Host Adapted Metabolism And Its Regulation In Bacterial Pathogens
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Host Adapted Metabolism And Its Regulation In Bacterial Pathogens
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Author : Thomas Dandekar
language : en
Publisher: Frontiers Media SA
Release Date : 2015-06-17
Host Adapted Metabolism And Its Regulation In Bacterial Pathogens written by Thomas Dandekar and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-17 with Infectious and parasitic diseases categories.
Pathogens adapt their metabolism rapidly to the host. Our topic covers these phenomenon regarding extracellular and intracellular pathogens as well as general methods to elucidate different metabolic adaptation processes - an essential guide for any scientist wanting to keep abreast of recent developments in infection biology.
Host Adapted Metabolism And Its Regulation In Bacterial Pathogens
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Author : Thomas Dandekar
language : en
Publisher:
Release Date : 2015
Host Adapted Metabolism And Its Regulation In Bacterial Pathogens written by Thomas Dandekar and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Electronic book categories.
Metabolism And Bacterial Pathogenesis
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Author : Tyrrell Conway
language : en
Publisher: John Wiley & Sons
Release Date : 2020-07-24
Metabolism And Bacterial Pathogenesis written by Tyrrell Conway and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-24 with Science categories.
Groundbreaking thinking on how bacterial metabolism is foundational to pathogenesis For too long, bacterial metabolism and bacterial pathogenesis have been studied as separate entities. However, the scientific community is beginning to realize that not only are bacterial nutrient acquisition and utilization essential for pathogenesis, but that interfering with the pathogen-specific metabolic pathways used during infection can regulate virulence factor expression and might lead to effective breakthroughs in a variety of treatments. Editors Paul Cohen and Tyrrell Conway, who pioneered the use of metabolic mutants in competitive colonization assays, an approach now widely used to investigate the nutrition of pathogens in vivo, are uniquely qualified to advance our knowledge of this integrative field of research. They convened a group of contributors who are breaking new ground in understanding how bacterial metabolism is foundational to pathogenesis to share their expert perspectives and outlook for the future. Beginning with overviews, Metabolism and Bacterial Pathogenesis covers a wide range of diseases and both Gram-positive and -negative bacteria that serve as model systems for in vitro and in vivo investigations intracellular, respiratory, and enteric pathogens pathogen-specific nutrient acquisition in hosts mechanisms of host-driven metabolic adaptation by pathogens metabolic regulation of virulence gene expression Useful for specialists in bacterial pathogenesis and specialists in metabolism as well as molecular biologists, physicians, veterinarians, dentists, graduate and undergraduate students, and laboratory technicians, Metabolism and Bacterial Pathogenesis is also essential reading for scientists studying the microbiome.
Molecular Biology Of The Cell
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Author :
language : en
Publisher:
Release Date : 2004
Molecular Biology Of The Cell written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Cells categories.
Regulating With Rna In Bacteria And Archaea
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Author : Gisela Storz
language : en
Publisher: John Wiley & Sons
Release Date : 2020-07-10
Regulating With Rna In Bacteria And Archaea written by Gisela Storz and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-10 with Medical categories.
Revealing the many roles of RNA in regulating gene expression For decades after the discoveries of messenger RNA, transfer RNA, and ribosomal RNA, it was largely assumed that the role of RNA in the cell was limited to shuttling the genomic message, chaperoning amino acids, and toiling in the ribosomes. Eventually, hints that RNA molecules might have regulatory roles began to appear. With the advent of genomics and bioinformatics, it became evident that numerous other RNA forms exist and have specific functions, including small RNAs (sRNA), RNA thermometers, and riboswitches to regulate core metabolic pathways, bacterial pathogenesis, iron homeostasis, quorum sensing, and biofilm formation. All of these functions, and more, are presented in Regulating with RNA in Bacteria and Archaea, written by RNA biologists from around the globe. Divided into eight sections-RNases and Helicases, Cis-Acting RNAs, Cis Encoded Base Pairing RNAs, Trans-Encoded Base Pairing RNAs, Protein Titration and Scaffolding, General Considerations, Emerging Topics, and Resources-this book serves as an excellent resource for established RNA biologists and for the many scientists who are studying regulated cellular systems. It is no longer a fair assumption that gene expression regulation is the provenance of proteins only or that control is exerted primarily at the level of transcription. This book makes clear that regulatory RNAs are key partners along with proteins in controlling the complex interactions and pathways found within prokaryotes.
Bacterial Pathogenesis
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Author : Peter Williams
language : en
Publisher:
Release Date : 1998
Bacterial Pathogenesis written by Peter Williams and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Science categories.
