Neuroinflammation And Neurodegenerative Diseases
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Neuroinflammation And Neurodegenerative Diseases
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Author : Pradeep Kumar
language : en
Publisher: Frontiers Media SA
Release Date : 2025-02-27
Neuroinflammation And Neurodegenerative Diseases written by Pradeep Kumar and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-27 with Science categories.
Neuroinflammation is a crucial area of study that has garnered increasing attention in recent years due to its implications in various neurodegenerative conditions, such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis. This Research Topic aims to delve into the intricate relationship between neuroinflammation and the pathogenesis of these neurodegenerative diseases, with a primary focus on identifying novel therapeutic interventions that could mitigate or halt disease progression. Despite considerable research progress in the field of neurodegenerative diseases, the exact underlying mechanisms and triggers remain partially understood. There is mounting evidence suggesting that neuroinflammation plays a critical role in the development and progression of these disorders. Immune-mediated inflammatory responses within the central nervous system can exacerbate neuronal damage, propagate neurodegeneration, and contribute to disease complexity. Understanding the precise interplay between neuroinflammation and neurodegenerative processes is of utmost importance for devising targeted therapies.
Clinical Immunology
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Author : Robert R. Rich
language : en
Publisher: Mosby Incorporated
Release Date : 2008
Clinical Immunology written by Robert R. Rich and has been published by Mosby Incorporated this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Medical categories.
Offers answers to challenges in clinical immunology. This book contains immunology knowledge and includes a companion web site to give you two ways to find the answers you need.
Neuroinflammation And Neurodegeneration
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Author : Phillip K. Peterson
language : en
Publisher: Springer
Release Date : 2014-07-08
Neuroinflammation And Neurodegeneration written by Phillip K. Peterson and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-08 with Medical categories.
State of the art reviews by experts in the fields of neuroscience, immunology, microbiology/infectious diseases and pharmacology addressing the convergence of the immune system (neuroinflammation) and the loss of neurons (neurodegeneration). Many of the diseases that are discussed in the book are of epidemic proportion, e.g., Alzheimer’s disease, Parkinson’s disease, stroke, viral encephalitides and substance abuse. In addition to discussions of the involvement of neuroinflammation and neurodegeneration in these disorders, scientific reviews are presented on the cells and mediators that participate in defense of and damage to the nervous system. With rare exception, no or inadequate treatment exists for the diseases discussed in this book. An underlying premise of the book is that understanding of their shared pathogenic mechanisms will lead to improved therapies. Given the rapid evolution of the field of Neuroimmune Pharmacology, readers will find this book to be the most timely and authoritative reference on the subject of each of its chapters.
Neuroinflammation Neurodegeneration And Metabolic Disease From Molecular Mechanisms To Therapeutic Innovation
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Author : Fawaz Alzaid
language : en
Publisher: Frontiers Media SA
Release Date : 2024-09-05
Neuroinflammation Neurodegeneration And Metabolic Disease From Molecular Mechanisms To Therapeutic Innovation written by Fawaz Alzaid and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-09-05 with Medical categories.
Neuroinflammation manifests as changes to cognition or behavior, or as altered function in peripheral tissues. Patients with metabolic diseases (e.g., diabetes, obesity) are more likely to suffer with neuroinflammation since the disrupted metabolism and chronic low-grade inflammation that accompany metabolic diseases extends to the nervous system. Neuroinflammation will then lead to functional impairment and progressive loss of neuronal structure, with neurodegeneration being the end result. Factors like chronic hyperglycemia, dyslipidemia and insulin resistance are candidate drivers of neuroinflammation and neurodegeneration. The effects on the nervous system also contribute to worsening insulin resistance and a further loss of metabolic function and homeostasis in innervated peripheral tissues (e.g., liver, adipose tissue). Persistent metabolic stress predisposes patients to peripheral neuropathies, cognitive dysfunction, and development of neurodegenerative diseases (e.g., Alzheimer’s disease). Multiple associations link metabolic disease to neuropathology, targeting neuroinflammation to preserve neuronal integrity holds promise for managing metabolic diseases and associated neurological complications. Research on "Neuroinflammation, Neurodegeneration and Metabolic Disease: From Molecular Mechanisms to Therapeutic Innovation" is necessary to address several critical gaps in our understanding and treatment of metabolic diseases and of neuropathology. Firstly, while the role of systemic inflammation in metabolic diseases has been extensively studied, the specific impact of nervous system inflammation – neuroinflammation – and resulting neurodegeneration on these conditions is still an emerging field. Investigating the mechanisms by which neuroinflammation and neurodegeneration contribute to metabolic diseases can provide valuable insights into the pathogenesis and progression of these conditions.
