Intraflagellar Transport In Caenorhabditis Elegans
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Intraflagellar Transport In Caenorhabditis Elegans
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Author : Peter Nicholas Inglis
language : en
Publisher:
Release Date : 2009
Intraflagellar Transport In Caenorhabditis Elegans written by Peter Nicholas Inglis and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Caenorhabditis elegans categories.
Intraflagellar transport (IFT) is the dynamic bidirectional process required for the biogenesis and maintenance of eukaryotic cilia. Landmark studies exploiting the model organism Chlamydomonas reinhardtii have provided a basic mechanism for the process, although recent research examining IFT in the nematode Caenorhabditis elegans has revealed a greater complexity to the original model of IFT described in Chlamydomonas, which includes the orthologues of several human proteins involved in cilium-associated diseases. The wealth of genomic, bioinformatic, and molecular tools available to C. elegans researchers is exploited in this thesis to uncover and characterise a number of novel proteins involved in the process of IFT, namely DYF-11, MKS-1, MKSR-1, and MKSR-2. DYF-11 localises throughout nematode ciliary structures and acts as a key component of the core IFT subcomplex B. The latter three proteins are members of a previously uncharacterised family of B9-domain containing polypeptides, all of which appear to localise at the base of cilia (basal body/transition zone), where they are found to regulate a cilium-based insulin signalling pathway. The results of this study contribute to the growing realisation in C. elegans cilia research that a network of transition-zone-specific proteins are participating in ciliary processes ranging from subtle modulation of ciliary signalling pathways to the actual biogenesis and maintenance of the organelle. Next, we examine previously isolated nematode strains that are defective in paraquat resistance for impaired retrograde IFT. We identify a retrograde-IFT deficient strain that likely represents a mutation in an IFT component that has not been previously characterised in C. elegans; the mutation maps closely to a highly conserved protein identified as a core component of IFT subcomplex A. Finally, we examine the role played by the IFT-associated Bardet-Biedl syndrome (BBS) proteins in C. elegans thermosensation. bbs mutant worms appear to be slightly defective in responding to both noxious and physiological temperatures. Furthermore, the nature of the physiological temperature defect correlates with a decreased roaming ability that is not the result of impaired locomotion. Altogether, the studies presented in this thesis offer novel insights into both the molecular makeup and physiological functions of IFT in C. elegans.
Regulation Of Intraflagellar Transport In The Sensory Cilia Of Caenorhabditis Elegans
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Author : Jan Adrianus Burghoorn
language : en
Publisher:
Release Date : 2006
Regulation Of Intraflagellar Transport In The Sensory Cilia Of Caenorhabditis Elegans written by Jan Adrianus Burghoorn and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.
Dissection Of The Intraflagellar Transport Protein Machinery In C Elegans Neurons
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Author : Guangshuo Ou
language : en
Publisher:
Release Date : 2006
Dissection Of The Intraflagellar Transport Protein Machinery In C Elegans Neurons written by Guangshuo Ou and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.
Ensemble And Single Molecule Dynamics Of Intraflagellar Transport In C Elegans
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Author :
language : en
Publisher:
Release Date : 2018
Ensemble And Single Molecule Dynamics Of Intraflagellar Transport In C Elegans written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
In Vitro Dissection Of Intraflagellar Transport In C Elegans Sensory Cilia
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Author : Mohamed Antar Aziz Mohamed
language : en
Publisher:
Release Date : 2020
In Vitro Dissection Of Intraflagellar Transport In C Elegans Sensory Cilia written by Mohamed Antar Aziz Mohamed and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.
Mechanism Of Kinesin Ii Function In Intraflagellar Transport In Caenorhabditis Elegans Sensory Cilia
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Author : Xiaoyu Pan
language : en
Publisher:
Release Date : 2008
Mechanism Of Kinesin Ii Function In Intraflagellar Transport In Caenorhabditis Elegans Sensory Cilia written by Xiaoyu Pan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.
Cilia Model Organisms And Intraflagellar Transport
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Author :
language : en
Publisher: Academic Press
Release Date : 2009-12-01
Cilia Model Organisms And Intraflagellar Transport written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-01 with Science categories.
Cilia are highly conserved organelles that serve motile functions, sensory functions, or both. These organelles power cell movement, generate fluid flow in various organs, act as sensors of the extracellular environment and have been modified for various specialized tasks such as light reception and smell. Defects in these ubiquitous organelles lead to a broad array of human genetic disorders that range from polycystic kidney disease, retinal degeneration, epilepsy and infertility to developmental defects such as situs inversus and polydactyly. This volume is the third in a three-part series on cilia that focuses on the use of model organisms to gain insight into ciliary function and on the process of intraflagellar transport that is essential for the assembly and maintenance of ciliary structures. Includes both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time Covers forward and reverse genetic analysis of IFT and biochemical methods to define the role of IFT components Methods presented cover molecular, genetic, and biochemical approaches to ciliary function in model organisms
Microtubule Based Transport In Ciliated Chemosensory Neurons Of Caenorhabditis Elegans
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Author : Dawn Signor
language : en
Publisher:
Release Date : 2000
Microtubule Based Transport In Ciliated Chemosensory Neurons Of Caenorhabditis Elegans written by Dawn Signor and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with categories.
Elucidating The Role Of The C Elegans Nephrocystins In Cilia
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Author : Andrew Jauregui
language : en
Publisher:
Release Date : 2007
Elucidating The Role Of The C Elegans Nephrocystins In Cilia written by Andrew Jauregui and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with categories.
Molecular Mechanisms Of Sensory Receptor Trafficking In Caenorhabditis Elegans
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Author : Young-Kyung Bae
language : en
Publisher:
Release Date : 2008
Molecular Mechanisms Of Sensory Receptor Trafficking In Caenorhabditis Elegans written by Young-Kyung Bae and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.