Intrinsically Disordered Proteins
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Structure And Function Of Intrinsically Disordered Proteins
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Author : Peter Tompa
language : en
Publisher: CRC Press
Release Date : 2009-11-18
Structure And Function Of Intrinsically Disordered Proteins written by Peter Tompa and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-18 with Science categories.
The existence and functioning of intrinsically disordered proteins (IDPs) challenge the classical structure-function paradigm that equates function with a well-defined 3D structure. Uncovering the disordered complement of proteomes and understanding their functioning can extend the structure-function paradigm to herald new breakthroughs in drug dev
Biomolecular Forms And Functions
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Author : Manju Bansal
language : en
Publisher: World Scientific
Release Date : 2013
Biomolecular Forms And Functions written by Manju Bansal and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Computers categories.
Understanding the functions and properties of molecules in living systems requires a detailed knowledge of their three-dimensional structures and the conformational variability that allows them to adopt multiple functional forms. Interpreting biological systems in the language of three-dimensional structures is of fundamental importance and innumerable research groups around the world are working in this area. This book is a compilation of articles describing attempts at understanding the intricacies of biological systems through the structures of and interactions between their constituent molecules.
Intrinsically Disordered Proteins And Disease
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Author : Rudyard Ramsey
language : en
Publisher: Hayle Medical
Release Date : 2023-09-26
Intrinsically Disordered Proteins And Disease written by Rudyard Ramsey and has been published by Hayle Medical this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-26 with Science categories.
An intrinsically disordered protein (IDP) is a protein in which the fixed or ordered three-dimensional structure is absent, generally when its macromolecular interaction partners, such as other proteins or RNA are absent. The flexible structure of these proteins allows them to accomplish their biological functions. IDPs play an important role in DNA regulation and cell signaling owing to their ability to participate in weak multivalent interactions that are highly cooperative and dynamic. There are various IDPs that can adopt a fixed three-dimensional structure after they bind themselves to other macromolecules. IDPs are associated with numerous diseases such as cancer, cardiovascular disease, amyloidoses, neurodegenerative diseases and diabetes. This book includes some of the vital pieces of works being conducted across the world, on various topics related to the relationship between intrinsically disordered proteins and diseases. Its extensive content provides the readers with a thorough understanding of the subject.
Intrinsically Disordered Proteins
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Author : Vladimir N. Uversky
language : en
Publisher: Springer
Release Date : 2014-08-05
Intrinsically Disordered Proteins written by Vladimir N. Uversky and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-05 with Science categories.
In this brief, Vladimir Uversky discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). Beginning with an introduction to the concept of protein intrinsic disorder, Uversky then goes on to describe the peculiar amino acid sequences of IDPs, their structural heterogeneity, typical functions and disorder-based binding modes. In the final sections, Uversky discusses IDPs in human diseases and as potential drug targets. This volume provides a snapshot to researchers entering the field as well as providing a current overview for more experienced scientists in related areas.
Intrinsically Disordered Proteins
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Author :
language : en
Publisher: Academic Press
Release Date : 2018-11-21
Intrinsically Disordered Proteins written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-21 with Science categories.
Intrinsically Disordered Proteins, Volume 611, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics of interest, including the Characterization of Structure-Function relationships in the intrinsically disordered protein complexin, Distances, distance distributions, and ensembles of IDPs from single-molecule FRET, Biophysical characterization of disordered protein liquid phases, The Use of Mass Spectrometry to Examine IDPs – Unique Insights and Caveats, Fluorescence Depolarization Kinetics to Study Conformational Preference, Structural Plasticity and Membrane Binding of Intrinsically Disordered Proteins, Characterizing the Function of Intrinsically Disordered Proteins in the Circadian Clock, and more. - Breadth of experimental approaches and systems that will be covered - The expertise of the contributors writing the articles
Intrinsically Disordered Proteins
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Author : Nicola Salvi
language : en
Publisher: Academic Press
Release Date : 2019-06-14
Intrinsically Disordered Proteins written by Nicola Salvi and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-14 with Science categories.
Intrinsically Disordered Proteins: Dynamics, Binding, and Function thoroughly examines and ties together the fundamental biochemical functions of intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs), including signaling, binding, and regulation, with the methodology for study and the associated pathways for drug design and therapeutic intervention. The role of new mechanistic, computational, and experimental approaches in IDP study are explored in depth, with methods for the characterization of IDP dynamics; models, simulations, and mechanisms of IDP and IDR binding; and biological and medical implications of IDP dynamics prominently featured. Written and edited by leading scientists in the field, this book explores groundbreaking areas such as ensemble descriptions of IDPs and IDRs, single-molecule studies of IDPs and IDRs, IDPs and IDRs in membraneless organelles, and molecular mechanisms of fibrillation of IDPs. Intrinsically Disordered Proteins provides students and researchers in biochemistry, molecular biology, and applied microbiology with a comprehensive and updated discussion of the complex dynamics of IDPs and IDRs. - Provides in-depth discussion of fundamental IDP and IDR dynamics, function, and binding, with mechanistic insight to support new drug development - Describes the role of new computational and experimental approaches in characterizing the binding of IDPs to their functional targets - Features chapter contributions from international experts in IDP and IDR biochemical function and methods of study
Instrumental Analysis Of Intrinsically Disordered Proteins
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Author : Vladimir Uversky
language : en
Publisher: John Wiley & Sons
Release Date : 2011-01-31
Instrumental Analysis Of Intrinsically Disordered Proteins written by Vladimir Uversky and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-01-31 with Science categories.
