The Long And Short Non Coding Rnas In Cancer Biology

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The Long And Short Non Coding Rnas In Cancer Biology

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Author : Erwei Song
language : en
Publisher: Springer
Release Date : 2016-07-04

The Long And Short Non Coding Rnas In Cancer Biology written by Erwei Song and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-04 with Medical categories.

The book conveys a comprehensive knowledge of long and short ncRNAs in cancer regulation and their potentials as diagnostic biomarkers and therapeutic targets. Topics covered include the molecular mechanisms of various classes of ncRNAs (with emphasis on long non-coding RNAs and microRNAs) in cancer, the functional roles of ncRNAs in regulating different cancer hallmarks (including proliferation, apoptosis, stem-cell properties, epithelial-mesenchymal transition, metabolism, angiogenesis, tumor-host interactions and therapeutic resistance), the role of ncRNAs in regulating cancer signaling circuitry programs (highlighting their involvement in c-myc, p53 and NFkB signaling), a systemic summary of clinical and preclinical studies that evaluate the potential of ncRNA signatures for cancer diagnosis and prognosis and strategies to delivery short ncRNAs as therapeutic molecules for cancer treatment. This book may serve as a comprehensive resource for researchers, graduate students and oncologists in ncRNA and cancer research and help drug development by identifying ncRNA targets.

Long Non Coding Rnas In Cancer

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Author : Alfons Navarro
language : en
Publisher: Humana
Release Date : 2021-06-24

Long Non Coding Rnas In Cancer written by Alfons Navarro and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-24 with Medical categories.

This volume presents techniques needed for the study of long non-coding RNAs (lncRNAs) in cancer from their identification to functional characterization. Chapters guide readers through identification of lncRNA expression signatures in cancer tissue or liquid biopsies by RNAseq, single Cell RNAseq, Phospho RNAseq or Nanopore Sequencing techniques; validation of lncRNA signatures by Real time PCR, digital PCR or in situ hybridization; and functional analysis by siRNA or CRISPR based methods for lncRNA silencing or overexpression. Lipid based nanoparticles for delivery of siRNAs in vivo, lncRNA-protein interactions, viral lncRNAs and circRNAs are also treated in this volume. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and practical, Long Non-Coding RNAs in Cancer aims to provide a collection of laboratory protocols, bioinformatic pipelines, and review chapters to further research in this vital field.

Clinical Applications Of Noncoding Rnas In Cancer

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Author : Subash Gupta
language : en
Publisher: Academic Press
Release Date : 2022-01-19

Clinical Applications Of Noncoding Rnas In Cancer written by Subash Gupta and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-19 with Science categories.

Clinical Applications of Noncoding RNAs in Cancer summarizes the existing strategies, advances, and future opportunities on the role of noncoding RNAs in cancer patients. Established clinicians and researchers from all around the world share their views and expertise and provide readers with invaluable knowledge on the subject. This book provides a comprehensive collection of information on the utility of noncoding RNAs in the diagnosis, prognosis, and therapy of cancer. It also discusses the evolutionary significance of noncoding RNAs and how the molecular tools such as RNA-seq, RNA-FISH, ic-SHAPE, and quantitative real-time PCR help in the detection and elucidation of the functions of noncoding RNAs. Additionally, the challenges associated with noncoding RNA approaches and future developments are discussed. It is a valuable resource for cancer researchers, oncologists, clinicians, and other biomedical field members who want to learn more about noninvasive ways to diagnose and efficiently treat diverse cancer types. - Presents a beginning chapter summary to help readers understand the content thoroughly - Encompasses detailed description of information from clinical studies on noncoding RNAs in cancer therapy - Discusses one cancer type per chapter making the content easy to reference

Non Coding Rnas In Cardiovascular Diseases

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Author : Junjie Xiao
language : en
Publisher: Springer Nature
Release Date : 2020-04-13

Non Coding Rnas In Cardiovascular Diseases written by Junjie Xiao and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-13 with Science categories.

This book presents the latest research on non-coding RNAs in cardiovascular disease, a major cause of death worldwide. Non-coding RNAs play a significant role in development, proliferation, differentiation and apoptosis. Since altered non-coding RNA expression is often associated with various diseases, their potential use in diagnostics, prognostics and therapeutics is an important current area of study. The book consists of six parts: 1) An overview of non-coding RNAs and cardiovascular system, 2) Bioinformatics and interactions, 3) Non-coding RNA regulation in cardiovascular system, 4) Non-coding RNAs and cardiovascular diseases, 5) Potential biomarkers and therapeutic implications, 6) Future prospects. It is particularly useful for researchers and students in the field of non-coding RNA and cardiovascular biology, as well as for cardiologists, pharmacologists and physiologists.

Molecular Biology Of Long Non Coding Rnas

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Author : Ahmad M. Khalil
language : en
Publisher: Springer
Release Date : 2019-06-06

Molecular Biology Of Long Non Coding Rnas written by Ahmad M. Khalil and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-06 with Medical categories.

