Interplay Of Connexins And Pannexins In Tissue Function And Disease

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Interplay Of Connexins And Pannexins In Tissue Function And Disease

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Author : Brenda R. Kwak
language : en
Publisher: MDPI
Release Date : 2018-11-30

Interplay Of Connexins And Pannexins In Tissue Function And Disease written by Brenda R. Kwak and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-30 with Science categories.

This book is a printed edition of the Special Issue "Interplay of Connexins and Pannexins in Tissue Function and Disease" that was published in IJMS

Interplay Of Connexins And Pannexins In Tissue Function And Disease

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Author : Patricia Martin
language : en
Publisher:
Release Date : 2018

Interplay Of Connexins And Pannexins In Tissue Function And Disease written by Patricia Martin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.

This Special Issue is related to the 18th biannual International Gap Junction Conference (IGJC2017), which has been held at the Crowne Plaza Hotel, Glasgow and hosted by Glasgow Caledonian University, 29 July-3 August, 2017. This Special Issue, entitled "Interplay of Connexins and Pannexins in Tissue Function and Disease", focuses on six key state-of-the-art reviews, written by leads in the field on cutting edge topics and the latest developments in clinical trials in diverse organ systems. A further 14 original articles contributed by delegates attending the meeting are also included and celebrate 50 years of Gap Junction Research. Topics: Connexins and Pannexins: Trafficking, Assembly, Gating, and Protein-Protein Interactions Roles in the Cardiovascular System Roles in Tumorigenesis Roles in Epithelial Tissue and Wound Healing Connexin Therapy Translated to Clinic.

Gap Junctions Hemichannels And Pannexons New Implications In Neuroplasticity And Neuroinflammation

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Author : Juan Andrés Orellana
language : en
Publisher: Frontiers Media SA
Release Date : 2022-02-01

Gap Junctions Hemichannels And Pannexons New Implications In Neuroplasticity And Neuroinflammation written by Juan Andrés Orellana and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-01 with Science categories.

Biology And Regulation Of Blood Tissue Barriers

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Author : C. Yan Cheng
language : en
Publisher: Springer Science & Business Media
Release Date : 2014-01-25

Biology And Regulation Of Blood Tissue Barriers written by C. Yan Cheng and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-25 with Medical categories.

This book was written by many outstanding investigators who have spent decades to study different aspects of blood‐tissue barrier function. They have summarized some of the latest and fascinating development in their fields of research including the blood‐brain barrier, the blood‐retinal barrier, the gut barrier, the blood‐biliary barrier, the blood‐follicle barrier, the blood‐epididymis barrier, the blood‐testis barrier, the tight junction barrier in general as well as barriers in the female reproductive tract. Included are also chapters that focus on topics that are physiologically applicable to all blood‐tissue barriers. Many of these chapters also include information on specific human diseases, such as pathological changes of the gut barrier that cause bowel disorders resulting from inflammation of the epithelial lining in the intestine, and infertility in men as a result of disruption of the blood‐epididymal and/or blood‐testis barriers; and on new therapeutic approaches (e.g., drug delivery across the blood‐brain and the blood‐retinal barriers).

Zipes And Jalife S Cardiac Electrophysiology From Cell To Bedside E Book

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Author : Jose Jalife
language : en
Publisher: Elsevier Health Sciences
Release Date : 2021-12-16

Zipes And Jalife S Cardiac Electrophysiology From Cell To Bedside E Book written by Jose Jalife and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-16 with Medical categories.

Fully updated from cover to cover, Zipes and Jalife's Cardiac Electrophysiology: From Cell to Bedside, 8th Edition, provides the comprehensive, multidisciplinary coverage you need—from new knowledge in basic science to the latest clinical advances in the field. Drs. José Jalife and William Gregory Stevenson lead a team of global experts who provide cutting-edge content and step-by-step instructions for all aspects of cardiac electrophysiology. - Packs each chapter with the latest information necessary for optimal basic research as well as patient care. - Covers new technologies such as CRISPR, protein research, improved cardiac imaging, optical mapping, and wearable devices. - Contains significant updates in the areas of molecular biology and genetics, iPSCs (induced pluripotent stem cells), embryonic stem cells, precision medicine, antiarrhythmic drug therapy, cardiac mapping with advanced techniques, and ablation technologies including stereotactic radioablation. - Includes 47 new chapters covering both basic science and clinical topics. - Discusses extensive recent progress in the understanding, diagnosis, and management of arrhythmias, including new clinical insights on atrial fibrillation and stroke prevention, new advances in the understanding of ventricular arrythmias in genetic disease, and advances in implantable devises and infection management. - Features 1,600 high-quality photographs, anatomic and radiographic images, electrocardiograms, tables, algorithms, and more., with additional figures, tables, and videos online. - Recipient of a 2018 Highly Commended award from the British Medical Association. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Single Membrane Channels Formed By Connexins Or Pannexins Focus On The Nervous System

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Author : Juan Andrés Orellana
language : en
Publisher: Frontiers Media SA
Release Date : 2016-09-26

Single Membrane Channels Formed By Connexins Or Pannexins Focus On The Nervous System written by Juan Andrés Orellana and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-26 with Neurosciences. Biological psychiatry. Neuropsychiatry categories.