Instrumental techniques for analyzing intrinsically disordered proteins The recently recognized phenomenon of protein intrinsic disorder is gaining significant interest among researchers, especially as the number of proteins and protein domains that have been shown to be intrinsically disordered rapidly grows. The first reference to tackle this little-documented area, Instrumental Analysis of Intrinsically Disordered Proteins: Assessing Structure and Conformation provides researchers with a much-needed, comprehensive summary of recent achievements in the methods for structural characterization of intrinsically disordered proteins (IDPs). Chapters discuss: Assessment of IDPs in the living cell Spectroscopic techniques for the analysis of IDPs, including NMR and EPR spectroscopies, FTIR, circular dichroism, fluorescence spectroscopy, vibrational methods, and single-molecule analysis Single-molecule techniques applied to the study of IDPs Assessment of IDP size and shape Tools for the analysis of IDP conformational stability Mass spectrometry Approaches for expression and purification of IDPs With contributions from an international selection of leading researchers, Instrumental Analysis of Intrinsically Disordered Proteins: Assessing Structure and Conformation fills an important need in a rapidly growing field. It is required reading for biochemists, biophysicists, molecular biologists, geneticists, cell biologists, physiologists, and specialists in drug design and development, proteomics, and molecular medicine with an interest in proteins and peptides.
Osmolytes And Intrinsically Disordered Proteins From Functional Regulation To Disease Pathogenesis
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Author :
language : en
Publisher: Elsevier
Release Date : 2025-02-18
Osmolytes And Intrinsically Disordered Proteins From Functional Regulation To Disease Pathogenesis written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-18 with Science categories.
Osmolytes and Intrinsically Disordered Proteins: From Functional Regulation to Disease Pathogenesis, Volume 112 delves into the fascinating interplay between osmolytes and intrinsically disordered proteins (IDPs), exploring their pivotal roles in cellular function and disease mechanisms. This volume brings together experts to present cutting-edge research on how osmolytes regulate functional behavior of IDPs and ensure cellular stability and adaptability under stress conditions. Specific chapters cover Functional diversity of IDPs and their structural heterogeneity: Protein structure-function continuum, Osmolytes as structure-function regulators of intrinsically disordered casein, Synergism of the effects of osmolytes and crowders on structure and function of IDPs/IDRs: The natural habitat, and more.Additional chapters delve into Osmolyte-IDP Interactions during Desiccation, Modulation of aggregation/fibrillation propensity of IDPs by osmolytes, Osmolytes in modulating the structural and functional integrity of α-synuclein: a study based on Parkinson's disease, Regulation of the structural dynamics, aggregation, and pathogenicity of polyQ-expanded Huntingtin by osmolytes, Aggregation and inhibitory strategies of amyloid fibrillation, and much more. - Offers an in-depth exploration of the relationship between osmolytes and intrinsically disordered proteins (IDPs), spanning from basic functional regulation to roles in the pathogenesis of various disease - Features chapters written by leading researchers and experts in the field - Provides the latest findings on osmolyte-IDP interactions in molecular levels and implications in important biological processes - Elucidates on the fundamental science behind IDPs and osmolytes - It highlights potential therapeutic approaches, making it a valuable resource for both researchers and clinicians aiming to develop new treatments for related diseases
Dancing Protein Clouds Intrinsically Disordered Proteins In The Norm And Pathology Part C
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Author :
language : en
Publisher: Academic Press
Release Date : 2021-10-14
Dancing Protein Clouds Intrinsically Disordered Proteins In The Norm And Pathology Part C written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-14 with Science categories.
Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C, Volume 183 represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this volume include discussions on the evolution of disorder, consideration of the peculiarities of phase separation of the prion protein, a general discussion of the relationships between intrinsic disorder and protein functions, coverage of the structural and functional characterization of several important intrinsically disordered proteins, such as transcription factors, outer membrane porins, trans-membrane and membrane associated proteins with ID regions, discussion of molecular simulations of IDPs, and much more. - Provides recent studies on the intrinsically disordered proteins and their functions, along with the involvement of intrinsically disordered proteins in the pathogenesis of various diseases - Contains numerous illustrative materials (color figures, diagrams and tables) to help readers delve into the information provided - Includes contributions from recognized experts in the field
Dancing Protein Clouds Intrinsically Disordered Proteins In Health And Disease Part A
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Author :
language : en
Publisher: Academic Press
Release Date : 2019-09-12
Dancing Protein Clouds Intrinsically Disordered Proteins In Health And Disease Part A written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-12 with Science categories.
"Dancing protein clouds: Intrinsically disordered proteins in the norm and pathology" represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain.