Insights Into Prostate Cancer Pathogenesis
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Insights Into Prostate Cancer Pathogenesis
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Author : Behnam Sayanjali
language : en
Publisher:
Release Date : 2016
Insights Into Prostate Cancer Pathogenesis written by Behnam Sayanjali and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
Precision Molecular Pathology Of Prostate Cancer
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Author : Brian D. Robinson
language : en
Publisher: Springer
Release Date : 2018-02-13
Precision Molecular Pathology Of Prostate Cancer written by Brian D. Robinson and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-13 with Medical categories.
This volume focuses on our current understanding of the molecular underpinnings of prostate cancer and their potential application for precision medicine approaches. The emergence and applications of new technologies has allowed for a rapid expansion of our understanding of the molecular basis of prostate cancer and has revealed a remarkable genetic heterogeneity that may underlie the clinically variable behavior of the disease. The book consists of five sections which provide insight about the following: (1) General principles; (2) Molecular signatures of primary prostate cancer; (3) Molecular signatures of advanced prostate cancer; (4) Key molecular pathways in prostate cancer development and progression; (5) and Precision medicine approach: Diagnosis, treatment, prognosis. Precision Molecular Pathology of Prostate Cancer is an important resource for the practicing oncologist, urologist, and pathologist, and will also be useful for researchers in the prostate cancer community.
Challenges In Prostate Cancer
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Author : Winsor Bowsher
language : en
Publisher: John Wiley & Sons
Release Date : 2008-04-15
Challenges In Prostate Cancer written by Winsor Bowsher and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-15 with Medical categories.
Prostate cancer continues to be a major threat to men's health, thesecond most common cancer in men, in many countries. Therefore itis increasingly important that those faced with difficult clinicalquestions make the right decisions. Since the first volume waspublished in 2000, many debates persist but new controversies havealso emerged, reflected in the chapters of this new volume. Newauthors have been recruited to give their insight into newer areasof this controversial topic. Challenges in prostate cancer provides a series ofstate-of-the-art review articles, each of which addresses andanswers a contentious question. It includes chapters on medical andsurgical management of all stages of prostate cancer, clinicalinvestigation, epidemiology, clinical trials and basic scientificresearch and covers issues such as the genetic basis of cancer,clinical economics and influence. The authors have used their expertise to distil the availableevidence into practical advice to be used by busy urologists intheir day-to-day practice. And as well as being an overview ofcurrent practice many chapters attempt to give insights into thefuture direction of prostate cancer research and clinicalmanagement.
Prostate Cancer
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Author : Gordana Kocic
language : en
Publisher: Springer Nature
Release Date :
Prostate Cancer written by Gordana Kocic and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Signaling Pathways In Cancer Pathogenesis And Therapy
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Author : David A. Frank
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-11-12
Signaling Pathways In Cancer Pathogenesis And Therapy written by David A. Frank and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-11-12 with Medical categories.
In recent years, increasing evidence has suggested that abnormal activation of signaling pathways is a critical event in cancer pathogenesis. In particular, activation of these pathways can lead to inappropriate cellular survival, proliferation, pluripotency, invasion, metastasis, and angiogenesis. Thus, understanding the mechanisms by which signaling pathways become subverted in a cancer cell can provide insight into critical events in cancer pathogenesis. Furthermore, as our ability to target specific molecular interactions advances, we now have the ability to design small molecules, protein therapeutics, and other forms of targeted therapies. By focusing on the specific molecular abnormalities in a cancer cell, these agents hold the potential to be much more effective and much less toxic than current cytotoxic therapies.
Development Of New Treatments For Prostate Cancer
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Author :
language : en
Publisher:
Release Date : 2005
Development Of New Treatments For Prostate Cancer written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with categories.
