Redox And Nitrosative Signaling In Cardiovascular System From Physiological Response To Disease
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Redox And Nitrosative Signaling In Cardiovascular System From Physiological Response To Disease
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Author : Mariarosaria Santillo
language : en
Publisher: Frontiers Media SA
Release Date : 2019-01-22
Redox And Nitrosative Signaling In Cardiovascular System From Physiological Response To Disease written by Mariarosaria Santillo and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-22 with categories.
The role of ROS/RNS signaling in cardiovascular functions and diseases is increasingly emerging in the last decades. The involvement of ROS/RNS in the control of a large number of cardiovascular functions like the regulation of the vascular tone, the control of blood pressure or myocyte excitation-contraction coupling and force development has been broadly investigated and in part clarified. On the other hand, many efforts have been focused in clarifying the redox mechanisms involved in cardiovascular diseases like ischemia/reperfusion injury, diabetes-associated cardiovascular dysfunctions, atherosclerosis or hypertension, just to mention the major ones. However, in most cases the two levels of investigation remain separate and not interlaced, failing in the attempt to provide a unified vision of the pathophysiologic mechanisms of cardiovascular diseases. The major aim of the Research Topic has been to collect original papers and review articles dealing with the issue from basic to translation research point of views. The topic includes contributions that highlight different interesting aspects of cardiovascular biology with an integrated approach useful for the development of new ideas and advancements in the field of redox signaling in the control of normal cardiovascular functions and their disruption in diseases.
Physiological And Pathological Role Of Ros Benefits And Limitations Of Antioxidant Treatment
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Author : Sergio Di Meo
language : en
Publisher: MDPI
Release Date : 2021-01-21
Physiological And Pathological Role Of Ros Benefits And Limitations Of Antioxidant Treatment written by Sergio Di Meo and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-21 with Science categories.
ROS were long considered one of the key players in tissue injury. Indeed, overproduction of ROS results in oxidative stress, a process leading to the development of many pathological conditions. For the treatment of these conditions, the use of antioxidants was proposed. Over time, it was shown that ROS at low concentrations act as signaling molecules, leading to the regulation of physiological functions. Moreover, several interventions that increase ROS generation activate stress-adaptive responses that extend the lifespan. It was also shown that excessive use of antioxidants can counter the beneficial effects of ROS. Currently, much progress has been made in understanding the role of ROS in human diseases and aging, as well as in the regulation of physiological functions, and in identifying the signaling pathways involved in ROS. However, much remains to be understood about the mutual interactions among signaling pathways underlying organisms’ adaptive responses, their modifications (which occur during aging), and some disease states. The aim of this Special Issue is to underline the effects of ROS production and antioxidant treatment in living organisms, focusing on their impact on health, disease, and aging.
Pulmonary Vasculature Redox Signaling In Health And Disease
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Author : Yong-Xiao Wang
language : en
Publisher: Springer
Release Date : 2017-10-18
Pulmonary Vasculature Redox Signaling In Health And Disease written by Yong-Xiao Wang and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-18 with Medical categories.
The main goal of this book is to form a high-quality platform in which well-known and emerging pioneering basic, translational and clinical scientists can present their latest, exciting findings in the studies of redox signaling in the pulmonary vasculature. Content from outstanding investigators with unique expertise and skills of molecular and cell biology, biochemistry, physiology, pharmacology, biophysics, biotechnology and medicine will update our current out-of-date concepts with new knowledge. Rapidly increasing scientific studies have gathered a large volume of novel and important information on redox signaling in healthy and diseased pulmonary vasculature. This volume covers the need for a cohesive book to display state-of-the-art advances in the field. The second major aim of this book is to help direct future research. Redox signaling is a major molecular process involved in almost every physiologic cellular response in the pulmonary vasculature including energy metabolism, host defense, gene expression, contraction, proliferation, and migration. Aberrancy in this important signaling pathway leads to a critical role in the development of nearly all pulmonary diseases, such as pulmonary hypertension, cor pulmonale, pulmonary edema, and vasculitis, among others.
