Human Variability In Response To Chemical Exposures
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Human Variability In Response To Chemical Exposures
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Author : David A. Neumann
language : en
Publisher: International Life Science Inst
Release Date : 1998
Human Variability In Response To Chemical Exposures written by David A. Neumann and has been published by International Life Science Inst this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Medical categories.
and for those interested in toxic effects of chemicals on humans, Human Variability in Response to Chemical Exposures: Measures, Modeling, & Risk Assessment recognizes & addresses the increasing awareness that individual biological differences be reflected when assessing human health risks associated with exposure to chemicals. Eight original manuscripts, commissioned by the ILSI Risk Science Institute, address the evidence for variability in human response to chemicals associated with reproductive & developmental effects, effects on the nervous system & lungs, & cancer. Their reports convey both the current state of scientific understanding of response variability & the genetic basis for such observations. This book recognizes that understanding of variability in response is critical in accounting for interindividual variability in susceptibility and, hence, risk, if the regulatory community & others are expected to characterize human health risks associated with exposure to chemicals. Models for incorporating measures of response variability in the risk assessment process are critically reviewed & illustrated with published data. This authoritative work indicates that, in the case of certain chemicals & in the context of certain specific toxic effects, we have considerable ability to predictively & quantitatively characterize human variability, but, in the majority of cases, our ability to do so is limited. If we improve both quantity & quality of information available on response variability & increase our understanding of target tissue dosimetry, we should be better able to account for variability in human susceptibility to the toxic effects of chemicals.
Human Variability In Response To Chemical Exposures Measures Modeling And Risk Assessment
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Author : David A. Neumann
language : en
Publisher: CRC Press
Release Date : 1998-08-25
Human Variability In Response To Chemical Exposures Measures Modeling And Risk Assessment written by David A. Neumann and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-08-25 with Medical categories.
and for those interested in toxic effects of chemicals on humans, Human Variability in Response to Chemical Exposures: Measures, Modeling, and Risk Assessment recognizes and addresses the increasing awareness that individual biological differences be reflected when assessing human health risks associated with exposure to chemicals. Eight original manuscripts, commissioned by the ILSI Risk Science Institute, address the evidence for variability in human response to chemicals associated with reproductive and developmental effects, effects on the nervous system and lungs, and cancer. Their reports convey both the current state of scientific understanding of response variability and the genetic basis for such observations. This book recognizes that understanding of variability in response is critical in accounting for interindividual variability in susceptibility and, hence, risk, if the regulatory community and others are expected to characterize human health risks associated with exposure to chemicals. Models for incorporating measures of response variability in the risk assessment process are critically reviewed and illustrated with published data. This authoritative work indicates that, in the case of certain chemicals and in the context of certain specific toxic effects, we have considerable ability to predictively and quantitatively characterize human variability, but, in the majority of cases, our ability to do so is limited. If we improve both quantity and quality of information available on response variability and increase our understanding of target tissue dosimetry, we should be better able to account for variability in human susceptibility to the toxic effects of chemicals.
Human Variability In Response To Chemical Exposures Measures Modeling And Risk Assessment
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Author : David A. Eckerman
language : en
Publisher: CRC Press
Release Date : 1998-08-25
Human Variability In Response To Chemical Exposures Measures Modeling And Risk Assessment written by David A. Eckerman and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-08-25 with Medical categories.
and for those interested in toxic effects of chemicals on humans, Human Variability in Response to Chemical Exposures: Measures, Modeling, and Risk Assessment recognizes and addresses the increasing awareness that individual biological differences be reflected when assessing human health risks associated with exposure to chemicals. Eight original manuscripts, commissioned by the ILSI Risk Science Institute, address the evidence for variability in human response to chemicals associated with reproductive and developmental effects, effects on the nervous system and lungs, and cancer. Their reports convey both the current state of scientific understanding of response variability and the genetic basis for such observations. This book recognizes that understanding of variability in response is critical in accounting for interindividual variability in susceptibility and, hence, risk, if the regulatory community and others are expected to characterize human health risks associated with exposure to chemicals. Models for incorporating measures of response variability in the risk assessment process are critically reviewed and illustrated with published data. This authoritative work indicates that, in the case of certain chemicals and in the context of certain specific toxic effects, we have considerable ability to predictively and quantitatively characterize human variability, but, in the majority of cases, our ability to do so is limited. If we improve both quantity and quality of information available on response variability and increase our understanding of target tissue dosimetry, we should be better able to account for variability in human susceptibility to the toxic effects of chemicals.
