Intracellular Signal Transduction The Jak Stat Pathway
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Intracellular Signal Transduction The Jak Stat Pathway
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Author : Andrew F. Wilks
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Intracellular Signal Transduction The Jak Stat Pathway written by Andrew F. Wilks and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.
This book is the first one written about the JAK/STAT pathway. The JAK (Janus Kinase) Protein tyrosine kinases are novel phosphotransferases absolutely required for cellular signalling downstream of non-catalytic cytokine receptors (amongst others). These molecules are components in pathways utilising the STAT (Signal Transducers and Activators of Transcription) transcription factors. The basic components of the JAK/STAT pathway are covered in detail, and the centre piece of the book is a guided tour of the pathway itself. An interesting addition to the book is the chapter on the use of Drosophila melanogaster as a genetic system to probe the pathway at the whole organism level. The book is targeted to researchers who have an interest in intracellular signalling.
Intracellular Signal Transduction
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Author : Hiroyoshi Hidaka
language : en
Publisher:
Release Date : 1996-01-01
Intracellular Signal Transduction written by Hiroyoshi Hidaka and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-01-01 with Cellular signal transduction categories.
Signal transduction is one of the most rapidly expanding fields in biomedical research. Written by renowned experts, Intracellular Signal Transduction provides up-to-date reviews on the role of protein phosphorylation cascades, and the structure, regulation, and function of protein kinases and phosphatases. This volume was compiled in honor of Dr. Edwin Krebs' pioneering work in the field of signal transduction which earned him a Nobel Prize. It provides information in a variety of areas relating to the biochemistry, cell biology, and pharmacology of the signal transduction process in eukaryotic cells. Key Features * Contains current reviews in signal transduction processes in eukaryotic cells * Presents the structure and function of protein kinases and phosphatases * Highlights MAP kinase cascades, tyrosine phophatases, pharmacology of protein kinases, and cyclic nucleotide phosphodiesterases
Jak Stat Signaling In Diseases
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Author : Ritobrata Goswami
language : en
Publisher: CRC Press
Release Date : 2020-02-28
Jak Stat Signaling In Diseases written by Ritobrata Goswami and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-28 with Medical categories.
JAK-STAT pathway is one of the few signal transduction pathways that transduce signals involved in multiple homeostatic biological processes including cell differentiation and proliferation, cell death, hematopoiesis and immune responses. JAK-STAT is an elegant pathway that is relatively simple and evolutionary conserved as gene expression is regulated by external parameters. Activated by growth factors or cytokines, this signal transduction cascade regulates the transcription of genes at the nucleus. Mutations and polymorphisms in JAK-STAT pathway are associated with inflammatory diseases and cancers that could impede regular homeostasis. Features: Details activation and microRNA-mediated regulation of JAK-STAT pathway Provides exclusive information about the association of the pathway in various diseases including allergic inflammation, neuro-inflammatory disorder, atopic dermatitis hematopoietic malignancies, cardiovascular disorder, renal disorder, immunodeficiency, liver fibrosis, diabetes and obesity that affect individuals across the globe Clinical relevance of the signaling cascade has been discussed in context of novel class of therapeutics that targets this pathway. An overview of JAK-STAT signaling pathway and the structure-function relationship of different domains of the cascade are discussed. This book provides detailed information on various diseases that are associated with JAK-STAT pathway. It will act as a very good reference book for basic science researchers, academicians, industry professionals involved in translational research leading to product development. This book will excite future professionals towards better understanding of the regulation of this pathway, its association with other signaling cascades to design novel therapeutics.
Signal Transducers And Activators Of Transcription Stats
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Author : P. Sehgal
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Signal Transducers And Activators Of Transcription Stats written by P. Sehgal and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.
The only fully comprehensive reference for STAT proteins and their biology, this book describes the current state of ongoing research in this broad area, and looks toward the future to try to predict the discoveries that lie ahead.
Jak Stat Pathway In Disease
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Author : Jr., Richard H. Bell
language : en
Publisher: CRC Press
Release Date : 2009-06-11
Jak Stat Pathway In Disease written by Jr., Richard H. Bell and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-06-11 with Medical categories.
