Innate Immunity And Neurodegenerative Diseases Triggers From Self And Non Self
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Innate Immunity And Neurodegenerative Diseases Triggers From Self And Non Self
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Author : Kiran Bhaskar
language : en
Publisher: Frontiers Media SA
Release Date : 2023-06-30
Innate Immunity And Neurodegenerative Diseases Triggers From Self And Non Self written by Kiran Bhaskar and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-30 with Science categories.
Innate Immunity And Neurodegenerative Disorders
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Author : Roger A Barker
language : en
Publisher: Frontiers E-books
Release Date : 2014-11-03
Innate Immunity And Neurodegenerative Disorders written by Roger A Barker and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-03 with Medicine (General) categories.
Inflammation of the brain in the context of neurodegenerative disorders is an area of intense debate and discussion, not least in terms of its pathogenic significance and the extent to which it drives disease processes and pathology. This inflammation can take several forms including innate responses recruiting microglia, humoral responses involving antibody, complement mediated processes and cellular T-cell activation, of which the role and extent of each may differ between diseases. Whilst some diseases have been more intensely linked to inflammation and long-term degeneration (e.g. MS), more traditional chronic neurodegenerative disorders have been thought of in terms of intrinsic neuronal pathology with a secondary innate response. However, it has been described that microglia activation is an early event of many degenerative disorders and evidence is accumulating that it may play a critical role in actually causing pathology and driving disease processes. If true, this would have major therapeutic implications, but what is the evidence that this is the case? The initial observations by Patrick McGeer’s group of post-mortem tissue from patients with Parkinson’s disease revealed the presence of activated brain microglia and has thus lead to the hypothesis that chronic inflammation could participate to neuronal degenerative processes. The significance of these original observations has only been recently revisited, and the development of more powerful tools to study the brain immune response has certainly contributed to this field of research. Chronic inflammation in the brain can take many forms but of particular interest has been the resident microglia and the role they play in this process. In this context, microglia have often been thought to become activated only after the disease has begun and then to contribute minimally to the degenerative process. Emerging new concepts challenge this view by proposing that microglial senescence, for example, may release the disease process and/or accelerate it. In addition, microglia, once activated, can adopt different phenotypes which can be both pro-inflammatory and pro-repair and may impact not only on the healthy adult neuronal population but on those new neurons derived from neurogenic niches of the adult brain. In this Research Topic, we attempt to explore this by first considering the innate immune responses in the brain and the methods by which they can be studied experimentally and in patients with various neurodegenerative disorders. This sets the scene for then discussing a range of different disorders including Alzheimer’s, Parkinson’s, Huntington’s disease and amyotrophic lateral sclerosis. These papers seek to discuss the evidence for an innate immune response and whether this is beneficial or detrimental, as well as its therapeutic implications.
Neuroinflammation And Neurodegenerative Diseases
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Author : Pradeep Kumar
language : en
Publisher: Frontiers Media SA
Release Date : 2025-02-27
Neuroinflammation And Neurodegenerative Diseases written by Pradeep Kumar and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-27 with Science categories.
Neuroinflammation is a crucial area of study that has garnered increasing attention in recent years due to its implications in various neurodegenerative conditions, such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis. This Research Topic aims to delve into the intricate relationship between neuroinflammation and the pathogenesis of these neurodegenerative diseases, with a primary focus on identifying novel therapeutic interventions that could mitigate or halt disease progression. Despite considerable research progress in the field of neurodegenerative diseases, the exact underlying mechanisms and triggers remain partially understood. There is mounting evidence suggesting that neuroinflammation plays a critical role in the development and progression of these disorders. Immune-mediated inflammatory responses within the central nervous system can exacerbate neuronal damage, propagate neurodegeneration, and contribute to disease complexity. Understanding the precise interplay between neuroinflammation and neurodegenerative processes is of utmost importance for devising targeted therapies.
The Neurology Of Aids
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Author : Howard E. Gendelman, MD
language : en
Publisher: Oxford University Press
Release Date : 2011-11-29
The Neurology Of Aids written by Howard E. Gendelman, MD and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-11-29 with Medical categories.
From basic science to clinical care, to epidemiological disease patters, The Neurology of AIDS is the only complete textbook available on AIDS neurology and the only one comprehensive enough to stand alone in each segment of study in brain disorders affected by the human immunodeficiency virus. It is an indispensable resource for students, resident physicians, practicing physicians, and for researchers and experts in the HIV/AIDS field. Oxford Clinical Neuroscience is a comprehensive, cross-searchable collection of resources offering quick and easy access to eleven of Oxford University Press's prestigious neuroscience texts. Joining Oxford Medicine Online these resources offer students, specialists and clinical researchers the best quality content in an easy-to-access format.