Ieh Report On Variability And Susceptibility In Human Response To Occupational Exposure To Chemicals In The Uk
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Author : Medical Research Council (Great Britain). Institute for Environment and Health
language : en
Publisher:
Release Date : 2002
Ieh Report On Variability And Susceptibility In Human Response To Occupational Exposure To Chemicals In The Uk written by Medical Research Council (Great Britain). Institute for Environment and Health and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Environmental toxicology categories.
Chemical Specific Adjustment Factors For Interspecies Differences And Human Variability
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Author : International Program on Chemical Safety
language : en
Publisher: World Health Organization
Release Date : 2005-12-31
Chemical Specific Adjustment Factors For Interspecies Differences And Human Variability written by International Program on Chemical Safety and has been published by World Health Organization this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-12-31 with Law categories.
Published under the joint sponsorship of the WHO, the ILO and the UNEP and produced within the framework of the Inter-Organization Programme for the Sound Management of Chemicals. On cover: IPCS: International Programme on Chemical Safety
Applications Of Toxicogenomic Technologies To Predictive Toxicology And Risk Assessment
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2007-11-19
Applications Of Toxicogenomic Technologies To Predictive Toxicology And Risk Assessment written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-19 with Science categories.
The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new waysâ€"an effort requiring funding, interagency coordination, and data management strategies.
Genetic Variability In Responses To Chemical Exposure
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Author : Gilbert S. Omenn
language : en
Publisher:
Release Date : 1984
Genetic Variability In Responses To Chemical Exposure written by Gilbert S. Omenn and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984 with Carcinogens, Environmental categories.
Science And Decisions
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2009-03-24
Science And Decisions written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-03-24 with Political Science categories.
Risk assessment has become a dominant public policy tool for making choices, based on limited resources, to protect public health and the environment. It has been instrumental to the mission of the U.S. Environmental Protection Agency (EPA) as well as other federal agencies in evaluating public health concerns, informing regulatory and technological decisions, prioritizing research needs and funding, and in developing approaches for cost-benefit analysis. However, risk assessment is at a crossroads. Despite advances in the field, risk assessment faces a number of significant challenges including lengthy delays in making complex decisions; lack of data leading to significant uncertainty in risk assessments; and many chemicals in the marketplace that have not been evaluated and emerging agents requiring assessment. Science and Decisions makes practical scientific and technical recommendations to address these challenges. This book is a complement to the widely used 1983 National Academies book, Risk Assessment in the Federal Government (also known as the Red Book). The earlier book established a framework for the concepts and conduct of risk assessment that has been adopted by numerous expert committees, regulatory agencies, and public health institutions. The new book embeds these concepts within a broader framework for risk-based decision-making. Together, these are essential references for those working in the regulatory and public health fields.
Monitoring Human Tissues For Toxic Substances
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 1991-02-01
Monitoring Human Tissues For Toxic Substances written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-02-01 with Science categories.
The National Human Monitoring Program (NHMP) identifies concentrations of specific chemicals in human tissues, including toxicologic testing and risk assessment determinations. This volume evaluates the current activities of the NHMP; identifies important scientific, technical, and programmatic issues; and makes recommendations regarding the design of the program and use of its products.
Principles And Methods Of Toxicology Fifth Edition
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Author : A. Wallace Hayes
language : en
Publisher: CRC Press
Release Date : 2007-09-25
Principles And Methods Of Toxicology Fifth Edition written by A. Wallace Hayes and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-09-25 with Medical categories.
Founded on the paradox that all things are poisons and the difference between poison and remedy is quantity, the determination of safe dosage forms the base and focus of modern toxicology. In order to make a sound determination there must be a working knowledge of the biologic mechanisms involved and of the methods employed to define these mechanisms. While the vastness of the field and the rapid accumulation of data may preclude the possibility of absorbing and retaining more than a fraction of the available information, a solid understanding of the underlying principles is essential. Extensively revised and updated with four new chapters and an expanded glossary, this fifth edition of the classic text, Principles and Methods of Toxicology provides comprehensive coverage in a manageable and accessible format. New topics include 'toxicopanomics', plant and animal poisons, information resources, and non-animal testing alternatives. Emphasizing the cornerstones of toxicology-people differ, dose matters, and things change, the book begins with a review of the history of toxicology and followed by an explanation of basic toxicological principles, agents that cause toxicity, target organ toxicity, and toxicological testing methods including many of the test protocols required to meet regulatory needs worldwide. The book examines each method or procedure from the standpoint of technique and interpretation of data and discusses problems and pitfalls that may be associated with each. The addition of several new authors allow for a broader and more diverse treatment of the ever-changing and expanding field of toxicology. Maintaining the high-quality information and organizational framework that made the previous editions so successful, Principles and Methods of Toxicology, Fifth Edition continues to be a valuable resource for the advanced practitioner as well as the new disciple of toxicology.