Non Coding Rnas In Gastrointestinal And Gynecological Cancers New Insights Into The Mechanisms Of Cancer Therapeutic Resistance
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Non Coding Rnas In Gastrointestinal And Gynecological Cancers New Insights Into The Mechanisms Of Cancer Therapeutic Resistance
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Author : Peixin Dong
language : en
Publisher: Frontiers Media SA
Release Date : 2022-07-13
Non Coding Rnas In Gastrointestinal And Gynecological Cancers New Insights Into The Mechanisms Of Cancer Therapeutic Resistance written by Peixin Dong and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-13 with Science categories.
Women In Molecular And Cellular Oncology Volume Ii 2022
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Author : Sharon Prince
language : en
Publisher: Frontiers Media SA
Release Date : 2023-10-27
Women In Molecular And Cellular Oncology Volume Ii 2022 written by Sharon Prince and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-27 with Medical categories.
Long Non Coding Rnas In Cancer
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Author : Alfons Navarro
language : en
Publisher: Humana
Release Date : 2021-06-24
Long Non Coding Rnas In Cancer written by Alfons Navarro and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-24 with Medical categories.
This volume presents techniques needed for the study of long non-coding RNAs (lncRNAs) in cancer from their identification to functional characterization. Chapters guide readers through identification of lncRNA expression signatures in cancer tissue or liquid biopsies by RNAseq, single Cell RNAseq, Phospho RNAseq or Nanopore Sequencing techniques; validation of lncRNA signatures by Real time PCR, digital PCR or in situ hybridization; and functional analysis by siRNA or CRISPR based methods for lncRNA silencing or overexpression. Lipid based nanoparticles for delivery of siRNAs in vivo, lncRNA-protein interactions, viral lncRNAs and circRNAs are also treated in this volume. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and practical, Long Non-Coding RNAs in Cancer aims to provide a collection of laboratory protocols, bioinformatic pipelines, and review chapters to further research in this vital field.
Molecular Mechanism Of Congenital Heart Disease And Pulmonary Hypertension
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Author : Toshio Nakanishi
language : en
Publisher: Springer Nature
Release Date : 2020-02-28
Molecular Mechanism Of Congenital Heart Disease And Pulmonary Hypertension written by Toshio Nakanishi and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-28 with Medical categories.
This open access book focuses on the molecular mechanism of congenital heart disease and pulmonary hypertension, offering new insights into the development of pulmonary circulation and the ductus arteriosus. It describes in detail the molecular mechanisms involved in the development and morphogenesis of the heart, lungs and ductus arteriosus, covering a range of topics such as gene functions, growth factors, transcription factors and cellular interactions, as well as stem cell engineering technologies. The book also presents recent advances in our understanding of the molecular mechanism of lung development, pulmonary hypertension and molecular regulation of the ductus arteriosus. As such, it is an ideal resource for physicians, scientists and investigators interested in the latest findings on the origins of congenital heart disease and potential future therapies involving pulmonary circulation/hypertension and the ductus arteriosus.
Essential Concepts In Molecular Pathology
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Author : William B. Coleman
language : en
Publisher: Academic Press
Release Date : 2019-11-23
Essential Concepts In Molecular Pathology written by William B. Coleman and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-23 with Medical categories.
Essential Concepts in Molecular Pathology, Second Edition, offers an introduction to molecular genetics and the "molecular" aspects of human disease. The book illustrates how pathologists harness their understanding of these entities to develop new diagnostics and treatments for various human diseases. This new edition offers pathology, genetics residents, and molecular pathology fellows an advanced understanding of the molecular mechanisms of disease that goes beyond what they learned in medical and graduate school. By bridging molecular concepts of pathogenesis to the clinical expression of disease in cell, tissue and organ, this fully updated, introductory reference provides the background necessary for an understanding of today's advances in pathology and medicine. - Explains the practice of "molecular medicine" and the translational aspects of molecular pathology, including molecular diagnostics, molecular assessment and personalized medicine - Orients non-pathologists on what pathologists look for and how they interpret their observational findings based on histopathology - Provides the reader with what is missing from most targeted introductions to pathology—the cell biology behind pathophysiology
Childhood Acute Lymphoblastic Leukemia
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Author : Ajay Vora
language : en
Publisher: Springer
Release Date : 2017-04-21
Childhood Acute Lymphoblastic Leukemia written by Ajay Vora and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-21 with Medical categories.
This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail. This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia.
Gynaecological Malignancies
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Author : Gwo Yaw Ho
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-06-17
Gynaecological Malignancies written by Gwo Yaw Ho and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-17 with Medical categories.
