Human Hemoglobins
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Human Hemoglobins
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Author : Howard Franklin Bunn
language : en
Publisher: W.B. Saunders Company
Release Date : 1977
Human Hemoglobins written by Howard Franklin Bunn and has been published by W.B. Saunders Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 1977 with Hemoglobin categories.
Since the dawn of the era of molecular biology, hemoglobin has been subjected to more scrutiny than any other protein, and Bunn, Forget, and Ranney can each lay claim to major contributions to the saga of hemoglobin. Their well-organized, comprehensive, and superbly illustrated work is an excellent review of the abnormal hemoglobin field. Early chapters deal with the structure and function of human hemoglobin and the way in which this is modified in various disease states. Later sections deal with the various structural hemoglobin variants and their associated clinical manifestations, the thalassaemias, and the acquired disorders of hemoglobin. The sections that deal with the modification of hemoglobin function in various disease states are particularly good. The book contains an extensive and up-to-date bibliography and is remarkably free from errors of fact or type--the best standard of reference on the subject as of the year 1977.
Human Hemoglobin Genetics
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Author : G.R. Honig
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Human Hemoglobin Genetics written by G.R. Honig and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The discovery in the late 1940's that sickle cell anemia is a "molecular disease" of hemoglobin was the crucial advance that gave birth to the scientific discipline of human molecular genetics. In subsequent years, with the continued expansion of knowledge about the biology and genetics of the hemoglobins, and particularly as a result of the characterization of the very large numbers of globin gene mutations, the human hemoglobin system has remained as the premier model of gene expression at the molecular level in man. With the recent explosion of new information about the genetic properties of the hemoglobins, it appears inevitable that this gene system will continue to occupy a unique position in human molecular genetics for many years in the future. Hemoglobin genetics has also recently come of age as a diagnostic and clinical discipline. The heightening of public awareness in recent years about sickle cell disease, thalassemia, and other inherited disorders has brought increasing demands for carrier detection services as well as for genetic counseling and education. The more recent development of prac tical and reliable methods for the antenatal diagnosis of hemoglobin dis orders has further increased the scope of clinical hemoglobin genetics, and it can be anticipated that these potent diagnostic techniques will have increasing application in the years ahead.
Abnormal Hemoglobins In Human Populations
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Author : Frank. B. Livingstone
language : en
Publisher: Routledge
Release Date : 2019-01-15
Abnormal Hemoglobins In Human Populations written by Frank. B. Livingstone and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-15 with Medical categories.
Research on abnormal human hemoglobins (protein in blood that carries oxygen), has taught us about the inheritance, biochemistry, and distribution of these traits. This knowledge, coupled with mathematical research using computer models of population genetics, has enabled researchers to marry biological fact and genetic theory. This volume places medical understanding in an evolutionary framework. Using published data on the frequencies of abnormal hemoglobins in the world's populations, Livingston analyzes and interprets these frequencies in the light of world distribution of different forms of diseases such as malaria. He further develops the genetic theory of the evolutionary homeostasis. Livingston discusses the relation of abnormal hemoglobins to endemic malaria and, shows how natural selection pressures explain the known distribution of these traits. Where non-coinciding distributions arise, the book presents other genetic, anthropological, evolutionary, and epidemiological evidence to explain these discrepancies. This classic work remains a useful sourcebook for professors and graduate students of anthropology, genetics, epidemiology, and hematology.
Human Hemoglobin Genetics
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Author : George R. Honig
language : en
Publisher:
Release Date : 1985
Human Hemoglobin Genetics written by George R. Honig and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985 with Hemoglobin categories.
Biochemical And Clinical Aspects Of Hemoglobin Abnormalities
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Author : Winslow Caughey
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Biochemical And Clinical Aspects Of Hemoglobin Abnormalities written by Winslow Caughey and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Medical categories.
