Human Population Genomics
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Human Population Genomics
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Author : Kirk E. Lohmueller
language : en
Publisher: Springer Nature
Release Date : 2021-03-13
Human Population Genomics written by Kirk E. Lohmueller and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-13 with Science categories.
This textbook provides a concise introduction and useful overview of the field of human population genomics, making the highly technical and contemporary aspects more accessible to students and researchers from various fields. Over the past decade, there has been a deluge of genetic variation data from the entire genome of individuals from many populations. These data have allowed an unprecedented look at human history and how natural selection has impacted humans during this journey. Simultaneously, there have been increased efforts to determine how genetic variation affects complex traits in humans. Due to technological and methodological advances, progress has been made at determining the architecture of complex traits. Split in three parts, the book starts with the basics, followed by more advanced and current research. The first part provides an introduction to essential concepts in population genetics, which are relevant for any organism. The second part covers the genetics of complex traits in humans. The third part focuses on applying these techniques and concepts to genetic variation data to learn about demographic history and natural selection in humans. This new textbook aims to serve as a gateway to modern human population genetics research for those new to the field. It provides an indispensable resource for students, researchers and practitioners from disparate areas of expertise.
Genomic Diversity
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Author : Surinder Singh Papiha
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Genomic Diversity written by Surinder Singh Papiha and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Social Science categories.
One of the major themes of human population genetics is assaying genetic variation in human populations. The ultimate goal of this objective is to understand the extent of genetic diversity and the use of this knowledge to reconstruct our evolutionary history. The discipline had undergone a revolutionary transition with the advent of molecular techniques in the 1980s. With this shift, statistical methods have also been developed to perceive the biological and molecular basis of human genetic variation. Using the new perspectives gained during the above transition, this volume describes the applications of molecular markers spanning the autosomal, Y-chromosomal and mitochondrial genome in the analysis of human diversity in contemporary populations. This is the first reference book of its kind to bring together data from these diverse sets of markers for understanding evolutionary histories and relationships of modern humans in a single volume.
The Genetics Of Human Populations
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Author : Luigi Luca Cavalli-Sforza
language : en
Publisher: Courier Corporation
Release Date : 1999-01-01
The Genetics Of Human Populations written by Luigi Luca Cavalli-Sforza and has been published by Courier Corporation this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-01-01 with Science categories.
Comprehensive, advanced treatment of nature and source of inherited characteristics, with treatment of mathematical techniques. Mendelian populations, mutations, polymorphisms, genetic demography, much more. Emphasizes interpretation of data in relation to theoretical models.
Human Population Genetics
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Author : P.P. Majumder
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Human Population Genetics written by P.P. Majumder and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
J. B. S. Haldane, R. A. Fisher and Sewall Wright simultaneously, and largely independently, laid the foundations of population genetics and the mathematical theory of evolution. Hal dane was born on November 5, 1892. Although he primarily worked at the University College London (UCL), in 1957 he resigned from the UCL and joined the Indian Statistical Institute, Calcutta (India) as a Research Professor. In celebration of his birth centenary, the Indian Statistical Institute organized an International Conference on Human Genetics from 15 to 19 December, 1992. The prime motive in holding this Conference was to bring together a group of scientists - geneticists, anthropologists, clinicians and statisticians - to evaluate the impact of Haldane's contributions to various areas of human genetics, and also to review recent developments in the subject. Session and lecture themes were so chosen that they covered areas theoretical and applied, classical and emerging. Speakers were then identified and invited to deliver lectures on these themes. Manuscripts of all invited presentations and a selected number of contributed presentations were considered for inclusion in this Proceed ings Volume. Each manuscript was reviewed by at least one Conference participant, which resulted in revision of several manuscripts and rejection of some. This volume is a collection of the manuscripts which have been 'accepted' after the review-process. The Conference began with the "J. B. S. Haldane Centenary Lecture" delivered by C. R. Rao.
Human Population Genetics And Genomics
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Author : Alan R. Templeton
language : en
Publisher: Academic Press
Release Date : 2018-11-08
Human Population Genetics And Genomics written by Alan R. Templeton and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-08 with Science categories.
Human Population Genetics and Genomics provides researchers/students with knowledge on population genetics and relevant statistical approaches to help them become more effective users of modern genetic, genomic and statistical tools. In-depth chapters offer thorough discussions of systems of mating, genetic drift, gene flow and subdivided populations, human population history, genotype and phenotype, detecting selection, units and targets of natural selection, adaptation to temporally and spatially variable environments, selection in age-structured populations, and genomics and society. As human genetics and genomics research often employs tools and approaches derived from population genetics, this book helps users understand the basic principles of these tools. In addition, studies often employ statistical approaches and analysis, so an understanding of basic statistical theory is also needed. Comprehensively explains the use of population genetics and genomics in medical applications and research Discusses the relevance of population genetics and genomics to major social issues, including race and the dangers of modern eugenics proposals Provides an overview of how population genetics and genomics helps us understand where we came from as a species and how we evolved into who we are now
Population Genomics
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Author : Om P. Rajora
language : en
Publisher: Springer
Release Date : 2019-01-07
Population Genomics written by Om P. Rajora and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-07 with Science categories.
