Hypertension Heredity And Stroke
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Hypertension Heredity And Stroke
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Author : Cristina Moratinos
language : en
Publisher: Nova Science Publishers
Release Date : 2009
Hypertension Heredity And Stroke written by Cristina Moratinos and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Brain categories.
This book gathers the latest research from around the world on hypertension and stroke. While it is widely known how raised heart rate adversely affects ischaemic heart disease and congestive heart failure, it has not been clearly shown how low heart rate increases tendency to stroke. Thus the influence of heart rate on development of stroke is examined in this book. The etiology of paediatric stroke, a potentially devastating condition, is also discussed, since it is an important condition that often remains unknown in a considerable number of patients. Furthermore, arterial hypertension and cardiovascular complications in patients with glomerular kidney disease are also explored in this book. The progress that has been made towards identifying the genetics of risk factors in polygenic and multifactorial intracerebral hemorrhage (ICH) is presented and data regarding monogenic conditions associated with ICH is summarised. Other chapters in this book include the examination of the association between blood pressure (BP) and bone mineral content (BMC) in paediatrics; arterial hypertension as one of the main clinical symptoms of aortic coarctation in children, and a review of ambulatory blood pressure monitoring (ABPM) as a non-invasive method of blood pressure assessment, which is considered to be a very useful tool in the diagnosis of arterial hypertension in adults, teenagers and children.
Stroke Genetics
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Author : Hugh S. Markus
language : en
Publisher: Oxford University Press
Release Date : 2003-05-01
Stroke Genetics written by Hugh S. Markus and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-05-01 with Medical categories.
Stroke is a major cause of death and the major cause of adult neurological disability in most of the world. Despite its importance on a population basis, research into the genetics of stroke has lagged behind that of many other disorders. However, the situation is now changing. An increasing number of single gene disorders causing stroke are being described, and there is growing evidence that polygenic factors are important in the risk of apparently "sporadic" stroke. Stroke Genetics provides an up-to-date review of the area, suitable for clinicians treating stroke patients, and both clinical and non-clinical researchers in the field of cerebrovascular disease. The full range of monogenic stroke disorders causing cerebrovascular disease, including ischaemic stroke, intracerebral haemorrhage, aneurysms and arteriovenous malformations, are covered. For each, clinical features, diagnosis, and genetics are described. Increasing evidence suggest that genetic factors are also important for the much more common multifactorial stroke; this evidence is reviewed along with the results of genetic studies in this area. Optimal and novel strategies for investigating multifactorial stroke, including the use of intermediate phenotypes such as intima-media thickness and MRI detected small vessel disease are reviewed. The book concludes by describing a practical approach to investigating patients with stroke for underlying genetic disorders. Also included is a list of useful websites.
Risk Factors For Cerebrovascular Disease And Stroke
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Author : Sudha Seshadri
language : en
Publisher: Oxford University Press
Release Date : 2015-07-10
Risk Factors For Cerebrovascular Disease And Stroke written by Sudha Seshadri and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-10 with Medical categories.
Risk Factors for Cerebrovascular Disease and Stroke address the relationship of a wide variety of vascular risk factors in the spectrum of cerebrovascular diseases. An international group of professionals the forefront of research and education, provide their expertise about environmental and genetic determinants for cerebrovascular disease and stroke. The authors aim to provide information on developments of genetic, environmental and lifestyle-related risk factors of various subtypes of stroke, and MRI-markers of cerebrovascular disease. One in two men, and one in three women after the age of 40, will develop a stroke in their lifetime. The burden of cerebrovascular disease extends far beyond that of acute clinical events such as stroke, with "covert" vascular injury on brain MRI being highly prevalent in older community-dwelling persons. Therefore, improving our understanding of the risk factors for stroke and cerebrovascular disease is of paramount importance for improving prevention strategies. Secular trends in stroke epidemiology, risk factors, and intermediate markers (including carotid ultrasound, brain MRI and circulating biomarkers) are presented. Cutting edge information on genetic, environmental and lifestyle-related risk factors of various subtypes of stroke and MRI-markers of cerebrovascular diseases are displayed. This important book is an essential reference to physicians interested in more effective primary prevention of stroke.