The Dean and Betty Gallo Prostate Cancer Center (GPCC) was established with the goal of eradicating prostate cancer and improving the lives of men at risk for the disease through research, treatment, education and prevention. GPCC was founded in the memory of Dean Gallo, a beloved New Jersey Congressman who died tragically of prostate cancer diagnosed at an advanced stage. GPCC unites a team of outstanding researchers and clinicians who are committed to high-quality basic research, translation of innovative research to the clinic, exceptional patient care, and improving public education and awareness of prostate cancer. GPCC is a center of excellence of The Cancer Institute of New Jersey, which is the only NCI-designated comprehensive cancer center in the state. GPCC efforts are now integrated well as part of our Prostate Program at CINJ, in which Dr. Robert DiPaola and Dr. Cory Abate-Shen are co-leaders. The Prostate Program unites 19 investigators from 10 academic departments who have broad and complementary expertise in prostate cancer research. The overall goal and unifying theme is to elucidate basic mechanisms of prostate growth and oncogenesis, with the ultimate goal of promoting new and effective strategies for the eradication of prostate cancer. Members' wide range of research interests collectively optimize the chances of providing new insights into normal prostate biology and unraveling the molecular pathophysiology of prostate cancer. Cell culture and powerful animal models developed by program members recapitulate the various stages of prostate cancer progression, including prostatic intraepithelial neoplasia, adenocarcinoma, androgen-independence, invasion and metastases. These models promise to further strengthen an already robust program of investigator-initiated therapeutic clinical trials, including studies adopted by national cooperative groups. Efforts to translate laboratory results into clinical studies of early detection and chemoprevention are underway. The specific goals of this program are: (1) To investigate the molecular mechanisms underlying normal prostate growth and differentiation and elucidate the molecular mechanisms underlying prostate oncogenesis. (2) To build on fundamental knowledge to develop effective therapeutic approaches for the treatment of prostate cancer. (3) To improve the control of prostate cancer through early detection, chemoprevention, and outreach and education. This new disease-based program is structured to improve interdisciplinary interactions and translational results. Already, through the dynamic leadership of Drs. Cory Abate-Shen and Robert DiPaola, new investigators were attracted to the field, new collaborations engendered, and numerous investigator-initiated trials implemented. Progress in GPCC and the program overall has been outstanding. The Center has success in uniting investigators with broad and complementary expertise in prostate cancer research. The overall goal and unifying theme is to elucidate basic mechanisms of prostate growth and oncogenesis, with the ultimate goal of promoting new and effective strategies for the eradication of prostate cancer in patients and populations at risk. Members wide range of research interests collectively optimize the chances of providing new insights into normal prostate biology and unraveling the molecular pathophysiology of prostate cancer. Studies in cell culture and powerful animal models developed recapitulate the various stages of prostate cancer progression, including prostatic intraepithelial neoplasia, adenocarcinoma, androgen-independence, invasion and metastases. These models promise to further strengthen an already robust program of investigator-initiated therapeutic clinical trials, including studies adopted by national cooperative groups. Efforts to translate laboratory results into clinical studies of early detection and chemoprevention are underway.
Prostate Cancer
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Author : Jack H. Mydlo
language : en
Publisher: Elsevier
Release Date : 2003-07-11
Prostate Cancer written by Jack H. Mydlo and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-07-11 with Science categories.
An important translational book bridging the gap between science and clinical medicine, Prostate Cancer reviews the biological processes that can be implicated in the disease, reviews current treatments, highlighting the pitfalls where relevant and examines the scientific developments that might result in novel treatments in the future. Key Features * Provides a translational resource for scientists and clinicians working on prostate cancer * Reviews current surgical interventions and highlights their related pitfalls * Presents the latest laparoscopic techniques with figures and illustrations of step-by-step procedures * Offers insight into the potential for novel approaches to treatment in the future * Includes personal perspectives from patients
Ovarian Cancer
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Author : Omer Devaja
language : en
Publisher: BoD – Books on Demand
Release Date : 2018-10-24
Ovarian Cancer written by Omer Devaja and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-24 with Medical categories.
Ovarian cancer management is a rapidly changing field with new treatment agents available as a result of a greater understanding of the pathogenesis of this disease. In addition, both surgical and chemotherapeutic treatment strategies are evolving to maximise response in this disease. This book brings together leading specialists from around the world to discuss and outline a variety of new concepts in ovarian cancer, ranging from molecular biology and genetics through screening to both surgical and chemotherapeutic management.
Pharmacogenomic Insights Into Cancer Prevention
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Author : Sujit Nair
language : en
Publisher: LAP Lambert Academic Publishing
Release Date : 2012
Pharmacogenomic Insights Into Cancer Prevention written by Sujit Nair and has been published by LAP Lambert Academic Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.
Pharmacogenomic profiling of cancer has recently seen much activity with the accessibility of the newest generation of high-throughput platforms & technologies. Myriad mechanistic studies have been devoted to identifying dietary phytochemicals from fruit or vegetables that can help prevent cancer, with evidence suggesting an inverse correlation between intake & risk of certain cancers. To develop a comprehensive understanding of cancer pathogenesis, & potential for chemopreventive intervention with dietary factors, an integrated approach that encompasses both pharmacogenomic & mechanistic aspects is desirable. This work discusses the identification of germane molecular targets by expression profiling using dietary factors, synergistic effects in combinatorial use of dietary factors in colon cancer, regulatory studies in prostate cancer, concerted modulation of key players in inflammation & carcinogenesis, & delineation of prostate cancer biological networks. This will greatly enhance our understanding of the transcriptional circuitry in cancer & important master regulators in the cell that may potentially be exploited for preventive intervention using dietary phytomedicines.
Molecular Biology Of Prostate Cancer
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Author : Manfred Wirth
language : en
Publisher: Walter de Gruyter
Release Date : 2013-05-22
Molecular Biology Of Prostate Cancer written by Manfred Wirth and has been published by Walter de Gruyter this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-22 with Medical categories.