Hippocampal Microcircuits
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Hippocampal Microcircuits
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Author : Vassilis Cutsuridis
language : en
Publisher: Springer
Release Date : 2019-02-04
Hippocampal Microcircuits written by Vassilis Cutsuridis and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-04 with Medical categories.
This is the 2nd edition of a very well received and popular book that reflects the current state-of-the-art of the ongoing research avenues concerning the hippocampus and processing units bridging the gap between single cell activity, network activity and global brain function. It aims to provide a methodology to anyone interested in developing microcircuit level models of the hippocampus. The book is divided into two thematic areas: (I) Experimental background and (II) Computational analysis. In part I, leading experimental neuroscientists discuss the morphological, physiological and molecular characteristics as well as the connectivity and synaptic properties of the various cell types found in the hippocampus. Behaviour-related ensemble activity patterns of morphologically identified neurons in anesthetized and freely moving animals provide insights on the function of the hippocampal areas. In part II, computational neuroscientists present models of the hippocampal microcircuits at various levels of detail (e.g. single cell level, network level, etc.). Synaptomics and connectomics models of hippocampal structures are initially discussed. Then, network models of memory, rhythm generation and spatial navigation are presented, followed by abstract and biophysical models of synaptic plasticity. Network models of hippocampal implicated disorders (epilepsy and schizophrenia) are then detailed and how their network topologies, connectivities and activities change in these diseases. Finally, two chapters are dedicated to describing simulator environments of single neurons and networks currently used by computational neuroscientists in developing their models and modelling tools to parametrically constrain them. This engaging volume is invaluable to experimental and computational neuroscientists, electrical engineers, physicists, mathematicians and others interested in developing microcircuit models of the hippocampus. Graduate level students and trainees in all of these fields can find this book a significant source of information.
Structure Function And Plasticity Of Hippocampal Dentate Gyrus Microcircuits
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Author : Peter Jonas
language : en
Publisher: Frontiers Media SA
Release Date : 2015-02-13
Structure Function And Plasticity Of Hippocampal Dentate Gyrus Microcircuits written by Peter Jonas and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-02-13 with Neurosciences. Biological psychiatry. Neuropsychiatry categories.
The hippocampus mediates several higher brain functions, such as learning, memory, and spatial coding. The input region of the hippocampus, the dentate gyrus, plays a critical role in these processes. Several lines of evidence suggest that the dentate gyrus acts as a preprocessor of incoming information, preparing it for subsequent processing in CA3. For example, the dentate gyrus converts input from the entorhinal cortex, where cells have multiple spatial fields, into the spatially more specific place cell activity characteristic of the CA3 region. Furthermore, the dentate gyrus is involved in pattern separation, transforming relatively similar input patterns into substantially different output patterns. Finally, the dentate gyrus produces a very sparse coding scheme in which only a very small fraction of neurons are active at any one time. How are these unique functions implemented at the level of cells and synapses? Dentate gyrus granule cells receive excitatory neuron input from the entorhinal cortex and send excitatory output to the hippocampal CA3 region via the mossy fibers. Furthermore, several types of GABAergic interneurons are present in this region, providing inhibitory control over granule cell activity via feedback and feedforward inhibition. Additionally, hilar mossy cells mediate an excitatory loop, receiving powerful input from a small number of granule cells and providing highly distributed excitatory output to a large number of granule cells. Finally, the dentate gyrus is one of the few brain regions exhibiting adult neurogenesis. Thus, new neurons are generated and functionally integrated throughout life. How these specific cellular and synaptic properties contribute to higher brain functions remains unclear. One way to understand these properties of the dentate gyrus is to try to integrate experimental data into models, following the famous Hopfield quote: “Build it, and you understand it.” However, when trying this, one faces two major challenges. First, hard quantitative data about cellular properties, structural connectivity, and functional properties of synapses are lacking. Second, the number of individual neurons and synapses to be represented in the model is huge. For example, the dentate gyrus contains ~1 million granule cells in rodents, and ~10 million in humans. Thus, full scale models will be complex and computationally demanding. In this Frontiers Research Topic, we collect important information about cells, synapses, and microcircuit elements of the dentate gyrus. We have put together a combination of original research articles, review articles, and a methods article. We hope that the collected information will be useful for both experimentalists and modelers. We also hope that the papers will be interesting beyond the small world of “dentology,” i.e., for scientists working on other brain areas. Ideally, the dentate gyrus may serve as a blueprint, helping neuroscientists to define strategies to analyze network organization of other brain regions.
Hippocampal Microcircuits
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Author : Vassilis Cutsuridis
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-02-01
Hippocampal Microcircuits written by Vassilis Cutsuridis and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-02-01 with Medical categories.
