Immunological Precision Therapeutics Integrating Multi Omics Technologies And Comprehensive Approaches For Personalized Immune Intervention
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Immunological Precision Therapeutics Integrating Multi Omics Technologies And Comprehensive Approaches For Personalized Immune Intervention
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Author : Wenyi Jin
language : en
Publisher: Frontiers Media SA
Release Date : 2025-03-20
Immunological Precision Therapeutics Integrating Multi Omics Technologies And Comprehensive Approaches For Personalized Immune Intervention written by Wenyi Jin and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-20 with Medical categories.
In the realm of modern immunology, the pursuit of precision therapeutics has emerged as a paramount endeavor. This research field harnesses the power of advanced multi-omics technologies and comprehensive methodologies to revolutionize personalized immune interventions. Immunotherapy, a cornerstone of precision medicine, targets the intricate dynamics of the immune system to combat diseases ranging from cancer to autoimmune disorders. Integrating multi-omics analyses, including genomics, transcriptomics, proteomics, and metabolomics, enables a holistic understanding of immune responses at various molecular levels. Immune signatures derived from these analyses unveil individualized patterns, offering crucial insights into disease susceptibility and treatment efficacy. Leveraging this wealth of data through sophisticated computational models and machine learning algorithms enhances our ability to predict immune responses and identify optimal therapeutic strategies. By amalgamating diverse approaches, from single-cell profiling to spatial transcriptomics, we delve deeper into the complexities of immune regulation and cellular interactions within the microenvironment. Through collaborative efforts, the pursuit of immunological precision therapeutics aims to tailor interventions precisely to each patient's immune landscape, ushering in a new era of personalized immune modulation.
Systems Biology And In Depth Applications For Unlocking Diseases
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Author : Babak Sokouti
language : en
Publisher: Elsevier
Release Date : 2024-11-05
Systems Biology And In Depth Applications For Unlocking Diseases written by Babak Sokouti and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-05 with Science categories.
Systems Biology and In-Depth Applications for Unlocking Diseases provides the essence of systems biology approaches in a practical manner illustrating the basic principles essential to develop and model in real life science applications. Methodologies covered show how to interrogate biological data, with the purpose of obtaining insight about disease diagnosis, prognosis, and treatment.Systematically written in 4 parts, this book first provides an introduction and history of systems biology; second, it provides the tools and resources needed for the structure and function of biological systems; next, it provides the evidence of systems biology in action to better understand disease connections; and finally, it provides the extensions of systems biology in various scientific fields including pharmacology, immunology, vaccinology, neuroscience, virology, and medicine. Examples include big data techniques, scale networks, mathematical model development, and much more.This is the perfect reference to provide the fundamental base of knowledge needed for systems biologists, professionals in systems medicine, computational biologists, and bioinformaticians, whether needed for immediate application or for building a comprehensive understanding of the field. - Provides detailed and comprehensive coverage of the field of systems biology - Delivers instruction on how to interrogate biological data, with the purpose of obtaining insight about disease diagnosis, prognosis, and treatment - Makes effective steps towards personalized medicine in the treatment of disease - Explains effective disease treatment strategies at early diagnosis stages
Ai Assisted Computational Approaches For Immunological Disorders
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Author : Chen, Jen-Tsung
language : en
Publisher: IGI Global
Release Date : 2025-05-13
Ai Assisted Computational Approaches For Immunological Disorders written by Chen, Jen-Tsung and has been published by IGI Global this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-05-13 with Medical categories.