Established almost 30 years ago, Methods in Microbiology is the most prestigious series devoted to techniques and methodology in the field. Now totally revamped, revitalized, with a new format and expanded scope, Methods in Microbiology will continue to provide you with tried and tested, cutting-edge protocols to directly benefit your research. Key Features * Focuses on the methods most useful for the microbiologist interested in the way in which bacteria cause disease * Includes section devoted to 'Approaches to characterising pathogenic mechanisms' by Stanley Falkow * Covers safety aspects, detection, identification and speciation * Includes techniques for the study of host interactions and reactions in animals and plants * Describes biochemical and molecular genetic approaches * Essential methods for gene expression and analysis * Covers strategies and problems for disease control
Outsmarting The Host How Bacterial Pathogens Modulate Immune Responses In The Lung
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Author : Gee W. Lau
language : en
Publisher: Frontiers Media SA
Release Date : 2021-03-22
Outsmarting The Host How Bacterial Pathogens Modulate Immune Responses In The Lung written by Gee W. Lau and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-22 with Medical categories.
Contemporary Topics In Critical Care Medicine
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Author : Atul P Kulkarni
language : en
Publisher: Jaypee Brothers Medical Publishers
Release Date : 2022-12-20
Contemporary Topics In Critical Care Medicine written by Atul P Kulkarni and has been published by Jaypee Brothers Medical Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-20 with Medical categories.
SECTION 1: Airway Management -- Current Controversies 1. Can Sellick Maneuver Prevent Pulmonary Aspiration in the Critically Ill? 2. Etomidate vs. Ketamine -- What Should We Use for Intubation in ICU SECTION 2: Extracorporeal Therapies 3. Plasmapheresis: Current Indications in the Critically Ill 4. Are Super High-Flux Membrane Dialyzers the Future of RRT? 5. What is New in Artificial Liver Support Systems? SECTION 3: Sepsis 6. Back to the Genes: Does Genetic Polymorphism have a Role in Sepsis Management? 7. Controversies in Surviving Sepsis Guidelines 2021 8. Are We Back to Square One? Early Fluids vs. Vasopreressors in Septic Shock 9. Have We Achieved Balance in Fluid Therapy: Balanced Salt Solutions vs. Normal Saline? SECTION 4: Biomarkers 10. Novel Biomarkers During Circulatory Shock 11. Biomarkers in Acute Intoxications 12. Do Biomarkers have a Role in Patients with Primary Brain Injury? 13. Utility of MicroRNAs in the Critically Ill 14. Neutrophil to Lymphocyte Ratio in Critically Ill: A Simple but Useful Marker? 15. Do Vocal Biomarkers have a Future in Critical Care SECTION 5: COVID-19 Pandemic: Lessons Learnt 16. Awake Prone Positioning in ARDS? 17. Immunomodulators for COVID-19 Therapy 18. Has Critical Care Telemedicine Come of Age During the Pandemic 19. Post-COVID Conditions (PCCs) or Long COVID Syndrome 20. Capacity Building During Large Scale Disasters 21. Clearing the Air: Alternatives to Isolation Rooms SECTION 6: Mechanical Ventilation 22. Revisiting Exogenous Surfactant Therapy in Acute Lung Injury and ARDS 23. Mechanical Power 24. Volumetric Capnography in 2022 25. Metabolic Alkalosis in Critical Care: A Classical and Physicochemical Approach 26. Oxygen Revisited SECTION 7 28. High-flow Nasal Cannula: Beyond a COVID-19 Therapy 29. Cefiderocol 30. Newer Fluoroquinolones: Levonadifloxacin, Delafloxacin and Lascufloxacin 31. Newer Combinations of B-Lactam/B-Lactamase 32. Newer Tetracyclines -- Eravacycline and Omadacycline 33. Plazomicin: A New Aminoglycoside 34. Lefamulin: A Pleuromutilin Antibiotic 35. Pretomanid for Antitubercular Therapy 36. Contezolid Acefosamil: A New Oxazolidinone 37. Solithromycin and Nafithromycin: The New Macrolides 38. Benapenem and Sulopenem 39. The Dsb (Disulfide bond) 40. Antivirulence Strategies: The Future of Antibacterial Therapy 41. Alternatives to Conventional Antibacterials: Use of Nanomaterials 42. Newer Treatment Approach to Clostridioides Difficile - Fidaxomicin and Bezlotoxumab 43. Recent Advances for Immunotherapies Against Infectious Disease SECTION 8: What's New Elsewhere? 44. Risk Scoring Systems in Upper Gastrointestinal Bleed 45. Has Hypotension Prediction Index Come of Age 46. Postintensive Care Syndrome and Postintensive Care Syndrome-Family 47. Closed-Loop Hemodynamic Resuscitation In Shock 48. Is Electrical Impedance Tomography Finally Here to Stay 49. Cardiac Output Measurement: Capnodynamic Method and Auto VTI Tool 50. What's New in Glucose Management Technologies for the Critically-ill 51. Vitamins and Trace Element Supplementation for Critically Ill Patients in 2022 Index
Virulence Mechanisms Of Bacterial Pathogens
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Author : Indira T. Kudva
language : en
Publisher: John Wiley & Sons
Release Date : 2020-07-10
Virulence Mechanisms Of Bacterial Pathogens written by Indira T. Kudva and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-10 with Medical categories.
