Neuroinflammation Neurodegeneration And Metabolic Disease From Molecular Mechanisms To Therapeutic Innovation

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Neuroinflammation Neurodegeneration And Metabolic Disease From Molecular Mechanisms To Therapeutic Innovation

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Author : Fawaz Alzaid
language : en
Publisher: Frontiers Media SA
Release Date : 2024-09-05

Neuroinflammation Neurodegeneration And Metabolic Disease From Molecular Mechanisms To Therapeutic Innovation written by Fawaz Alzaid and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-09-05 with Medical categories.

Neuroinflammation manifests as changes to cognition or behavior, or as altered function in peripheral tissues. Patients with metabolic diseases (e.g., diabetes, obesity) are more likely to suffer with neuroinflammation since the disrupted metabolism and chronic low-grade inflammation that accompany metabolic diseases extends to the nervous system. Neuroinflammation will then lead to functional impairment and progressive loss of neuronal structure, with neurodegeneration being the end result. Factors like chronic hyperglycemia, dyslipidemia and insulin resistance are candidate drivers of neuroinflammation and neurodegeneration. The effects on the nervous system also contribute to worsening insulin resistance and a further loss of metabolic function and homeostasis in innervated peripheral tissues (e.g., liver, adipose tissue). Persistent metabolic stress predisposes patients to peripheral neuropathies, cognitive dysfunction, and development of neurodegenerative diseases (e.g., Alzheimer’s disease). Multiple associations link metabolic disease to neuropathology, targeting neuroinflammation to preserve neuronal integrity holds promise for managing metabolic diseases and associated neurological complications. Research on "Neuroinflammation, Neurodegeneration and Metabolic Disease: From Molecular Mechanisms to Therapeutic Innovation" is necessary to address several critical gaps in our understanding and treatment of metabolic diseases and of neuropathology. Firstly, while the role of systemic inflammation in metabolic diseases has been extensively studied, the specific impact of nervous system inflammation – neuroinflammation – and resulting neurodegeneration on these conditions is still an emerging field. Investigating the mechanisms by which neuroinflammation and neurodegeneration contribute to metabolic diseases can provide valuable insights into the pathogenesis and progression of these conditions.

Neuroinflammation And Its Resolution From Molecular Mechanisms To Therapeutic Perspectives

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Author : Morena Zusso
language : en
Publisher: Frontiers Media SA
Release Date : 2020-07-14

Neuroinflammation And Its Resolution From Molecular Mechanisms To Therapeutic Perspectives written by Morena Zusso and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-14 with categories.

Central Nervous System Acting Drugs Molecular Mechanisms Of Neuroprotection And Neurodegeneration

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Author : Nesrine Salah El Dine El Sayed
language : en
Publisher: Frontiers Media SA
Release Date : 2023-04-14

Central Nervous System Acting Drugs Molecular Mechanisms Of Neuroprotection And Neurodegeneration written by Nesrine Salah El Dine El Sayed and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-14 with Science categories.

Lipids And Inflammation In Health And Disease

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Author : Alexander Nikolaevich Orekhov
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-31

Lipids And Inflammation In Health And Disease written by Alexander Nikolaevich Orekhov and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-31 with Medical categories.

Nutrigenomics

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Author : Carsten Carlberg
language : en
Publisher: Springer Nature
Release Date : 2025-04-28

Nutrigenomics written by Carsten Carlberg and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-04-28 with Medical categories.

Now in its second edition, this concise textbook provides an overview of the field of nutrigenomics, a topic at the intersection of nutrition and genetics that explores how dietary molecules interact with our genome and epigenome to influence health and disease. Substantially updated and expanded, the book offers a fresh perspective on how diet has shaped human evolution and our susceptibility to conditions such as type 2 diabetes and cardiovascular disease. The 11 chapters cover a wide range of topics, beginning with an overview of the role of nutrients in health and disease, basic mechanisms of nutrient sensing and nuclear receptors, and the impact of epigenetic regulation on health. Readers will discover how chromatin-modifying enzymes and energy status-sensing kinases play critical roles in signaling pathways between diet and the genome. The book also explores the influence of diet on cancer prevention, the importance of the microbiome, and low-grade chronic inflammation and aging. Written in an accessible style, this textbook is intended for undergraduate and graduate students in nutrition, biochemistry, molecular biology, and biology as well as for students and practitioners in medicine. Numerous color illustrations aid in the transfer of knowledge by graphically summarizing complex processes. Combined with a glossary that explains key terms, this work is an indispensable resource for anyone interested in how our daily dietary choices interact with our genome.

Diabetes And Cardiovascular Disease New Therapeutic Interventions

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Author : Ludwig Weckbach
language : en
Publisher: Frontiers Media SA
Release Date : 2024-08-22

Diabetes And Cardiovascular Disease New Therapeutic Interventions written by Ludwig Weckbach and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-08-22 with Science categories.

Diabetes, also known as diabetes mellitus (DM), is a disease that occurs when the glucose level in the blood becomes too high (hyperglycaemia). Chronic hyperglycaemia is accompanied by both biochemical and pathological complications such as retinopathy, nephropathy, neuropathy, and cardiovascular diseases. Diabetes mellitus can be classified into two types: type I which results from the destruction of pancreatic β-cells, leading to insulin insufficiency and type II diabetes mellitus, which is mainly related to insulin resistance. Optimal control of blood glucose levels remains the cornerstone of managing DM. To date, the major classes of antidiabetic medications used to treat diabetes include: biguanides, dipeptidyl peptidase 4 (DPP-4) inhibitors, sulfonylureas, meglitinides, thiazolidinediones (TZDs), sodium-glucose cotransporter (SGLT2) inhibitors, α-glucosidase inhibitors, glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) receptor agonists and the various types of insulin. Several of these drugs may have, besides their antidiabetic properties, also important cardiovascular complications for the patients taking them.

Alzheimer S Disease New Insights Into Biomechanisms And Therapeutic Target

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Author : Wenjuan Yao
language : en
Publisher: Frontiers Media SA
Release Date : 2025-03-19

Alzheimer S Disease New Insights Into Biomechanisms And Therapeutic Target written by Wenjuan Yao and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-19 with Science categories.

With the prevalence of Alzheimer's disease on the rise among aging populations, it becomes crucial to acquire a comprehensive understanding of the underlying biomechanisms to enhance preventive measures for patients. Recent advances in the elucidation of basic biomechanisms such as the major role of the influential genetic factor TREM2 in the immunological basis of Alzheimer’s disease and the establishment of mechanobiology with relevance to Alzheimer’s diseases, hold promising translational value and potential for clinical applications. This research topic aims to elucidate the most recent progress in the field of basic and clinical research. Specifically, we will focus on areas such as the pathogenesis of Alzheimer's disease, neurodegenerative processes and early changes, perception and cognition deficits, immune regulation, as well as new therapeutic targets and innovative strategies. The topic editorial team is dedicated to advancing the field of Alzheimer's disease and creating a platform which future progress can be built upon.

Crosstalk In Ferroptosis Immunity Inflammation

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Author : Qi Feng
language : en
Publisher: Frontiers Media SA
Release Date : 2025-04-17

Crosstalk In Ferroptosis Immunity Inflammation written by Qi Feng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-04-17 with Medical categories.

Ferroptosis represents a critical form of regulated cell death, notable for its reliance on iron and its triggering by lipid peroxidation. The process becomes particularly significant in the context of inflammation, a crucial bodily response intended to tackle various threats and ensure tissue equilibrium. Issues arise when inflammation is uncontrolled, leading towards immune dysfunction and cellular demise. Current studies have further postulated that inflammation may instigate ferroptosis, releasing damage-associated molecular patterns (DAMPs) that activate the immune response and exacerbate inflammation. This bi-directional relationship highlights a complex interplay where ferroptosis and inflammation are both cause and consequence. This Research Topic aims to delineate the complex interactions between ferroptosis and inflammation, uncovering how this nexus influences disease treatment, particularly in inflammatory diseases and cancers. We intend to dissect the interaction between ferroptosis and various immune cells and assess ferroptosis's role in conditions like infection, inflammation, and cancer. These insights are anticipated to reveal novel therapeutic avenues and advance the development of targeted medicinal interventions.

Decipher Cellular And Molecular Mechanism Of The Development And Degeneration Of Functional Spinal Unit With Potential Therapeutic Approaches

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Author : Bo Gao
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-09

Decipher Cellular And Molecular Mechanism Of The Development And Degeneration Of Functional Spinal Unit With Potential Therapeutic Approaches written by Bo Gao and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-09 with Science categories.

Novel Mechanisms Involved In Aging And Neurodegeneration Seeking Potential Therapeutic Targets For Neurodegenerative Diseases

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Author : Natalia Salvadores
language : en
Publisher: Frontiers Media SA
Release Date : 2023-01-10

Novel Mechanisms Involved In Aging And Neurodegeneration Seeking Potential Therapeutic Targets For Neurodegenerative Diseases written by Natalia Salvadores and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-10 with Science categories.