Intermediate Filament Mechanics Across Scales From Single Filaments To Single Interactions And Networks In Cells

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Intermediate Filament Mechanics Across Scales From Single Filaments To Single Interactions And Networks In Cells

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Author : Anna Veronika Schepers
language : en
Publisher: Universitätsverlag Göttingen
Release Date : 2022

Intermediate Filament Mechanics Across Scales From Single Filaments To Single Interactions And Networks In Cells written by Anna Veronika Schepers and has been published by Universitätsverlag Göttingen this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with categories.

The mechanical properties of cells are largely determined by the cytoskeleton. The cytoskeleton is an intricate and complex structure formed by protein filaments, motor proteins, and crosslinkers. The three main types of protein filaments are microtubules, actin filaments, and intermediate filaments ( IFs ). Whereas the proteins that form microtubules and actin filaments are exceptionally conserved throughout cell types and organisms, the family of IFs is diverse. For example, the IF protein vimentin is expressed in relatively motile fibroblasts, and keratin IFs are found in epithelial cells. This variety of IF proteins might therefore be linked to the various mechanical properties of different cell types. In the scope of this thesis, I combine studies of IF mechanics on different time scales and in systems of increasing complexity, from single filaments to networks in cells. This multiscale approach allows for the simplification necessary to interpret observations while adding increasing physiological context in subsequent experiments. We especially focus on the tunability of the IF mechanics by environmental cues in these increasingly complex systems. In a series of experiments, including single filament elongation studies, single filament stretching measurements with optical tweezers, filament-filament interaction measurements with four optical tweezers, microrheology, and isotropic cell stretching, we characterize how electrostatic (pH and ion concentration) and hydrophobic interactions (detergent) provide various mechanisms by which the mechanics of the IF cytoskeleton can be tuned. These studies reveal how small changes, such as charge shifts, influence IF mechanics on multiple scales. In combination with simulations, we determine the mechanisms by which charge shifts alter single vimentin filament mechanics and we extract energy landscapes for interactions between single filaments. Such insights will provide a deeper understanding of the mechanisms by which cells can maintain their integrity and adapt to the mechanical requirements set by their environment.

Intermediate Filament Mechanics Across Scales

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Author : Anna Veronika Schepers
language : en
Publisher:
Release Date : 2022

Intermediate Filament Mechanics Across Scales written by Anna Veronika Schepers and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with categories.

The mechanical properties of cells are largely determined by the cytoskeleton. The cytoskeleton is an intricate and complex structure formed by protein filaments, motor proteins, and crosslinkers. The three main types of protein filaments are microtubules, actin filaments, and intermediate filaments (IFs). Whereas the proteins that form microtubules and actin filaments are exceptionally conserved throughout cell types and organisms, the family of IFs is diverse. For example, the IF protein vimentin is expressed in relatively motile fibroblasts, and keratin IFs are found in epithelial cells....

Viscoelasticity From Individual Cell Behavior To Collective Tissue Remodeling

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Author : Ivana Dusan Pajic-Lijakovic
language : en
Publisher: Frontiers Media SA
Release Date : 2021-11-25

Viscoelasticity From Individual Cell Behavior To Collective Tissue Remodeling written by Ivana Dusan Pajic-Lijakovic and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-25 with Science categories.

Intermediate Filaments Structure Function And Clinical Significance

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Author : Yaming Jiu
language : en
Publisher: Frontiers Media SA
Release Date : 2023-01-02

Intermediate Filaments Structure Function And Clinical Significance written by Yaming Jiu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-02 with Science categories.

Molecular Biology Of The Cell

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Author :
language : en
Publisher:
Release Date : 2004

Molecular Biology Of The Cell written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Cells categories.

Advances In Cell Mechanics

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Author : Shaofan Li
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-11-17

Advances In Cell Mechanics written by Shaofan Li and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-11-17 with Technology & Engineering categories.