Modulation Of Oxidative Stress In Heart Disease
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Author : Sajal Chakraborti
language : en
Publisher: Springer Nature
Release Date : 2019-11-10
Modulation Of Oxidative Stress In Heart Disease written by Sajal Chakraborti and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-10 with Science categories.
This book highlights the multifaceted roles of Reactive Oxygen Species (ROS) in modulating normal cellular and molecular mechanisms during the development of different types of heart disease. Each chapter in the book deals with the role that altered redox homeostasis plays in the pathophysiology of heart disease. In addition, the book explains how reactive oxidant species interact with their targets and provides novel strategies for attenuating oxidative stress-induced types of heart disease. The book not only covers ROS-induced response in heart disease at the cellular level, but also demonstrates that an imbalance of redox states has its roots in our genes, and explains the ways gene expression is regulated. In turn, it reviews potential sources of ROS, their pathological effects on the heart, and potential sites for therapeutic interventions.
Stress Physiology Biochemistry And Pathology
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Author : George Fink
language : en
Publisher: Academic Press
Release Date : 2019-01-12
Stress Physiology Biochemistry And Pathology written by George Fink and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-12 with Science categories.
Stress impacts the daily lives of humans and all species on Earth.Physiology, Biochemistry, and Pathology, the third volume of the Handbook of Stress series, covers stress-related or induced physiology, biochemistry, and pathology. Integrated closely with new behavioral findings and relevance to human conditions, the concepts and data in this volume offer readers cutting-edge information on the physiology of stress.A sequel to Elsevier's Encyclopedia of Stress (2000 and 2007), this Handbook of Stress series covers the many significant advances made since then and comprises self-contained volumes that each focus on a specific area within the field of stress. Targeted at scientific and clinical researchers in neuroendocrinology, neuroscience, biomedicine, endocrinology, psychology, psychiatry, the social sciences, and stress and its management in the workplace, this volume and series are ideal for graduate students, post-doctoral fellows, and faculty interested in stress and its consequences. - Chapters offer impressive scope, with topics addressing stress-related or induced physiology, biochemistry, and pathology - Articles carefully selected by eminent stress researchers and prepared by contributors representing outstanding scholarship in the field, with each chapter fully vetted for reliable expert knowledge - Richly illustrated with explanatory figures and tables - Each chapter has a boxed "Key points call out section - The volume is fully indexed - All chapters are electronically available via ScienceDirect - Affordably priced, self-contained volume for readers specifically interested in the physiology, biochemistry and pathology of stress, avoiding the need to purchase the whole Handbook series
Endothelial Signaling In Vascular Dysfunction And Disease
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Author : Shampa Chatterjee
language : en
Publisher: Academic Press
Release Date : 2021-01-20
Endothelial Signaling In Vascular Dysfunction And Disease written by Shampa Chatterjee and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-20 with Science categories.
Endothelial Signaling in Vascular Dysfunction and Disease: From Bench to Bedside provides a detailed understanding of the endothelium, its activation and their link to some common clinical disorders. In addition, the book covers earlier discoveries, including those from the last and 19th centuries. It is split into five sections that cover the vascular tree as an integrative structure, the endothelium in inflammation, endothelial signaling, activation and toxicity with chemotherapy, radiation induced endothelial dysfunction and vascular disease, and therapies in combating vascular diseases. Each section is discussed with a translational approach in order to make the content truly applicable. This book is a valuable source for basic researchers, clinicians in the fields of Oncology, Cardiovascular Medicine and Radiology, and members of the biomedical field who are conducting studies related to the endothelium and vascular disease. - Discusses the most relevant discoveries in endothelial biology and their link to manifestations of clinical disease - Presents history and diagrams in each section to highlight the original biological discovery and its link of clinical manifestations of vascular disease - Includes recent findings on the relationship between endothelial signaling, chemotherapy and radiation induced endothelial dysfunction
Novel Prospects In Oxidative And Nitrosative Stress
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Author : Pinar Atukeren
language : en
Publisher: BoD – Books on Demand
Release Date : 2018-05-09
Novel Prospects In Oxidative And Nitrosative Stress written by Pinar Atukeren and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-09 with Science categories.
