Hypothesis Driven Simulation Studies
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Hypothesis Driven Simulation Studies
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Author : Fabian Lorig
language : en
Publisher: Springer
Release Date : 2019-08-16
Hypothesis Driven Simulation Studies written by Fabian Lorig and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-16 with Computers categories.
Fabian Lorig develops a procedure model for hypothesis-driven simulation studies which supports the design, conducting, and analysis of simulation experiments. It is aimed at facilitating the execution of simulation studies with regard to the replicability and reproducibility of the results. In comparison to existing models, this approach is based on a formally specified hypothesis. Each step of the simulation study can be adapted to the central hypothesis and performed in such a way that it can optimally contribute to the verification and thus to the confirmation or rejection of the hypothesis.
Model Based Hypothesis Testing In Biomedicine
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Author : Rikard Johansson
language : en
Publisher: Linköping University Electronic Press
Release Date : 2017-10-03
Model Based Hypothesis Testing In Biomedicine written by Rikard Johansson and has been published by Linköping University Electronic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-03 with categories.
The utilization of mathematical tools within biology and medicine has traditionally been less widespread compared to other hard sciences, such as physics and chemistry. However, an increased need for tools such as data processing, bioinformatics, statistics, and mathematical modeling, have emerged due to advancements during the last decades. These advancements are partly due to the development of high-throughput experimental procedures and techniques, which produce ever increasing amounts of data. For all aspects of biology and medicine, these data reveal a high level of inter-connectivity between components, which operate on many levels of control, and with multiple feedbacks both between and within each level of control. However, the availability of these large-scale data is not synonymous to a detailed mechanistic understanding of the underlying system. Rather, a mechanistic understanding is gained first when we construct a hypothesis, and test its predictions experimentally. Identifying interesting predictions that are quantitative in nature, generally requires mathematical modeling. This, in turn, requires that the studied system can be formulated into a mathematical model, such as a series of ordinary differential equations, where different hypotheses can be expressed as precise mathematical expressions that influence the output of the model. Within specific sub-domains of biology, the utilization of mathematical models have had a long tradition, such as the modeling done on electrophysiology by Hodgkin and Huxley in the 1950s. However, it is only in recent years, with the arrival of the field known as systems biology that mathematical modeling has become more commonplace. The somewhat slow adaptation of mathematical modeling in biology is partly due to historical differences in training and terminology, as well as in a lack of awareness of showcases illustrating how modeling can make a difference, or even be required, for a correct analysis of the experimental data. In this work, I provide such showcases by demonstrating the universality and applicability of mathematical modeling and hypothesis testing in three disparate biological systems. In Paper II, we demonstrate how mathematical modeling is necessary for the correct interpretation and analysis of dominant negative inhibition data in insulin signaling in primary human adipocytes. In Paper III, we use modeling to determine transport rates across the nuclear membrane in yeast cells, and we show how this technique is superior to traditional curve-fitting methods. We also demonstrate the issue of population heterogeneity and the need to account for individual differences between cells and the population at large. In Paper IV, we use mathematical modeling to reject three hypotheses concerning the phenomenon of facilitation in pyramidal nerve cells in rats and mice. We also show how one surviving hypothesis can explain all data and adequately describe independent validation data. Finally, in Paper I, we develop a method for model selection and discrimination using parametric bootstrapping and the combination of several different empirical distributions of traditional statistical tests. We show how the empirical log-likelihood ratio test is the best combination of two tests and how this can be used, not only for model selection, but also for model discrimination. In conclusion, mathematical modeling is a valuable tool for analyzing data and testing biological hypotheses, regardless of the underlying biological system. Further development of modeling methods and applications are therefore important since these will in all likelihood play a crucial role in all future aspects of biology and medicine, especially in dealing with the burden of increasing amounts of data that is made available with new experimental techniques. Användandet av matematiska verktyg har inom biologi och medicin traditionellt sett varit mindre utbredd jämfört med andra ämnen inom naturvetenskapen, såsom fysik och kemi. Ett ökat behov av verktyg som databehandling, bioinformatik, statistik och matematisk modellering har trätt fram tack vare framsteg under de senaste decennierna. Dessa framsteg är delvis ett resultat av utvecklingen av storskaliga datainsamlingstekniker. Inom alla områden av biologi och medicin så har dessa data avslöjat en hög nivå av interkonnektivitet mellan komponenter, verksamma på många kontrollnivåer och med flera återkopplingar både mellan och inom varje nivå av kontroll. Tillgång till storskaliga data är emellertid inte synonymt med en detaljerad mekanistisk