Population genomics has revolutionized various disciplines of biology including population, evolutionary, ecological and conservation genetics, plant and animal breeding, human health, medicine and pharmacology by allowing to address novel and long-standing questions with unprecedented power and accuracy. It employs large-scale or genome-wide genetic information and bioinformatics to address various fundamental and applied aspects in biology and related disciplines, and provides a comprehensive genome-wide perspective and new insights that were not possible before. These advances have become possible due to the development of new and low-cost sequencing and genotyping technologies and novel statistical approaches and software, bioinformatics tools, and models. Population genomics is tremendously advancing our understanding the roles of evolutionary processes, such as mutation, genetic drift, gene flow, and natural selection, in shaping up genetic variation at individual loci and across the genome and populations; improving the assessment of population genetic parameters or processes such as adaptive evolution, effective population size, gene flow, admixture, inbreeding and outbreeding depression, demography, and biogeography; resolving evolutionary histories and phylogenetic relationships of extant, ancient and extinct species; understanding the genomic basis of fitness, adaptation, speciation, complex ecological and economically important traits, and disease and insect resistance; facilitating forensics, genetic medicine and pharmacology; delineating conservation genetic units; and understanding the genetic effects of resource management practices, and assisting conservation and sustainable management of genetic resources. This Population Genomics book discusses the concepts, approaches, applications and promises of population genomics in addressing most of the above fundamental and applied crucial aspects in a variety of organisms from microorganisms to humans. The book provides insights into a range of emerging population genomics topics including population epigenomics, landscape genomics, seascape genomics, paleogenomics, ecological and evolutionary genomics, biogeography, demography, speciation, admixture, colonization and invasion, genomic selection, and plant and animal domestication. This book fills a vacuum in the field and is expected to become a primary reference in Population Genomics world-wide.
Population Genomics In The Developing World
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Author : Marlo Möller
language : en
Publisher: Academic Press
Release Date : 2024-11-01
Population Genomics In The Developing World written by Marlo Möller and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-01 with Science categories.
Population Genomics in the Developing World: Concepts, Applications, and Challenges, a new volume in the Translational and Applied Genomics series, provides a comprehensive, up-to-date summary of the field of population genomics in developing countries. The book equips students, researchers, and clinicians with the practical skills and approaches necessary to face the unique challenges and opportunities of practicing population genomics in developing countries. Following a brief foundational overview, more than a dozen authors working in developing nations share applied case studies from the field, including rationale, methods, analysis, and outcomes to reinforce understanding. Key themes across the country specific chapters include efficient genetic data generation and effective computational and statistical tools to analyze population-level data. The book then discusses clinical interpretation of this data, from direct-to-consumer ancestry testing to translational and applied precision medicine. A final chapter considers ethical aspects of conducting genomic research in developing countries.
Human Population Genetics
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Author : John Relethford
language : en
Publisher:
Release Date : 2012
Human Population Genetics written by John Relethford and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Electronic books categories.
Providing an introduction to mathematical population genetics, Human Population Genetics gives basic background on the mechanisms of human microevolution. This text combines mathematics, biology, and anthropology and is best suited for advanced undergraduate and graduate study.
Evaluating Human Genetic Diversity
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 1998-01-19
Evaluating Human Genetic Diversity written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-01-19 with Science categories.
This book assesses the scientific value and merit of research on human genetic differencesâ€"including a collection of DNA samples that represents the whole of human genetic diversityâ€"and the ethical, organizational, and policy issues surrounding such research. Evaluating Human Genetic Diversity discusses the potential uses of such collection, such as providing insight into human evolution and origins and serving as a springboard for important medical research. It also addresses issues of confidentiality and individual privacy for participants in genetic diversity research studies.
Progress In Population Genetics And Human Evolution
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Author : Peter Donnelly
language : en
Publisher: Springer Verlag
Release Date : 1997-02-27
Progress In Population Genetics And Human Evolution written by Peter Donnelly and has been published by Springer Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-02-27 with Mathematics categories.
This book is devoted to the collection, interpretation and analysis of population genetic data. Among the topics included here are studies on human evolutionary history, molecular techniques for generating data, statistical and computational techniques for the interpretation of such data, and stochastic models for genealogy and population structure. The chapters reflect the close interaction between experimental molecular biologists and theoreticians. The book will be useful for specialists in the area, as well as mathematicians, statisticians, computer scientists and biologists wanting a brief overview of current problems in the field.