Investigating Random And Genetic Models For X Chromosome Inactivation
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Investigating Random And Genetic Models For X Chromosome Inactivation
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Author : Sonja Merida Pritchett
language : en
Publisher:
Release Date : 2009
Investigating Random And Genetic Models For X Chromosome Inactivation written by Sonja Merida Pritchett and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with X chromosome categories.
Investigating X Chromosome Inactivation
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Author : Sonja Pritchett
language : en
Publisher: LAP Lambert Academic Publishing
Release Date : 2011-01
Investigating X Chromosome Inactivation written by Sonja Pritchett and has been published by LAP Lambert Academic Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-01 with categories.
Females have two alleles for each gene on the X- chromosome, whereas males have only one. This inequality is balanced by X-chromosome inactivation (XCI). This process transcriptionally silences one X- chromosome in every female cell. The choice of which X-chromosome should be "turned-o " is considered to be random. Studies on mice have revealed that a locus on the X-chromosome, the X controlling element (Xce), signi cantly in uences the choice of which X- chromosome is inactivated. Renault et al. (2007) studied a family of which many of the females exhibit symptoms of the X-linked recessive disease, Haemophilia A. The XCI ratios of the women in this family were signi cantly di erent from what would be expected if the XCI process was random. This studies result is consistent with the human XCE hypothesis. Random and genetic models of XCI ratios are investigated here in theory and are compared to a sample of XCI ratios. Using goodness-of- fit testing, it is determined which models best fit the data. Anderson-Darling statistics and visual inspection of graphics suggest that a three allele genetic model is a good fit to the data, supporting the human XCE hypothesis.
Human Na Ve Pluripotent Stem Cells
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Author : Peter Rugg-Gunn
language : en
Publisher: Humana
Release Date : 2021-12-07
Human Na Ve Pluripotent Stem Cells written by Peter Rugg-Gunn and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-07 with Science categories.
This volume provides readers with a comprehensive collection of methods to guide them on how to generate, characterize, and use naïve human pluripotent stem cells (hPSCs). The chapters in this book cover topics such as three predominant routes to generate naïve hPSC lines; methods to differentiate naïve hPSCs into specialized cell types; and techniques to characterize naïve hPSCs using key molecular landmarks that benchmark and quality control the cell lines. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Human Naïve Pluripotent Stem Cells: Methods and Protocols is a valuable resource for novice and expert researchers who are looking to learn more or expand their research in this developing field.
Exploring The Biological Contributions To Human Health
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2001-07-02
Exploring The Biological Contributions To Human Health written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-07-02 with Medical categories.
It's obvious why only men develop prostate cancer and why only women get ovarian cancer. But it is not obvious why women are more likely to recover language ability after a stroke than men or why women are more apt to develop autoimmune diseases such as lupus. Sex differences in health throughout the lifespan have been documented. Exploring the Biological Contributions to Human Health begins to snap the pieces of the puzzle into place so that this knowledge can be used to improve health for both sexes. From behavior and cognition to metabolism and response to chemicals and infectious organisms, this book explores the health impact of sex (being male or female, according to reproductive organs and chromosomes) and gender (one's sense of self as male or female in society). Exploring the Biological Contributions to Human Health discusses basic biochemical differences in the cells of males and females and health variability between the sexes from conception throughout life. The book identifies key research needs and opportunities and addresses barriers to research. Exploring the Biological Contributions to Human Health will be important to health policy makers, basic, applied, and clinical researchers, educators, providers, and journalists-while being very accessible to interested lay readers.
The Sex Chromatin
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Author : Keith L. Moore
language : en
Publisher:
Release Date : 1966
The Sex Chromatin written by Keith L. Moore and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1966 with Sex Chromatin categories.
Handbook Of Dna Profiling
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Author : Hirak Ranjan Dash
language : en
Publisher: Springer
Release Date : 2022-06-29
Handbook Of Dna Profiling written by Hirak Ranjan Dash and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-29 with Science categories.