Ground-breaking overview of an enduring topic Despite the use of antibiotics, bacterial diseases continue to be a critical issue in public health, and bacterial pathogenesis remains a tantalizing problem for research microbiologists. This new edition of Virulence Mechanisms of Bacterial Pathogens broadly covers the knowledge base surrounding this topic and presents recently unraveled bacterial virulence strategies and cutting-edge therapies. A team of editors, led by USDA scientist Indira Kudva, compiled perspectives from experts to explain the wide variety of mechanisms through which bacterial pathogens cause disease: the host interface, host cell enslavement, and bacterial communication, secretion, defenses, and persistence. A collection of reviews on targeted therapies rounds out the seven sections of this unique book. The new edition provides insights into some of the most recent advances in the area of bacterial pathogenesis, including how metabolism shapes the host-pathogen interface interactions across species and genera mechanisms of the secretion systems evasion, survival, and persistence mechanisms new therapies targeting various adaptive and virulence mechanisms of bacterial pathogens Written to promote discussion, extrapolation, exploration, and multidimensional thinking, Virulence Mechanisms of Bacterial Pathogens serves as a textbook for graduate courses on bacterial pathogenesis and a resource for specialists in bacterial pathogenicity, such as molecular biologists, physician scientists, infectious disease clinicians, dental scientists, veterinarians, molecular biologists, industry researchers, and technicians.
Systems Biology Of Microbial Infection
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Author : Reinhard Guthke
language : en
Publisher: Frontiers E-books
Release Date :
Systems Biology Of Microbial Infection written by Reinhard Guthke and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
The systems biology of microbial infections aims at describing and analysing the confrontation of the host with bacterial and fungal pathogens. It intends to understand and to model the interaction of the host, in particular the immune system of humans or animals, with components of pathogens. This comprises experimental studies that provide spatio-temporal data from monitoring the response of host and pathogenic cells to perturbations or when interacting with each other, as well as the integrative analysis of genome-wide data from both the host and the pathogen. In perspective, the host-pathogen interaction should be described by a combination of spatio-temporal models with interacting molecular networks of the host and the pathogen. The aim is to unravel the main mechanisms of pathogenicity, to identify diagnostic biomarkers and potential drug targets, and to explore novel strategies for personalized therapy by computer simulations. Some microorganisms are part of the normal microbial flora, existing either in a mutualistic or commensal relationship with the host. Microorganisms become pathogenic if they posses certain physiological characteristics and virulence determinants as well as capabilities for immune evasion. Despite the different pathogenesis of infections, there are several common traits: (1) Before infection, pathogens must be able to overcome (epithelial) barriers. The infection starts by adhesion and colonization and is followed by entering of the pathogen into the host through the mucosa or (injured) skin. (2) Next, infection arises if the pathogen multiplies and overgrows the normal microbial flora, either at the place of entrance or in deeper tissue layers or organs. (3) After the growth phase, the pathogen damages the host’s cells, tissues and organs by producing toxins or destructive enzymes. Thus, systems biology of microbial infection comprises all levels of the pathogen and the host’s immune system. The investigation may start with the pathogen, its adhesion and colonization at the host, its interaction with host cell types e.g. epithelia cells, dendritic cells, macrophages, neutrophils, natural killer cells, etc. Because infection diseases are mainly found in patients with a weakened immune system, e.g. reduced activities of immune effector cells or defects in the epithelial barriers, systems biology of infection can also start with modelling of the immune defence including innate and adaptive immunity. Systems biological studies comprise both experimental and theoretical approaches. The experimental studies may be dedicated to reveal the relevance of certain genes or proteins in the above mentioned processes on the side of the pathogen and/or the host by applying functional and biochemical analyses based on knock-out mutants and knock- down experiments. At the theoretical, i.e. mathematical and computational, side systems biology of microbial infection comprises: (1) modelling of molecular mechanisms of bacterial or fungal infections, (2) modelling of non-protective and protective immune defences against microbial pathogens to generate information for possible immune therapy approaches, (3) modelling of infection dynamics and identification of biomarkers for diagnosis and for individualized therapy, (4) identifying essential virulence determinants and thereby predicting potential drug targets.