Interactions Between Proteins Involved In Mammalian Endocytic And Secretory Pathways
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Interactions Between Proteins Involved In Mammalian Endocytic And Secretory Pathways
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Author :
language : en
Publisher:
Release Date : 2004
Interactions Between Proteins Involved In Mammalian Endocytic And Secretory Pathways written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.
Membrane Trafficking And Endocytosis In Neurons
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Author : Ayesha Murshid
language : en
Publisher:
Release Date : 2008
Membrane Trafficking And Endocytosis In Neurons written by Ayesha Murshid and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.
"In mammalian cells, two main membrane trafficking pathways, the secretory and endocytic pathways are important for many biological functions. Secretory proteins are synthesized on ribosomes inside the cells, translocated into the ER for proper folding, later mature in the Golgi and continue their journey to the plasma membrane. Endocytosis is defined as a process of vesicle formation from the plasma membrane, where external solutes like nutrients, growth factors and transmembrane proteins are internalized by the cell to endosomal compartments. Internalized protein can either be degraded in lysosomes or recycled back to the plasma membrane. Clathrin mediated endocytosis (CME) is one of the most commonly used endocytic mechanisms in mammalian cells and its mechanism has been intensively studied over the years. Clathrin with the help of other adaptor/accessory proteins are able to form vesicles in the plasma membrane which are removed from the membrane by dynamin. There are many other kinds of internalization pathways which include phagocytosis, macropinocytosis, caveolae-dependent endocytosis, and caveolae and clathrin-independent endocytosis. In the first part of the thesis, we characterized a newly identified WVQF motif containing, AP2-binding protein, NECAP1 in neurons. We found that NECAP1 plays a vital role in the CME of transferrin and synaptotagmin in neuronal cells. In the second part, we studied endocytosis of nerve growth factor (NGF) receptor (TrkA) in PC 12 cells. At a low dose (1 ng/ml) of NGF, we found that CME of TrkA is AP2- and NECAP1-independent in PC12 cells and that beta arrestin 1 can act as an alternate adaptor for its internalization. At higher extracellular concentration of NGF, uptake is clathrin- and dynamin- and beta-arrestin 1-independent, but requires actin, Cdc42 and sphingolipids, suggesting a different pathway. Our results show that large extracellular concentrations of NGF lead to strong signals of finite duration which is later terminated by degradation of NGF or NGF-TrkA whereas low concentrations of NGF leads to long lived signals. In the third chapter, we characterized newly identified Rabs, mainly Rab18 and Rab43. We found that Rab18 is involved in COPI independent trafficking of cargo beta-1,4-galactosyltransferase (Galtase)-YFP suggesting its role in retrograde trafficking from Golgi to ER, whereas Rab43 has a regulatory role in the interaction between microtubule and pre-Golgi intermediates possibly via interaction with motor proteins. Taken together, the data in this thesis contribute to our understanding of the endocytic and secretory pathways of mammalian cells."--
Molecular Biology Of The Cell
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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002
Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.
Trafficking Inside Cells
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Author : Nava Segev
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-05-30
Trafficking Inside Cells written by Nava Segev and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-05-30 with Science categories.
This book covers the past, present and future of the intra-cellular trafficking field, which has made a quantum leap in the last few decades. It details how the field has developed and evolved as well as examines future directions.
Cellular Migration And Formation Of Neuronal Connections
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Author :
language : en
Publisher: Academic Press
Release Date : 2013-05-06
Cellular Migration And Formation Of Neuronal Connections written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-06 with Science categories.
The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 2 offers 56 high level articles devoted mainly to Formation of Axons and Dendrites, Migration, Synaptogenesis, Developmental Sequences in the Maturation of Intrinsic and Synapse Driven Patterns. Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop Features leading experts in various subfields as Section Editors and article Authors All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship Volume 2 sections include coverage of mechanisms which regulate: the formation of axons and dendrites, cell migration, synapse formation and maintenance during development, and neural activity, from cell-intrinsic maturation to early correlated patterns of activity
The Golgi Apparatus
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Author : Alexander A. Mironov
language : ar
Publisher: Springer Science & Business Media
Release Date : 2009-03-04
The Golgi Apparatus written by Alexander A. Mironov and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-03-04 with Science categories.
This book summarizes all new data obtained after development of methods of Golgi complex sub fractionation, molecular biology and microscopy. It collects the full range of expertise, different points of view and different approaches. The book is devoted to molecular modes of the function of the Golgi apparatus as a whole, taking into account all experimental data. The book aims to make the functional organization of the Golgi apparatus more understandable.
Exocytosis And Endocytosis
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Author : Andrei I. Ivanov
language : en
Publisher: Springer Science & Business Media
Release Date : 2008
Exocytosis And Endocytosis written by Andrei I. Ivanov and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Medical categories.
In this book, skilled experts provide the most up-to-date, step-by-step laboratory protocols for examining molecular machinery and biological functions of exocytosis and endocytosis in vitro and in vivo. The book is insightful to both newcomers and seasoned professionals. It offers a unique and highly practical guide to versatile laboratory tools developed to study various aspects of intracellular vesicle trafficking in simple model systems and living organisms.
Protein Kinase D Downstream Effectors
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Author : An Rykx
language : en
Publisher:
Release Date : 2007-05
Protein Kinase D Downstream Effectors written by An Rykx and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-05 with categories.
The Golgi Apparatus
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Author : Eric G. Berger
language : en
Publisher: Springer Science & Business Media
Release Date : 1997
The Golgi Apparatus written by Eric G. Berger and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Golgi apparatus categories.
In 1898 Camillo Golgi reported his newly observed intracellular structure, the apparato reticolare interno, now universally known as the Golgi Apparatus. The method he used was an ingenious histological technique (La reazione nera) which brought him fame for the discovery of neuronal networks and culminated in the award of the Nobel Prize for Physiology and Medicine in 1906. This technique, however, was not easily reproducible and led to a long-lasting controversy about the reality of the Golgi apparatus. Its identification as a ubiquitous organelle by electron microscopy turned out to be the breakthrough and incited an enormous wave of interest in this organelle at the end of the sixties. In recent years immunochemical techniques and molecular cloning approaches opened up new avenues and led to an ongoing resurgence of interest. The role of the Golgi apparatus in modifying, broadening and refining the structural information conferred by transcription/translation is now generally accepted but still incompletely understood. During the coming years, this topic certainly will remain center stage in the field of cell biology. The centennial of the discovery of this fascinating organelle prompted us to edit a new comprehensive book on the Golgi apparatus whose complexity necessitated the contributions of leading specialists in this field. This book is aimed at a broad readership of glycobiologists as well as cell and molecular biologists and may also be interesting for advanced students of biology and life sciences.
Molecular Regulation Of Endocytosis
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Author : Brian Ceresa
language : en
Publisher: BoD – Books on Demand
Release Date : 2012-07-06
Molecular Regulation Of Endocytosis written by Brian Ceresa and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-06 with Science categories.
Molecular Regulation of Endocytosis is a compilation of scientific "short stories" about the entry of external substances into cells. As one can see from the chapters, endocytosis regulates diverse processes such as homeostasis of the cell, signal transduction, entry of pathogens and viruses. In addition to the experimental techniques embedded in each chapter, entire chapters are dedicated to experimental approaches that will be useful to all scientists and their model systems. For those more clinically oriented, the final chapters look to the future and ways of utilizing endocytic pathways for therapeutic purposes.