Integrating Emerging Technologies Into Chemical Safety Assessment
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Integrating Emerging Technologies Into Chemical Safety Assessment
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Author : Council of Canadian Academies. Expert Panel on the Integrated Testing of Pesticides
language : en
Publisher:
Release Date : 2012-01
Integrating Emerging Technologies Into Chemical Safety Assessment written by Council of Canadian Academies. Expert Panel on the Integrated Testing of Pesticides and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01 with Pesticides categories.
Integrating Emerging Technologies Into Chemical Safety Assessment
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Author : The Expert Panel on the Integrated Testing of Pesticides
language : en
Publisher: Council of CanadianAcademies
Release Date : 2012
Integrating Emerging Technologies Into Chemical Safety Assessment written by The Expert Panel on the Integrated Testing of Pesticides and has been published by Council of CanadianAcademies this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Technology & Engineering categories.
"In May 2009, the Government of Canada, through the Pest Management Regulatory Agency (PMRA) of Health Canada, asked the Council of Canadian Academies to appoint an expert panel to answer the question, "What is the scientific status of the use of integrated testing strategies in the human and environmental regulatory risk assessment of pesticides?" The charge to the Panel was further specified in a series of sub-questions: [1] What is the state of the science of the tools and data sources associated with integrated testing strategies? [2] What is the current status of the use of integrated testing strategies for the risk assessment of pesticides, pharmaceuticals, industrial chemicals, and other chemical substances by regulatory agencies around the world? [3] Could there be potential impacts on the public's perception and confidence in regulatory risk assessment and risk management decisions for pesticides if integrated testing strategies were implemented?"--P. xiii-xiv.
Applications Of Toxicogenomics In Safety Evaluation And Risk Assessment
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Author : Darrell R. Boverhof
language : en
Publisher: John Wiley & Sons
Release Date : 2011-10-11
Applications Of Toxicogenomics In Safety Evaluation And Risk Assessment written by Darrell R. Boverhof and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-10-11 with Science categories.
This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process – including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm.
Chemical Testing Using New Approach Methodologies Nams
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Author : Amy J. Clippinger
language : en
Publisher: Frontiers Media SA
Release Date : 2022-12-16
Chemical Testing Using New Approach Methodologies Nams written by Amy J. Clippinger and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-16 with Science categories.
The History Of Alternative Test Methods In Toxicology
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Author :
language : en
Publisher: Academic Press
Release Date : 2018-10-20
The History Of Alternative Test Methods In Toxicology written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-20 with Medical categories.
The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement,Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated, miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing, capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialized areas, such as inhalation toxicity studies. The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement, Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now-classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialised areas, such as inhalation toxicity studies.
Validation Of Alternative Methods For Toxicity Testing
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Author : Chantra Eskes
language : en
Publisher: Springer
Release Date : 2016-09-26
Validation Of Alternative Methods For Toxicity Testing written by Chantra Eskes and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-26 with Medical categories.
This book provides information on best practices and new thinking regarding the validation of alternative methods for toxicity testing. It covers the validation of experimental and computational methods and integrated approaches to testing and assessment. Validation strategies are discussed for methods employing the latest technologies such as tissue-on-a-chip systems, stem cells and transcriptomics, and for methods derived from pathway-based concepts in toxicology. Validation of Alternative Methods for Toxicity Testing is divided into two sections, in the first, practical insights are given on the state-of-the-art and on approaches that have resulted in successfully validated and accepted alternative methods. The second section focuses on the evolution of validation principles and practice that are necessary to ensure fit-for-purpose validation that has the greatest impact on international regulatory acceptance of alternative methods. In this context validation needs to keep pace with the considerable scientific advancements being made in toxicology, the availability of sophisticated tools and techniques that can be applied in a variety of ways, and the increasing societal and regulatory demands for better safety assessment. This book will be a useful resource for scientists in the field of toxicology, both from industry and academia, developing new test methods, strategies or techniques, as well as Governmental and regulatory authorities interested in understanding the principles and practicalities of validation of alternative methods for toxicity testing.
