Human Mast Cells
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Human Mast Cells
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Author : Ann M. Dvorak
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Human Mast Cells written by Ann M. Dvorak and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This book looks in detail at human mast cells. It includes a review of previous and current ultrastructural studies, whereby the latter are illustrated with numerous high-quality electron micrographs obtained from a large number of structural and functional experiments using highly purified isolated human lung mast cells. Specifically, the book provides criteria for the identification of human mast cells, discusses the unique role in mast cell function of granules and lipid bodies, describes the ultrastructural anatomy of two release reactions - i.e., anaphylactic degranulation and piecemeal degranulation - and defines the recovery, cyclical and maturational properties of human mast cells. All of these new morphological-biochemical and functional studies are correlated with the author's wide experience in the visual properties of human mast cells as seen in biopsy material obtained from a diagnostic ultrastructural pathology service.
Mast Cells
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Author : Guha Krishnaswamy
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-04
Mast Cells written by Guha Krishnaswamy and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-04 with Medical categories.
A cutting-edge collection of readily reproducible techniques for the isolation, culture, and study of activation and signaling in human mast cells. These methods take advantage of the latest advances in molecular biology, technology, and information science. They include methods for the identification of mast cells, the development of mast cells in vitro, the study of mast cell signaling and gene expression, and the measurement of mast cell expression of inflammatory mediators. Additional chapters cover methods for studying mast cell interactions with other cell types (endothelial cells, fibroblasts, and B cells), the roles of mast cells in host defense, and mast cell apoptosis.
Mast Cells Mediators And Disease
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Author : Stephen T. Holgate
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Mast Cells Mediators And Disease written by Stephen T. Holgate and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
In 1879 Paul Ehrlich first described the mast cell as a tissue fixed cell contain ing many granules which, when stained with basic dyes, such as toluidine blue, changed the colour spectrum of the dye in a process called meta chromasia. Since this early description, pathologists, physicians and pharmacologists have been fascinated by this cell on account of its central involvement in human allergic diseases. Approximately four decades after Ehrlich's first description of the mast cell, Prausnitz and Kiistner reported their pioneer experiment, demonstrating that the immediate skin wheal response to allergen could be passively transferred with serum. They named the antigen-specific serum factor reagin. A further four and one half decades had to pass before the connection between the mast cell and reagin could be made with the identification of reagin as an immunoglobulin E by Johansson and Ishizaka and its unique property to bind with high affinity to specific receptors on mast cells and basophils. Meanwhile in the 1920s Coca published a series of papers in which he described the clinical features of acute allergic responses and first used the term atopy. This, together with the fundamental pharmacological studies of Sir Henry Dale in identifying histamine as one mediator of the acute ana phylactic reaction, provided the second approach which eventually linked the mast cell to allergic tissue reactions. Indeed, it was Best, working in Dale's group who first showed that histamine was a chemical stored in mast cells.
The Mast Cell In Health And Disease
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Author : Kaliner
language : en
Publisher: CRC Press
Release Date : 1992-10-29
The Mast Cell In Health And Disease written by Kaliner and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-10-29 with Medical categories.
Offers coverage of practical and theoretical implications of current research into mast cell biology, emphasizing the role of the mast cell in human diseases. The text covers all aspects of the mast cell from growth and differentiation to its function in such conditions as asthma and skin disease.
Mast Cells And Basophils
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Author : Gianni Marone
language : en
Publisher: Academic Press
Release Date : 2000-05-25
Mast Cells And Basophils written by Gianni Marone and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-05-25 with Medical categories.
Mast Cells and Basophils will be essential reading for immunologists, biochemists and medical researchers. Detailed chapters cover all aspects of mast cell and basophil research, from cell development, proteases, histamine, cysteinyl leukotrienes, physiology and pathology to the role of these cells in health and disease. Chapters also discuss the clinical implications of histamine receptor antagonists.
Human Basophils And Mast Cells
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Author : Gianni Marone
language : en
Publisher: S. Karger AG (Switzerland)
Release Date : 1995
Human Basophils And Mast Cells written by Gianni Marone and has been published by S. Karger AG (Switzerland) this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Basophils categories.
