Jak Stat Signaling In Diseases
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Jak Stat Signaling In Diseases
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Author : Ritobrata Goswami
language : en
Publisher: CRC Press
Release Date : 2020-02-28
Jak Stat Signaling In Diseases written by Ritobrata Goswami and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-28 with Medical categories.
JAK-STAT pathway is one of the few signal transduction pathways that transduce signals involved in multiple homeostatic biological processes including cell differentiation and proliferation, cell death, hematopoiesis and immune responses. JAK-STAT is an elegant pathway that is relatively simple and evolutionary conserved as gene expression is regulated by external parameters. Activated by growth factors or cytokines, this signal transduction cascade regulates the transcription of genes at the nucleus. Mutations and polymorphisms in JAK-STAT pathway are associated with inflammatory diseases and cancers that could impede regular homeostasis. Features: Details activation and microRNA-mediated regulation of JAK-STAT pathway Provides exclusive information about the association of the pathway in various diseases including allergic inflammation, neuro-inflammatory disorder, atopic dermatitis hematopoietic malignancies, cardiovascular disorder, renal disorder, immunodeficiency, liver fibrosis, diabetes and obesity that affect individuals across the globe Clinical relevance of the signaling cascade has been discussed in context of novel class of therapeutics that targets this pathway. An overview of JAK-STAT signaling pathway and the structure-function relationship of different domains of the cascade are discussed. This book provides detailed information on various diseases that are associated with JAK-STAT pathway. It will act as a very good reference book for basic science researchers, academicians, industry professionals involved in translational research leading to product development. This book will excite future professionals towards better understanding of the regulation of this pathway, its association with other signaling cascades to design novel therapeutics.
Jak Stat Pathway In Disease
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Author : Jr., Richard H. Bell
language : en
Publisher: CRC Press
Release Date : 2009-06-11
Jak Stat Pathway In Disease written by Jr., Richard H. Bell and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-06-11 with Medical categories.
This book reviews current understanding of the biological roles of the signal transducer and activator of transcription (STAT) proteins and their dysregulation in diseases. STAT proteins were named after their role as signal transducers and activators of transcription. STAT proteins are highly conserved among species, thus reflecting the importance
Jak Stat Signaling From Basics To Disease
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Author : Thomas Decker
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-06-06
Jak Stat Signaling From Basics To Disease written by Thomas Decker and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-06 with Science categories.
JAK tyrosine kinases and STAT transcription factors constitute a signaling pathway, which is activated by cytokines. By activating gene transcription it regulates essential biological responses to environmental cues. The Jak-Stat pathway is involved in the regulation of cell development, differentiation, proliferation and apoptosis. Improper function may contribute to hematopoietic malignancies and cancer. This book provides comprehensive insights into the latest basic and clinical developments in the field. The first part reviews recent findings and new technologies pertaining to basics of Jak-Stat function. The second part describes the evolution of Jak-Stat signaling and the role of the pathway in invertebrate organisms. The third part focuses on Jak-Stat signaling in hematopoietic cells under both physiological and pathophysiological conditions. Finally, chapters in the fourth section describe the relationship of Jak-Stat signaling to various states of disease, particularly infection, leukemias and solid cancers. The book is intended for all scientists in molecular biology, biochemistry and cell biology dealing with biomedical issues.
Jak Stat Signaling
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Author :
language : en
Publisher: Springer
Release Date : 2012-08-31
Jak Stat Signaling written by and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-08-31 with categories.
The Jak Stat Pathway In Hematopoiesis And Disease
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Author : Alister C. Ward
language : en
Publisher: Springer Science & Business Media
Release Date : 2002-12-31
The Jak Stat Pathway In Hematopoiesis And Disease written by Alister C. Ward and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-12-31 with Science categories.
This book for the first time comprehensively surveys the research investigating the Jak-Stat pathway and its role in normal blood development as well as its perturbation in disease. It draws on the expertise of world-renowned medical researchers to take the reader from basic biology through to recent therapeutic advances.
The Jak Stat Pathway In Hematopoiesis And Disease
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Author : Alister C. Ward
language : en
Publisher: Eurekah.Com Incorporated
Release Date : 2002
The Jak Stat Pathway In Hematopoiesis And Disease written by Alister C. Ward and has been published by Eurekah.Com Incorporated this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Medical categories.
Signal Transducers And Activators Of Transcription Stats
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Author : P. Sehgal
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Signal Transducers And Activators Of Transcription Stats written by P. Sehgal and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.
The only fully comprehensive reference for STAT proteins and their biology, this book describes the current state of ongoing research in this broad area, and looks toward the future to try to predict the discoveries that lie ahead.
Signal Transduction And Human Disease
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Author : Toren Finkel
language : en
Publisher: John Wiley & Sons
Release Date : 2003-07-18
Signal Transduction And Human Disease written by Toren Finkel and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-07-18 with Science categories.
This book uniquely relates the broad impact of signal transduction research on the understanding and treatment of human disease. There have been significant advances in the area of signaling in disease processes, yet no resource presently connects these advances with understanding of disease processes and applications for novel therapeutics. Given the emphasis on translational research and biological relevance in biotechnology, and, conversely, the importance of molecular approaches for clinical research, it is evident that a single resource bridging signaling research and human disease will be invaluable.
Encyclopedia Of Exercise Medicine In Health And Disease
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Author : Frank C. Mooren
language : en
Publisher: Springer
Release Date : 2012-04-19
Encyclopedia Of Exercise Medicine In Health And Disease written by Frank C. Mooren and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-19 with Medical categories.
The Encyclopedia of Exercise Medicine is intelligently structured, easy accessible and user-friendly: A-Z format, clear, concise language and uniform essay structure as well as extensive cross references between keywords and related articles enables efficient searches in a user-friendly manner both for experts and newcomers. It is intended to be a comprehensive up-to-date data base on the adaptation of the human body to exercise and on the therapeutic use of exercise with up to 2,000 keywords. It covers all aspects within the full range of modern exercise medicine of each particular scientific discipline (cancer, parasitology, aging, etc.). This includes information on methodological approaches to measuring the principle components of motor fitness, and practical aspects of their enhancement by trainings regimes as well as by nutrition and the application of drugs. Such a wide range of entries, all written by leading experts in their respective fields, will therefore address both the basic/clinical scientist as well as the practitioner. Moreover, the Encyclopedia of Exercise Medicine is aimed at people in related fields, health care professionals, physiotherapists, trainers, students, informed athletes and interested laypersons. It is available both in print and as a fully searchable and hyperlinked electronic online edition.
Adipose Tissue In Health And Disease
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Author : Todd Leff
language : en
Publisher: John Wiley & Sons
Release Date : 2010-03-19
Adipose Tissue In Health And Disease written by Todd Leff and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03-19 with Science categories.
This timely and most comprehensive reference available on the topic covers all the different aspects vital in the fight against the global obesity epidemic. Following a look at adipose tissue development and morphology, the authors go on to examine its metabolic and endocrine functions and its role in disease. The final section deals with comparative and evolutionary aspects of the tissue. The result is an essential resource for cell and molecular biologists, physiologists, biochemists, pharmacologists, and those working in the pharmaceutical industry.