Chemical Testing Using New Approach Methodologies Nams
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Chemical Testing Using New Approach Methodologies Nams
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Author : Amy J. Clippinger
language : en
Publisher: Frontiers Media SA
Release Date : 2022-12-16
Chemical Testing Using New Approach Methodologies Nams written by Amy J. Clippinger and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-16 with Science categories.
Nordic Workshop On New Approach Methodologies Nams
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Author : Wojewodzic, Marcin W.
language : en
Publisher: Nordic Council of Ministers
Release Date : 2022-05-20
Nordic Workshop On New Approach Methodologies Nams written by Wojewodzic, Marcin W. and has been published by Nordic Council of Ministers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-20 with Science categories.
Available online: https://pub.norden.org/temanord2022-526/ New Approach Methodologies (NAMs) are an emerging tool in toxicology for performing chemical risk assessment. NAMs reduce animal testing while increasing robustness, throughput and providing a mechanistic understanding of chemical modes-of-actions, in accordance with the Next Generation Risk Assessment principles. The workshop’s objective was to increase risk assessors’ understanding of the data produced by NAMs and their ability to use it for regulatory actions under REACH and CLP. It aimed to highlight the main challenges for NAMs, discuss possible advancements in using NAMs, and increase knowledge and competence within the relevant Nordic authorities. It also served to facilitate discussions about the obstacles to implementing NAMs in regulatory processes, and to identify strategies (including omics approaches) for increasing their use in read-across and grouping processes.
Reducing Animal Use In Carcinogenicity Testing
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Author : Joseph Manuppello
language : en
Publisher: Frontiers Media SA
Release Date : 2024-12-31
Reducing Animal Use In Carcinogenicity Testing written by Joseph Manuppello and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-12-31 with Medical categories.
Carcinogenicity to rats and mice is evaluated for substances to which humans are exposed, including pharmaceuticals, agrochemicals, and industrial chemicals. For pharmaceuticals, recent efforts to reduce animal use in long-term studies include an addendum to the International Council for Harmonisation (ICH) guideline S1B(R1) that prioritizes short-term studies in transgenic mice and recommends assessing the weight of evidence available to first determine whether a long-term study in rats would add value. For other sectors, an expert group of the Organisation for Economic Cooperation and Development (OECD) is developing an Integrated Approach to the Testing and Assessment (IATA) of non-genotoxic carcinogens based on common hallmarks of cancers and on key characteristics of carcinogens. Within current regulations, animal use could be reduced by evaluating toxicokinetics in main study animals with microsampling methods, by including only one negative control group, and by genotyping transgenic mice instead of using positive control groups in each study.
An Introduction To Interdisciplinary Toxicology
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Author : Carey N. Pope
language : en
Publisher: Academic Press
Release Date : 2020-02-18
An Introduction To Interdisciplinary Toxicology written by Carey N. Pope and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-18 with Technology & Engineering categories.
An Introduction to Interdisciplinary Toxicology: From Molecules to Man integrates the various aspects of toxicology, from "simple molecular systems, to complex human communities, with expertise from a spectrum of interacting disciplines. Chapters are written by specialists within a given subject, such as a chemical engineer, nutritional scientist, or a microbiologist, so subjects are clearly explained and discussed within the toxicology context. Many chapters are comparative across species so that students in ecotoxicology learn mammalian toxicology and vice versa. Specific citations, further reading, study questions, and other learning features are also included. The book allows students to concurrently learn concepts in both biomedical and environmental toxicology fields, thus better equipping them for the many career opportunities toxicology provides. This book will also be useful to those wishing to reference how disciplines interact within the broad field of toxicology. - Covers major topics and newer areas in toxicology, including nanotoxicology, Tox21, epigenetic toxicology, and organ-specific toxicity - Includes a variety of perspectives to give a complete understanding of toxicology - Written by specialists within each subject area, e.g., a chemical engineer, to ensure concepts are clearly explained
Law Animals And Toxicity Testing
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Author : Anne M. Wordsworth
language : en
Publisher: Taylor & Francis
Release Date : 2024-09-02
Law Animals And Toxicity Testing written by Anne M. Wordsworth and has been published by Taylor & Francis this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-09-02 with Law categories.
Drawing on our growing knowledge of animal cognition, this book provides a critical analysis of the use of animals in the legal regime and the practice of toxicity testing. Although animal abuse has become a major issue, animal testing remains largely in the shadows, even though it involves substantial cruelty. Toxicity testing, in particular, imposes considerable pain, suffering and ultimately death on those laboratory animals – often mice – chosen to demonstrate the characteristics of chemicals and their commercial potential. This book documents and critically analyzes the animal protection laws of the European Union, the United States and Canada. It not only examines the tests themselves and the suffering they inflict on animals but also exposes the failure of both the testing and the toxicity laws to effectively protect human health and the environment. Finally, the book takes up the potential of alternative non-animal testing methods to replace the current regimen and to reduce current damage to health and the environment. This book will be of interest to scholars and researchers in the fields of animal studies, environmental law and sociolegal studies, as well as activists and others with an interest in ethics and animal rights.