The Molecular Basis Of Programmed Cell Death And Neuroinflammation In Neurodegenerative Diseases
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Author : Ramkumar Mathur
language : en
Publisher: Frontiers Media SA
Release Date : 2024-01-25
The Molecular Basis Of Programmed Cell Death And Neuroinflammation In Neurodegenerative Diseases written by Ramkumar Mathur and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-25 with Science categories.
Age-related neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease are characterized by progressive neuroinflammation as well as neuronal degeneration. Apoptosis, necrosis, and autophagy are all types of programmed cell death that are morphologically distinct from one another. Over the last decade, extensive research has been conducted on necroptosis, resulting in a better understanding of its molecular underpinnings and role in neurodegenerative diseases. A later study investigates the processes of apoptosis and necroptosis, as well as their roles in the activation of inflammatory immune responses. Although there is a distinct mode of cell death with distinct morphological characteristics, its identification and implications in neurological diseases are still unknown. Interestingly, emerging evidence has established a direct link between epigenetic and posttranslational modifications and neurodegenerative disease. Using epigenetic and proteomic methods, researchers uncovered genes and proteins that may play a function in the area of neuroinflammation, a role that has hitherto been overlooked. New pharmacological targets and therapeutic options for neurodegenerative diseases are being investigated in order to gain a better understanding of the disease's origins and progression by using neuronal death and neuroinflammation models that are associated with epigenetic changes.
Neuroinflammation And Cognition
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Author : Ashok Kumar
language : en
Publisher: Frontiers Media SA
Release Date : 2019-03-22
Neuroinflammation And Cognition written by Ashok Kumar and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-22 with categories.
Aging is one of the major risk factors for the onset and progression of various neurodegenerative diseases. Neuroinflammation is a common feature of virtually every central nervous system disease, and is acknowledged as a likely mediator of cognitive impairments. Systemic inflammation levels are augmented with advanced age and neurodegeneration. The influence of age on neuroinflammatory responses including glial activation, increased production of proinflammatory cytokines, and aberrant neuronal signaling could magnify the deterioration of the central nervous system microenvironment in disease, and may contribute to enhanced cognitive impairment. This eBook is a collection of highly informative original research articles, providing comprehensive aspect of neuroinflammation and possible therapeutic interventions in rescuing cognitive impairments.
Targeting Neuroinflammation For Novel Therapeutics In Neurodegenerative Diseases
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Author : Pukar Khanal
language : en
Publisher: Frontiers Media SA
Release Date : 2025-06-02
Targeting Neuroinflammation For Novel Therapeutics In Neurodegenerative Diseases written by Pukar Khanal and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-02 with Science categories.
Neurodegenerative disorders have increasing incidence with limited treatment options. Approaches to target neuroinflammation in various neurodegenerative disorders, such as Alzheimer’s disease (AD), involve a quest for innovative therapeutics. A comprehensive understanding of the quest for small compounds that improve amyloid processing, regulate autophagy, hinder Aß accumulation, and investigate the array of phytochemicals present in naturally occurring nootropics (ethnomedicines) and polypharmacology may facilitate the exploration of diverse pharmacological approaches to impede disease advancement. Galantamine from snowdrops (Galanthus spp.) is just one example of a current core medication used in the management of cognitive decline, pointing to the potential of small molecules in this context. In addition, the combinations of computational and experimental pharmacological methods enable the exploration of small molecules within crucial neurodegenerative processes, which can help to develop potential therapeutic compounds.
Common Pathways Linking Neurodegenerative Diseases The Role Of Inflammation
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Author : Grzegorz Kreiner
language : en
Publisher: Frontiers Media SA
Release Date : 2021-11-01
Common Pathways Linking Neurodegenerative Diseases The Role Of Inflammation written by Grzegorz Kreiner and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-01 with Science categories.
Role Of Inflammation In Neurodegenerative Diseases
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Author : Maya Koronyo-Hamaoui
language : en
Publisher: Frontiers Media SA
Release Date : 2022-07-13
Role Of Inflammation In Neurodegenerative Diseases written by Maya Koronyo-Hamaoui and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-13 with Medical categories.
Neuroinflammation From Bench To Bedside
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Author : H. Kettenmann
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-14
Neuroinflammation From Bench To Bedside written by H. Kettenmann and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-14 with Medical categories.
Recent work has implicated inflammatory processes in the pathophysiology of a variety of neurodegenerative diseases such as Alzheimer's disease, stroke and multiple sclerosis. In this book leading experts in the field discuss molecular, in vivo and clinical aspects of neuroinflammation. It is hoped, with the wealth of research being conductied in this area, that novel therapeutic targets will be identified which will allow successful therapeutic intervention in a variety of neurodegenerative diseases.