This second edition shows how long non-coding RNAs (lnc)RNAs have emerged as a new paradigm in epigenetic regulation of the genome. Thousands of lncRNAs have been identified and observed in a wide range of organisms. Unlike mRNA, lncRNA have no protein-coding capacity. So, while their function is not entirely clear, they may serve as key organizers of protein complexes that allow for higher order regulatory events. Advances in the field also include better characterization of human long non-coding RNAs, novel insights into their roles in human development and disease, their diverse mechanisms of action and novel technologies to study them.

Non Coding Rna Transcripts In Cancer Therapy Pre Clinical And Clinical Implications

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Author : Gautam Sethi
language : en
Publisher: World Scientific
Release Date : 2023-03-14

Non Coding Rna Transcripts In Cancer Therapy Pre Clinical And Clinical Implications written by Gautam Sethi and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-14 with Medical categories.

'Non-coding RNA Transcripts in Cancer Therapy: Pre-clinical and Clinical Implications' provides a new insight towards role of non-coding RNAs molecules including microRNAs, long non-coding RNAs and circular RNAs in cancer. The reason of focusing on cancer is that this malignant disease is responsible for high death around the world and after cardiovascular diseases, it is a leading cause of death. In the current book, the basic information and knowledge about ncRNAs, their biogenesis and their biological functions are covered. It is shown that ncRNAs can regulate expression level of genes at transcriptional and post-transcriptional levels and therefore, ncRNAs are master and key players in molecular pathways. Then, the impact of regulation of molecular pathways by ncRNAs on important molecular mechanisms such as proliferation, metastasis, epithelial-to-mesenchymal transition, apoptosis and autophagy are described. All of these aspects are integrated in cancer and for treatment of this disease. In case of miRNAs, their biogenesis and biological functions in physiological conditions are described. Then, impact of miRNAs on proliferation, metastasis, therapy response (drug resistance and radio-resistance) is described. For lncRNAs and circRNAs, a same way is followed and their biogenesis and functional roles in cells are discussed. At the next step, function of lncRNAs and circRNAs in regulating proliferation, metastasis and therapy response (chemoresistance and radio-resistance) is introduced. These subjects are discussed based on pre-clinical studies and in order to make the book more comprehensive and broaden its scope, the function of exosomal ncRNAs in diagnosis and prognosis of cancer patients is described.

Osteosarcoma

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Author : Matthew Gregory Cable
language : en
Publisher: BoD – Books on Demand
Release Date : 2019-12-04

Osteosarcoma written by Matthew Gregory Cable and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-04 with Medical categories.

This book is titled Osteosarcoma - Diagnosis, Mechanisms, and Translational Developments, and focuses on recent advancements and novel ideas in osteosarcoma research. In a manner of speaking, we have taken the multidisciplinary mindset essential for treating osteosarcoma and broadened it to include other areas of cancer research. By learning from gains in other areas of oncology, such as new lncRNAs, the understanding of cancer metabolism and oxidative phosphorylation, and new chemotherapy agents, we can apply them to the niche of osteosarcoma for treatment development. By drawing more attention to these novel and clever discoveries, we hope to continue this enthusiasm for advancements in basic and translational research in the field of osteosarcoma.

Next Generation Sequencing In Cancer Research

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Author : Wei Wu
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-08-04

Next Generation Sequencing In Cancer Research written by Wei Wu and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-08-04 with Medical categories.

​​​​This volume provides an interdisciplinary perspective of applying Next Generation Sequencing (NGS) technology to cancer research. It aims to systematically introduce the concept of NGS, a variety of NGS platforms and their practical implications in cancer biology.This unique and comprehensive text will integrate the unprecedented NGS technology into various cancer research projects as opposed to most books which offer a detailed description of the technology. This volume will present true experimental results with concrete data processing pipelines, discuss the bottleneck of each platform for real project in cancer research. In additional, single cancer cell sequencing as the proof of concept will be introduced in this book, along with cutting-edge information provided will help the intended audience to develop a comprehensive understanding of the NGS technology and practical whole genome sequencing data analysis and rapidly translate into their own research, specifically in the field of cancer biology.

Recent Progresses Of Non Coding Rnas In Biological And Medical Research 2nd Edition

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Author : Yun Zheng
language : en
Publisher: Frontiers Media SA
Release Date : 2020-11-04

Recent Progresses Of Non Coding Rnas In Biological And Medical Research 2nd Edition written by Yun Zheng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-04 with Science categories.

Publisher’s note: In this 2nd edition, the following article has been updated: Xun Y, Tang Y, Hu L, Xiao H, Long S, Gong M, Wei C, Wei K and Xiang S (2019) Purification and Identification of miRNA Target Sites in Genome Using DNA Affinity Precipitation. Front. Genet. 10:778. doi: 10.3389/fgene.2019.00778

Non Coding Rnas

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Author : Lütfi Tutar
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-03-04

Non Coding Rnas written by Lütfi Tutar and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-04 with Medical categories.

Noncoding RNAs (ncRNAs) are an attractive research field in the RNA world. ncRNAs play important roles in regulating gene expression in animals, plants, and various human diseases. It is clear that current and further research on ncRNAs will change our knowledge of the nature of genome composition by editing previous dogmas. This book provides an overview of current knowledge on ncRNA research by dealing with miRNA and ncRNA-related human diseases, plant miRNA markers, and the roles of lncRNAs in cancer and epigenetics.