förståelse för det underliggande systemet. Snarare uppnås en mekanisk förståelse först när vi bygger en hypotes vars prediktioner vi kan testa experimentellt. Att identifiera intressanta prediktioner som är av kvantitativ natur, kräver generellt sett matematisk modellering. Detta kräver i sin tur att det studerade systemet kan formuleras till en matematisk modell, såsom en serie ordinära differentialekvationer, där olika hypoteser kan uttryckas som precisa matematiska uttryck som påverkar modellens output. Inom vissa delområden av biologin har utnyttjandet av matematiska modeller haft en lång tradition, såsom den modellering gjord inom elektrofysiologi av Hodgkin och Huxley på 1950?talet. Det är emellertid just på senare år, med ankomsten av fältet systembiologi, som matematisk modellering har blivit ett vanligt inslag. Den något långsamma adapteringen av matematisk modellering inom biologi är bl.a. grundad i historiska skillnader i träning och terminologi, samt brist på medvetenhet om exempel som illustrerar hur modellering kan göra skillnad och faktiskt ofta är ett krav för en korrekt analys av experimentella data. I detta arbete tillhandahåller jag sådana exempel och demonstrerar den matematiska modelleringens och hypotestestningens allmängiltighet och tillämpbarhet i tre olika biologiska system. I Arbete II visar vi hur matematisk modellering är nödvändig för en korrekt tolkning och analys av dominant-negativ-inhiberingsdata vid insulinsignalering i primära humana adipocyter. I Arbete III använder vi modellering för att bestämma transporthastigheter över cellkärnmembranet i jästceller, och vi visar hur denna teknik är överlägsen traditionella kurvpassningsmetoder. Vi demonstrerar också frågan om populationsheterogenitet och behovet av att ta hänsyn till individuella skillnader mellan celler och befolkningen som helhet. I Arbete IV använder vi matematisk modellering för att förkasta tre hypoteser om hur fenomenet facilitering uppstår i pyramidala nervceller hos råttor och möss. Vi visar också hur en överlevande hypotes kan beskriva all data, inklusive oberoende valideringsdata. Slutligen utvecklar vi i Arbete I en metod för modellselektion och modelldiskriminering med hjälp av parametrisk ”bootstrapping” samt kombinationen av olika empiriska fördelningar av traditionella statistiska tester. Vi visar hur det empiriska ”log-likelihood-ratio-testet” är den bästa kombinationen av två tester och hur testet är applicerbart, inte bara för modellselektion, utan också för modelldiskriminering. Sammanfattningsvis är matematisk modellering ett värdefullt verktyg för att analysera data och testa biologiska hypoteser, oavsett underliggande biologiskt system. Vidare utveckling av modelleringsmetoder och tillämpningar är därför viktigt eftersom dessa sannolikt kommer att spela en avgörande roll i framtiden för biologi och medicin, särskilt när det gäller att hantera belastningen från ökande datamängder som blir tillgänglig med nya experimentella tekniker.
The Foundations Of Statistics A Simulation Based Approach
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Author : Shravan Vasishth
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-11-11
The Foundations Of Statistics A Simulation Based Approach written by Shravan Vasishth and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-11 with Mathematics categories.
Statistics and hypothesis testing are routinely used in areas (such as linguistics) that are traditionally not mathematically intensive. In such fields, when faced with experimental data, many students and researchers tend to rely on commercial packages to carry out statistical data analysis, often without understanding the logic of the statistical tests they rely on. As a consequence, results are often misinterpreted, and users have difficulty in flexibly applying techniques relevant to their own research — they use whatever they happen to have learned. A simple solution is to teach the fundamental ideas of statistical hypothesis testing without using too much mathematics. This book provides a non-mathematical, simulation-based introduction to basic statistical concepts and encourages readers to try out the simulations themselves using the source code and data provided (the freely available programming language R is used throughout). Since the code presented in the text almost always requires the use of previously introduced programming constructs, diligent students also acquire basic programming abilities in R. The book is intended for advanced undergraduate and graduate students in any discipline, although the focus is on linguistics, psychology, and cognitive science. It is designed for self-instruction, but it can also be used as a textbook for a first course on statistics. Earlier versions of the book have been used in undergraduate and graduate courses in Europe and the US. ”Vasishth and Broe have written an attractive introduction to the foundations of statistics. It is concise, surprisingly comprehensive, self-contained and yet quite accessible. Highly recommended.” Harald Baayen, Professor of Linguistics, University of Alberta, Canada ”By using the text students not only learn to do the specific things outlined in the book, they also gain a skill set that empowers them to explore new areas that lie beyond the book’s coverage.” Colin Phillips, Professor of Linguistics, University of Maryland, USA
Multi Agent Based Simulation Xxiv
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Author : Luis G. Nardin
language : en
Publisher: Springer Nature
Release Date :
Multi Agent Based Simulation Xxiv written by Luis G. Nardin and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Principles Of Data Science
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Author : Hamid R. Arabnia
language : en
Publisher: Springer Nature
Release Date : 2020-07-08
Principles Of Data Science written by Hamid R. Arabnia and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-08 with Technology & Engineering categories.