Genetics Of Hypertension
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Author : Anna F. Dominiczak
language : en
Publisher: Elsevier Health Sciences
Release Date : 2007-01-01
Genetics Of Hypertension written by Anna F. Dominiczak and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-01-01 with Medical categories.
Classic and modern tools of genetics have been applied to hypertension research for some 20 years. This volume in the Handbook of Hypertension series aims to go beyond a simple summary of discoveries and provides a critical commentary on many controversial issues. It will be particularly useful for clinician scientists at all stages of their careers, graduate students and post-doctoral scientists as well as all those interested in cardiovascular medicine and research throughout the entire spectrum from bench to bedside. As in every relatively young area of research, the initial excitement over the early positive observations has not always been confirmed by subsequent larger studies with greater statistical power. Issues related to current recommendations on design of studies and their analysis are therefore included. Pharmacogenetics and pharmacogenomics have been the subjects of many debates in recent years and are of particular importance in hypertension as life-long treatments, frequently with multiple drugs are given to millions of people world-wide. A critical appraisal of this controversial topic is provided. Several chapters on experimental genetics of hypertension with a special focus on physiological genomics are also included.
Genetics Of Hypertension
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Author : Xi Cheng
language : en
Publisher: Biota Publishing
Release Date : 2015-08-01
Genetics Of Hypertension written by Xi Cheng and has been published by Biota Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-01 with Medical categories.
Hypertension, or elevated blood pressure, is a major risk factor for various cardiovascular, renal diseases, and stroke. The form of hypertension with no identifiable cause is referred to as Essential Hypertension. Familial studies indicate that Essential Hypertension is heritable and, thereby, classical genetic approaches have been applied on both human and other mammalian models of hypertension to map the locations of the allelic variants within quantitative trait loci for blood pressure. The post genome era has further elevated this area of research into large-scale genome-wide association studies of hypertension in humans. Collectively, these studies have resulted in the prioritization and cataloging of several genomic regions containing allelic variants as candidates linked or associated with essential hypertension. Further, they are providing evidence to suggest that the inheritance of hypertension is rather complex, encompassing multiple variants both within protein-coding and non-coding annotations, each of which may act independently or interactively with other genes and/or environmental factors to differentially regulate blood pressure. This book provides an overview of the various methods employed to study the genetics of hypertension and discuss the progress and prospects of this area of research that may contribute towards individualized clinical management of hypertension in the future.
Stroke Genetics
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Author : Pankaj Sharma
language : en
Publisher: Springer
Release Date : 2012-08-27
Stroke Genetics written by Pankaj Sharma and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-08-27 with Medical categories.
Over the last decade there has been a substantial increase in our understanding of the genetic basis of common disorders such as stroke. Stroke Genetics is designed to give the reader an overall understanding of the genetics of complex diseases by using stroke as a paradigm. The reader will gain a comprehensive understanding of cerebrovascular genetics including the epidemiological evidence for the genetic basis of ischemic and hemorrhagic stroke, knowledge of its molecular basis from association, linkage and recent genome-wide studies, and also monogenic disorders. Finally, the legal and ethical complexities in dealing with these issues are discussed. Stroke Genetics benefits from the contribution of renowned experts from throughout the world who have been intimately involved in unraveling the genetic etiology of stroke. Stroke Genetics is a valuable resource for neurologists, stroke physicians, hypertension specialists, internists, clinical pharmacologists and those in training, as well as researchers in the field of disease genetics.
Molecular Genetics Of Stroke
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Author : Yoshiji Yamada
language : en
Publisher: Morgan & Claypool Publishers
Release Date : 2012-04
Molecular Genetics Of Stroke written by Yoshiji Yamada and has been published by Morgan & Claypool Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04 with Medical categories.
