High Throughput Screening Methods In Toxicity Testing
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High Throughput Screening Methods In Toxicity Testing
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Author : Pablo Steinberg
language : en
Publisher: John Wiley & Sons
Release Date : 2013-02-26
High Throughput Screening Methods In Toxicity Testing written by Pablo Steinberg and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-02-26 with Science categories.
Explores the benefits and limitations of the latest high-throughput screening methods With its expert coverage of high-throughput in vitro screening methods for toxicity testing, this book makes it possible for researchers to accelerate and streamline the evaluation and risk assessment of chemicals and drugs for toxicity. Moreover, it enables them to comply with the latest standards set forth by the U.S. National Research Council's "Toxicity Testing in the 21st Century: A Vision and Strategy" and the E.U.'s REACH legislation. Readers will discover a variety of state-of-the-science, high-throughput screening methods presented by a group of leading authorities in toxicology and toxicity testing. High-Throughput Screening Methods in Toxicity Testing is divided into five parts: General aspects, including predicting the toxicity potential of chemicals and drugs via high-throughput bioactivity profiling Assessing different cytotoxicity endpoints Assessing DNA damage and carcinogenesis Assessing reproductive toxicity, cardiotoxicity, and haematotoxicity Assessing drug metabolism and receptor-related toxicity Each chapter describes method principles and includes detailed information about data generation, data analysis, and applications in risk assessment. The authors not only enumerate the advantages of each high-throughput method over comparable conventional methods, but also point out the high-throughput method's limitations and potential pitfalls. In addition, the authors describe current research efforts to make high-throughput toxicity screening even more cost effective and streamlined. Throughout the book, readers will find plenty of figures and illustrations to help them understand and perform the latest high-throughput toxicity screening methods. This book is ideal for toxicologists and other researchers who need to implement high-throughput screening methods for toxicity testing in their laboratories as well as for researchers who need to evaluate the data generated by these methods.
Applications Of Toxicogenomic Technologies To Predictive Toxicology And Risk Assessment
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2007-11-19
Applications Of Toxicogenomic Technologies To Predictive Toxicology And Risk Assessment written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-19 with Science categories.
The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new waysâ€"an effort requiring funding, interagency coordination, and data management strategies.
High Throughput Screening In Drug Discovery
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Author : Jörg Hüser
language : en
Publisher: John Wiley & Sons
Release Date : 2006-12-13
High Throughput Screening In Drug Discovery written by Jörg Hüser and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-12-13 with Science categories.
Backed by leading authorities, this is a professional guide to successful compound screening in pharmaceutical research and chemical biology, including the chemoinformatic tools needed for correct data evaluation. Chapter authors from leading pharmaceutical companies as well as from Harvard University discuss such factors as chemical genetics, binding, cell-based and biochemical assays, the efficient use of compound libraries and data mining using cell-based assay results. For both academics and professionals in the pharma and biotech industries working on small molecule screening.
A New Paradigm For Environmental Chemistry And Toxicology
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Author : Guibin Jiang
language : en
Publisher: Springer
Release Date : 2019-08-09
A New Paradigm For Environmental Chemistry And Toxicology written by Guibin Jiang and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-09 with Science categories.
This book provides comprehensive coverage of the theoretical developments and technological breakthroughs that have deepened our understanding of environmental pollution and human health, while also promoting a comprehensive strategy to address these problems. The respective chapters highlight groundbreaking concepts fueling the development of environmental chemistry and toxicology; revolutionary analytical and computational approaches providing novel insights into environmental health; and nature-inspired, innovative engineering solutions for tackling complex hazardous exposures. The book also features a forward-looking perspective on emerging environmental issues that call for new research and regulatory paradigms, laying the groundwork for future advances in the broad field of environmental chemistry and toxicology. Written by respected authorities in the field, A New Paradigm for Environmental Chemistry and Toxicology - From Concepts to Insights will offer an invaluable reference guide for concerned researchers and professional practitioners for years to come.
Cell Based Assays For High Throughput Screening
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Author : Paul A. Clemons
language : en
Publisher: Humana Press
Release Date : 2009-04-28
Cell Based Assays For High Throughput Screening written by Paul A. Clemons and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-04-28 with Science categories.
As the use of high-throughput screening expands and creates more interest in the academic community, the need for detailed reference materials becomes ever more pressing. Cell-Based Assays for High-Throughput Screening: Methods and Protocols aims to fill an important part of this need by providing an easily accessible reference volume for cell-based phenotypic screening. Leading researchers in the field contribute state-of-the-art methods with actionable protocols covering four major areas of study: model biological systems, screening modalities and assay systems, detection technologies, and approaches to data analysis. Written in the highly successful Methods in Molecular BiologyTM series format, each chapter includes a brief introduction to the subject, lists of necessary materials and reagents, step-by-step laboratory protocols, and a Notes section detailing tips on troubleshooting and avoiding known pitfalls. Cutting-edge and easy-to-use, Cell-Based Assays for High-Throughput Screening: Methods and Protocols presents an overview of relevant approaches, enabling the direct application of existing methods to new discoveries while also inspiring researchers to approach their screening projects in a conceptually modular fashion, enhancing the power to discover through new combinations of existing approaches.
