In Vivo Models To Study Angiogenesis
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In Vivo Models To Study Angiogenesis
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Author : Domenico Ribatti
language : en
Publisher: Academic Press
Release Date : 2017-08-18
In Vivo Models To Study Angiogenesis written by Domenico Ribatti and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-18 with Science categories.
In Vivo Models to Study Angiogenesis provides the latest information and an overview of the most common assays for studying angiogenesis in vivo. Under physiological conditions, angiogenesis is tightly controlled, whereas increased production of angiogenic stimuli and/or reduced production of angiogenic inhibitors leads to abnormal neovascularization, such as occurs in cancer, chronic inflammatory disease, diabetic retinopathy, macular degeneration and cardiovascular disorders. Several genetic and epigenetic mechanisms are involved in the early development of the vascular system. This book presents the latest information from the extensive literature and research available. Evidence is now emerging that blood vessels themselves have the ability to provide instructive regulatory signals to surrounding non-vascular target cells during organ development. Thus, endothelial cell signaling is currently believed to promote fundamental cues for cell fate specification, embryo patterning, organ differentiation and postnatal tissue remodeling. Provides information on the most common assays to study angiogenesis in vivo Presents an ideal reference for those interested in angiogenesis as a normal and vital process in growth and development Covers wound healing, the formation of granulation tissue, and the transition of tumors from benign to malignant
Tumor Angiogenesis Assays
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Author : Domenico Ribatti
language : en
Publisher: Springer Nature
Release Date : 2022-09-26
Tumor Angiogenesis Assays written by Domenico Ribatti and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-26 with Medical categories.
This second edition provides new and updated methods and protocols for studying tumor angiogenesis in vitro and in vivo. Chapters detail morphological aspects of tumor angiogenesis, aortic ring, ex vivo tissue culture model for anti-angiogenic drug testing, transgenic zebrafish, orthotopic models of ovarian cancer, and uncovering metabolic effects of anti-angiogenic therapy in tumors by induced metabolic bioluminescence imaging.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Tumor Angiogenesis Assays: Methods and Protocols, Second Edition is a valuable resource for all researchers interested in learning more about this important and developing field.
Angiogenesis Assays
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Author : Carolyn A. Staton
language : en
Publisher: John Wiley & Sons
Release Date : 2007-01-11
Angiogenesis Assays written by Carolyn A. Staton and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-01-11 with Medical categories.
Angiogenesis, the development of new blood vessels from the existing vasculature, is essential for physiological growth and over 18,000 research articles have been published describing the role of angiogenesis in over 70 different diseases, including cancer, diabetic retinopathy, rheumatoid arthritis and psoriasis. One of the most important technical challenges in such studies has been finding suitable methods for assessing the effects of regulators of eh angiogenic response. While increasing numbers of angiogenesis assays are being described both in vitro and in vivo, it is often still necessary to use a combination of assays to identify the cellular and molecular events in angiogenesis and the full range of effects of a given test protein. Although the endothelial cell - its migration, proliferation, differentiation and structural rearrangement - is central to the angiogenic process, it is not the only cell type involved. the supporting cells, the extracellular matrix and the circulating blood with its cellular and humoral components also contribute. In this book, experts in the use of a diverse range of assays outline key components of these and give a critical appraisal of their strengths and weaknesses. Examples include assays for the proliferation, migration and differentiation of endothelial cells in vitro, vessel outgrowth from organ cultures, assessment of endothelial and mural cell interactions, and such in vivo assays as the chick chorioallantoic membrane, zebrafish, corneal, chamber and tumour angiogenesis models. These are followed by a critical analysis of the biological end-points currently being used in clinical trials to assess the clinical efficacy of anti-angiogenic drugs, which leads into a discussion of the direction future studies should take. This valuable book is of interest to research scientists currently working on angiogenesis in both the academic community and in the biotechnology and pharmaceutical industries. Relevant disciplines include cell and molecular biology, oncology, cardiovascular research, biotechnology, pharmacology, pathology and physiology.
Angiogenesis In Health And Disease
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Author : Michael E. Maragoudakis
language : en
Publisher: Springer
Release Date : 2011-10-02
Angiogenesis In Health And Disease written by Michael E. Maragoudakis and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-10-02 with Medical categories.
Angiogenesis describes the formation of new blood vessels, which arise as outgrowths from existing vessels. In many physiological processes such as ovulation and wound healing angiogenesis is involved for a relatively short time. Otherwise under normal physiological conditions in the adult organism angiogenesis is an extremely slow process. By contrast in certain disease states such as diabetic retinopathy, arthritis, chronic inflammation, hemangiomas, etc., angiogenesis persists and contributes to the pathology of these disease states. Some 50 such "angiogenic diseases" have been described where angiogeneSiS is involved. Also in tumor growth and metastasis angiogenesis is an essential process and precedes neoplastic transformation. Hence, angiogenesis could become an important diagnostic tool and a target for developing therapeutic agents. This book contains the proceedings of the NATO Advanced Study Institute on "Angiogenesis in Health and Disease" held in Porto Hydra, Greece, from June 16-27, 1991. This meeting was a comprehensive review of endothelial cell biology and endothelial cell phenotypic and functional heterogeneity in relation to angiogenesis under physiological and pathological conditions. Numerous in vitro and in vivo models were presented, which are used to study angiogenesis at the molecular and cellular levels and to evaluate chemical compounds or naturally occuring substances for their effect on angiogenesis. The presentations and discussions at this meeting provided an opportunity for the basic science and the clinical disciplines to meet, exchange information and provide future research directions for many investigators engaged in the study of angiogenesis.
