Long Non Coding Rnas In Cancer
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Long Non Coding Rnas In Cancer
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Author : Alfons Navarro
language : en
Publisher: Humana
Release Date : 2022-06-25
Long Non Coding Rnas In Cancer written by Alfons Navarro and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-25 with Medical categories.
This volume presents techniques needed for the study of long non-coding RNAs (lncRNAs) in cancer from their identification to functional characterization. Chapters guide readers through identification of lncRNA expression signatures in cancer tissue or liquid biopsies by RNAseq, single Cell RNAseq, Phospho RNAseq or Nanopore Sequencing techniques; validation of lncRNA signatures by Real time PCR, digital PCR or in situ hybridization; and functional analysis by siRNA or CRISPR based methods for lncRNA silencing or overexpression. Lipid based nanoparticles for delivery of siRNAs in vivo, lncRNA-protein interactions, viral lncRNAs and circRNAs are also treated in this volume. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and practical, Long Non-Coding RNAs in Cancer aims to provide a collection of laboratory protocols, bioinformatic pipelines, and review chapters to further research in this vital field.
Long Non Coding Rna Biology
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Author : M.R.S. Rao
language : en
Publisher: Springer
Release Date : 2017-08-16
Long Non Coding Rna Biology written by M.R.S. Rao and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-16 with Medical categories.
This contributed volume offers a comprehensive and detailed overview of the various aspects of long non-coding RNAs and discusses their emerging significance. Written by leading experts in the field, it motivates young researchers around the globe, and offers graduate and postgraduate students fascinating insights into genes and their regulation in eukaryotes and higher organisms.
The Long And Short Non Coding Rnas In Cancer Biology
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Author : Erwei Song
language : en
Publisher: Springer
Release Date : 2016-07-04
The Long And Short Non Coding Rnas In Cancer Biology written by Erwei Song and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-04 with Medical categories.
The book conveys a comprehensive knowledge of long and short ncRNAs in cancer regulation and their potentials as diagnostic biomarkers and therapeutic targets. Topics covered include the molecular mechanisms of various classes of ncRNAs (with emphasis on long non-coding RNAs and microRNAs) in cancer, the functional roles of ncRNAs in regulating different cancer hallmarks (including proliferation, apoptosis, stem-cell properties, epithelial-mesenchymal transition, metabolism, angiogenesis, tumor-host interactions and therapeutic resistance), the role of ncRNAs in regulating cancer signaling circuitry programs (highlighting their involvement in c-myc, p53 and NFkB signaling), a systemic summary of clinical and preclinical studies that evaluate the potential of ncRNA signatures for cancer diagnosis and prognosis and strategies to delivery short ncRNAs as therapeutic molecules for cancer treatment. This book may serve as a comprehensive resource for researchers, graduate students and oncologists in ncRNA and cancer research and help drug development by identifying ncRNA targets.
Non Coding Rnas And Cancer
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Author : Muller Fabbri
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-10-28
Non Coding Rnas And Cancer written by Muller Fabbri and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-28 with Medical categories.
The discovery of microRNAs and its role as gene expression regulators in human carcinogenesis represents one of the most important scientific achievements of the last decade. More recently, other non-coding RNAs have been discovered and its implications in cancer are emerging as well, suggesting a broader than anticipated involvement of the non-coding genome in cancer. Moreover, completely new and unexpected functions for microRNAs are being revealed, leading to the identification of new anticancer molecular targets. This book represents a comprehensive guide on non-coding RNAs and cancer, spanning from its role as cancer biomarkers, to providing the most useful bioinformatic tools, to presenting some of the most relevant discoveries, which indicates how these fascinating molecules act as fine orchestrators of cancer biology.
Non Coding Rnas
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Author : Lütfi Tutar
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-03-04
Non Coding Rnas written by Lütfi Tutar and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-04 with Medical categories.
Noncoding RNAs (ncRNAs) are an attractive research field in the RNA world. ncRNAs play important roles in regulating gene expression in animals, plants, and various human diseases. It is clear that current and further research on ncRNAs will change our knowledge of the nature of genome composition by editing previous dogmas. This book provides an overview of current knowledge on ncRNA research by dealing with miRNA and ncRNA-related human diseases, plant miRNA markers, and the roles of lncRNAs in cancer and epigenetics.
Cancer And Noncoding Rnas
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Author : Jayprokas Chakrabarti
language : en
Publisher: Academic Press
Release Date : 2017-10-13
Cancer And Noncoding Rnas written by Jayprokas Chakrabarti and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-13 with Medical categories.
