and protein kinase A-dependent phosphorylation in vitro confirmed the impaired ability of the mutant Hsp20 to become phosphorylated at Ser16. These findings indicate that the P20L substitution in Hsp20, may adversely affect the ability of human carriers to cope with cellular stress. Furthermore, a C29T transversion was identified exclusively in black cardiomyopathic males. This mutation results in substitution of serine at position 10 to phenylalanine (S10F), with similar structural alterations to the P20L mutant, suggesting that the S10F substitution may also have adverse effects on Hsp20's cardioprotective properties. Collectively, this dissertation provides novel insights into the role of these key regulatory proteins in the diseased myocardium, further illuminating the molecular and genetic defects, associated with cardiovascular disease, which may provide potential therapeutic strategies to alleviate its detriment.
Heat Shock Proteins And Whole Body Physiology
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Author : Alexzander A. A. Asea
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-12-10
Heat Shock Proteins And Whole Body Physiology written by Alexzander A. A. Asea and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-10 with Medical categories.
Heat Shock Proteins and Whole Body Physiology is an exciting new book in the Heat Shock Proteins series which provides the most up-to-date review on novel mechanisms insights into the important role played by heat shock proteins in human physiology. Written by leaders in the field of heat shock protein exercise physiology, neuroscience and aging, the chapters systematically and in a step wise fashion takes the reader through the fascinating mechanisms by which heat shock proteins modulate human disease and pathophysiology and provides answers as to its biological significance to the host. Section I, introduces the readers to the role played by heat shock proteins in various diseases and disorders (Heat Shock Proteins and Disease). Section II, addresses the role heat shock proteins play in psychological disorders including post traumatic stress disorders and learning (Heat Shock Proteins and Psychological Stress). Section III, present a detailed review of the role played by heat shock proteins in exercise physiology (Heat Shock Proteins and Exercise Physiology). This book is a must read for heat shock protein researchers, graduate and postgraduate fellows in the field of Medicine in general and specialities in Excersie Physiology, Neuroscience, Immunology, Aging and Pathology.
Small Heat Shock Proteins And Protection Against Cardiac Ischemic Damage
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Author : Jody L. Martin
language : en
Publisher:
Release Date : 1997
Small Heat Shock Proteins And Protection Against Cardiac Ischemic Damage written by Jody L. Martin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with categories.
Redox And Nitrosative Signaling In Cardiovascular System From Physiological Response To Disease
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Author : Mariarosaria Santillo
language : en
Publisher: Frontiers Media SA
Release Date : 2019-01-22
Redox And Nitrosative Signaling In Cardiovascular System From Physiological Response To Disease written by Mariarosaria Santillo and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-22 with Electronic books categories.
The role of ROS/RNS signaling in cardiovascular functions and diseases is increasingly emerging in the last decades. The involvement of ROS/RNS in the control of a large number of cardiovascular functions like the regulation of the vascular tone, the control of blood pressure or myocyte excitation-contraction coupling and force development has been broadly investigated and in part clarified. On the other hand, many efforts have been focused in clarifying the redox mechanisms involved in cardiovascular diseases like ischemia/reperfusion injury, diabetes-associated cardiovascular dysfunctions, atherosclerosis or hypertension, just to mention the major ones. However, in most cases the two levels of investigation remain separate and not interlaced, failing in the attempt to provide a unified vision of the pathophysiologic mechanisms of cardiovascular diseases. The major aim of the Research Topic has been to collect original papers and review articles dealing with the issue from basic to translation research point of views. The topic includes contributions that highlight different interesting aspects of cardiovascular biology with an integrated approach useful for the development of new ideas and advancements in the field of redox signaling in the control of normal cardiovascular functions and their disruption in diseases.