Immunological Effects Of Blood Transfusion
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Immunological Effects Of Blood Transfusion
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Author : Dharam P. Singal
language : en
Publisher: CRC Press
Release Date : 1994-12-08
Immunological Effects Of Blood Transfusion written by Dharam P. Singal and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-12-08 with Medical categories.
This concise monograph examines the novel and distinct feature of blood transfusion (BT). It critically reviews the areas of major concern to the public and scientific/medical community. Topics include: Transmission of disease(s) from the blood donor to the recipient and the transfusion-induced alloimmunization of the recipient BT-induced immunomodulatory effects, both beneficial and deleterious Beneficial effects in clinical organ transplantation and in treatment of women with unexplained recurrent abortions Adverse effects of BT in patients undergoing curative surgery for different types of cancer and in patients at risk for bacterial infections Deleterious effects of BT on enhanced tumor growth and infections in experimental animals Attempts by a number of investigators to treat autoimmune diseases by BT in humans and in experimental animals Mechanism(s) of the BT effect from various perspectives, including the component of blood, host factors, and hypotheses for beneficial and damaging effects
Transfusion Immunology And Medicine
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Author : Carel J. van Oss
language : en
Publisher: CRC Press
Release Date : 1995-01-27
Transfusion Immunology And Medicine written by Carel J. van Oss and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-01-27 with Medical categories.
Based on the proceedings of the International Convocation on Immunology held recently at the State University of New York at Buffalo, this up-to-date resource provides a state-of-the-art examination of blood transfusion practice and its future possibilities. Explains the immunological effects of blood transfusion as well as its immunological and
Transfusion Immunology And Medicine
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Author : Carel J. van Oss
language : en
Publisher: CRC Press
Release Date : 1995-01-27
Transfusion Immunology And Medicine written by Carel J. van Oss and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-01-27 with Medical categories.
Based on the proceedings of the International Convocation on Immunology held recently at the State University of New York at Buffalo, this up-to-date resource provides a state-of-the-art examination of blood transfusion practice and its future possibilities. Explains the immunological effects of blood transfusion as well as its immunological and microbiological hazards and offers potential remedies!
Immunology And Blood Transfusion
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Author : C.Th. Smit Sibinga
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Immunology And Blood Transfusion written by C.Th. Smit Sibinga and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
In transfusion medicine the scientific fundamentals of immunology have had a considerable clinical impact. Transfusion may suppress the immunity but some patients could suffer disadvantages including GvHD, alloimmunisation and possible cancer, where white cells (WBC) play pivotal roles in this phenomenon, presenting antigens and producing cytokines. A clinical application of this practice is LAK-cells targeted against cancer. MHC on the WBC may provide additional immunological modulations through series of secondary messengers. Thus reduction of WBC in the blood and bone marrow may be advantageous for patients. On the other hand, sharing a part of MHC or making the transplanted white cells anergic by storage may be even more advantageous for patients. CMV infection could mimic part of this MHC. UV radiation is effective in the inactivation of the WBC although filters are easy means for such removal. However, their accurate quantification requires flow cytometry that has considerable potential application in blood transfusions. Idiotypic antibody could play an important role in platelet theory. However, the potential infection risks in transfusion like HIV and HCV remain, but application of molecular biological methods like PCR or RT/PCR has great potentials in detection of infectious diseases, transplantation and genetic disorders. Immuno affinity purified concentrates, like factor IX and protein C, could reduce patients' immune functions, where in the future protein C could be derived from transgenic animals. Advances are sure to emerge through adoptive immunotherapy and gene therapies are exciting prospects when genes transferred into lymphocytes could be used to correct cell mediated immune deficiency, as in ADA.
Immunologic Concepts In Transfusion Medicine
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Author : Robert W Maitta
language : en
Publisher: Elsevier Health Sciences
Release Date : 2019-08-27
Immunologic Concepts In Transfusion Medicine written by Robert W Maitta and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-27 with Medical categories.
Immunological Concepts in Transfusion Medicine provides a thorough discussion of the immune aspects of blood component transfusion, with in-depth information on the intricacies of immune responses to blood components and the immune processes that may be initiated in response to blood exposure. Written to increase knowledge and awareness of immune challenges such as alloimmunization and transfusion-related acute lung injury, this title bridges current basic scientific discoveries and the potential effects seen in blood recipients. Complies the knowledge and expertise of Dr. Robert Maitta, an expert in immune responses and antibody function/structure studies. Helps clinicians in the daily practice of caring for patients in need of transfusion support, as well as physicians in training when considering utilizing blood transfusions in a limited scope or in the setting of massive transfusion. Includes an immunology primer as an introduction to in-depth chapters covering allergic immune reactions to blood components, transfusion-related immunomodulation, fetal and neonatal alloimmune thrombocytopenia and neonatal neuthropenia, complications of haploidentical and mismatched HSC transplantation, chimeric antibody receptor therapies, and much more. Consolidates today’s available information on this timely topic into a single, convenient resource.
Immunobiology Of Transfusion Medicine
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Author : George Garratty
language : en
Publisher: CRC Press
Release Date : 1993-09-21
Immunobiology Of Transfusion Medicine written by George Garratty and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-09-21 with Medical categories.
Describes the immunological aspects of blood transfusion medicine, examining the immuno-chemistry of blood group antigens, the immune destruction of cells, correlations between blood groups and disease, and the effect transfusion-induced retroviral infection has on immune response.
