Iminosugars
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Iminosugars
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Author : Philippe Compain
language : en
Publisher: John Wiley & Sons
Release Date : 2007-10-22
Iminosugars written by Philippe Compain and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-10-22 with Medical categories.
Iminosugars form undoubtedly the most attractive of carbohydrate mimics reported so far. In these structures, the substitution of the endocyclic oxygen of sugars by a basic nitrogen atom leads to remarkable biological properties and raises many challenges in organic synthesis. Since the discovery of their biological activity as glycosidase inhibitors in the 1970’s, these polyvalent molecules have progressively made their way from the laboratory to the clinic. The impressive series of discoveries in the field over the past ten years indicates clearly that it is “a boom time” for iminosugar chemistry and biology. The scope of their profile as inhibitors has been extended to a number of enzymes such as phosphorylases, glycosyltransferases or metalloproteinases, and iminosugars now constitute lead compounds for the development of new therapeutic agents for a wide range of diseases including diabetes, viral infections, lysosomal storage disorders and tumor metastasis. Latest developments, from iminosugar synthesis to their use in clinical studies, are presented in this book, which contains contributions from over fifteen of the major chemists, biochemists and drug developers in this rapidly expanding field. An extensive table correlating the structures of more than 600 iminosugars of therapeutic interest with their biological activities is also included in the book and should prove particularly useful to aid with the design and the discovery of novel bioactive substances. Iminosugars: From Synthesis to Therapeutic Application provides a unique resource for academic and industrial researchers working in the field of iminosugars and glycomimetics of biological and/or therapeutic interest: organic chemists, medicinal chemists, carbohydrate chemists and medical scientists.
Iminosugars As Glycosidase Inhibitors
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Author : Arnold E. Stütz
language : en
Publisher: Wiley-VCH
Release Date : 1999-01-21
Iminosugars As Glycosidase Inhibitors written by Arnold E. Stütz and has been published by Wiley-VCH this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-01-21 with Medical categories.
Iminosugars as Glycosidase Inhibitors Nojirimycin and Beyond Edited by Arnold E. Stutz "Nowadays as a result of these manifold synthetic efforts a large number of inhibitors are available, that can be applied selectively for many different glycosidases. They are important aids to explain the construction and degradation particularly of complex carbohydrate side chains such as those found in glycoproteins and glycolipids. The amount of chemical and biochemical information has meanwhile grown to such an extent that it is almost impossible to keep track of the developments. Therefore it is particularly pleasing that contributions from experts for the individual fields are collected together in one work, thus providing a comprehensive overview. In this way this book gives a representative cross-section of the field. The book will be a generally interesting source of information for chemists and biochemists." (From the foreword by H. Paulsen). A table which lists over 400 glycosidase inhibitors, more than 200 enzymes with 323 citations and over 1500 invaluable sets of data completes the book.
Enantioselective Synthesis Of Iminosugars And Hexoses From Furfural
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Author : Michael Hans Haukaas
language : en
Publisher:
Release Date : 2002
Enantioselective Synthesis Of Iminosugars And Hexoses From Furfural written by Michael Hans Haukaas and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.
Advances In Carbohydrate Chemistry And Biochemistry
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Author : Derek Horton
language : en
Publisher: Academic Press
Release Date : 2011-12-12
Advances In Carbohydrate Chemistry And Biochemistry written by Derek Horton and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-12 with Science categories.
Since its inception in 1945, this serial has provided critical and integrating articles written by research specialists that bring together industrial, analytical and technological aspects of biochemistry, organic chemistry and instrumentation methodology in the study of carbohydrates. The articles provide a definitive interpretation of the current status and future trends in carbohydrate chemistry and biochemistry. Features contributions from leading authorities and industry experts Informs and updates on all the latest developments in the field
Carbohydrates In Drug Discovery And Development
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Author : Vinod K. Tiwari
language : en
Publisher: Elsevier
Release Date : 2020-07-31
Carbohydrates In Drug Discovery And Development written by Vinod K. Tiwari and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-31 with Science categories.