This book provides readers with a thorough understanding of various research areas within the field of data science. The book introduces readers to various techniques for data acquisition, extraction, and cleaning, data summarizing and modeling, data analysis and communication techniques, data science tools, deep learning, and various data science applications. Researchers can extract and conclude various future ideas and topics that could result in potential publications or thesis. Furthermore, this book contributes to Data Scientists’ preparation and to enhancing their knowledge of the field. The book provides a rich collection of manuscripts in highly regarded data science topics, edited by professors with long experience in the field of data science. Introduces various techniques, methods, and algorithms adopted by Data Science experts Provides a detailed explanation of data science perceptions, reinforced by practical examples Presents a road map of future trends suitable for innovative data science research and practice
Handbook Of Driving Simulation For Engineering Medicine And Psychology
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Author : Donald L. Fisher
language : en
Publisher: CRC Press
Release Date : 2011-04-25
Handbook Of Driving Simulation For Engineering Medicine And Psychology written by Donald L. Fisher and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-25 with Technology & Engineering categories.
Effective use of driving simulators requires considerable technical and methodological skill along with considerable background knowledge. Acquiring the requisite knowledge and skills can be extraordinarily time consuming, yet there has been no single convenient and comprehensive source of information on the driving simulation research being conduc
Modeling And Interpreting Interactive Hypotheses In Regression Analysis
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Author : Robert Franzese
language : en
Publisher: University of Michigan Press
Release Date : 2009-09-23
Modeling And Interpreting Interactive Hypotheses In Regression Analysis written by Robert Franzese and has been published by University of Michigan Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-23 with Political Science categories.
Social scientists study complex phenomena about which they often propose intricate hypotheses tested with linear-interactive or multiplicative terms. While interaction terms are hardly new to social science research, researchers have yet to develop a common methodology for using and interpreting them. Modeling and Interpreting Interactive Hypotheses in Regression Analysis provides step-by-step guidance on how to connect substantive theories to statistical models and how to interpret and present the results. "Kam and Franzese is a must-have for all empirical social scientists interested in teasing out the complexities of their data." ---Janet M. Box-Steffensmeier, Ohio State University "Kam and Franzese have written what will become the definitive source on dealing with interaction terms and testing interactive hypotheses. It will serve as the standard reference for political scientists and will be one of those books that everyone will turn to when helping our students or doing our work. But more than that, this book is the best text I have seen for getting students to really think about the importance of careful specification and testing of their hypotheses." ---David A. M. Peterson, Texas A&M University "Kam and Franzese have given scholars and teachers of regression models something they've needed for years: a clear, concise guide to understanding multiplicative interactions. Motivated by real substantive examples and packed with valuable examples and graphs, their book belongs on the shelf of every working social scientist." ---Christopher Zorn, University of South Carolina "Kam and Franzese make it easy to model what good researchers have known for a long time: many important and interesting causal effects depend on the presence of other conditions. Their book shows how to explore interactive hypotheses in your own research and how to present your results. The book is straightforward yet technically sophisticated. There are no more excuses for misunderstanding, misrepresenting, or simply missing out on interaction effects!" ---Andrew Gould, University of Notre Dame Cindy D. Kam is Assistant Professor, Department of Political Science, University of California, Davis. Robert J. Franzese Jr. is Associate Professor, Department of Political Science, University of Michigan, and Research Associate Professor, Center for Political Studies, Institute for Social Research, University of Michigan. For datasets, syntax, and worksheets to help readers work through the examples covered in the book, visit: www.press.umich.edu/KamFranzese/Interactions.html
Nia Annual Report
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Author : National Institute on Aging
language : en
Publisher:
Release Date : 1978
Nia Annual Report written by National Institute on Aging and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1978 with categories.
Annual Report
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Author : National Institute on Aging
language : en
Publisher:
Release Date : 1980
Annual Report written by National Institute on Aging and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980 with Aging categories.
Report To Council On Program
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Author : National Institute on Aging
language : en
Publisher:
Release Date : 1980
Report To Council On Program written by National Institute on Aging and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980 with Aging categories.