Immunohematology And Blood Banking
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Author : Pritam Singh Ajmani
language : en
Publisher: Springer Nature
Release Date : 2020-11-02
Immunohematology And Blood Banking written by Pritam Singh Ajmani and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-02 with Medical categories.
The book covers the basics of genetics and immunology, technical aspects of blood banking and transfusion.It offers a concise, and practical approach for different blood tests and guidelines on the best ways to take donor history, screen donors, store blood components, ensure safety, and anticipate the potentially adverse effects of blood transfusion, components and its management at the bedside. Different chapters include important topics such as collection, storage and transportation of blood, introduction to blood transfusion, blood group serology, discovery of blood groups, donor selection, interview, and its preparation, and storage, pretransfusion testing, transfusion therapy, clinical considerations, and safety, quality assurance, and data management developed specifically for medical technologists and resident doctors. The book also goes beyond preoperative patient blood management, with detailed accounts of coagulation disorder management and the administration of coagulation products and platelet concentrates. The book also defines the components of a learning health system necessary to enable continued improvement in trauma care in both the civilian and the military sectors. This book offers a succinct and user-friendly resource with key points, boxes, tables & charts and is a quick reference guide for pathology and transfusion medicine residents and doctors in blood centers and hospitals dealing with regulatory aspects, transfusion safety, production and storage and donor care.
Cytokines And Growth Factors In Blood Transfusion
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Author : C.Th. Smit Sibinga
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Cytokines And Growth Factors In Blood Transfusion written by C.Th. Smit Sibinga and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Cytokines are cellular growth factors which also provide communication between cells and their milieu. This clearly is an exciting area in modern medicine that will have significant impact on various facets of transfusion. Erythropoietin therapy stimulates red cell production while thrombopoietin seems to positively affect megakaryopoiesis and can be an added armamentarium for the thrombocytopenic patient. Using haematnopoietic growth factors, stem cells could be mobilized early to the peripheral blood for collection and subsequent transplantation into haemato-oncology patients instead of bone marrow transplantation. Using a cocktail of cytokines in cell culture, stem cells could be expanded and selected for therapy. Cytokines and growth factors can even be modified, which may lead to successful gene therapy in malignancies, including solid tumour vaccines. However, the presence of cytokines in certain blood products could have biological effects following transfusion, although its clinical relevance needs to be ascertained. There is much potential for the use of cytokines in the treatment of infections. Early diagnostic methods are now available to monitor their levels and relevance. It is likely that cytokines will increasingly play a role in therapy and could develop our fundamental knowledge about the development of T-cells. An ethical dilemma remains, however, regarding the use of cytokines in healthy donors for harvesting suitable specific cells. Longer clinical observation will be necessary to gather the necessary information. Cytokines and growth factors in blood transfusion was the theme of the 21st International Symposium in Blood Transfusion, where twenty clinicians and scientists, experts in their own fields, were invited to update the above information. Their findings are presented in four sections in this volume: Fundamental aspects - cytokines in development of T-cells, growth factors in haematopoiesis, growth factor receptors and signal transduction, cytokine response in platelet and whole blood transfusions. Function, production and diagnosis – laboratory diagnostics of cytokines and growth factors, cytokines in blood components, cytokines and growth factors in cell expansions, cytokines for genetic modification towards gene therapy, progenitor cells from healthy donors. Application in clinical medicine – clinical relevance of cytokines in transfusion products, cytokines and growth factors in solid tumours, gene therapy in malignancies, vaccine strategies inducing T-cell immunity against tumours, cytokines in the treatment of infections, thrombopoietin and megakaryopoiesis. Future potential use in transfusion medicine – erythropoietin, immunotherapy, ethical aspects of the use of cytokines and growth factors in donors, potential of cytokines and growth factors in transfusion medicine.
White Cells And Platelets In Blood Transfusion
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Author : C.Th. Smit Sibinga
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
White Cells And Platelets In Blood Transfusion written by C.Th. Smit Sibinga and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
As a clinical discipline blood transfusion encompasses enormous vista, vary ing from biotechnology to molecular biology, from plasma products, cell biology and growth factors to interleukines. Growth of knowledge in this field has been rapid, and expertise is now required to be mastered and renewed in translating these ideas for patient care. Various types of cells could be harvested - progenitor stem cells derived from bone marrow or from circulating blood as a source for transplants; in the hemostatic armoury platelets could be used prophylactically; granulocytes and mononuclear cells are available for treatment of infections or immune modulations. However, their therapeutic use carries potential complications including graft versus host disease and CMV-infection. Prevention of such complications by irradiation and by removal of immunocompetent leukocytes are important issues. Thus, production of such therapeutic materials ought to address the issues at the earliest, to eliminate those problems while adhering to the con cept of high quality; the impact of storing platelets for longer periods by using improved plastic containers or storing almost indefinitely in frozen state should be explored. Rapid progress in cell culture techniques and bio technology have enriched the transfusion medicine armoury with lympho kines, interferons and cell colony growth factors which have great potentials for enhancement of basic knowledge as well as considerable therapeutic applications in patients.
Blood Groups And Red Cell Antigens
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Author : Laura Dean
language : en
Publisher:
Release Date : 2005
Blood Groups And Red Cell Antigens written by Laura Dean and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Blood group antigens categories.