Iminosugars As Glycosidase Inhibitors

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Iminosugars As Glycosidase Inhibitors

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Author : Arnold E. Stütz
language : en
Publisher: Wiley-VCH
Release Date : 1999-01-21

Iminosugars As Glycosidase Inhibitors written by Arnold E. Stütz and has been published by Wiley-VCH this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-01-21 with Medical categories.

Iminosugars as Glycosidase Inhibitors Nojirimycin and Beyond Edited by Arnold E. Stutz "Nowadays as a result of these manifold synthetic efforts a large number of inhibitors are available, that can be applied selectively for many different glycosidases. They are important aids to explain the construction and degradation particularly of complex carbohydrate side chains such as those found in glycoproteins and glycolipids. The amount of chemical and biochemical information has meanwhile grown to such an extent that it is almost impossible to keep track of the developments. Therefore it is particularly pleasing that contributions from experts for the individual fields are collected together in one work, thus providing a comprehensive overview. In this way this book gives a representative cross-section of the field. The book will be a generally interesting source of information for chemists and biochemists." (From the foreword by H. Paulsen). A table which lists over 400 glycosidase inhibitors, more than 200 enzymes with 323 citations and over 1500 invaluable sets of data completes the book.

Iminosugars

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Author : Philippe Compain
language : en
Publisher: John Wiley & Sons
Release Date : 2007-10-22

Iminosugars written by Philippe Compain and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-10-22 with Medical categories.

Iminosugars form undoubtedly the most attractive of carbohydrate mimics reported so far. In these structures, the substitution of the endocyclic oxygen of sugars by a basic nitrogen atom leads to remarkable biological properties and raises many challenges in organic synthesis. Since the discovery of their biological activity as glycosidase inhibitors in the 1970’s, these polyvalent molecules have progressively made their way from the laboratory to the clinic. The impressive series of discoveries in the field over the past ten years indicates clearly that it is “a boom time” for iminosugar chemistry and biology. The scope of their profile as inhibitors has been extended to a number of enzymes such as phosphorylases, glycosyltransferases or metalloproteinases, and iminosugars now constitute lead compounds for the development of new therapeutic agents for a wide range of diseases including diabetes, viral infections, lysosomal storage disorders and tumor metastasis. Latest developments, from iminosugar synthesis to their use in clinical studies, are presented in this book, which contains contributions from over fifteen of the major chemists, biochemists and drug developers in this rapidly expanding field. An extensive table correlating the structures of more than 600 iminosugars of therapeutic interest with their biological activities is also included in the book and should prove particularly useful to aid with the design and the discovery of novel bioactive substances. Iminosugars: From Synthesis to Therapeutic Application provides a unique resource for academic and industrial researchers working in the field of iminosugars and glycomimetics of biological and/or therapeutic interest: organic chemists, medicinal chemists, carbohydrate chemists and medical scientists.

Carbohydrates 2018

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Author : Amélia Pilar Rauter
language : en
Publisher: MDPI
Release Date : 2020-03-25

Carbohydrates 2018 written by Amélia Pilar Rauter and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-25 with Medical categories.

This book contains original papers and reviews on carbohydrate research in medicine, authored by participants of the 29th International Carbohydrate Symposium, where this topic had a special emphasis. The focus on biological events involving carbohydrates and glycoconjugates has delivered reliable approaches for disease treatment and diagnosis. Research on carbohydrate-based compounds for therapeutic applications is illustrated in various contributions, namely those covering the development of novel agents against Alzheimer’s disease, e.g. the neuroprotective C-glucosylated flavones and the isonucleoside-based cholinesterase inhibitors. New imino sugar glucosidase inhibitors are also disclosed, a class of compounds with potential for diabetes, Gaucher disease or cancer treatment. Also the development of a useful synthetic method towards multivalent glycoclusters of biomedical interest is here highlighted. The relevance of glycomimetics in drug discovery and the progress on carbohydrates in early diagnosis and cancer treatment are reviewed. Noteworthy is the chitosan-based delivery system for drug oral administration, a new biomaterial-based approach to improve bioavailability. Another study on the conformation of Streptococcus capsular polysaccharide backbones by molecular modelling provides useful information for bacterial immunotherapeutic approaches. All original contributions and reviews clearly demonstrate the potential of glycosciences for innovation in medicinal (glyco)chemistry and pharmaceutical research.

Carbohydrate Chemistry

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Author : Amelia Pilar Rauter
language : en
Publisher: Royal Society of Chemistry
Release Date : 2017-12-12

Carbohydrate Chemistry written by Amelia Pilar Rauter and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-12 with Carbohydrates categories.

This invaluable volume contains analysed, evaluated and distilled information on the latest in carbohydrate research.The discovery and synthesis of novel carbohydrates and mimetics with diverse applications continues to be a major challenge for carbohydrate chemists. The understanding of the structure and function of carbohydrates and glycoconjugates remains vital in medicine and molecular biology. Covering both chemical and biological science related to the particular volume topic, this series demonstrates the interdisciplinary nature of modern carbohydrate research, and benefits any researcher who wishes to learn about the latest developments in the carbohydrate field.

Dengue And Zika Control And Antiviral Treatment Strategies

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Author : Rolf Hilgenfeld
language : en
Publisher: Springer
Release Date : 2018-05-29

Dengue And Zika Control And Antiviral Treatment Strategies written by Rolf Hilgenfeld and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-29 with Medical categories.

