Jak Stat Signaling From Basics To Disease
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Jak Stat Signaling From Basics To Disease
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Author : Thomas Decker
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-06-06
Jak Stat Signaling From Basics To Disease written by Thomas Decker and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-06 with Science categories.
JAK tyrosine kinases and STAT transcription factors constitute a signaling pathway, which is activated by cytokines. By activating gene transcription it regulates essential biological responses to environmental cues. The Jak-Stat pathway is involved in the regulation of cell development, differentiation, proliferation and apoptosis. Improper function may contribute to hematopoietic malignancies and cancer. This book provides comprehensive insights into the latest basic and clinical developments in the field. The first part reviews recent findings and new technologies pertaining to basics of Jak-Stat function. The second part describes the evolution of Jak-Stat signaling and the role of the pathway in invertebrate organisms. The third part focuses on Jak-Stat signaling in hematopoietic cells under both physiological and pathophysiological conditions. Finally, chapters in the fourth section describe the relationship of Jak-Stat signaling to various states of disease, particularly infection, leukemias and solid cancers. The book is intended for all scientists in molecular biology, biochemistry and cell biology dealing with biomedical issues.
Jak Stat Signaling
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Author :
language : en
Publisher: Springer
Release Date : 2012-08-31
Jak Stat Signaling written by and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-08-31 with categories.
Jak Stat Signaling In Diseases
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Author : Ritobrata Goswami
language : en
Publisher: CRC Press
Release Date : 2020-02-28
Jak Stat Signaling In Diseases written by Ritobrata Goswami and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-28 with Medical categories.
JAK-STAT pathway is one of the few signal transduction pathways that transduce signals involved in multiple homeostatic biological processes including cell differentiation and proliferation, cell death, hematopoiesis and immune responses. JAK-STAT is an elegant pathway that is relatively simple and evolutionary conserved as gene expression is regulated by external parameters. Activated by growth factors or cytokines, this signal transduction cascade regulates the transcription of genes at the nucleus. Mutations and polymorphisms in JAK-STAT pathway are associated with inflammatory diseases and cancers that could impede regular homeostasis. Features: Details activation and microRNA-mediated regulation of JAK-STAT pathway Provides exclusive information about the association of the pathway in various diseases including allergic inflammation, neuro-inflammatory disorder, atopic dermatitis hematopoietic malignancies, cardiovascular disorder, renal disorder, immunodeficiency, liver fibrosis, diabetes and obesity that affect individuals across the globe Clinical relevance of the signaling cascade has been discussed in context of novel class of therapeutics that targets this pathway. An overview of JAK-STAT signaling pathway and the structure-function relationship of different domains of the cascade are discussed. This book provides detailed information on various diseases that are associated with JAK-STAT pathway. It will act as a very good reference book for basic science researchers, academicians, industry professionals involved in translational research leading to product development. This book will excite future professionals towards better understanding of the regulation of this pathway, its association with other signaling cascades to design novel therapeutics.
Jak Stat Pathway In Disease
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Author : Jr., Richard H. Bell
language : en
Publisher: CRC Press
Release Date : 2009-06-11
Jak Stat Pathway In Disease written by Jr., Richard H. Bell and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-06-11 with Medical categories.
This book reviews current understanding of the biological roles of the signal transducer and activator of transcription (STAT) proteins and their dysregulation in diseases. STAT proteins were named after their role as signal transducers and activators of transcription. STAT proteins are highly conserved among species, thus reflecting the importance
The Jak Stat Pathway In Hematopoiesis And Disease
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Author : Alister C. Ward
language : en
Publisher: Springer Science & Business Media
Release Date : 2002-12-31
The Jak Stat Pathway In Hematopoiesis And Disease written by Alister C. Ward and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-12-31 with Science categories.
This book for the first time comprehensively surveys the research investigating the Jak-Stat pathway and its role in normal blood development as well as its perturbation in disease. It draws on the expertise of world-renowned medical researchers to take the reader from basic biology through to recent therapeutic advances.
The Jak Stat Pathway In Hematopoiesis And Disease
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Author : Alister C. Ward
language : en
Publisher: Eurekah.Com Incorporated
Release Date : 2002
The Jak Stat Pathway In Hematopoiesis And Disease written by Alister C. Ward and has been published by Eurekah.Com Incorporated this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Medical categories.
Signal Transducers And Activators Of Transcription Stats
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Author : P. Sehgal
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Signal Transducers And Activators Of Transcription Stats written by P. Sehgal and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.
The only fully comprehensive reference for STAT proteins and their biology, this book describes the current state of ongoing research in this broad area, and looks toward the future to try to predict the discoveries that lie ahead.
Pathogenesis Of Systemic Lupus Erythematosus
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Author : Alberta Hoi
language : en
Publisher: Springer Nature
Release Date : 2021-11-15
Pathogenesis Of Systemic Lupus Erythematosus written by Alberta Hoi and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-15 with Medical categories.
The scope of this contributed volume is to provide an overview of the latest translational research in the field of lupus pathogenesis, with particular emphasis on how these discoveries progress in parallel with therapeutic drug development. Systemic lupus erythematosus (SLE) is a multifaceted disease with a number of well-defined immune pathways that are dysregulated, resulting in an immune-mediated chronic inflammatory injury at target organs. As knowledge of these pathways evolves to provide opportunities for targeted drug therapy and lays the foundation for personalized medicine, clinicians and researchers need to keep up with the ever-expanding medical literature. This book will critically appraise the current understanding of important immunological pathways that contribute to the pathogenesis of lupus. We will review the role of interferons as part of the innate immune defects that perpetuate the loss of self-tolerance in SLE. B cell hyperactivity, as a defining hallmark of SLE, and different strategies of B cell targeted therapy will be discussed. The role of co-stimulation or immune checkpoint molecules in activating B and T cells will be reviewed, as well as other cytokines that serve in the amplification loop promoting a more proinflammatory Th1 or Th17 responses. Intracellular targets, such as signaling molecules in the JAK/STAT pathway, or a variety of kinases and proteasomes, can cause a cascading downstream effect of transcriptional responses that are important in SLE. Immune homeostasis can also be restored by bolstering the naturally occurring anti-inflammatory mechanisms. Glucocorticoid, as a potent natural anti-inflammatory hormone, can mediate its effects by recruiting histone deacetylase that serve to repress gene transcription. Glucocorticoid-induced leucine zipper is a gene upregulated by glucocorticoid that can be a potential target for development of anti-inflammatory strategy. Finally, T regulatory cells can be utilized to help restore to immune tolerance and are amongst the latest focus of therapeutic development in SLE.
Jak Stat Pathway In Disease
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Author : Richard H. Bell, Jr.
language : en
Publisher: CRC Press
Release Date : 2005-11-08
Jak Stat Pathway In Disease written by Richard H. Bell, Jr. and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-11-08 with Medical categories.
Performing a surgical operation must be one of the most complex motor tasks undertaken by humans. To the student rotating on a third-year clerkship, or to the resident beginning a surgical career, the complexity can no doubt be daunting. It is the goal of this handbook to try to bring some degree of order to the complexity, focusing on many of the common operations in general, plastic, thoracic, and vascular surgery, and in organ transplantation. We have done so by dividing each procedure into specific and well-defined steps.
Molecular Biology Of The Cell
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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002
Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.