Oxidative stress plays a crucial role in the pathophysiology of various diseases when there is a disruption of the intracellular redox balance and the homeostatic balance between cellular oxidants and antioxidants. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) react with molecular targets including proteins, lipids, and nucleic acids contributing to mitochondrial injury and cellular dysfunction. This book intends to provide the readers with an extensive overview of the novel approaches and prospects based on oxidative and nitrosative stress in the pathophysiology of various diseases and in the current treatment strategies with antioxidants.
Primer On The Autonomic Nervous System
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Author : Italo Biaggioni
language : en
Publisher: Academic Press
Release Date : 2022-12-07
Primer On The Autonomic Nervous System written by Italo Biaggioni and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-07 with Medical categories.
Primer on the Autonomic Nervous System, Fourth Edition provides a concise and accessible overview of autonomic neuroscience for students, scientists, and clinicians. The book's 142 chapters draw on the expertise of more than 215 basic scientists and clinicians who discuss key information on how the autonomic nervous system controls the body, particularly in response to stress. This new edition also focuses on the translational crossover between basic and clinical research. In addition to comprehensively covering all aspects of autonomic physiology and pathology, topics such as psychopharmacology decoding and modulating nerve function are also explored. - Provides concise and practical information on the autonomic nervous system - Discusses all aspects of autonomic physiology and pathology - Contains new content on psychopharmacology and modulating nerve function
Free Radical Biology Of Endocrine Metabolic Immune Disorders
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Author : Asis Bala
language : en
Publisher: Bentham Science Publishers
Release Date : 2022-04-20
Free Radical Biology Of Endocrine Metabolic Immune Disorders written by Asis Bala and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-20 with Medical categories.
This reference explores the science of signaling mechanisms associated with diseases like endocrine, metabolic and immune disorders which are linked to oxidative stress mediated disease mechanisms. The common diseases in these categories include diabetes mellitus and arthritis and conditions defined by inflammation and autoimmunity. These diseases involve metabolic pathways mediated by reactive oxygen species or free radicals. The pathways are targets in the mechanism of drugs which aim to treat related disorders. The book covers key topics in free radical biology that help to understand the nature of the pathways and the pharmacology of the drugs that are designed to target them.5 chapters elucidate the free radical biology of the diseases.1. Role of free radical biology in diabetes mellitus2. Role of GSK3 in regulation of insulin release and glucose metabolism3. Regulatory role of NRF2 in rheumatoid arthritis4. Role of free radical biology in Alzheimer’s disease5. Regulatory role of immune cells mediated antibody on rheumatoid arthritis Key features:- Elucidates the key biochemical and pharmacological mechanisms that are mediated by free radicals in common endocrine, metabolic and immune diseases- Explains the activation of immunological factors (like RF and ACPA) that trigger inflammation and arthritis- Covers the role of free radicals in Alzheimer’s disease and new interventions that target mitochondrial mechanisms- Systematically explains the molecular biology of free radicals with the help of schematic diagrams - Includes references for further reading The accessible and structured text in this reference make it a suitable resource for all biomedical scientists, faculty and postgraduate students in academia and industry.
Oxidative Nitrosative Stress And Disease Volume 1203
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Author : Debra L. Laskin
language : en
Publisher: Wiley-Blackwell
Release Date : 2010-09-07
Oxidative Nitrosative Stress And Disease Volume 1203 written by Debra L. Laskin and has been published by Wiley-Blackwell this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-07 with Medical categories.
"This volume presents manuscripts stemming from the '4th International Conference on Oxidative/Nitrosative Stress and Disease,' held on October 29-30, 2009 at the New York Academy of Sciences"--Contents