Aquatic Ecotoxicology
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Author : Claude Amiard-Triquet
language : en
Publisher: Academic Press
Release Date : 2015-06-11
Aquatic Ecotoxicology written by Claude Amiard-Triquet and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-11 with Science categories.
Aquatic Ecotoxicology: Advancing Tools for Dealing with Emerging Risks presents a thorough look at recent advances in aquatic ecotoxicology and their application in assessing the risk of well-known and emerging environmental contaminants. This essential reference, brought together by leading experts in the field, guides users through existing and novel approaches to environmental risk assessment, then presenting recent advances in the field of ecotoxicology, including omics-based technologies, biomarkers, and reference species. The book then demonstrates how these advances can be used to design and perform assays to discover the toxicological endpoints of emerging risks within the aquatic environment, such as nanomaterials, personal care products, PFOS and chemical mixtures. The text is an invaluable reference for any scientist who studies the effects of contaminants on organisms that live within aquatic environments. Provides the latest perspectives on emerging toxic risks to aquatic environments, such as nanomaterials, pharmaceuticals, chemical mixtures, and perfluorooctane sulfonate (PFOS) Offers practical guidance on recent advances to help in choosing the most appropriate toxicological assay Presents case studies and information on a variety of reference species to help put the ecotoxicological theory into practical risk assess
Guidelines For Integrating Process Safety Management Environment Safety Health And Quality
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Author : CCPS (Center for Chemical Process Safety)
language : en
Publisher: John Wiley & Sons
Release Date : 2010-09-07
Guidelines For Integrating Process Safety Management Environment Safety Health And Quality written by CCPS (Center for Chemical Process Safety) and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-07 with Technology & Engineering categories.
Over the years, companies have developed independent systems for managing process safety, environment, health, safety, and quality. Many aspects of these management systems are similar. Integrating EHS management systems can yield economies and improved system effectiveness. This book explains how integration reduces cost of delivery through a reduction in the number of management program steps and avoidance of redundancy; how it results in more effective programs, since the best practices can be combined into a single process; and how this integration brings a faster, and more cost effective response to new demands.
Toxicogenomics In Predictive Carcinogenicity
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Author : Michael D. Waters
language : en
Publisher: Royal Society of Chemistry
Release Date : 2016
Toxicogenomics In Predictive Carcinogenicity written by Michael D. Waters and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Medical categories.
Describes toxicogenomics methods in predictive carcinogenicity testing and cancer risk assessment. Addresses the use of stem cells and bioinformatics in toxicogenomics. For postgraduates, academics and industrialists.
Guidelines For Integrating Management Systems And Metrics To Improve Process Safety Performance
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Author : CCPS (Center for Chemical Process Safety)
language : en
Publisher: John Wiley & Sons
Release Date : 2016-02-23
Guidelines For Integrating Management Systems And Metrics To Improve Process Safety Performance written by CCPS (Center for Chemical Process Safety) and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-23 with Technology & Engineering categories.
This book combines the synergies between performance improvement systems to help ensure safe and reliable operations, streamline procedures and cross-system auditing, and supporting regulatory and corporate compliance requirements. Many metrics are common to more than one area, such that a well-designed and implemented integrated management system will reduce the load on the Process Safety, SHE, Security and Quality groups, and improve manufacturing efficiency and customer satisfaction. Systems to improve performance include: process safety; traditional safety, health and environment; and, product quality. Chapters include: Integrating Framework; Securing Support & Preparing for Implementation; Establishing Common Risk Management Systems – How to Integrate PSM into Other EH; Testing Implementation Approach; Developing and Agreeing on Metrics; Management Review; Tracking Integration Progress and Measuring Performance; Continuous Improvement; Communication of Results to Different Stakeholders; Case Studies; and Examples for Industry.