Histone Deacetylase Inhibitors As Cancer Therapeutics
DOWNLOAD
FREE 30 Days
Download Histone Deacetylase Inhibitors As Cancer Therapeutics PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Histone Deacetylase Inhibitors As Cancer Therapeutics book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Histone Deacetylase Inhibitors As Cancer Therapeutics
DOWNLOAD
FREE 30 Days
Author : Steven Grant
language : en
Publisher: Academic Press
Release Date : 2012-11
Histone Deacetylase Inhibitors As Cancer Therapeutics written by Steven Grant and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11 with Business & Economics categories.
Provides information on the exciting and fast-moving field of cancer research.
Epigenetic Therapy With Histone Deacetylase Inhibitors Implications For Cancer Treatment
DOWNLOAD
FREE 30 Days
Author : Christiane Pienna Soares
language : en
Publisher: Frontiers Media SA
Release Date : 2021-06-02
Epigenetic Therapy With Histone Deacetylase Inhibitors Implications For Cancer Treatment written by Christiane Pienna Soares and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-02 with Science categories.
Histone Deacetylase Inhibitors In Combinatorial Anticancer Therapy
DOWNLOAD
FREE 30 Days
Author : Shabir Ahmad Ganai
language : en
Publisher: Springer Nature
Release Date : 2020-11-23
Histone Deacetylase Inhibitors In Combinatorial Anticancer Therapy written by Shabir Ahmad Ganai and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-23 with Medical categories.
This book reviews the latest developments in the design, synthesis, and molecular mechanism of action of Histone Deacetylase (HDAC) inhibitors in the context of potential cancer therapy. HDAC inhibitors are emerging as promising anticancer drug molecules that promote growth arrest, differentiation and apoptosis of cancer cells with tumor selective toxicity. The book begins with an overview of various epigenetic modifying enzymes that are involved in cancer transition and progression; before exploring the potential of HDACs in cancer treatment. It provides a classification of HDAC inhibitors based on their structural attributes, and addresses HDAC-induced cytotoxicity.. Lastly, it discusses and assesses the rationale behind therapies that combine HDAC inhibitors with other anticancer agents to treat solid tumors. Given its scope, it offers a valuable resource for all researchers, clinicians, and students working in formulation, drug discovery, oncology, and personalized medicine.
Advances In Targeted Cancer Therapy
DOWNLOAD
FREE 30 Days
Author : Richard M. Schultz
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-01-24
Advances In Targeted Cancer Therapy written by Richard M. Schultz and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-01-24 with Medical categories.
There have been tremendous advances in our understanding of molecular and tumor biology during the past few years. In the field of cancer therapeutics, it is expected that cytotoxic drug approaches will be gradually replaced with treatments based on biological targeted approaches. Hopefully these new targeted therapies will significantly increase efficacy and lack the devastating and troublesome side effects elicited by cytotoxic chemotherapy. This volume is the first book to cover the general topic of targeted cancer therapy. It presents a range of targets such as tumor angiogenesis, cell cycle control and cell signalling, COX-2, apoptosis/cell survival, invasion and metastasis and approaches like kinase inhibitors, antisense, and antibody-based therapeutics. The emphasis is on preclinical development, including target validation, development of biomarkers, strategies for combination approaches, and development of resistance. The particular challenges involved in translating these data to clinical application are discussed. This volume should be of broad general interest to researchers and clinicians involved in cancer therapy as well as other scientists interested in current strategies for cancer treatment.
Resistance To Targeted Therapies In Lymphomas
DOWNLOAD
FREE 30 Days
Author : Ana C. Xavier
language : en
Publisher: Springer Nature
Release Date : 2019-09-13
Resistance To Targeted Therapies In Lymphomas written by Ana C. Xavier and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-13 with Medical categories.
Over the past few decades, lymphoma patient outcomes have improved as a result of multidrug chemotherapy and radiation therapy, intensification of treatment, improvement in supportive care, and better imaging and staging systems. Even more recently, there has been tremendous progress in the understanding of cancer cell biology and its microenvironment which has resulted in the development of biologic agents, also called "target" therapies. These therapies are more specific in targeting cancer cells either directly or via enhancement of the immune system. Many clinical studies have focused on biological agents in combination with traditional chemotherapy with the goal of improved outcomes, or reduced acute long term complications that are associated with lymphoma therapy. This volume will review different classes of "target" drugs that have been developed, approved, or are under investigation in the field of lymphoma therapy. The discussion will not only be on the understanding of the mechanisms of action or clinical response of those agents, but will also help the reader to understand the nature of lymphoma biology in patients who relapse or are refractor after exposure to those drugs. Contributors will discuss what is currently known about mechanisms of tumor-related or host-related resistance, and how to overcome this resistance. This understanding is crucial given the dismal outcomes of patients with relapsed or refractory lymphomas. The book provides a unique opportunity to review and reflect on the recent successes and pitfalls of the modern lymphoma therapy era.