This book reviews current understanding of the biological roles of the signal transducer and activator of transcription (STAT) proteins and their dysregulation in diseases. STAT proteins were named after their role as signal transducers and activators of transcription. STAT proteins are highly conserved among species, thus reflecting the importance
Signal Transduction
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Author : Bastien D. Gomperts
language : en
Publisher: Gulf Professional Publishing
Release Date : 2003-10-15
Signal Transduction written by Bastien D. Gomperts and has been published by Gulf Professional Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-10-15 with Medical categories.
Signal Transduction is a text reference on cellular signalling processes. Starting with the basics, it explains how cells respond to external cues (hormones, cytokines, neurotransmitters, adhesion molecules, extracellular matrix etc), and shows how these inputs are integrated and co-ordinated. The first half of the book provides the conceptual framework, explaining the formation and action of second messengers, particularly cyclic nucleotides and calcium, and the mediation of signal pathways by GTP-binding proteins. The remaining chapters deal with the formation of complex signalling cascades employed by cytokines and adhesion molecules, starting at the membrane and ending in the nucleus, there to regulate gene transcription. In this context, growth is an important potential outcome and this has relevance to the cellular transformations that underlie cancer. The book ends with a description at the molecular level of how signalling proteins interact with their environment and with each other through their structural domains. Each main topic is introduced with a historical essay, detailing the sources, key observations and experiments that set the scene for recent and current work.
Extracellular And Intracellular Signaling
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Author : James D. Adams
language : en
Publisher: Royal Society of Chemistry
Release Date : 2011
Extracellular And Intracellular Signaling written by James D. Adams and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Medical categories.
Intracellular cell signaling is a well understood process. However, extracellular signals such as hormones, adipokines, cytokines and neurotransmitters are just as important but have been largely ignored in other works. Aimed at medical professionals and pharmaceutical specialists, this book integrates extracellular and intracellular signalling processes and offers a fresh perspective on new drug targets.
Signal Transduction And Human Disease
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Author : Toren Finkel
language : en
Publisher: John Wiley & Sons
Release Date : 2003-07-18
Signal Transduction And Human Disease written by Toren Finkel and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-07-18 with Science categories.
This book uniquely relates the broad impact of signal transduction research on the understanding and treatment of human disease. There have been significant advances in the area of signaling in disease processes, yet no resource presently connects these advances with understanding of disease processes and applications for novel therapeutics. Given the emphasis on translational research and biological relevance in biotechnology, and, conversely, the importance of molecular approaches for clinical research, it is evident that a single resource bridging signaling research and human disease will be invaluable.
International Textbook Of Diabetes Mellitus
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Author : R. A. DeFronzo
language : en
Publisher: John Wiley & Sons
Release Date : 2015-03-11
International Textbook Of Diabetes Mellitus written by R. A. DeFronzo and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-11 with Medical categories.
The International Textbook of Diabetes Mellitus has been a successful, well-respected medical textbook for almost 20 years, over 3 editions. Encyclopaedic and international in scope, the textbook covers all aspects of diabetes ensuring a truly multidisciplinary and global approach. Sections covered include epidemiology, diagnosis, pathogenesis, management and complications of diabetes and public health issues worldwide. It incorporates a vast amount of new data regarding the scientific understanding and clinical management of this disease, with each new edition always reflecting the substantial advances in the field. Whereas other diabetes textbooks are primarily clinical with less focus on the basic science behind diabetes, ITDM's primary philosophy has always been to comprehensively cover the basic science of metabolism, linking this closely to the pathophysiology and clinical aspects of the disease. Edited by four world-famous diabetes specialists, the book is divided into 13 sections, each section edited by a section editor of major international prominence. As well as covering all aspects of diabetes, from epidemiology and pathophysiology to the management of the condition and the complications that arise, this fourth edition also includes two new sections on NAFLD, NASH and non-traditional associations with diabetes, and clinical trial evidence in diabetes. This fourth edition of an internationally recognised textbook will once again provide all those involved in diabetes research and development, as well as diabetes specialists with the most comprehensive scientific reference book on diabetes available.
Molecular Biology Of The Cell
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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002
Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.