Based on accelerated computing and advanced algorithms, artificial intelligence (AI) has become a game-changer in diverse fields. In biomedical science, AI models based on machine learning, deep learning, and generative AI, together with upgraded computational and systems biology, provide smart, precise, and personalized medicine and healthcare. In the field of clinical immunology, which deals with intrinsic complicated immune systems for combating immunological disorders, AI technologies have the potential to solve problems based on identification, prediction, simulation, and modeling. AI algorithms may impact sustainable clinical healthcare and future immunology diagnoses. AI-Assisted Computational Approaches for Immunological Disorders explores precision clinical medicine and personalized healthcare in major immunological disorders, such as immunodeficiency, autoimmune diseases, allergies, asthma, cancers, and neurological diseases. It analyzes clinical healthcare big data, genomics, and high-throughput multiple omics based on single-cell and high-dimensional data for their technical advances, clinical applications, challenges, and future directions. Covering topics such as cell therapy, reducing complications, and drug development, this book is an excellent resource for immunologists, biologists, healthcare practitioners, professionals, researchers, scholars, academicians, and more.
Community Series In Towards Precision Medicine For Immune Mediated Disorders Advances In Using Big Data And Artificial Intelligence To Understand Heterogeneity In Inflammatory Responses Volume Ii
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Author : Alex Tsoi
language : en
Publisher: Frontiers Media SA
Release Date : 2025-01-27
Community Series In Towards Precision Medicine For Immune Mediated Disorders Advances In Using Big Data And Artificial Intelligence To Understand Heterogeneity In Inflammatory Responses Volume Ii written by Alex Tsoi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-01-27 with Medical categories.
The ability to understand the underlying mechanisms that drive the heterogeneity in inflammatory responses among patients suffering from immune-mediated conditions is critical. The nature of the immune mechanism ranges from the degree of immune cell activation, to the HLA genotypes, and the intensity of responses of target tissues to cytokines. High throughput experiments have generated significant information for us to facilitate the identification of disease-associated components for different complex immune-mediated conditions (e.g. psoriasis, lupus, rheumatoid arthritis, inflammatory bowel diseases), and the advances in biotechnologies and efficiency in computational resources have further promised cost-effective opportunities to simultaneously study the different aspects in the basic and translational domains of these human diseases. The critical questions we face are to provide efficient inference to integrate these datasets, and translate what we have learned from the disease-associated components to understand the heterogeneity (e.g. ethnic, gender, genetic differences) in disease manifestation and prognosis of these immune-mediated conditions. Translating and integrating big data to understand the intrinsic factors that shape the different unique natures of inflammation processes require an efficient and flexible framework to incorporate signatures of different types.
Reproductive Immunogenetics A Molecular And Clinical Overview
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Author : Shafat Ali
language : en
Publisher: Elsevier
Release Date : 2025-06-30
Reproductive Immunogenetics A Molecular And Clinical Overview written by Shafat Ali and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-30 with Medical categories.
Immunogenetics: A Molecular and Clinical Overview: Immunogenetic Factors and Signaling Pathways in Recurrent Miscarriage, Volume Four provides an overview of the scientific knowledge, achievements, and findings in the field of immunogenetics of recurrent pregnancy loss. With a strong focus on the role immune cells can play in recurrent pregnancy loss, the book also examines immune therapeutic aspects. In seventeen chapters, the book describes the roles of several different signaling pathways and the role of JLA and microRNAs in recurrent pregnancy loss. Several chapters are dedicated to the role autoimmune antibodies play in recurrent pregnancy loss. This book is a valuable resource for health professionals, scientists, researchers, and all those who wish to broaden their knowledge in the allied field. - Contains global information about research on immunogenetics of recurrent pregnancy loss - Assists clinicians and medical practitioners by presenting the most recent research information, ideas, thoughts of scientists and researchers, and trends in this research area - Provides the prerequisite requirements for any researcher who wants to work on immunogenetics and its applications to recurrent pregnancy loss
Molecular Mechanisms And Therapeutic Strategies In Inflammation
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Author : Pengpeng Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2025-07-29
Molecular Mechanisms And Therapeutic Strategies In Inflammation written by Pengpeng Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-07-29 with Medical categories.