Rich in detail, Hippocampal Microcircuits: A Computational Modeler’s Resource Book provides succinct and focused reviews of experimental results. It is an unparalleled resource of data and methodology that will be invaluable to anyone wishing to develop computational models of the microcircuits of the hippocampus. The editors have divided the material into two thematic areas. Covering the subject’s experimental background, leading neuroscientists discuss the morphological, physiological and molecular characteristics as well as the connectivity and synaptic properties of the various cell types found in the hippocampus. Here, ensemble activity, related to behavior, on the part of morphologically identified neurons in anesthetized and freely moving animals, lead to insights into the functions of hippocampal areas. In the second section, on computational analysis, computational neuroscientists present models of hippocampal microcircuits at various levels of detail, including single-cell and network levels. A full chapter is devoted to the single-neuron and network simulation environments currently used by computational neuroscientists in developing their models. In addition to the above, the chapters also identify outstanding questions and areas in need of further clarification that will guide future research by computational neuroscientists.
Diversity In The Neuronal Machine
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Author : Ivan Soltesz
language : en
Publisher: Oxford University Press
Release Date : 2006
Diversity In The Neuronal Machine written by Ivan Soltesz and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Medical categories.
Aims to provide insights into the striking degree of cellular diversity found in the interneuronal microcircuits in the brain's neocortex and hippocampus. This book elaborates on different ideas about interneuronal diversity that rest upon theoretical and experimental results and is useful for neuroscientists.
Handbook Of Brain Microcircuits
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Author : Gordon M. Shepherd
language : en
Publisher: Oxford University Press
Release Date : 2018
Handbook Of Brain Microcircuits written by Gordon M. Shepherd and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Medical categories.
In order to focus on principles, each chapter in this work is brief, organized around 1-3 wiring diagrams of the key circuits, with several pages of text that distil the functional significance of each microcircuit
Handbook Of Brain Microcircuits
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Author : Gordon Shepherd
language : en
Publisher: Oxford University Press
Release Date : 2010-09-22
Handbook Of Brain Microcircuits written by Gordon Shepherd and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-22 with Medical categories.
Microcircuits are the specific arrangements of cells and their connections that carry out the operations unique to each brain region. This resource summarizes succinctly these circuits in over 40 regions - enabling comparisons of principles across both vertebrates and invertebrates. It provides a new foundation for understanding brain function that will be of interest to all neuroscientists. Oxford Clinical Neuroscience is a comprehensive, cross-searchable collection of resources offering quick and easy access to eleven of Oxford University Press's prestigious neuroscience texts. Joining Oxford Medicine Online these resources offer students, specialists and clinical researchers the best quality content in an easy-to-access format.
The Ca3 Region Of The Hippocampus How Is It What Is It For How Does It Do It
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Author : Enrico Cherubini
language : en
Publisher: Frontiers Media SA
Release Date : 2015-08-19
The Ca3 Region Of The Hippocampus How Is It What Is It For How Does It Do It written by Enrico Cherubini and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-19 with Electronic book categories.
The CA3 hippocampal region receives information from the entorhinal cortex either directly from the perforant path or indirectly from the dentate gyrus via the mossy fibers (MFs). According to their specific targets (principal/mossy cells or interneurons), MFs terminate with large boutons or small filopodial extensions, respectively. MF-CA3 synapses are characterized by a low probability of release and pronounced frequency-dependent facilitation. In addition MF terminals are endowed with mGluRs that regulate their own release. We will describe the intrinsic membrane properties of pyramidal cells, which can sometimes fire in bursts, together with the geometry of their dendritic arborization. The single layer of pyramidal cells is quite distinct from the six-layered neocortical arrangement. The resulting aligned dendrites provides the substrate for laminated excitatory inputs. They also underlie a precise, diversity of inhibitory control which we will also describe in detail. The CA3 region has an especially rich internal connectivity, with recurrent excitatory and inhibitory loops. In recent years both in vivo and in vitro studies have allowed to better understand functional properties of the CA3 auto-associative network and its role in information processing. This circuit is implicated in encoding spatial representations and episodic memories. It generates physiological population synchronies, including gamma, theta and sharp-waves that are presumed to associate firing in selected assemblies of cells in different behavioral conditions. The CA3 region is susceptible to neurodegeneration during aging and after stresses such as infection or injury. Loss of some CA3 neurones has striking effects on mossy fiber inputs and can facilitate the generation of pathologic synchrony within the CA3 micro-circuit. The aim of this special topic is to bring together experts on the cellular and molecular mechanisms regulating the wiring properties of the CA3 hippocampal microcircuit in both physiological and pathological conditions, synaptic plasticity, behavior and cognition.We will particularly emphasize the dual glutamatergic and GABAergic phenotype of MF-CA3 synapses at early developmental stages and the steps that regulate the integration of newly generated neurons into the adult dentate gyrus-CA3 circuit.
Microcircuits
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Author : Sten Grillner
language : en
Publisher: MIT Press
Release Date : 2006
Microcircuits written by Sten Grillner and has been published by MIT Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Anatomy categories.