This reference book comprehensively reviews the significance of DNA technology in forensic science. After presenting the theory, basic principles, tools and techniques that are used in forensic DNA typing, it summarizes various techniques, including autosomal STR, Y-STR, X-STR, mitochondrial DNA and NGS, used in solving both criminal as and civil cases, such as paternity disputes, identification of mutilated remains, and culprit identification in sexual assault and murder cases. It also provides an overview of DNA-based genetic diagnostics for various diseases, and discusses the role of DNA typing in drug reactions, as well as the application of non-human DNA profiling of animals and plants in forensic science investigations. Lastly, the book examines the role of internal quality control in maintaining the high quality of DNA profiling.
Heritable Human Genome Editing
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Author : The Royal Society
language : en
Publisher: National Academies Press
Release Date : 2021-01-16
Heritable Human Genome Editing written by The Royal Society and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-16 with Medical categories.
Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.
Evolution By Gene Duplication
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Author : Susumu Ohno
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-12-11
Evolution By Gene Duplication written by Susumu Ohno and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-11 with Medical categories.
It is said that "necessity is the mother of invention". To be sure, wheels and pulleys were invented out of necessity by the tenacious minds of upright citi zens. Looking at the history of mankind, however, one has to add that "Ieisure is the mother of cultural improvement". Man's creative genius flourished only when his mind, freed from the worry of daily toils, was permitted to entertain apparently useless thoughts. In the same manner, one might say with regard to evolution that "natural selection mere(y tnodifted, while redundanry created". Natural selection has been extremely effective in policing alleHe mutations which arise in already existing gene loci. Because of natural selection, organisms have been able to adapt to changing environments, and by adaptive radiation many new species were created from a common ancestral form. Y et, being an effective policeman, natural selection is extremely conservative by nature. Had evolution been entirely dependent upon natural selection, from a bacterium only numerous forms of bacteria would have emerged. The creation of metazoans, vertebrates and finally mammals from unicellular organisms would have been quite impos sible, for such big leaps in evolution required the creation of new gene loci with previously nonexistent functions. Only the cistron which became redun dant was able to escape from the relentless pressure of natural selection, and by escaping, it accumulated formerly forbidden mutations to emerge as a new gene locus.
Sex Chromosomes And Sex Linked Genes
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Author : Susumu Ohno
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Sex Chromosomes And Sex Linked Genes written by Susumu Ohno and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.
Natural selection operates among individual organisms which differ in their genetic constitution. The degree of hereditary variability within a species is greatly enhanced by cross-fertilization. Indeed, the mechanism of sexual reproduction occurred very early in evolution, for it is seen today even in bacteria. In Escherichia coli, fertilization occurs by passage of the single chromosome from the male into the female bacterium (LEDERBERG, 1959). In multicellular organisms, the separation of germ from soma, and the production of haploid gametes became mandatory. The gametes were of two types. One, extremely mobile, was designed to seek out and penetrate the other, which loaded with nutrients, received the mobile gamete and intiated the development of a new individual. The foundation for true bisexuality was thus laid. In the primitive state of bisexuality, whether an individual is to be a sperm-producing male or an egg-producing female appears to be decided rather haphazardly. In the worm, Banelia viridis, the minute males are parasites in the female. Larvae that become attached to the proboscis of an adult female become males, while unattached larvae sink to the bottom and become females (BALTZER, 1935). The more sophisticated state of bisexuality was initiated by setting aside a particular pair of chromosomes for specialization and making either the male or the female a heterogametic sex. Sex chromosomes as we know them were thus born.
Genetics For Surgeons
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Author : Patrick John Morrison
language : en
Publisher: Remedica
Release Date : 2005
Genetics For Surgeons written by Patrick John Morrison and has been published by Remedica this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Medical categories.
Morrison (human genetics, University of Ulster, UK) and Spence (biomedical science, University of Ulster, UK) offer an accessible reference on the genetic disorders that surgeons can expect to meet in general surgical practice. Written in non-technical language, with a glossary, list of abbreviations, and color and b&w photos and medical images, the book supplies an introduction to the nomenclature and technology of molecular biology, and will be a useful starting point for those who wish to extend their knowledge. Annotation :2005 Book News, Inc., Portland, OR (booknews.com).