Immunotherapy And The Regulatory Immune System In Blood Cancers From Mechanisms To Clinical Applications
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Immunotherapy And The Regulatory Immune System In Blood Cancers From Mechanisms To Clinical Applications
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Author : Ken H. Young
language : en
Publisher: Frontiers Media SA
Release Date : 2019-08-16
Immunotherapy And The Regulatory Immune System In Blood Cancers From Mechanisms To Clinical Applications written by Ken H. Young and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-16 with categories.
Oncoimmunology
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Author : Laurence Zitvogel
language : en
Publisher: Springer
Release Date : 2017-12-13
Oncoimmunology written by Laurence Zitvogel and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-13 with Medical categories.
In this book, leading experts in cancer immunotherapy join forces to provide a comprehensive guide that sets out the main principles of oncoimmunology and examines the latest advances and their implications for clinical practice, focusing in particular on drugs with FDA/EMA approvals and breakthrough status. The aim is to deliver a landmark educational tool that will serve as the definitive reference for MD and PhD students while also meeting the needs of established researchers and healthcare professionals. Immunotherapy-based approaches are now inducing long-lasting clinical responses across multiple histological types of neoplasia, in previously difficult-to-treat metastatic cancers. The future challenges for oncologists are to understand and exploit the cellular and molecular components of complex immune networks, to optimize combinatorial regimens, to avoid immune-related side effects, and to plan immunomonitoring studies for biomarker discovery. The editors hope that this book will guide future and established health professionals toward the effective application of cancer immunology and immunotherapy and contribute significantly to further progress in the field.
Immunological Surveillance
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Author : Sir Frank Macfarlane Burnet
language : en
Publisher: Elsevier Science & Technology
Release Date : 1970
Immunological Surveillance written by Sir Frank Macfarlane Burnet and has been published by Elsevier Science & Technology this book supported file pdf, txt, epub, kindle and other format this book has been release on 1970 with Medical categories.
Inflammation And Cancer
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Author : Bharat B. Aggarwal
language : en
Publisher: Springer
Release Date : 2014-05-12
Inflammation And Cancer written by Bharat B. Aggarwal and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-12 with Medical categories.
This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.
Research Awards Index
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Author :
language : en
Publisher:
Release Date : 1989
Research Awards Index written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Medicine categories.
Guide To Cancer Immunotherapy
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Author : Suzanne Walker
language : en
Publisher:
Release Date : 2025
Guide To Cancer Immunotherapy written by Suzanne Walker and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025 with Health & Fitness categories.
"Immunotherapy has evolved as a cornerstone of treatment for many cancers, and there continue to be major advances in this therapeutic arena. The second edition of the Guide to Cancer Immunotherapy provides a detailed update on new immunotherapy agents and indications, as well as the latest information on the management of immunotherapy-related toxicities. This edition also expands on the historical development of immunotherapy from its rudimentary beginnings in the 19th century to the modern era of sophisticated immunotargets. Principles of immunology are also reviewed and offer a solid foundation for understanding the complex interplay among cancer, the immune system, and contemporary immunotherapy treatments. Special considerations related to the unique needs of patients receiving immunotherapy treatments are covered in this edition, and case-based discussions highlight recommendations for nursing practice. Principles of patient education pertinent to immunotherapy treatments are reviewed. With the rapidly changing landscape of cancer therapies, oncology nurses must remain current in their understanding of these treatments. We hope the second edition of the Guide to Cancer Immunotherapy offers a valuable resource for oncology nurses and other healthcare professionals involved in the care of patients receiving these increasingly complex treatments"--
The Immune Escape Mechanism And Novel Immunotherapeutic Strategies Of Leukemia
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Author : Shenghui Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2023-05-02
The Immune Escape Mechanism And Novel Immunotherapeutic Strategies Of Leukemia written by Shenghui Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-02 with Medical categories.
Biomedical Index To Phs Supported Research
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Author :
language : en
Publisher:
Release Date : 1991
Biomedical Index To Phs Supported Research written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Medicine categories.
Subject Index Of Current Extramural Research Administered By The National Cancer Institute
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Author :
language : en
Publisher:
Release Date : 1978
Subject Index Of Current Extramural Research Administered By The National Cancer Institute written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1978 with Cancer categories.
Tailoring Nk Cell Receptor Ligand Interactions An Art In Evolution 2nd Edition
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Author : Ulrike Koehl
language : en
Publisher: Frontiers Media SA
Release Date : 2018-11-13
Tailoring Nk Cell Receptor Ligand Interactions An Art In Evolution 2nd Edition written by Ulrike Koehl and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-13 with Immunologic diseases. Allergy categories.
Recognition and killing of aberrant, infected or tumor targets by Natural Killer (NK) cells is mediated by positive signals transduced by activating receptors upon engagement of ligands on target surface. These stimulatory pathways are counterbalanced by inhibitory receptors that raise NK cell activation threshold through negative antagonist signals. While regulatory effects are necessary for physiologic control of autoimmune aggression, they may restrain the ability of NK cells to activate against disease. Overcoming this barrier to immune surveillance, multiple approaches to enhance NK-mediated responses are being investigated since two decades. Propelled by considerable advances in the understanding of NK cell biology, these studies are critical for effective translation of NK-based immunotherapy principles into the clinic. In humans, dominant inhibitory signals are transduced by Killer Immunoglobulin Like Receptors (KIR) recognizing cognate HLA class I on target cells. Conversely, KIR recognition of “missing self-HLA” - due to HLA loss or HLA/ KIR mismatch - triggers NK-mediated tumor rejection. Initially observed in murine transplant models, these antitumor effects were later found to have important implications for the clinical outcome of haplotype-mismatched stemcell transplantation. Here, donor NK subsets protect against acute myeloid leukemia (AML) relapse through missing self recognition of donor HLA-C allele groups (C1 or C2) and/or Bw4 epitope. These studies were subsequently extended by trials investigating the antileukemia effects of adoptively transferred haplotype-mismatched NK cells in non-transplant settings. Other mechanisms have been found to induce clinically relevant NK cell alloreactivity in transplantation, e.g., post-reconstitution functional reversal of anergic NK cells. More recently, activating KIR came into the spotlight for their potential ability to directly activate donor NK cells through in vivo recognition of HLA or other ligands. Novel therapeutic monoclonal antibodies (mAb) may optimize NK-mediated effects. Examples include obinutuzumab (GA101), a glyco-engineered anti-CD20 mAb with increased affinity for the FcγRIIIA receptor, enhancing antibody-dependent cellular cytotoxicity; lirilumab (IPH2102), a first-in-class NK-specific checkpoint inhibitor, blocking the interaction between the major KIR and cognate HLA-C antigens; and elotuzumab (HuLuc63), a humanized monoclonal antibody specific for SLAMF7, whose anti-myeloma therapeutic effects are partly due to direct activation of SLAMF7-expressing NK cells. In addition to conventional antibodies, NK cell-targeted bispecific (BiKEs) and trispecific (TriKEs) killer engagers have also been developed. These proteins elicit potent effector functions by binding target ligands (e.g., CD19, CD22, CD30, CD133, HLA class II, EGFR) on one arm and NK receptors on the other. An additional innovative approach to direct NK cell activity is genetic reprogramming with chimeric antigen receptors (CAR). To date, primary NK cells and the NK92 cell line have been engineered with CAR specific for antigens expressed on multiple tumors. Encouraging preclinical results warrant further development of this approach. This Research Topic welcomes contributions addressing mechanisms of NK-mediated activation in response to disease as well as past and contemporary strategies to enhance NK mediated reactivity through control of the interactions between NK receptors and their ligands.