Leading neuroscientists discuss the function of microcircuits, functional modules that act as elementary processing units bridging single cells to systems and behavior. Microcircuits, functional modules that act as elementary processing units bridging single cells to systems and behavior, could provide the link between neurons and global brain function. Microcircuits are designed to serve particular functions; examples of these functional modules include the cortical columns in sensory cortici, glomeruli in the olfactory systems of insects and vertebrates, and networks generating different aspects of motor behavior. In this Dahlem Workshop volume, leading neuroscientists discuss how microcircuits work to bridge the single cell and systems levels and compare the intrinsic function of microcircuits with their ion channel subtypes, connectivity, and receptors, in order to understand the design principles and function of the microcircuits. The chapters cover the four major areas of microcircuit research: motor systems, including locomotion, respiration, and the saccadic eye movements; the striatum, the largest input station of the basal ganglia; olfactory systems and the neural organization of the glomeruli; and the neocortex. Each chapter is followed by a group report, a collaborative discussion among senior scientists. Contributors Lidia Alonso-Nanclares, Hagai Bergman, Maria Blatow, J. Paul Bolam, Ansgar Büschges, Antonio Caputi, Jean-Pierre Changeux, Javier DeFelipe, Carsten Duch, Paul Feinstein, Stuart Firestein, Yves Frégnac, Rainer W. Friedrich, C. Giovanni Galizia, Ann M. Graybiel, Charles A. Greer, Sten Grillner, Tadashi Isa, Ole Kiehn, Minoru Kimura, Anders Lanser, Gilles Laurent, Pierre-Marie Lledo, Wolfgang Maass, Henry Markram, David A. McCormick, Christoph M. Michel, Peter Mombaerts, Hannah Monyer, Hans-Joachim Pflüger, Dietmar Plenz, Diethelm W. Richter, Silke Sachse, H. Sebastian Seung, Keith T. Sillar, Jeffrey C. Smith, David L. Sparks, D. James Surmeier, Eörs Szathmáry, James M. Tepper, Jeff R. Wickens, Rafael Yuste
Artificial Neural Networks Icann 2010
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Author : Konstantinos Diamantaras
language : en
Publisher: Springer
Release Date : 2010-09-13
Artificial Neural Networks Icann 2010 written by Konstantinos Diamantaras and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-13 with Computers categories.
th This volume is part of the three-volume proceedings of the 20 International Conference on Arti?cial Neural Networks (ICANN 2010) that was held in Th- saloniki, Greece during September 15–18, 2010. ICANN is an annual meeting sponsored by the European Neural Network Society (ENNS) in cooperation with the International Neural Network So- ety (INNS) and the Japanese Neural Network Society (JNNS). This series of conferences has been held annually since 1991 in Europe, covering the ?eld of neurocomputing, learning systems and other related areas. As in the past 19 events, ICANN 2010 provided a distinguished, lively and interdisciplinary discussion forum for researches and scientists from around the globe. Ito?eredagoodchanceto discussthe latestadvancesofresearchandalso all the developments and applications in the area of Arti?cial Neural Networks (ANNs). ANNs provide an information processing structure inspired by biolo- cal nervous systems and they consist of a large number of highly interconnected processing elements (neurons). Each neuron is a simple processor with a limited computing capacity typically restricted to a rule for combining input signals (utilizing an activation function) in order to calculate the output one. Output signalsmaybesenttootherunitsalongconnectionsknownasweightsthatexcite or inhibit the signal being communicated. ANNs have the ability “to learn” by example (a large volume of cases) through several iterations without requiring a priori ?xed knowledge of the relationships between process parameters.
Computational Models Of Brain And Behavior
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Author : Ahmed A. Moustafa
language : en
Publisher: John Wiley & Sons
Release Date : 2017-09-11
Computational Models Of Brain And Behavior written by Ahmed A. Moustafa and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-11 with Psychology categories.
A comprehensive Introduction to the world of brain and behavior computational models This book provides a broad collection of articles covering different aspects of computational modeling efforts in psychology and neuroscience. Specifically, it discusses models that span different brain regions (hippocampus, amygdala, basal ganglia, visual cortex), different species (humans, rats, fruit flies), and different modeling methods (neural network, Bayesian, reinforcement learning, data fitting, and Hodgkin-Huxley models, among others). Computational Models of Brain and Behavior is divided into four sections: (a) Models of brain disorders; (b) Neural models of behavioral processes; (c) Models of neural processes, brain regions and neurotransmitters, and (d) Neural modeling approaches. It provides in-depth coverage of models of psychiatric disorders, including depression, posttraumatic stress disorder (PTSD), schizophrenia, and dyslexia; models of neurological disorders, including Alzheimer’s disease, Parkinson’s disease, and epilepsy; early sensory and perceptual processes; models of olfaction; higher/systems level models and low-level models; Pavlovian and instrumental conditioning; linking information theory to neurobiology; and more. Covers computational approximations to intellectual disability in down syndrome Discusses computational models of pharmacological and immunological treatment in Alzheimer's disease Examines neural circuit models of serotonergic system (from microcircuits to cognition) Educates on information theory, memory, prediction, and timing in associative learning Computational Models of Brain and Behavior is written for advanced undergraduate, Master's and PhD-level students—as well as researchers involved in computational neuroscience modeling research.