Stroke is an important clinical problem because of its large contribution to mortality. The main causal and treatable risk factors for stroke include hypertension, diabetes mellitus, dyslipidemia, and smoking. In addition to these risk factors, recent studies have shown the importance of genetic factors and interactions between multiple genes and environmental factors. Genetic linkage analyses of families and sib-pairs as well as candidate gene association studies have implicated several loci and many candidate genes in predisposition to ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage. Recent genome-wide association studies identified various loci and genes that confer susceptibility to ischemic stroke or intracranial aneurysm. Such studies may provide insight into the function of implicated genes as well as into the role of genetic factors in the development of ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage. Table of Contents: Introduction / Genetics of Stroke / Single-Gene Disorders Associated with Stroke / Genetics of Common Forms of Stroke / Clinical Implications / Conclusion / References / Titles of Related Interest
Experimental And Genetic Models Of Hypertension
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Author : Wybren de Jong
language : en
Publisher:
Release Date : 1994
Experimental And Genetic Models Of Hypertension written by Wybren de Jong and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Animal models in research categories.
Hardbound. This volume is a worthy successor to volume 4 by virtue of its focus on the recent conceptual revolution in fundamental hypertension research. Without neglecting the heritage of earlier achievements, it highlights such brilliant breakthroughs in molecular genetics as the creation of transgenic animals as a source of a new pathogenesis of hypertension.A core of (patho)physiological mechanisms operative in experimental hypertension is provided, including several which act to maintain a normotensive state. The volume provides background and technical information on the use of different models of hypertension in a variety of animal species. A wealth of new information regarding the several different complications observed in genetic and other models of hypertension, as well as new animal models dedicated to these aspects, are also presented. Furthermore, new chapters addressing genotyping and the use of transgenics in hypertension are included.
Beat The Heart Attack Gene
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Author : Bradley Bale
language : en
Publisher: Turner Publishing Company
Release Date : 2014-02-04
Beat The Heart Attack Gene written by Bradley Bale and has been published by Turner Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-04 with Health & Fitness categories.
A revolutionary, personalized guide to preventing heart disease—America’s #1 killer Heart disease is the #1 cause of death in America. It affects 81 million Americans and is the culprit in one of every two deaths in the United States. Most people think that they are not at risk of a heart attack if they control their cholesterol and blood pressure, but they aren’t aware of other major risk factors. The good news is that with the right information and strategies, heart attacks are preventable—even if heart disease runs in the family. In Beat the Heart Attack Gene, world-renowned cardiovascular specialists Bradley Bale, MD and Amy Doneen, ARNP, present a new model for understanding and preventing heart disease. They explain the three different genetic types of cholesterol profiles and tailor treatments for each type, using their cutting-edge Bale/Doneen Method, a comprehensive, evidence-based medical treatment plan that detects cardiovascular disease (CVD) at early stages and stabilizes it with individualized medical and lifestyle therapy. Beat the Heart Attack Gene includes easy quizzes and self-tests that show how to determine cholesterol genotype as well as advice for how to apply that knowledge through and individualized lifestyle advice. For heart attack and stroke survivors, the Bale/Doneen Method also helps prevent recurrences by identifying and treating what's triggering the patient's disease—a crucial step that many cardiologists neglect. With their proven method utilized by healthcare professionals worldwide, Bale and Doneen empower readers by alerting them to potential health threats, and then offer personalized strategies so they can live healthy, active lives without fear of heart attack or stroke. Specifically, Beat the Heart Attack Gene addresses: *The hidden cause of most heart attacks *Early prevention methods *The dangerous cholesterol most doctors don’t check *Major red flags for heart attack and stroke risk, including gum disease *The genes that increase cardiovascular risk as much as smoking *The best and worst supplements and foods for your heart *10 surprising ways to prevent heart attacks
Genetic Influences On Atherothrombotic Disease
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Author : Richard Manford Sherva
language : en
Publisher:
Release Date : 2006
Genetic Influences On Atherothrombotic Disease written by Richard Manford Sherva and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Cardiovascular system categories.