“Gynaecological Malignancies - Updates and Advances” aims to present a review of the significant advances in the understanding and management of gynaecological malignancies. Major areas of importance in this field will be covered, incorporating new knowledge that has arisen due to the advancements in molecular techniques and the ability to correlate these molecular changes with clinical behaviour of gynaecologic tumours. The therapeutic implications of molecular subtyping to match appropriate therapies and the appreciation of the use of up to date radiotherapy techniques will be explored.
Genome Chaos
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Author : Henry H. Heng
language : en
Publisher: Academic Press
Release Date : 2024-06-15
Genome Chaos written by Henry H. Heng and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-15 with Science categories.
Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine, Second Edition transports readers from Mendelian genetics to 4D genomics, building a case for genes and genomes as distinct biological entities, and positing that the genome, rather than individual genes, defines system inheritance and represents a clear unit of selection for macroevolution. In authoring this thought-provoking text, Dr. Henry Heng invigorates fresh discussions in Genome Architecture Theory and helps readers reevaluate their current understanding of human genetics, evolution, and new pathways for advancing molecular and precision medicine. In this fully updated, new edition Dr. Heng fully embraces the integration of system information with genome-mediated evolutionary mechanisms, and supports this framework with recent findings and growing, interdisciplinary research supporting Genome Architecture Theory. Ten evidence-based chapters discuss 4D genomics, genes, and genomes as distinct biological entities, genome chaos and macrocellular evolution, karyotype coding and fuzzy inheritance, as well as an entirely novel information flow-driven model of evolution, and more. All new chapters consider the creation and maintenance of system information for complexity and biodiversity, as well as modes of analyzing information-based and historically contingent evolutionary theory. This synthesis offers an updated evolutionary theory, unifying physical, chemical, and biological mechanisms within organismal systems, and details the evolution of information packages where information flow, matter arrangement, and energy interact.
Non Coding Rnas In Colorectal Cancer
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Author : Ondrej Slaby
language : en
Publisher: Springer
Release Date : 2016-08-29
Non Coding Rnas In Colorectal Cancer written by Ondrej Slaby and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-29 with Medical categories.
This is the first book to provide a broad framework for obtaining an in depth understanding of the state-of-the-art knowledge on abnormalities of non-coding RNAs found to be associated with colorectal cancer pathogenesis. Readers will discover possible mechanisms underlying the substantial roles played by non-coding RNAs in molecular hallmarks of colorectal cancer. This work further provides the comprehensive overview and novel insights into using of non-coding RNAs as colorectal cancer biomarkers enabling early detection of the disease, prognostic stratification of the patients and prediction of therapeutic response. The reader is introduced to the overview of modern non-coding RNAs-based therapeutic strategies, and summary of their preclinical testing performed in colorectal cancer. The work is written for researchers who want to explore current state of the knowledge in this interesting field of molecular oncology.
Non Coding Rna Transcripts In Cancer Therapy Pre Clinical And Clinical Implications
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Author : Gautam Sethi
language : en
Publisher: World Scientific
Release Date : 2023-03-14
Non Coding Rna Transcripts In Cancer Therapy Pre Clinical And Clinical Implications written by Gautam Sethi and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-14 with Medical categories.
'Non-coding RNA Transcripts in Cancer Therapy: Pre-clinical and Clinical Implications' provides a new insight towards role of non-coding RNAs molecules including microRNAs, long non-coding RNAs and circular RNAs in cancer. The reason of focusing on cancer is that this malignant disease is responsible for high death around the world and after cardiovascular diseases, it is a leading cause of death. In the current book, the basic information and knowledge about ncRNAs, their biogenesis and their biological functions are covered. It is shown that ncRNAs can regulate expression level of genes at transcriptional and post-transcriptional levels and therefore, ncRNAs are master and key players in molecular pathways. Then, the impact of regulation of molecular pathways by ncRNAs on important molecular mechanisms such as proliferation, metastasis, epithelial-to-mesenchymal transition, apoptosis and autophagy are described. All of these aspects are integrated in cancer and for treatment of this disease. In case of miRNAs, their biogenesis and biological functions in physiological conditions are described. Then, impact of miRNAs on proliferation, metastasis, therapy response (drug resistance and radio-resistance) is described. For lncRNAs and circRNAs, a same way is followed and their biogenesis and functional roles in cells are discussed. At the next step, function of lncRNAs and circRNAs in regulating proliferation, metastasis and therapy response (chemoresistance and radio-resistance) is introduced. These subjects are discussed based on pre-clinical studies and in order to make the book more comprehensive and broaden its scope, the function of exosomal ncRNAs in diagnosis and prognosis of cancer patients is described.