Cancer and Noncoding RNAs offers an in-depth exploration of noncoding RNAs and their role in epigenetic regulation of complex human disease, most notably cancer. In addition to examining microRNAs, this volume provides a unique evaluation of more recently profiled noncoding RNAs now implicated in carcinogenesis, including lncRNAs, piRNAs, circRNAs, and tRNAs, identifying differences in function between these noncoding RNAs and how they interact with the rest of the epigenome. A broad range of chapters from experts in the field detail epigenetic regulation of various cancer types, along with recent next generation sequencing technologies, genome-wide association studies (GWAS) and bioinformatics approaches. This book will help researchers in genomic medicine and cancer biology better understand the role of noncoding RNAs in epigenetics, aiding in the development of useful biomarkers for diagnosis, prognosis and new RNA-based disease therapies. Provides a comprehensive analysis of noncoding RNAs implicated in epigenetic regulation of gene expression and chromatin dynamics Educates researchers and graduate students by highlighting, in addition to miRNAs, a range of noncoding RNAs newly associated with carcinogenesis Applies current knowledge of noncoding RNAs and epigenomics towards developing cancer and RNA-based disease therapies Features contributions by leading experts in the field
Non Coding Rna Transcripts In Cancer Therapy Pre Clinical And Clinical Implications
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Author : Gautam Sethi
language : en
Publisher: World Scientific
Release Date : 2023-03-14
Non Coding Rna Transcripts In Cancer Therapy Pre Clinical And Clinical Implications written by Gautam Sethi and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-14 with Medical categories.
'Non-coding RNA Transcripts in Cancer Therapy: Pre-clinical and Clinical Implications' provides a new insight towards role of non-coding RNAs molecules including microRNAs, long non-coding RNAs and circular RNAs in cancer. The reason of focusing on cancer is that this malignant disease is responsible for high death around the world and after cardiovascular diseases, it is a leading cause of death. In the current book, the basic information and knowledge about ncRNAs, their biogenesis and their biological functions are covered. It is shown that ncRNAs can regulate expression level of genes at transcriptional and post-transcriptional levels and therefore, ncRNAs are master and key players in molecular pathways. Then, the impact of regulation of molecular pathways by ncRNAs on important molecular mechanisms such as proliferation, metastasis, epithelial-to-mesenchymal transition, apoptosis and autophagy are described. All of these aspects are integrated in cancer and for treatment of this disease. In case of miRNAs, their biogenesis and biological functions in physiological conditions are described. Then, impact of miRNAs on proliferation, metastasis, therapy response (drug resistance and radio-resistance) is described. For lncRNAs and circRNAs, a same way is followed and their biogenesis and functional roles in cells are discussed. At the next step, function of lncRNAs and circRNAs in regulating proliferation, metastasis and therapy response (chemoresistance and radio-resistance) is introduced. These subjects are discussed based on pre-clinical studies and in order to make the book more comprehensive and broaden its scope, the function of exosomal ncRNAs in diagnosis and prognosis of cancer patients is described.
Clinical Applications Of Noncoding Rnas In Cancer
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Author : Subash Gupta
language : en
Publisher: Academic Press
Release Date : 2022-01-19
Clinical Applications Of Noncoding Rnas In Cancer written by Subash Gupta and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-19 with Science categories.
Clinical Applications of Noncoding RNAs in Cancer summarizes the existing strategies, advances, and future opportunities on the role of noncoding RNAs in cancer patients. Established clinicians and researchers from all around the world share their views and expertise and provide readers with invaluable knowledge on the subject. This book provides a comprehensive collection of information on the utility of noncoding RNAs in the diagnosis, prognosis, and therapy of cancer. It also discusses the evolutionary significance of noncoding RNAs and how the molecular tools such as RNA-seq, RNA-FISH, ic-SHAPE, and quantitative real-time PCR help in the detection and elucidation of the functions of noncoding RNAs. Additionally, the challenges associated with noncoding RNA approaches and future developments are discussed. It is a valuable resource for cancer researchers, oncologists, clinicians, and other biomedical field members who want to learn more about noninvasive ways to diagnose and efficiently treat diverse cancer types. Presents a beginning chapter summary to help readers understand the content thoroughly Encompasses detailed description of information from clinical studies on noncoding RNAs in cancer therapy Discusses one cancer type per chapter making the content easy to reference
Lncrnas In Cancer Metastasis And Therapy Resistance
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Author : Aamir Ahmad
language : en
Publisher: Frontiers Media SA
Release Date : 2023-10-30
Lncrnas In Cancer Metastasis And Therapy Resistance written by Aamir Ahmad and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-30 with Medical categories.
lncRNAs (long non-coding RNAs) are the relatively longer (more than 200 nucleotides long) subtypes of ncRNAs (non-coding RNAs) i.e the RNAs that do not code for any proteins. However, even without themselves being translated, lncRNAs impact the cellular gene expressions and functions in ways that are just beginning to be explored. The metastasis of human cancers as well as acquired resistance against the administered therapeutics are two major factors responsible for the cancer-associated mortality.
Non Coding Rnas In Breast Cancer
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Author : Wenwen Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-06
Non Coding Rnas In Breast Cancer written by Wenwen Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-06 with Medical categories.