Human Polymorphic Genes
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Human Polymorphic Genes
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Author : Arun K. Roychoudhury
language : en
Publisher: Oxford University Press, USA
Release Date : 1988
Human Polymorphic Genes written by Arun K. Roychoudhury and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Medical categories.
This extensive compilation of statistical data on human gene frequencies includes entries for blood groups, proteins, enzymes, HLA systems, immunoglobulins, and restriction-site polymorphisms, as well as maps of gene frequency distributions. The authors are noted experts in the field, making this an authoritative reference for geneticists, human biologists, and physical anthropologists.
Genetic Polymorphism And Disease
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Author : Syed Sameer Aga
language : en
Publisher: CRC Press
Release Date : 2022-12-06
Genetic Polymorphism And Disease written by Syed Sameer Aga and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-06 with Science categories.
Genetic polymorphisms are important determinants of phenotypic variations and may modulate the risk to or even cause various diseases including genetic disorders and multifactorial diseases. Genetic polymorphisms also serve as important genetic, population and evolutionary markers that allow the study of genetic and evolutionary aspects of individuals, populations and organisms and aid in tracing the evolutionary and parental lineages. Genetic polymorphisms in low penetrance genes are responsible for the alterations in the gene expression of critical signal transduction proteins and metabolic enzymes. Some of these polymorphisms are linked to increased susceptibility to various diseases especially cancers, cardiovascular diseases, immune disorders, neurological pathologies. This book collates the reviews on the roles played by polymorphisms in critical metabolic, signal transduction, cell cycle or DNA repair genes either directly or indirectly in the disease mechanisms. The focus is on various techniques for identifying the various Single Nucleotide Polymorphisms (SNPs). Polymorphism studies document the affect SNPs, and their expressions have upon the functionality of the enzymes, proteins. Key Features Describes the genetic polymorphism and its various types Discusses the role of genetic polymorphisms in modulating the risk of various human diseases Explores various molecular techniques used for detecting GPs Characterizes the role of SNPs in modulating the susceptibility of human diseases Provides a genetic basis for individual variations in response to therapeutics
Human Blood Cells Consequences Of Genetic Polymorphisms And Variations
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Author : May-jean King
language : en
Publisher: World Scientific
Release Date : 2000-07-04
Human Blood Cells Consequences Of Genetic Polymorphisms And Variations written by May-jean King and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-07-04 with Medical categories.
This important book uses selected molecules expressed on erythrocytes, lymphocytes, platelets and granulocytes to illustrate how genetic polymorphisms and variations in these molecules can affect their structure and function in mature human blood cells. The examples described tend to have a clinical association. Human blood group antigens and HLA antigens are classic examples of genetic polymorphism and they are important in blood transfusion and organ transplantation, respectively. In common with the blood group antigens, the polymorphic and variant antigens on platelets and granulocytes can be targets for antibodies in feto-maternal antigen incompatibility and transfusion reactions. Certain inherited haemolytic anaemias can be attributed to some of the polymorphic and variant forms of erythrocyte anion transport protein, spectrin, and glucose-6-phosphate dehydrogenase which exhibit abnormal structural or functional properties. Similarly, the study of cytokine gene polymorphism can provide a further understanding of the immune/inflammatory diseases and allogeneic transplantation./a
Genetic Polymorphisms
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Author : Narasimha Reddy Parine
language : en
Publisher: BoD – Books on Demand
Release Date : 2017-09-06
Genetic Polymorphisms written by Narasimha Reddy Parine and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-06 with Medical categories.
The objective of this Genetic Polymorphisms book is to rehighlight and provide few updates on the role of genetic polymorphisms in medicine and agriculture, which void emerging opinion on "full death" of genetic polymorphisms as useful genetic markers. Chapters presented here demonstrate the future benefit of SNPs in many genetic studies as well as prognosis disease and diagnosis.
Genetic Polymorphisms And Susceptibility To Disease
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Author : Mark Steven Miller
language : en
Publisher: CRC Press
Release Date : 2000-04-27
Genetic Polymorphisms And Susceptibility To Disease written by Mark Steven Miller and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-04-27 with Science categories.
Genetic Polymorphisms and Susceptibity to Disease provides a reference for established researchers in genetic research. The book provides a broad but thorough overview of how allelic gene differences influence disease susceptibility in the human population, and will be a useful reference to researchers across a range of disciplines, for example, on
Genetic Variation And Its Maintenance
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Author : Derek Frank Roberts
language : en
Publisher: Cambridge University Press
Release Date : 1986-10-30
Genetic Variation And Its Maintenance written by Derek Frank Roberts and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986-10-30 with Science categories.
This volume considers the genetic variability of human populations, particularly in the tropics: its origins and maintenance, and its contribution to the phenotypic variability of complex characters. The first section deals with the ways of analysing genetic variation and provides a valuable review of relevant developments in molecular biology. The origin and maintenance of genetic diversity is considered in the second section with data presented for Pacific, African, Asian and Central American populations. The final section concerns characters in which the genetic contribution to variability is complex and shows how such characters may be used to elucidate biological problems of affinity and differentiation, of adaptation and survival. Published as part of the Decade of the Tropics research programme of the International Union of Biological Sciences, this volume will be of particular interest to human geneticists, physical and biological anthropologists.
Genes Polymorphisms And The Making Of Societies
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Author : Hippokratis Kiaris
language : en
Publisher: Universal-Publishers
Release Date : 2021-06-15
Genes Polymorphisms And The Making Of Societies written by Hippokratis Kiaris and has been published by Universal-Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-15 with Science categories.
Our genes determine to a large extent who we are and why we are different from others. In this book, Hippokratis Kiaris explores how various genetic polymorphisms in different ethnic populations may affect the development of distinct cultures and eventually historical decisions. It should be read by anybody interested in history, anthropology, behavior, psychology or genetics. The reader will find clues linking together these scientific disciplines and how such genetically determined behavioral traits may play an undervalued, as yet, role in shaping historical outcomes. The book initially describes some basic concepts on genetics and proceeds with an outline of human evolution, the journey of early humans Out-of-Africa, and the colonization of Earth by different human populations that eventually resulted in the development of different cultures. Then, by focusing on the two major prototype cultural lines, the Eastern and the Western, the author discusses differences in the corresponding civilizations in view of specific genetic polymorphisms that affect behavior and differ in frequencies between people of Asian and European origin. Finally, in view of the contemporary increasing tendency for cultural globalization, the book attempts to predict future trends on cultures and behavioral patterns. In this revised and extended second edition new data are included and new chapters, focusing on how sets of genes, as opposed to individual ones, coexist in different populations and may potentially impact cultural divergence throughout history.
Genes Polymorphisms And The Making Of Societies
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Author : Hippokratis Kiaris
language : en
Publisher: Universal Publishers
Release Date : 2012
Genes Polymorphisms And The Making Of Societies written by Hippokratis Kiaris and has been published by Universal Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Social Science categories.
Our genes determine to a large extent who we are as individuals and why we are different from the other human beings. In this book, Hippokratis Kiaris explores how various genetic polymorphisms in different ethnic populations may affect the development of distinct cultures and eventually historical decisions. It should be read by anybody interested in history, anthropology, behavior, psychology or genetics. The reader will find clues linking together these scientific disciplines and how such genetically determined behavioral traits may play an undervalued, as yet, role in shaping historical outcomes. The book initially describes some basic concepts on genetics and proceeds with an outline of human evolution, the journey of early humans Out-of-Africa, and the colonization of Earth by different human populations that eventually resulted in the development of different cultures. Then, by focusing on the two major prototype cultural lines, the Eastern and the Western, the author discusses differences in the corresponding civilizations in view of specific genetic polymorphisms that affect behavior and differ in frequencies between people of Asian and European origin. Finally, in view of the contemporary increasing tendency for cultural globalization, the book attempts to predict future trends on cultures and behavioral patterns.
Human Blood Cells
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Author : Mary-Jean King
language : en
Publisher: World Scientific Publishing Company
Release Date : 1999-01-01
Human Blood Cells written by Mary-Jean King and has been published by World Scientific Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-01-01 with categories.