Natural Products And Cancer Drug Discovery
DOWNLOAD
FREE 30 Days
Author : Frank E. Koehn
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-11-09
Natural Products And Cancer Drug Discovery written by Frank E. Koehn and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-09 with Medical categories.
This volume will cover the natural products as they relate to cancer chemotherapy. The topics will include history and current status , recent launches, new clinical candidates and approved drugs directly derived from natural products, current and future cancer target opportunities for natural products, leveraging natural products as tools for new target generation , new approaches to cancer drug discovery through natural products based lead generation, and enabling technologies which leverage the unique attributes of natural products.
Programmed Cell Death In Cancer Progression And Therapy
DOWNLOAD
FREE 30 Days
Author : Roya Khosravi-Far
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-12-29
Programmed Cell Death In Cancer Progression And Therapy written by Roya Khosravi-Far and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-29 with Medical categories.
Programmed cell death (PCD) plays pivotal roles in tumor progression, cancer therapeutics and resistance of tumor cells to therapy. This book examines the mechanisms involved in mediating and regulating PCD in cancer. It also provides a detailed indication of the utility of PCD in cancer therapy. The book features chapters on the current and future of RNA interference in therapeutics and Pathways involved in Stem Cell Survival and Death.
Resistance To Proteasome Inhibitors In Cancer
DOWNLOAD
FREE 30 Days
Author : Q. Ping Dou
language : en
Publisher: Springer
Release Date : 2014-09-16
Resistance To Proteasome Inhibitors In Cancer written by Q. Ping Dou and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-16 with Medical categories.
The book explores cutting-edge strategies to overcome proteasome inhibitor resistance, including the second generation 20S proteasome inhibitors, novel combinational therapies, and new targets in the ubiquitin-proteasome pathway (e.g., ubiquitin E3 ligases, deubiquitinases, 19S proteasomal ATPases, histone deacetylases, oxidative stress and proteotoxic stress pathways and pharmacogenomic signature profiling) in resistant cancer cells. The mechanisms of action and resistance of proteasome inhibitors, such as bortezomib and carfilzomib in human cancers, including multiple myeloma, mantle cell lymphoma, acute leukemia, and solid tumors are explored in depth in this volume. This timely volume unveils the most current discoveries of the mechanisms behind proteasome inhibitor resistance, which will help illuminate the future of cancer therapies.
Histone Modifications In Therapy
DOWNLOAD
FREE 30 Days
Author : Pedro Castelo-Branco
language : en
Publisher: Academic Press
Release Date : 2020-09-04
Histone Modifications In Therapy written by Pedro Castelo-Branco and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-04 with Science categories.
Histone Modifications in Therapy provides an in-depth analysis of the role of histone mechanisms in major diseases and the promise of targeting histone modifications for disease prevention and treatment. Here, researchers, clinicians and students will discover a thorough, evidence-based discussion of the biology of histones, the diseases engaged by aberrant histone modifications, and pathways with therapeutic potential. Expert chapter addresses the role of histone modifications across a variety of disorders, including cancer, neuropsychiatric, neurodegenerative, cardiac, metabolic, infectious, bacterial, autoimmune and inflammatory disorders, among others. In relation to these disease types, histone modifications are discussed, both as mechanisms of prevention and possible treatment. A concluding chapter brings together future perspectives for targeting histone modifications in therapy and next steps in research. Examines the use of histone modifications in disease prevention and therapy Explores the role of histone modifications in cancer, neuropsychiatric, neurodegenerative, cardiac, metabolic, infectious, bacterial, and inflammatory disease, among others Features chapters from a broad range of international authors and disease specialists
Lucine Amara Collection
DOWNLOAD
FREE 30 Days
Author :
language : en
Publisher:
Release Date :
Lucine Amara Collection written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Collection contains clipping, photograph, program and publicity files.