Carbohydrates in Drug Discovery and Development: Synthesis and Applications examines recent and notable developments in the synthesis, biology, therapeutic, and biomedical applications of carbohydrates, which is considered to be a highly promising area of research in the field of medicinal chemistry. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell surface recognition formulate the carbohydrate systems to be an exceedingly considerable scaffold for the development of new chemical entities of pharmacological importance. In addition to their easy accessibility, high functionality and chiralpool characteristics are the few additional fascinating structural features of carbohydrates, which further enhance their utilities and thus they have been able to attract chemists and biologists toward harnessing these properties for the past several decades. This book covers an advanced aspect of carbohydrate-based molecular scaffolding, starting with a general introduction followed by a detailed discussion about the impact of diverse carbohydrate-containing molecules of great therapeutic values and their impact on drug discovery and development. The topics covered in this book include the significance of heparin mimetics as the possible tools for the modulation of biology and therapy, chemistry and bioactivities of C-glycosylated compounds, inositols, iminosugars, KDO, sialic acids, glycohybrids, macrocycles, plant oligosaccharides, anti-bacterial and anti-cancer vaccines, antibiotics, and more. • Presents a practical and detailed overview of a wide range of carbohydrate systems including KDO, sialic acids, inositols, iminosugars, etc relevant for drug discovery and development. • Highlights the use of functionalized carbohydrates as synthons for the construction of various systems. • Covers recent developments in the synthesis of various glycohybrid molecules and vaccines. • Highlights the significance of heparin mimetics as tools for the modulation of biology. • Provides an impact of glycan microarrays and carbohydrate– protein interaction.
I Studies Toward The Total Synthesis Of Iminosugars
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Author : Catherine Marie Smith
language : en
Publisher:
Release Date : 2002
I Studies Toward The Total Synthesis Of Iminosugars written by Catherine Marie Smith and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.
Synthetic Strategies In Carbohydrate Chemistry
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Author : Vinod Kumar Tiwari
language : en
Publisher: Elsevier
Release Date : 2023-11-01
Synthetic Strategies In Carbohydrate Chemistry written by Vinod Kumar Tiwari and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-01 with Science categories.
Synthetic Strategies in Carbohydrate Chemistry covers carbohydrate synthesis and its widespread application in various disciplines including catalysis. Basic and advanced aspects of carbohydrates are covered, starting with a brief introduction and then followed by protection-deprotection strategies in carbohydrate chemistry, glycosidic bond formation methodology, and their impact in oligosaccharide synthesis. Recent synthetic approaches for O-glycosides, N-glycosides, thioglycosides and C-glycosides, Intramolecular Aglycon Delivery (IAD), and carbohydrate modification are discussed, as well as stereoelectronic factors that control the chemical and biochemical behavior of carbohydrates in living cells. In addition, diverse applications of synthetic carbohydrate chemistry are covered, including sugar-based chiral catalyst in stereoselective synthesis, sugar-based ionic liquids, one-pot tandem reactions in carbohydrates, total synthesis of glycoconjugated natural products, impact of sugar in drug discovery and development, vaccine development, and glycoengineering. This reference is essential reading for researchers working in synthetic carbohydrate chemistry and biochemistry, and will be useful to those working in total synthesis, novel synthetic methodology, catalysis, polymer science, glycobiology, medicinal chemistry, and process development chemistry. Presents a practical and detailed overview on glycosylation methodology Covers automated glycosylation strategies in glycan synthesis Includes recent progress in the synthesis and significance of diverse thio-glycosides, C-glycosides, imino sugars and carbasugars Highlights the impact of enzymes in glycan synthesis Discusses the recent approaches for the synthesis of neoglycoconjugates
Dengue And Zika Control And Antiviral Treatment Strategies
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Author : Rolf Hilgenfeld
language : en
Publisher: Springer
Release Date : 2018-05-29
Dengue And Zika Control And Antiviral Treatment Strategies written by Rolf Hilgenfeld and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-29 with Medical categories.
This contributed volume contains 25 chapters from leading international scientists working on dengue and Zika viruses, who came together in Praia do Tofo in Mozambique to discuss the latest developments in the fields of epidemiology, pathogenesis, structural virology, immunology, antiviral drug discovery and development, vaccine efficacy, and mosquito control programs. The meeting venue offered an opportunity to discuss current research on these flaviviruses in an idyllic setting, and also to develop first-hand appreciation of the issues in infectious diseases facing developing countries and of the research gaps in Africa. For readers, who should include basic and clinical researchers in the field and public health professionals, the chapters are organized to provide a comprehensive overview of the various topics in current dengue and Zika virus research. A unique feature of the proceedings of this meeting is the inclusion of the discussions that took place following presentations. These have been transcribed and appended to the end of the relevant chapters, and they form the “salt in the soup” of this book.
Carbohydrates As Drugs
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Author : Peter H. Seeberger
language : en
Publisher: Springer
Release Date : 2014-11-14
Carbohydrates As Drugs written by Peter H. Seeberger and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-14 with Science categories.
Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.
Progress In Medicinal Chemistry
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Author :
language : en
Publisher: Elsevier
Release Date : 2011-02-09
Progress In Medicinal Chemistry written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-02-09 with Science categories.
Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry. This volume continues in the serial's tradition of providing an insight into the skills required of the modern medicinal chemist; in particular, the use of an appropriate selection of the wide range of tools now available to solve key scientific problems. Presents the latest research in the field of drug discovery Publishes on a twice yearly basis to bring you the most innovative updates in medicinal chemistry Available as an online resource via ScienceDirect