"Advances in Cell Mechanics" presents the latest developments in cell mechanics and biophysics, mainly focusing on interdisciplinary research in cell biology and the biophysics of cells. Moreover, a unique feature of the book is its emphasis on the molecular and complex continuum modeling and simulations of the cells. It may be the first work that brings rigorous and quantitative scientific analysis and state-of-the-art simulation technology into cell biology research. The book is intended for researchers and graduate students working in the fields of molecular cell biology, bio-engineering and bio-mechanics, soft matter physics, computational mechanics, bio-chemistry and bio-medicine. All contributors are leading scholars in their respective fields. Dr. Shaofan Li is a professor and an expert for computational mechanics at the University of California-Berkeley, USA; Dr. Bohua Sun is a professor at Cape Peninsula University of Technology, South Africa.

Mechanobiology Of Cell Cell And Cell Matrix Interactions

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Author : A. Wagoner Johnson
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-02-21

Mechanobiology Of Cell Cell And Cell Matrix Interactions written by A. Wagoner Johnson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-02-21 with Technology & Engineering categories.

Mechanobiology of Cell-Matrix Interactions focuses on characterization and modeling of interactions between cells and their local extracellular environment, exploring how these interactions may mediate cell behavior. Studies of cell-matrix interactions rely on integrating engineering, (molecular and cellular) biology, and imaging disciplines. Recent advances in the field have begun to unravel our understanding of how cells gather information from their surrounding environment, and how they interrogate such information during the cell fate decision making process. Topics include adhesive and integrin-ligand interactions; extracellular influences on cell biology and behavior; cooperative mechanisms of cell-cell and cell-matrix interactions; the mechanobiology of pathological processes; (multi-scale) modeling approaches to describe the complexity or cell-matrix interactions; and quantitative methods required for such experimental and modeling studies.

Cytokeratins

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Author : Gerhard Hamilton
language : en
Publisher: BoD – Books on Demand
Release Date : 2012-02-29

Cytokeratins written by Gerhard Hamilton and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-29 with Medical categories.

The first chapters of the volume "Cytokeratins - Tools in Oncology" discuss multiple functions of cytokeratins in organization of the intermediary filaments in normal intestine and liver as well as microfold L cells and the usability of cytokeratins 7, 8 and 20 in tumor diagnosis in detail. Epithelial to mesenchymal transition as a mechanism important in pathogenesis is touched in another chapter, followed by several articles dealing with the role of cytokeratins for detection of disseminated tumor cells and as response markers during chemotherapy. This book is therefore destined to all cancer researchers and therapists who want to understand the diagnostic application of cytokeratins in histology and, especially, the use of anti-cytokeratin antibodies to identify viable residual tumor cells accounting for a higher risk of tumor recurrence or cancer cells responding to chemotherapy, respectively.

Intermediate Filament Proteins

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Author :
language : en
Publisher: Academic Press
Release Date : 2016-01-19

Intermediate Filament Proteins written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-19 with Science categories.

Intermediate Filament Proteins, the latest volume in the Methods in Enzymology series covers all the intermediate filaments in vertebrates and invertebrates, providing a unique understanding of the multiple different tissue-specific intermediate filaments. This volume also covers the latest methods that are currently being used to study intermediate filament protein function and dynamics. It will be an important companion for any experimentalist interesting in studying this protein family in their cell or organism model system.

Cell Mechanics

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Author : Arnaud Chauviere
language : en
Publisher: CRC Press
Release Date : 2010-01-27

Cell Mechanics written by Arnaud Chauviere and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-01-27 with Mathematics categories.

Ubiquitous and fundamental in cell mechanics, multiscale problems can arise in the growth of tumors, embryogenesis, tissue engineering, and more. Cell Mechanics: From Single Scale-Based Models to Multiscale Modeling brings together new insight and research on mechanical, mathematical, physical, and biological approaches for simulating the behavior