Hayes Principles And Methods Of Toxicology
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Author : A. Wallace Hayes
language : en
Publisher: CRC Press
Release Date : 2014-10-10
Hayes Principles And Methods Of Toxicology written by A. Wallace Hayes and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-10 with Medical categories.
Hayes' Principles and Methods of Toxicology has long been established as a reliable reference to the concepts, methodologies, and assessments integral to toxicology. The new sixth edition has been revised and updated while maintaining the same high standards that have made this volume a benchmark resource in the field. With new authors and new chap
Law Animals And Toxicity Testing
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Author : Anne M. Wordsworth
language : en
Publisher: Taylor & Francis
Release Date : 2024-09-02
Law Animals And Toxicity Testing written by Anne M. Wordsworth and has been published by Taylor & Francis this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-09-02 with Law categories.
Drawing on our growing knowledge of animal cognition, this book provides a critical analysis of the use of animals in the legal regime and the practice of toxicity testing. Although animal abuse has become a major issue, animal testing remains largely in the shadows, even though it involves substantial cruelty. Toxicity testing, in particular, imposes considerable pain, suffering and ultimately death on those laboratory animals – often mice – chosen to demonstrate the characteristics of chemicals and their commercial potential. This book documents and critically analyzes the animal protection laws of the European Union, the United States and Canada. It not only examines the tests themselves and the suffering they inflict on animals but also exposes the failure of both the testing and the toxicity laws to effectively protect human health and the environment. Finally, the book takes up the potential of alternative non-animal testing methods to replace the current regimen and to reduce current damage to health and the environment. This book will be of interest to scholars and researchers in the fields of animal studies, environmental law and sociolegal studies, as well as activists and others with an interest in ethics and animal rights.
Public Health And Toxicology Issues In Drug Research Volume 2
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Author : Rakesh Kumar Tekade
language : en
Publisher: Elsevier
Release Date : 2024-03-26
Public Health And Toxicology Issues In Drug Research Volume 2 written by Rakesh Kumar Tekade and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-26 with Medical categories.
Toxicodynamics in Drug Research, Volume 2: Public Health and Toxicology Issues examines the implications of public health issues and the impact of pharmaceuticals, chemical and food toxicants, dietary phytochemicals, and medical treatments on human health. Volume 2: Public Health and Toxicology Issues in Drug Research: Toxicity and Toxicodynamics covers topics on pharmacokinetics and toxicokinetics such as population pharmacokinetics/toxicokinetics, the design of toxicokinetic studies, and the use of toxicokinetic data in preclinical safety assessments. The book investigates the health effect caused by the bioaccumulation of pharmaceutical and personal care products and the impact of drug-induced toxicity on different systems of the body. It discusses the mechanistic pathways of food toxicants and illustrates the molecular mechanisms of the chemopreventive role of dietary phytochemicals. It also delves into the toxic effects of medical treatments and materials. Ethical, legal, societal, and professional issues in toxicology round off the coverage providing a valuable resource to interested in learning more about the health impact and public health issues related to the toxicity of pharmaceuticals, dietary supplements, personal care products, and medical treatments. - Discusses the impact of pharmaceuticals, food, and chemical toxicants on human health - Examines the toxic effects of medical treatments, clinical administrations, and materials - Explores public health issues around drug safety and toxicology
Drug Testing In Vitro
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Author : Uwe Marx
language : en
Publisher: John Wiley & Sons
Release Date : 2007-02-27
Drug Testing In Vitro written by Uwe Marx and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-02-27 with Science categories.
Here, expert scientists from industry and academia share their knowledge on the assembly of functional human tissues in vitro and how to design drug screenings predictive of human exposure. In so doing, they combine the latest technological developments with strategic outlooks, such as novel cell and tissue systems for drug screening and testing, as well as emerging in vitro culture technologies. Equally importantly, the book does not shy away from regulatory acceptance and ethical issues.
Haschek And Rousseaux S Handbook Of Toxicologic Pathology Volume 5 Toxicologic Pathology Of Organ Systems
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Author : Wanda M Haschek
language : en
Publisher: Elsevier
Release Date : 2025-02-09
Haschek And Rousseaux S Handbook Of Toxicologic Pathology Volume 5 Toxicologic Pathology Of Organ Systems written by Wanda M Haschek and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-09 with Medical categories.
Haschek and Rousseaux's Handbook of Toxicologic Pathology is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. Volume 5 of the Fourth Edition continues coverage of Organ-Specific Toxicologic Pathology and major organ systems not covered in Volume 4. Completely revised, Volume 5 of the Handbook of Toxicologic Pathology is an essential part of the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists, and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants. - Includes completely revised chapters on systems toxicologic pathology - Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology - Features hundreds of full-color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations