Insights In Gastrointestinal Cancers 2021

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Insights In Gastrointestinal Cancers 2021

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Author : Liang Qiao
language : en
Publisher: Frontiers Media SA
Release Date : 2023-03-01

Insights In Gastrointestinal Cancers 2021 written by Liang Qiao and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-01 with Medical categories.

Gastrointestinal Cancers An Interdisciplinary Approach

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Author : Nima Rezaei
language : en
Publisher: Springer Nature
Release Date : 2024-01-01

Gastrointestinal Cancers An Interdisciplinary Approach written by Nima Rezaei and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-01 with Medical categories.

Gastrointestinal cancers are among the most prevalent malignancies worldwide, with high rate of global cancer incidence and cancer-related death. Gastrointestinal cancers include esophageal cancer, gastric cancer, colorectal cancer, pancreatic cancer, and liver cancer, which all, except the last one, are covered in this volume. The fourth volume of the “Interdisciplinary Cancer Research” series, entitled “Gastrointestinal Cancers: An Interdisciplinary Approach” publishes comprehensive volumes on mechanisms of gastrointestinal cancers and novel immunotherapy opportunities and presents the most updated and peer-reviewed chapters on gastrointestinal cancers therapy. This interdisciplinary series is of special value to researchers working on cell biology, immunology, biochemistry, genetics, and practitioners working on oncology and gastroenterology. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for researchers, oncologists, and gastroenterologists who wish to extend their knowledge on gastrointestinal cancers.

Reviews In Gastrointestinal Cancers

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Author : Fabrizio Bronte
language : en
Publisher: Frontiers Media SA
Release Date : 2023-08-02

Reviews In Gastrointestinal Cancers written by Fabrizio Bronte and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-08-02 with Medical categories.

Cancer Metabolism Molecular Insights Metabolic Crosstalk In The Tumor Microenvironment And Implications For Therapy

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Author : Balkrishna Chaube
language : en
Publisher: Frontiers Media SA
Release Date : 2023-10-04

Cancer Metabolism Molecular Insights Metabolic Crosstalk In The Tumor Microenvironment And Implications For Therapy written by Balkrishna Chaube and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-04 with Medical categories.

Microbiome In Gastrointestinal Cancer

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Author : Jun Yu
language : en
Publisher: Springer Nature
Release Date : 2023-01-16

Microbiome In Gastrointestinal Cancer written by Jun Yu and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-16 with Medical categories.

This book covers state-of-the-art topics covering evidences indicate that the gut microbiota can be harnessed for cancer prevention as well as to modulate the efficacy of chemotherapy and immunotherapy. This book includes: 1) characterization of the dysregulated microbiome in gastrointestinal cancers (Chapters 1-6); 2) the molecular mechanism of action of gut microbiota via microbial metabolites and direct interaction with host cancer or immune cells (Chapters 7-11); 3) key methodologies for studying the role of gut microbiota in cancers (Chapters 12-13); and 4) the potential application of gut microbes for the prevention and treatment of gastrointestinal cancers (Chapters 14-17). The contributors are international experts in molecular and cellular biology, microbiology, metabolomics, bioinformatics and physician scientists to provide in-depth reviews of this subject. This book provides a rich resource of information on this important topic for graduate students, basic researchers and physicians.

Non Coding Rnas In Gastrointestinal And Gynecological Cancers New Insights Into The Mechanisms Of Cancer Therapeutic Resistance

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Author : Peixin Dong
language : en
Publisher: Frontiers Media SA
Release Date : 2022-07-13

Non Coding Rnas In Gastrointestinal And Gynecological Cancers New Insights Into The Mechanisms Of Cancer Therapeutic Resistance written by Peixin Dong and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-13 with Science categories.

Chemo Resistance In Gastrointestinal Cancers

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Author : Xia Li
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-30

Chemo Resistance In Gastrointestinal Cancers written by Xia Li and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-30 with Medical categories.

Adult Diffuse Glioma Microenvironment Insight Into Cancer Ecology

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Author : Aleksi Sedo
language : en
Publisher: Frontiers Media SA
Release Date : 2023-03-29

Adult Diffuse Glioma Microenvironment Insight Into Cancer Ecology written by Aleksi Sedo and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-29 with Medical categories.

Gastrointestinal Cancer Immunotherapy From Drug Resistance Mechanisms To Overcoming Strategies

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Author : Xiaofang Che
language : en
Publisher: Frontiers Media SA
Release Date : 2023-06-15

Gastrointestinal Cancer Immunotherapy From Drug Resistance Mechanisms To Overcoming Strategies written by Xiaofang Che and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-15 with Medical categories.

Gastrointestinal (GI) cancers, including gastric cancer, colon cancer, liver cancer, esophageal cancer, and pancreatic cancer, seriously threaten the health of human beings worldwide with a high rate of morbidity and mortality. The clinical successes achieved with immune checkpoint inhibitors (ICIs) targeting PD-1/PD-L1 and CTLA-4 have opened a new cancer therapy era and brought new hope to cancer patients. However, the overall response rate (ORR) of ICI monotherapy in the non-selective population is only about 20%, in which some patients subsequently develop immunotherapy resistance. Moreover, the remaining 70-80% of patients displayed primary resistance to ICIs, and a few patients even experienced hyper progression disease (HPD). Although PD-L1 expression, mismatch repair deficient (MMRd), high tumor mutational burden (TMB-H) , high homologous recombination deficiency (HRD), and tumor infiltrated immune cells (TILs) are known as effective biomarkers for immunotherapy, growing studies have reported that ICIs could not improve the OS of all patients with PD-L1 expression higher than 50%, and the ORR of MSI-H patients was only about 60%, whereas some patients with low PD-L1 expression or MSS could still benefit from immunotherapy, indicating the complexity of ICI resistance. Therefore, it is of great importance and significance to explore the prediction biomarkers for primary or acquired immunotherapy resistance and elucidate their underlying molecular mechanisms and develop reversal strategies. Due to the multiple steps of the cancer immune cycle and complex immune microenvironment, any disorders of immune cell infiltration or T cell activation, such as lack of antigens and/or their presentation, lack of response to antigen presentation, and T cell priming, could contribute to ICI resistance. The combination with anti-angiogenesis therapy, radiotherapy, chemotherapy, and other ICIs has improved the efficacy of ICI therapy to some extent in the clinic. Although numerous studies related to ICI resistance were reported in GI cancers, due to the strong spatial/temporal heterogeneity and the complex immune microenvironment in different kinds of GI cancers and different individuals, many questions about ICI resistance and reversal strategies remain unsolved. The aim of this Research Topic is to provide a forum to exhibit the latest research achievement related to the exploration of biomarkers for immunotherapy resistance including HPD and the underlying molecular mechanisms, as well as the development of reversal strategies in GI cancers. We hope this Research Topic will lead to a better understanding of precision cancer immunotherapy and provide useful clues for clinical application to benefit more GI cancer patients with immunotherapy.

Repurposed Drugs Targeting Cancer Signaling Pathways Clinical Insights To Improve Oncologic Therapies Volume Ii

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Author : Gerardo Leyva-Gómez
language : en
Publisher: Frontiers Media SA
Release Date : 2025-06-12

Repurposed Drugs Targeting Cancer Signaling Pathways Clinical Insights To Improve Oncologic Therapies Volume Ii written by Gerardo Leyva-Gómez and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-12 with Medical categories.

The field of drug development is a time-consuming and costly process, with the development of individual pharmaceutical products estimated to take between 11 and 14 years and cost between 161-1,800 million dollars. This has led to the rise of drug repositioning, where existing drugs are tested against diseases unrelated to their initial use, as a prominent area in pharmacology. This approach is particularly relevant in the fight against cancer, a multifactorial disease where single molecular mechanisms, pathways, or biomarkers are often associated with a wide range of tumor types. The use of well-characterized, non-cancer drugs as potential anticancer agents has increased, often in combination with existing chemotherapeutics or other repurposed agents. However, there is a need for further research to advance these interventional approaches and introduce them into clinical practice to improve treatments for cancer patients. The goal of this research topic is to explore the effects of repurposed drugs or drug repurposing candidates on cancer signaling pathways. This includes both in vitro and in vivo studies, as well as computational approaches. The research aims to provide information about the antitumor effectiveness of a diverse range of non-cancer compounds, through preclinical experiments, clinical trials, and observational studies. The aim is to improve oncologic therapies by providing clinical insights into repurposed drugs targeting cancer signaling pathways. The scope of this research topic is limited to studies that provide information about the effects of repurposed drugs or drug repurposing candidates on cancer signaling pathways. We welcome articles addressing, but not limited to, the following themes: - The use of bioinformatics platforms to analyze the effect of potentially repositioned drugs - The application of cutting-edge molecular technologies, such as liposomes and CRISPR-Cas9, in the study of repurposed drugs - Preclinical experiments that test the antitumor effectiveness of non-cancer compounds - Clinical trials and observational studies that provide insights into the use of repurposed drugs in oncologic therapies. Please note that manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases, which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo), are out of scope for this section and will not be accepted as part of this Research Topic.