Tertiary Lymphoid Organs Tlos Powerhouses Of Disease Immunity
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Author : Changjun Yin
language : en
Publisher: Frontiers Media SA
Release Date : 2017-05-22
Tertiary Lymphoid Organs Tlos Powerhouses Of Disease Immunity written by Changjun Yin and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-22 with categories.
The immune system employs TLOs to elicit highly localized and forceful responses to unresolvable peripheral tissue inflammation. Current data indicate that TLOs are protective but they may also lead to collateral tissue injury and serve as nesting places to generate autoreactive lymphocytes. A better comprehension of these powerhouses of disease immunity will likely facilitate development to unprecedented and specific therapies to fight chronic inflammatory diseases.
The Journal Of Immunology
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Author :
language : en
Publisher:
Release Date : 2009
The Journal Of Immunology written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Immunology categories.
Amyotrophic Lateral Sclerosis
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Author : Martin Henrik Maurer
language : en
Publisher: BoD – Books on Demand
Release Date : 2012-01-20
Amyotrophic Lateral Sclerosis written by Martin Henrik Maurer and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-20 with Medical categories.
Though considerable amount of research, both pre-clinical and clinical, has been conducted during recent years, Amyotrophic Lateral Sclerosis (ALS) remains one of the mysterious diseases of the 21st century. Great efforts have been made to develop pathophysiological models and to clarify the underlying pathology, and with novel instruments in genetics and transgenic techniques, the aim for finding a durable cure comes into scope. On the other hand, most pharmacological trials failed to show a benefit for ALS patients. In this book, the reader will find a compilation of state-of-the-art reviews about the etiology, epidemiology, and pathophysiology of ALS, the molecular basis of disease progression and clinical manifestations, the genetics familial ALS, as well as novel diagnostic criteria in the field of electrophysiology. An overview over all relevant pharmacological trials in ALS patients is also included, while the book concludes with a discussion on current advances and future trends in ALS research.
Clinical Neuroimmunology
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Author : Jack Antel
language : en
Publisher: OUP Oxford
Release Date : 2005-10-06
Clinical Neuroimmunology written by Jack Antel and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-10-06 with Medical categories.
Clinical Neurimmunology is the major reference text in the field, providing broad and comprehensive coverage of the interaction between the nervous and immune systems in both normal and diseased states. Understanding this interaction is fundamental to developing therapeutic approaches to disease and injury of the nervous system that are currently only marginally amenable to therapy. Neuroimmunology is a well-recognised and growing specialty world wide, both at the basic science and clinical level. It is a fast moving field and this is the most up to date text available. Chapters are dedicated to the role of the immune system in disorders affecting both the central and peripheral nervous systems, including important neurodegenerative diseases (such as multiple sclerosis and HIV-related neural degeneration) which cause life-long disability. Extensive coverage is given to a whole array of immune-directed therapies. The book has a strong international team of well respected, high profile editors and authors. The first edition published to extensive and positive reviews and has established itself as the principal reference source in the field. This second edition summarizes recent advances in clinical neuroimmunology in a comprehensive and unbiased way.
Nuclear Receptors And Coregulators In Metabolism And Immunity
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Author : Rongrong Fan
language : en
Publisher: Frontiers Media SA
Release Date : 2022-02-04
Nuclear Receptors And Coregulators In Metabolism And Immunity written by Rongrong Fan and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-04 with Medical categories.
Novel Roles Of Non Coding Brain Rnas In Health And Disease
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Author : Hermona Soreq
language : en
Publisher: Frontiers E-books
Release Date : 2014-10-23
Novel Roles Of Non Coding Brain Rnas In Health And Disease written by Hermona Soreq and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-23 with Neurosciences. Biological psychiatry. Neuropsychiatry categories.
Non-coding RNAs (ncRNAs), and in particular microRNAs are rapidly becoming the focus of research interest in numerous basic and translational fields, including brain research; and their importance for many aspects in brain functioning merits special discussion. The wide-scope, multi-targeted and highly efficient manner of ncRNA regulatory activities draws attention to this topic by many, but the available research and analysis tools and experimental protocols are still at their infancy, and calls for special discussion given their importance for many aspects in brain functioning. This eBook is correspondingly focused on the search for, identification and exploration of those non-coding RNAs whose activities modulate the multi-leveled functions of the eukaryotic brain. The different articles strive to cover novel approaches for identifying and establishing ncRNA-target relationships, provide state of the art reports of the affected neurotransmission pathways, describe inherited and acquired changes in ncRNA functioning and cover the use of ncRNA mimics and blockade tools for interference with their functions in health and disease of the brain. Non-coding RNAs are here to stay, and this exciting eBook provides a glimpse into their impact on our brain’s functioning at the physiology, cell biology, behavior and immune levels.