The Jak Stat Pathway In Hematopoiesis And Disease
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The Jak Stat Pathway In Hematopoiesis And Disease
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Author : Alister C. Ward
language : en
Publisher: Springer Science & Business Media
Release Date : 2002-12-31
The Jak Stat Pathway In Hematopoiesis And Disease written by Alister C. Ward and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-12-31 with Science categories.
This book for the first time comprehensively surveys the research investigating the Jak-Stat pathway and its role in normal blood development as well as its perturbation in disease. It draws on the expertise of world-renowned medical researchers to take the reader from basic biology through to recent therapeutic advances.
The Jak Stat Pathway In Hematopoiesis And Disease
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Author : Alister C. Ward
language : en
Publisher: Eurekah.Com Incorporated
Release Date : 2002
The Jak Stat Pathway In Hematopoiesis And Disease written by Alister C. Ward and has been published by Eurekah.Com Incorporated this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Medical categories.
Jak Stat Signaling From Basics To Disease
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Author : Thomas Decker
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-06-06
Jak Stat Signaling From Basics To Disease written by Thomas Decker and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-06 with Science categories.
JAK tyrosine kinases and STAT transcription factors constitute a signaling pathway, which is activated by cytokines. By activating gene transcription it regulates essential biological responses to environmental cues. The Jak-Stat pathway is involved in the regulation of cell development, differentiation, proliferation and apoptosis. Improper function may contribute to hematopoietic malignancies and cancer. This book provides comprehensive insights into the latest basic and clinical developments in the field. The first part reviews recent findings and new technologies pertaining to basics of Jak-Stat function. The second part describes the evolution of Jak-Stat signaling and the role of the pathway in invertebrate organisms. The third part focuses on Jak-Stat signaling in hematopoietic cells under both physiological and pathophysiological conditions. Finally, chapters in the fourth section describe the relationship of Jak-Stat signaling to various states of disease, particularly infection, leukemias and solid cancers. The book is intended for all scientists in molecular biology, biochemistry and cell biology dealing with biomedical issues.
Jak Stat Signaling
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Author :
language : en
Publisher: Springer
Release Date : 2012-08-31
Jak Stat Signaling written by and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-08-31 with categories.
Jak Stat Signaling In Diseases
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Author : Ritobrata Goswami
language : en
Publisher: CRC Press
Release Date : 2020-02-28
Jak Stat Signaling In Diseases written by Ritobrata Goswami and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-28 with Medical categories.
JAK-STAT pathway is one of the few signal transduction pathways that transduce signals involved in multiple homeostatic biological processes including cell differentiation and proliferation, cell death, hematopoiesis and immune responses. JAK-STAT is an elegant pathway that is relatively simple and evolutionary conserved as gene expression is regulated by external parameters. Activated by growth factors or cytokines, this signal transduction cascade regulates the transcription of genes at the nucleus. Mutations and polymorphisms in JAK-STAT pathway are associated with inflammatory diseases and cancers that could impede regular homeostasis. Features: Details activation and microRNA-mediated regulation of JAK-STAT pathway Provides exclusive information about the association of the pathway in various diseases including allergic inflammation, neuro-inflammatory disorder, atopic dermatitis hematopoietic malignancies, cardiovascular disorder, renal disorder, immunodeficiency, liver fibrosis, diabetes and obesity that affect individuals across the globe Clinical relevance of the signaling cascade has been discussed in context of novel class of therapeutics that targets this pathway. An overview of JAK-STAT signaling pathway and the structure-function relationship of different domains of the cascade are discussed. This book provides detailed information on various diseases that are associated with JAK-STAT pathway. It will act as a very good reference book for basic science researchers, academicians, industry professionals involved in translational research leading to product development. This book will excite future professionals towards better understanding of the regulation of this pathway, its association with other signaling cascades to design novel therapeutics.
Jak Stat Pathway In Disease
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Author : Jr., Richard H. Bell
language : en
Publisher: CRC Press
Release Date : 2009-06-11
Jak Stat Pathway In Disease written by Jr., Richard H. Bell and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-06-11 with Medical categories.
This book reviews current understanding of the biological roles of the signal transducer and activator of transcription (STAT) proteins and their dysregulation in diseases. STAT proteins were named after their role as signal transducers and activators of transcription. STAT proteins are highly conserved among species, thus reflecting the importance
Jak Stat Signalling
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Author : Sandra E. Nicholson
language : en
Publisher: Humana Press
Release Date : 2016-05-01
Jak Stat Signalling written by Sandra E. Nicholson and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-05-01 with Science categories.
This Methods in Molecular Biology volume covers JAK and STAT specific approaches, the negative regulators of the pathway, and production and crystallization of JAK and STAT proteins, and more.Includes protocols, materials lists, tips and troubleshooting advice."
Fetal Embryonic Hematopoietic Progenitors And Their Impact On Adult Diseases
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Author : Silvia Brunelli
language : en
Publisher: Frontiers Media SA
Release Date : 2021-10-01
Fetal Embryonic Hematopoietic Progenitors And Their Impact On Adult Diseases written by Silvia Brunelli and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-01 with Science categories.
Tyrosine Kinases As Druggable Targets In Cancer
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Author :
language : en
Publisher:
Release Date : 2019
Tyrosine Kinases As Druggable Targets In Cancer written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
Damage Associated Molecular Patterns In Human Diseases
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Author : Walter Gottlieb Land
language : en
Publisher: Springer
Release Date : 2018-10-09
Damage Associated Molecular Patterns In Human Diseases written by Walter Gottlieb Land and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-09 with Medical categories.
This book presents current understanding of the importance of modern immunology in the etiopathogenesis of human diseases and explores how this understanding is impacting on diagnosis, prognosis, treatment, and prophylaxis. As the core of modern immunology, the “danger/injury model” is introduced and addressed throughout the book. Volume I of the book describes the network of damage-associated molecular pattern molecules (DAMPs) and examines the central role of DAMPs in cellular stress responses and associated regulated cell death, the promotion and resolution of inflammation, the activation of innate lymphoid cells and unconventional T cells, the stimulation of adaptive immunity, and tissue repair. The significance of DAMPs in a wide range of human diseases will then be explored in Volume II of the book, with discussion of the implications of injury-induced innate immunity for present and future treatments. This book is written for professionals from all medical and paramedical disciplines who are interested in the introduction of innovative data from immunity and inflammation research into clinical practice. The readership will include practitioners and clinicians such as hematologists, rheumatologists, traumatologists, oncologists, intensive care anesthetists, endocrinologists such as diabetologists, psychiatrists, neurologists, pharmacists, and transplantologists.