Inflammation is a fundamental response of the body to injury and infection, involving complex cellular and molecular mechanisms. While acute inflammation plays a crucial role in defending against pathogens and repairing tissues, chronic inflammation is closely associated with the occurrence and development of various diseases, including cancer, cardiovascular diseases, neurodegenerative diseases, and autoimmune disorders. The recent advancements in single-cell sequencing technologies have offered an unprecedented perspective on the cellular and molecular heterogeneity of inflammatory responses. Through high-resolution single-cell RNA sequencing, it is possible to uncover the specific gene expression profiles of different types of immune cells during inflammation, thereby providing an in-depth understanding of their functions. Single-cell sequencing also enables the monitoring of dynamic changes in cellular gene expression at different time points, tracking the key molecular expression patterns during the inflammatory process. Additionally, in combination with spatial transcriptomics techniques, single-cell sequencing can analyze the spatial distribution of cells in tissues and their gene expression, mapping out detailed cellular maps of inflammatory sites and identifying the cellular characteristics and interaction networks in different regions. The latest technological developments also include the integrated analysis of multi-omics data such as single-cell ATAC-seq, DNA sequencing, and proteomics, providing more comprehensive cellular functional information and revealing the complex mechanisms of gene expression regulation. Simultaneously, the application of novel computational tools and algorithms enables researchers to extract meaningful biological information from complex data and uncover the key pathways and molecular mechanisms in inflammatory responses. Therefore, this Research Topic aims to showcase the latest progress of single-cell sequencing technologies in inflammation research. We invite researchers interested in this topic to submit original research, brief research reports, and review articles, mainly but not limited to the following sub-themes: 1. New applications of single-cell RNA sequencing in the study of inflammatory processes. 2. Single-cell epigenomics and transcriptomics in inflammatory diseases. 3. Identification of key inflammatory mediators, signaling pathways, and immune cell heterogeneity at the single-cell level. 4. Interactions between immune and non-immune cells in the inflammatory microenvironment. 5. Identification of novel therapeutic targets and the development of personalized medical approaches for inflammatory diseases based on single-cell analysis. 6. Single-cell analysis of drug responses and resistance mechanisms in inflammation. 7. Innovations in single-cell sequencing technologies related to inflammation research. Please note that manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this Research Topic.
Advancements In Cancer Research Exploring Diagnostics And Therapeutic Breakthroughs
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Author : Sankha Bhattacharya, Mayank Sharma, Amit B. Page, Dhrubojyoti Mukherjee, Abhishek Kanugo
language : en
Publisher: Bentham Science Publishers
Release Date : 2025-02-24
Advancements In Cancer Research Exploring Diagnostics And Therapeutic Breakthroughs written by Sankha Bhattacharya, Mayank Sharma, Amit B. Page, Dhrubojyoti Mukherjee, Abhishek Kanugo and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-24 with Medical categories.
Advancements in Cancer Research: Exploring Diagnostics and Therapeutic Breakthroughs is a comprehensive resource that highlights the latest innovations in cancer research. This book bridges the gap between cutting-edge science and clinical applications, offering insights into the molecular mechanisms, diagnostic advancements, and novel therapeutic strategies revolutionizing cancer care. Organized into thematic sections, the book explores critical areas such as molecular biomarkers, immunotherapy, nanotechnology in diagnostics and treatment, and targeted therapies. Topics include the role of TP53 mutations in colorectal cancer, nanocarriers for melanoma therapy, RNA-based therapeutics for colon cancer, and biomaterials for bone tumor management. Readers will also discover how emerging technologies like nanotheranostics and transethosomes are paving the way for personalized cancer care. Key Features: - Insights into molecular and nanotechnology-driven cancer therapies. - Exploration of diagnostics and biomarker applications. - Multidisciplinary approaches to advancing patient care. - Analysis of current trends and prospects in oncology.