Biochemical and Clinical Aspects of Hemoglobin Abnormalities contains the proceedings of a symposium held on the Pingree Park campus of Colorado State University on October 2-7, 1977. Contributors discuss the biochemical and clinical aspects of hemoglobin abnormalities and cover topics ranging from amino acid substitutions to sickle cell disease, glycosylated hemoglobins, cystamine inhibition of sickling, and gelation of sickle cell hemoglobin. This volume is organized into 52 chapters and begins with a discussion of the role of distal residues in structure, ligand binding, and oxidation of hemoglobins A, Zurich, and Sydney. It then turns to functional abnormalities of whole blood in sickle cell anemia, inhibition of sickle hemoglobin gelation by amino acids and peptides, and intermolecular interactions in crystals of human deoxy hemoglobins A, C, F, and S. The chapters that follow focus on glycosylation of human hemoglobin, the phase transitions of sickle-cell hemoglobin, conformational effects of the HbS mutation, and mechanisms for hemoglobin oxidation. The reader is also introduced to oxidation of oxyhemoglobin by reductants, the kinetics of oxygen binding to human red blood cells, and oxidation of human hemoglobin by copper. A chapter that assesses the effect of physiological parameters, such as pH, oxygen concentration, protein concentration, non-gelling hemoglobins, and the erythrocyte membrane, on the kinetics of polymerization of deoxyhemoglobin S concludes the book. This book is intended for biochemists and clinicians interested in knowing more about hemoglobin abnormalities.
Human Haemoglobin Variants And Their Characteristics
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Author : Hermann Lehmann
language : en
Publisher: North-Holland
Release Date : 1976
Human Haemoglobin Variants And Their Characteristics written by Hermann Lehmann and has been published by North-Holland this book supported file pdf, txt, epub, kindle and other format this book has been release on 1976 with Medical categories.
The Analysis Of Human Haemoglobin Variants Using Mass Spectrometry
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Author : Brian N. Green
language : en
Publisher:
Release Date : 2021
The Analysis Of Human Haemoglobin Variants Using Mass Spectrometry written by Brian N. Green and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with Hemoglobin categories.
Hemoglobin And Its Abnormalities
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Author : Vernon M. Ingram
language : en
Publisher:
Release Date : 1961
Hemoglobin And Its Abnormalities written by Vernon M. Ingram and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1961 with Hemoglobin categories.
Hemoglobin Molecular Genetic And Clinical Aspects
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Author : Howard Franklin Bunn
language : en
Publisher: Saunders
Release Date : 1986
Hemoglobin Molecular Genetic And Clinical Aspects written by Howard Franklin Bunn and has been published by Saunders this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with Medical categories.
Hemoglobin Disorders
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Author : Ronald L. Nagel
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-01
Hemoglobin Disorders written by Ronald L. Nagel and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-01 with Medical categories.
Hemoglobin and Hemoglobinologists This volume, Hemoglobin Disorders: Molecular Methods and Protocols, will be introduced with a review of the great milestones in the field, and the scientists responsible for those achievements. The history of hemoglobin can be divided into three periods: the Classical period, the Modern period, and the Post-Modern period. I am inclined to include as the four major members of the classical period Francis Roughton, Quentin Gibson, Jeffries Wyman, and Linus Pauling, not only because of their achievements, but also because of the superb scientists they trained and/or influenced. Francis John Worsely Roughton (1899–1972) (Fig. 1), in his laboratory at Trinity College in Cambridge, England, made the first measurements of the rapid reaction of oxygen with hemoglobin at the millisecond scale, at first by flow-mixing methods and later by flash photolysis. He not only opened an era of molecular research of hemoglobin, but also invented the methodology for fast reactions through the use of laser technology, which was later improved by others so that even faster reactions could be detected. Another contribution of Roughton was the education of Quentin H. Gibson (Fig. 2), his favorite s- dent, who, in his laboratory in Sheffield, continued to expand the horizon of ligand binding to hemoglobin, defining the oxygen binding constants for each of the hemes of hemoglobin. Though this did not, as expected, solve the und- lying mechanism of ligand cooperativity as discussed below, it was nonet- less an important milestone.