Angiogenesis In Vivo Systems
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Author :
language : en
Publisher: Academic Press
Release Date : 2009-02-12
Angiogenesis In Vivo Systems written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-02-12 with Science categories.
Understanding how angiogenesis "works" and how to control it will have massive implications on the management, treatments, and ultimately the prevention of many common (and not so common) diseases. Angiogenesis is the growth of new blood vessels and is an important natural process in the body. A healthy body maintains a perfect balance of angiogenesis modulators. In many serious disease states, however, the body loses control over angiogenesis. Diseases that are angiogenesis-dependent result when blood vessels either grow excessively or insufficiently. * Tried-and-tested techniques written by researchers that developed them, used them, and brought them to fruition * Provides the "builder's manual" for essential techniques--a one-stop shop that eliminates needless searching among untested techniques * Includes step-by-step methods for understanding the cell and molecular basis of wound healing, vascular integrin signaling, mechanical signaling in blood vessels, and vascular proteomics
Vascular Morphogenesis In Vivo In Vitro In Mente
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Author : Charles D. Little
language : en
Publisher: Springer Science & Business Media
Release Date : 1998-09-29
Vascular Morphogenesis In Vivo In Vitro In Mente written by Charles D. Little and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-09-29 with Medical categories.
Reviews recent studies on the mechanisms by which blood vessels are built, both during vascular embryonic vasculogenesis and angiogenesis during fetal development and during cyclical renewal and repair in adults. In vivo studies include the morphogenesis of primordial vascular networks and insights into growth factors from gene knockout studies in mice. A three- dimensional assay of endothelial cell invasion and capillary tube morphogenesis, and the rat aorta model of angiogenesis and its applications are among the in vitro studies. Computer models are described for the formation of netlike structures, tumor- induced angiogenesis, and other phenomena. Annotation copyrighted by Book News, Inc., Portland, OR
Tumor Vascularization
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Author : Domenico Ribatti
language : en
Publisher: Academic Press
Release Date : 2020-01-21
Tumor Vascularization written by Domenico Ribatti and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-21 with Science categories.
Tumor Vascularization discusses the different types of growth of tumor blood vessels and their implications on research and healthcare. The book is divided into three parts: the first one, General Mechanisms, discusses different vessel growth mechanisms, such as sprouting angiogenesis, non-angiogenesis dependent growth, intussusceptive microvascular growth, vascular co-option and vasculogenic mimicry. The second and third parts, entitled Clinical Implications and Therapeutic Implications are dedicated to translating recent findings in this field to patient treatment and healthcare. This book is a valuable source for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in tumor progression and blood vessels. Explains new, non-orthodox concepts recently developed and related to the modality of growth of tumor blood vessels Provides information on the types of angiogenesis, non-angiogenesis dependent growth and vascular co-option, discussing both their similarities and differences Encompasses a discussion on clinical implications of tumor vascularization to translate research findings into treatment
Protocol Handbook For Cancer Biology
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Author : Gauri Misra
language : en
Publisher: Academic Press
Release Date : 2021-02-12
Protocol Handbook For Cancer Biology written by Gauri Misra and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-12 with Science categories.
Protocol Handbook for Cancer Biology brings together a comprehensive collection of the methods used for cancer assessment, diagnostics, and therapeutics. Various protocols are discussed along with alternative strategies, including the advantages and limitations of techniques that have been used in labs globally. These protocols are presented by cancer biology experts based on their real-world experience. The protocols in this book will be a valuable resource for cancer researchers and graduate students, who can utilize the techniques described to conduct research more efficiently and successfully. Presents comprehensive protocols used for cancer assessment, diagnostics, and therapeutics all in one place Encompasses alternative strategies considering the requirements of the end user and taking into consideration diverse research settings Discusses limitations and advantages of each method in experimental design and execution, thus saving time during the research process
Physiologic And Pathologic Angiogenesis
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Author : Dan Simionescu
language : en
Publisher: BoD – Books on Demand
Release Date : 2017-04-05
Physiologic And Pathologic Angiogenesis written by Dan Simionescu and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-05 with Medical categories.
The purpose of this book is to highlight novel advances in the field and to incentivize scientists from a variety of fields to pursue angiogenesis as a research avenue. Blood vessel formation and maturation to capillaries, arteries, or veins is a fascinating area which can appeal to multiple scientists, students, and professors alike. Angiogenesis is relevant to medicine, engineering, pharmacology, and pathology and to the many patients suffering from blood vessel diseases and cancer, among others. We are hoping that this book will become a source of inspiration and novel ideas for all.
Vascularization For Tissue Engineering And Regenerative Medicine
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Author : Wolfgang Holnthoner
language : en
Publisher: Springer
Release Date : 2021-06-09
Vascularization For Tissue Engineering And Regenerative Medicine written by Wolfgang Holnthoner and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-09 with Technology & Engineering categories.
This reference work presents the basic principles of angiogenesis induction, including the roles of signaling factors such as hypoxia-inducible factors, biophysical stimulation and angiogenic cells. The book also covers lymphogenesis induction. Both the established fundamentals in the field as well as new trends in the vascularization of engineered tissues are discussed. These include pre-vascularization strategies using preparation of channeled scaffolds and preparation of decellularized blood vessel trees, approaches to inducing formation of microvasculature and approaches to inducing the growth of vascular networks. The authors expand on these concepts with current studies of dual-level approaches to engineer vascularized tissue composites. The book concludes with a discussion of current clinical approaches and the use of vascular grafts in the context of providing clinical practice with new tissue engineering strategies.