Multi Omic Data Integration In Oncology
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Author : Chiara Romualdi
language : en
Publisher: Frontiers Media SA
Release Date : 2020-12-03
Multi Omic Data Integration In Oncology written by Chiara Romualdi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-03 with Medical categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Alopecia Areata Navigating The Complexities Of Genetics Immunology And Personalized Care
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Author : Dr. Spineanu Eugenia
language : en
Publisher: Dr. Spineanu Eugenia
Release Date : 2024-09-30
Alopecia Areata Navigating The Complexities Of Genetics Immunology And Personalized Care written by Dr. Spineanu Eugenia and has been published by Dr. Spineanu Eugenia this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-09-30 with Medical categories.
"Unveiling Alopecia Areata: Navigating the Complexities of Genetics, Immunology, and Personalized Care" is a groundbreaking treatise that delves into the multifaceted realm of alopecia areata, an autoimmune-induced hair loss condition. This comprehensive exploration spans from the foundational definitions and classifications to the cutting-edge frontiers of personalized medicine. The treatise meticulously unravels the historical evolution of knowledge surrounding alopecia areata, tracing its journey from early observations to contemporary research breakthroughs. One of the focal points of the treatise is the intricate interplay between genetics and immunology in the development and progression of alopecia areata. It meticulously examines the genetic factors contributing to susceptibility and hereditary patterns, shedding light on the evolving landscape of genetic research in this field. Furthermore, the exploration extends into the complex immunological cascades involved in the autoimmune attack on hair follicles, emphasizing the role of T cells, cytokines, and immune system dysregulation. A significant highlight of the treatise lies in its in-depth analysis of personalized medicine approaches for alopecia areata. Recognizing the diverse manifestations and treatment responses across individuals, the treatise explores how genetic and immunological insights guide tailored interventions. From predictive biomarkers and treatment optimization to individualized therapeutic combinations, the treatise outlines the exciting possibilities and challenges of navigating a personalized care paradigm.
Artificial Intelligence Big Data Blockchain And 5g For The Digital Transformation Of The Healthcare Industry
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Author : Patricia Ordonez de Pablos
language : en
Publisher: Elsevier
Release Date : 2023-11-24
Artificial Intelligence Big Data Blockchain And 5g For The Digital Transformation Of The Healthcare Industry written by Patricia Ordonez de Pablos and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-24 with Science categories.
Artificial intelligence, Big data, Blockchain and 5G for Digital Transformation of Healthcare Industry provides insights on the successes and failures in the field of IT and digital health during the pandemic and analyzes the lessons from these cases. The social and economic recovery after the pandemic requires urgent solutions for citizens, companies and economies around the world. From research centers, labs, hospitals and academia, researchers and academics are working collaboratively to explore new views and frameworks to develop solutions for emergent problems. Artificial intelligence, Big data, blockchain and 5G for digital transformation of healthcare industry includes cases highlighting the application of digital healthcare solutions from around the world. In 23 Chapters this book delivers a collection of relevant innovative research on digital healthcare, with a three mains goals: 1) study the successes and failures in the field of IT and digital health during the pandemic, and analyze the lessons from these cases; 2) discuss the latest advances in the field of digital healthcare, with a special focus on Artificial Intelligence, Big Data, Blockchain and 5G; and 3) discuss implications for main stakeholders (patients, doctors, IT experts, directors, policy managers. The global outbreak caused by covid-19 caused global disruption in societies, healthcare systems, and economies around the world. This book provides insight to Researchers, clinicians, CEOs and policy makers who need to learn from the failures and successes and exploit the potential of advanced information technologies to build stronger healthcare systems, better quality healthcare services, and more resilient societies. - Delivers a collection of relevant innovative research on digital healthcare - Discusses the latest advances in the field of digital healthcare, with a special focus on Artificial Intelligence, Big Data, Blockchain, and 5G - Provides current lessons learned from the pandemic - Includes case studies and experiences from around the world, including Asia, Europe, Gulf Region, Latin America, the United States, and more