Given that the extremely elaborated and dynamic functions performed by the nervous system require the close synchronization of brain cells, complex organisms have developed different mechanisms of intercellular communication. At this regard, paracrine signaling between neighboring cells is currently recognized as one of the most widely distributed mechanisms of synchronization in the brain parenchyma. In mammals, paracrine signaling is in part mediated by single membrane channels formed by connexins (connexons/hemichannels) or pannexins (pannexons), which are two different membrane protein families composed of about 20 and 3 members, respectively. Single membrane channels formed by these proteins serve as aqueous pores permeable to ions and small molecules, allowing the diffusional exchange between the intra- and extracellular milieu. Thus, connexin hemichannels and pannexons permit the release of significant quantities of autocrine/paracrine signaling molecules (e.g., ATP, glutamate, NAD+, adenosine and PGE2) into the extracellular milieu, as well as the uptake of small molecules. An increasing body of evidence has revealed that connexin hemichannels and pannexons play a crucial role in a plethora of brain processes including blood flow regulation, Ca2+ wave propagation, memory consolidation, glucose sensing and cell migration and adhesion. Considering the multiple cell signaling functions of these channels, their dysregulation is proposed not only as potential pathological biomarker, but it has been implicated in the pathogenesis and progression of diverse brain diseases (e.g., meningitis, Alzheimer’s disease and stroke). The aim of this Research Topic is to gather a collection of original research articles, method, protocols, short communications, opinions, perspectives, as well as review articles, providing the latest progress and insights in the field of connexin hemichannels and pannexons in the nervous system. Within this volume we plan to cover from basic research including channel structure, regulation, pharmacology and trafficking; to different biological functions in the physiology (behavior, plasticity, neurogenesis, blood flow control, neuron-glia crosstalk, cell migration and differentiation) as well as in the pathophysiology (neuroinflammation, mutation-related diseases, glial dysfunction and neurodegeneration) of the nervous system. We hope that this collection of articles will serve to understand how the signaling of connexin hemichannels and pannexons influences both normal and pathological brain function.

Lung Epithelial Biology In The Pathogenesis Of Pulmonary Disease

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Author : Venkataramana K Sidhaye
language : en
Publisher: Academic Press
Release Date : 2017-03-09

Lung Epithelial Biology In The Pathogenesis Of Pulmonary Disease written by Venkataramana K Sidhaye and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-09 with Medical categories.

Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease provides a one-stop resource capturing developments in lung epithelial biology related to basic physiology, pathophysiology, and links to human disease. The book provides access to knowledge of molecular and cellular aspects of lung homeostasis and repair, including the molecular basis of lung epithelial intercellular communication and lung epithelial channels and transporters. Also included is coverage of lung epithelial biology as it relates to fluid balance, basic ion/fluid molecular processes, and human disease. Useful to physician and clinical scientists, the contents of this book compile the important and most current findings about the role of epithelial cells in lung disease. Medical and graduate students, postdoctoral and clinical fellows, as well as clinicians interested in the mechanistic basis for lung disease will benefit from the books examination of principles of lung epithelium functions in physiological condition. - Provides a single source of information on lung epithelial junctions and transporters - Discusses of the role of the epithelium in lung homeostasis and disease - Includes capsule summaries of main conclusions as well as highlights of future directions in the field - Covers the mechanistic basis for lung disease for a range of audiences

P2x7 As Common Therapeutic Target In Brain Diseases

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Author : Tobias Engel
language : en
Publisher: Frontiers Media SA
Release Date : 2021-06-29

P2x7 As Common Therapeutic Target In Brain Diseases written by Tobias Engel and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-29 with Science categories.

Physiology Of Myelin Forming Cells From Myelination To Neural Modulators

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Author : Mauricio Antonio Retamal
language : en
Publisher: Frontiers Media SA
Release Date : 2020-01-16

Physiology Of Myelin Forming Cells From Myelination To Neural Modulators written by Mauricio Antonio Retamal and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-16 with categories.

Principles Of Bone Biology

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Author : John P. Bilezikian
language : en
Publisher: Academic Press
Release Date : 2019-08-22

Principles Of Bone Biology written by John P. Bilezikian and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-22 with Science categories.

Preface from the first edition (1996): "The world of modern science is undergoing a number of spectacular events that are redefining our understanding of ourselves. As with any revolution, we should take stock of where we have been, where we are, and where we are going. Our special world of bone biology is participating in and taking advantage of the larger global revolution in modern science... we assembled experts from all over the world and asked them to focus on the current state of knowledge and the prospects for new knowledge in their area of expertise. To this end, Principles of Bone Biology was conceived." - John P. Bilezikian, Lawrence G. Raisz, Gideon A. Rodan Praise for the previous edition: "Students, teachers, and practitioners will benefit from reading it, and investigators will use it as a reference work; it will certainly be consulted frequently." --The New England Journal of Medicine For over two decades, "Big Gray" has been the go-to repository of knowledge in the disciplines related to bone and mineral metabolism. The fourth edition is a must-have for students new to the field; young investigators at the graduate or postgraduate level beginning their research careers; established scientists who need to keep up with the changing nature of the field, looking to enrich their own research programs, or who are changing their career direction; clinicians who want ready access to up-to-date relevant basic science. This new edition builds on the successful formula from previous editions, taking the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics. Principles of Bone Biology, Fourth Edition provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. Bone research continues to generate enormous attention, due to the broad public health implications of osteoporosis and related bone disorders. This classic, fully updated, two volume reference is designed for anyone involved in the study of bone biology. - Provides a "one-stop" shopping paradise. Anything you want to find about bone biology is here and written by the world's experts - THE essential resource for anyone involved in the study of the skeleton and metabolic bone diseases - Covers everything from the basic scientific concepts to the underlying principles of therapeutics and management - Allows readers to easily search and locate information quickly in the online format - Volumes include: Basic Principles; Molecular Mechanisms of Metabolic Bone Disease; Pharmacological Mechanisms of Therapeutics; Methods in Bone Research