Toxicological Risk Assessment And Multi System Health Impacts From Exposure
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Author : Aristidis M. Tsatsakis
language : en
Publisher: Elsevier
Release Date : 2021-08-01
Toxicological Risk Assessment And Multi System Health Impacts From Exposure written by Aristidis M. Tsatsakis and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-01 with Medical categories.
Toxicological Risk Assessment and Multisystem Health Impacts From Exposure highlights the emerging problems of human and environmental health attributable to cumulative and multiple sources of long-term exposure to environmental toxicants. The book describes the cellular, biological, immunological, endocrinologic, genetic, and epigenetic effects of long-term exposure. It examines how the combined exposure to nanomaterials, metals, pharmaceuticals, multifrequency radiation, dietary mycotoxins, and pesticides accelerates ecotoxicity in humans, animals, plants, and the larger environment. The book goes on to also offer insights into mixture risk assessments, protocols for evaluating the risks, and how this information can serve the regulatory agencies in setting safer exposure limits. The book is a go-to resource for scientists and professionals in the field tackling the current and emerging trends in modern toxicology and risk assessment. - Bridges basic research with clinical, epidemiological, regulatory, and translational research, conveying both an introductory understanding and the latest developments in the field - Evaluates real-life human health risk assessment for long-term exposures to xenobiotic mixtures and the role they play in contributing to chronic disease - Discusses advances in predictive (in silico) toxicology tools and the benefits of using omics technologies in toxicology research
Environmental Pollutant Exposures And Public Health
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Author : R M Harrison
language : en
Publisher: Royal Society of Chemistry
Release Date : 2020-10-27
Environmental Pollutant Exposures And Public Health written by R M Harrison and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-27 with Medical categories.
Both genes and environment have profound effects upon our health. While some environmental factors such as polluted air are high in the public consciousness, there are many other pathways for people’s exposure to toxic chemicals, such as through food, water and contaminated land. It is not only chemicals that can affect health; environmental radioactivity, pathogenic organisms and our changing climate also have implications for public health, and all contribute to the global burden of disease, leading to both disability and deaths of millions of people annually across the world. An understanding of the pathways of environmental exposure, and its effects upon health is key to developing regulations and behaviours that reduce or prevent exposure, and the consequent impacts upon health. Covering topics from dietary exposure to chemicals through to the health effects of climate change, this book brings together contributors from around the world to highlight the latest science on the impacts of environmental pollutant exposure upon public health.
A Research Agenda For Water Law
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Author : Vanessa Casado Pérez
language : en
Publisher: Edward Elgar Publishing
Release Date : 2023-08-14
A Research Agenda For Water Law written by Vanessa Casado Pérez and has been published by Edward Elgar Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-08-14 with Law categories.
This timely Research Agenda provides imaginative solutions to existing and emerging challenges for the study, application, and development of water law. It argues for a dynamic approach to water law, anticipating how water and its relationship to humanity will shift due to climate change, modern societal norms and values, and technological innovation.
Elgar Concise Encyclopedia Of Animal Law
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Author : Joan E. Schaffner
language : en
Publisher: Edward Elgar Publishing
Release Date : 2025-07-15
Elgar Concise Encyclopedia Of Animal Law written by Joan E. Schaffner and has been published by Edward Elgar Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-07-15 with Law categories.
With contributions from over 135 international experts, this Encyclopedia provides an expansive overview of the emerging field of animal law. Focusing on the legal regulation of human interactions with non-human animals, the volume serves as an insightful guide to how the law can promote the wellbeing of animals as well as the environment.
Alternative Methods In Neurotoxicology
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Author :
language : en
Publisher: Elsevier
Release Date : 2023-06-08
Alternative Methods In Neurotoxicology written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-08 with Science categories.
Alternative Methods in Neurotoxicology, Volume Nine, the latest release in this series, provides an overview of important in vitro and non-vertebrate animal models available to study the neurotoxicity of a range of toxicants of occupational and environmental relevance. Chapters in this new release include Evaluation of mitochondrial function in neurotoxicology using alternative models, Planarians as a model to study neurotoxic agents, Role of Drosophila melanogaster in neurotoxicology studies: Responses to different harmful substances, Neurotoxicology of metals and metallic nanoparticles in Caenorhabditis elegans, Neurotoxicology of environmental toxicants using Caenorhabditis elegans as a model, Nauphoeta cinerea as an emerging model in neurotoxicology, and more. Other chapters cover Human Neural Stem Cells in Developmental Neurotoxicology: Current Scenario and Future Prospects, Use of Drosophila melanogaster for advances in developmental neurotoxicology studies, 3D neurospheres and neurotoxicity of organophosphorus and TCE, Genetic factors in methylmercury-induced neurotoxicity: what we have learned from Caenorhabditis elegans models, and more. - Give an up-to-date about the utilization of popular invertebrates (Drosophila melanogaster and Caenorhabditis elegans) in neurotoxicology - Brings concise information on emerging invertebrate models in neurotoxicology (from basic to environmental approaches) - Presents updates on the in vitro exploitation of human stem cell in developmental neurotoxicology