This important book uses selected molecules expressed on erythrocytes, lymphocytes, platelets and granulocytes to illustrate how genetic polymorphisms and variations in these molecules can affect their structure and function in mature human blood cells. The examples described tend to have a clinical association. Human blood group antigens and HLA antigens are classic examples of genetic polymorphism and they are important in blood transfusion and organ transplantation, respectively. In common with the blood group antigens, the polymorphic and variant antigens on platelets and granulocytes can be targets for antibodies in feto-maternal antigen incompatibility and transfusion reactions. Certain inherited haemolytic anaemias can be attributed to some of the polymorphic and variant forms of erythrocyte anion transport protein, spectrin, and glucose-6-phosphate dehydrogenase which exhibit abnormal structural or functional properties. Similarly, the study of cytokine gene polymorphism can provide a further understanding of the immune/inflammatory diseases and allogeneic transplantation.
Molecular Polymorphism Of Man
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Author : Sergeĭ Dmitrievich Varfolomeev
language : en
Publisher: Nova Science Pub Incorporated
Release Date : 2011-01-01
Molecular Polymorphism Of Man written by Sergeĭ Dmitrievich Varfolomeev and has been published by Nova Science Pub Incorporated this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-01-01 with Science categories.
Decoding of the human genome created a qualitatively new state in development of modern fields of science, technology and medicine. One of the basic results of this is formation of a basis for investigating genome of every individual with detection of differences at the gene and protein levels. The chemical-biological approach based on highly efficient physical methods provides an opportunity of detailed molecular genetic typing of the population, investigation of genetic polymorphism, individual features of enzymatic and molecular-receptor processes in every person. Achievements in human genomics and proteomics, chemical enzymology, bioinformatics and medical genetics form the basis of modern investigations and multiple practical uses. The accuracy and efficiency of modern analytical methods allows for assigning tasks of obtaining genetic and proteomic molecular portrait of every individual, detection of individual differences of personalities at the genetic and protein levels. In the nearest decade, post-genomic and proteomic investigations will lead to significant changes in many spheres of social life. At present, a new molecular medicine based on determination of the ultimate causes of many diseases is being established. Aptitudes and development of many diseases are genetically defined. Basing on post-genomic and proteomic studies, new branches, such as cardiogenomics, oncogenomics, neurogenomics, pharmacogenomics, based on objective appraisal and reduction of risks of cardiovascular diseases and cancer, forecast of neurodegenerative processes and ageing appear in medicine. Today it is referred to creation and development of individual medicine based on molecular-genetic and proteomic human portrait. Occupational guidance and study of personal dispositions in various spheres of action may be based on molecular-genetic analysis. Molecular genetic typing is the foundation for reasonable determination of potential professional abilities. The study of polymorphism of genes defining physical, psychological and intellectual human characteristics seems to be of crucial importance. In the modern post-genomic process, one of the main targets is creation of a unified platform for genetic analysis and the basis for genotyping of the population. Functional reserves of the human organism are significantly defined by the genotype of parents. At present in developed countries, and in the nearest future in Russia, a system for estimation of risks and abilities of children basing on genetic portrait of parents is being developed. It is expected that in full this system will start functioning in the nearest decade. Genetic forecasting of pathology risk and human abilities at the background of many social factors is the material basis for transition to genetically healthful population. Post-genomic projects suggest many special supplements; in particular, developed approaches provide full and unambiguous identification of an individual using superlow, trace quantities of biological materials. The molecular genetic approach becomes the foundation for many human sciences. Analysis of structural features of genomic DNA passed from generation to generation is fundamental for the modern approach to the study of origination and evolution of ethnoses. New fields of science, ethnogenomics and ethnogeography, appeared. Post-genomic development of the science touches upon many spheres of life of the modern society. Basing on molecular presentations created by modern physical, chemical and molecular biological methods and operating modern information technologies, which use an advanced mathematical apparatus, this field creates extremely socially meaningful products affecting development of the society in whole. This book is a review of modern scientific data and ideas of above-mentioned area.