This contributed volume contains 25 chapters from leading international scientists working on dengue and Zika viruses, who came together in Praia do Tofo in Mozambique to discuss the latest developments in the fields of epidemiology, pathogenesis, structural virology, immunology, antiviral drug discovery and development, vaccine efficacy, and mosquito control programs. The meeting venue offered an opportunity to discuss current research on these flaviviruses in an idyllic setting, and also to develop first-hand appreciation of the issues in infectious diseases facing developing countries and of the research gaps in Africa. For readers, who should include basic and clinical researchers in the field and public health professionals, the chapters are organized to provide a comprehensive overview of the various topics in current dengue and Zika virus research. A unique feature of the proceedings of this meeting is the inclusion of the discussions that took place following presentations. These have been transcribed and appended to the end of the relevant chapters, and they form the “salt in the soup” of this book.

Activity Based Protein Profiling

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Author : Benjamin F. Cravatt
language : en
Publisher: Springer
Release Date : 2019-01-25

Activity Based Protein Profiling written by Benjamin F. Cravatt and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-25 with Medical categories.

This volume provides a collection of contemporary perspectives on using activity-based protein profiling (ABPP) for biological discoveries in protein science, microbiology, and immunology. A common theme throughout is the special utility of ABPP to interrogate protein function and small-molecule interactions on a global scale in native biological systems. Each chapter showcases distinct advantages of ABPP applied to diverse protein classes and biological systems. As such, the book offers readers valuable insights into the basic principles of ABPP technology and how to apply this approach to biological questions ranging from the study of post-translational modifications to targeting bacterial effectors in host-pathogen interactions.

Synthesis And Characterization Of Glycosides

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Author : Marco Brito-Arias
language : en
Publisher: Springer Nature
Release Date : 2022-04-22

Synthesis And Characterization Of Glycosides written by Marco Brito-Arias and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-22 with Science categories.

This third edition is a comprehensive and extended study about the best known approaches for preparing the main types of glycosides, covering the classic and more recent glycosylation reactions used for preparing simple and challenging glycosides currently used as potent antiviral and antineoplastic drugs, or fluorogenic substrates used for enzymatic detection in cell biology. Besides, this new edition provides more examples of the glycosidic methodologies followed for preparing complex glycoconjugates such as glycoproteins and glycosphingolipids and gangliosides used as adjuvants or as synthetic vaccines candidates. Also, additional mechanistic evidence is presented for better understanding of the glycosylation reaction, trying to identify the variables mainly depending on protecting and leaving groups, as well as catalyst and reaction condition which altogether directs the anomeric stereo control. A chapter on the glycoside hydrolysis is included in view of the increasing interest in the use of biomass as a natural and renewable source for obtaining important intermediates or products used in food or valuable materials. The author includes information in the characterization of glycosides section with the aim of giving additional tools for the structural assignment through NMR, X-Ray and mass spectra techniques.

Handbook Of Glycosyltransferases And Related Genes

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Author : Naoyuki Taniguchi
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-06-28

Handbook Of Glycosyltransferases And Related Genes written by Naoyuki Taniguchi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-06-28 with Science categories.

The so-called postgenomic research era has now been launched, and the field of gly cobiology and glycotechnology has become one of the most important areas in life science because glycosylation is the most common post-translational modification reaction of proteins in vivo. On the basis of Swiss-Prot data, over 50% proteins are known to undergo glycosylation, but in fact the actual functions of most of the sugar chains in the glycoconjugates remain unknown. The complex carbohydrate chains of glycoproteins, glycolipids, and proteoglycans represent the secondary gene products formed through the reactions of glycosyl transferases. The regulation of the biosynthesis of sugar chains is under the control of the expression of glycosyltransferases, their substrate specificity, and their local ization in specific tissue sites. There is a growing body of evidence to suggest that these enzymes play pivotal roles in a variety of important cellular differentiation and developmental events, as well as in disease processes. Over 300 glycosyltransferases appear to exist in mammalian tissues. If the genes that have been purified and cloned from various species such as humans, cattle, pigs, rats and mice are counted as one, approximately 110 glycogenes that encode glycosyltransferases and related genes have been cloned at present, and this number continues to grow each day. However, most of the functions of the glycosyltransferase genes and related genes are unknown. This fact has stimulated numerous new and interesting approaches in molecular biologi cal investigations.

Glycoscience Chemistry And Chemical Biology I Iii

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Author : Bertram O. Fraser-Reid
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Glycoscience Chemistry And Chemical Biology I Iii written by Bertram O. Fraser-Reid and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.

Glycostructures play a highly diverse and crucial role in a myriad of organisms and systems in biology, physiology, medicine, and bioengineering and technology. Only in recent years have the tools been developed to partly understand the highly complex functions and chemistry behind them. In this set the editors present up-to-date information on glycostructures, their chemistry and chemical biology, in the form of a comprehensive survey. The text is accompanied by over 2000 figures, chemical structures and reaction schemes and more than 9000 references. The accompanying CD-ROM enables, besides text searches, searches for structures, schemes, and other information.

Neglected Diseases Extensive Space For Modern Drug Discovery

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Author :
language : en
Publisher: Academic Press
Release Date : 2018-10-19

Neglected Diseases Extensive Space For Modern Drug Discovery written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-19 with Medical categories.

"Neglected diseases: extensive space for modern drug discovery" provides in-depth reviews on the last progresses about neglected tropical diseases research. Topics covered in this volume include Leishmaniasis, Tripanosomiasis, Onchocerciasis and Ebolavirus infections, with insights on the future of the research on them. Part of the volume is devoted to recent contributions this field received from X-Ray crystallography. Provides accurate reviews from selected experts on the topic of Neglected Tropical Diseases Each chapter of the volume provides useful graphic material for ease of reading of the audience provides the latest insights and future perspectives on the covered neglected diseases