"Expert contributions cover disorders, such as mastocytosis and respiratory and cutaneous allergy, which are known to be associated with these cells. The less well-known involvement of the latter in atherosclerosis and gastrointestinal, cardiac, rheumatic and neoplastic diseases is emerging as an area of considerable interest as several informative chapters show. Written by clinical investigators specialising in diseases related to mast cells and basophils, this volume will be stimulating reading for those working in allergy, immunology, biochemistry, and respiration."--BOOK JACKET.Title Summary field provided by Blackwell North America, Inc. All Rights Reserved
Mast Cell Proteases In Immunology And Biology
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Author : Caughey
language : en
Publisher: CRC Press
Release Date : 1995-05-11
Mast Cell Proteases In Immunology And Biology written by Caughey and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-05-11 with Medical categories.
This state-of-the-art reference provides timely and clinically and experimentally useful information on the major proteins of mast cell secretory granules that are released into the lung, skin, gut, eye, and other tissues under the influence of diverse stimuli-including cytokines, growth factors, neuropeptides, and allergen-bound immunoglobulin E. Demonstrates the important roles proteases play in the maintenance of tissue homeostasis as well as in the damaging events linked with allergy and other varieties of inflammation!
The Mast Cell
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Author : Domenico Ribatti
language : en
Publisher: Springer
Release Date : 2019-07-11
The Mast Cell written by Domenico Ribatti and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-11 with Medical categories.
Mast cells (MC) are phylogenetically old cells which are distributed throughout the human organism. MC are found in almost all of the major organs and tissues of the body, particularly in association with connective tissue structures such as blood vessels, lymphatic vessels and nerves, and in proximity to surfaces that interface the external environment, such as those of the respiratory and gastrointestinal system and the skin. This selective accumulation at tissue sites where foreign material attempts to invade the host suggests that MC are among the first cells to initiate defensive mechanisms. MC have long been recognized as key cells of type I hypersensitivity reactions. Several lines of evidence, however, indicate that they not only express critical effector functions in classic IgE-associated allergic disorders, but also play important roles in host defense against parasites, bacteria and perhaps even viruses. Indeed, it is now clear that MC can contribute to host defense in the context of either acquired or innate immune responses through the release of a myriad of pro-inflammatory and immunoregulatory molecules and the expression of a wide spectrum of surface receptors for cytokines and chemokines. Moreover, there is growing evidence that MC exert distinct non-immunological functions, playing a relevant role in tissue homeostasis, remodeling and fibrosis as well as in the processes of tissue angiogenesis.
Basophil And Mast Cell Degranulation And Recovery
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Author : Ann M. Dvorak
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Basophil And Mast Cell Degranulation And Recovery written by Ann M. Dvorak and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Medical categories.
Basophils and mast cells are similar but unique secretory cells with a well-documented role in immediate-hypersensitivity reactions. The presence of these cells in various cell mediated hypersensitivity reactions, in tissues of multiple diseases, and as a component of the host reaction to injury and repair in numerous circumstances is well known. Release of stored and newly generated mediators of inflammation from basophils and mast cells contributes to the cascade of pathogenetic events in circumstances under which these release reactions occur. Despite insights acquired through studies of these pathologic events, the role of basophils and mast cells and their secretory products in health is not known. In this book, I review much of the structural information regarding basophils and mast cells of multiple species. Ultrastructural studies of rat mast cells historically precede and quantitatively exceed similar studies of basophils and mast cells of other species. Therefore, I first review these background studies as an entity. Then I discuss the contents of two prominent organelles-granules and lipid bodies-in basophils and mast cells of several species. The ultrastructural morphology of basophils and mast cells in three species is presented in detail to establish appropriate guidelines for their recognition and to provide general rules for analysis which are appropriate for the identification of these cells in other species as well.
Mast Cells In Allergic Diseases
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Author : Hirohisa Saito
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2005-01-01
Mast Cells In Allergic Diseases written by Hirohisa Saito and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-01-01 with Medical categories.
In this book, the editors have focused on the roles of mast cells in allergic diseases and discuss the future direction of discovering drugs. Another implication of this book is to understand mast cells at the system level. System biology is a research category to understand biology at the system level by examining the structure and dynamics of cellular and organismal functions, rather than the characteristics of isolated parts of a cell or organism.