Investigating The Contribution Of The Non Coding Gene Ftx To X Chromosome Inactivation In Mammals
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Investigating The Contribution Of The Non Coding Gene Ftx To X Chromosome Inactivation In Mammals
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Author : Giulia Furlan
language : en
Publisher:
Release Date : 2016
Investigating The Contribution Of The Non Coding Gene Ftx To X Chromosome Inactivation In Mammals written by Giulia Furlan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
X-chromosome inactivation (XCI) is a female-specific, chromosome-wide regulatory process that, in eutherians, ensures dosage compensation for X-linked genes between sexes. XCI is controlled by a cis-acting locus on the X-chromosome, the X-inactivation center (Xic), enriched in genes producing long non-coding RNAs (lncRNAs). The Xic-linked gene Xist is the master player of XCI, and produces a lncRNA that accumulates in cis on the X-chromosome and recruits the machinery responsible for initiation and propagation of silencing.The laboratory has identified an additional Xic-linked non-coding gene, Ftx. In this study, we could find that, in female Ftx-/- lines, XCI is strongly impaired, with a significant decrease in the levels of Xist expression and in the percentage of cells showing normal Xist accumulation patterns. Importantly, a high proportion of the cells that still retain Xist expression show abnormal X-chromosome coating and a decreased ability to silence X-linked genes. These data reveal that Ftx is a positive Xist regulator and it is required for proper XCI establishment. In female Ftx+/- lines, the levels of Xist expression and the percentage of cells showing normal Xist accumulation patterns are also decreased, albeit to a lower extent compared to Ftx-/- lines, suggesting that Ftx works in a copy-dependent manner. In addition, a high proportion of Ftx+/- cells display skewed X-inactivation, with preferential inactivation of the wild-type X chromosome. This suggests that Ftx role on Xist accumulation is mostly restricted in cis. Taken together, these results demonstrate that Ftx is required for XCI establishment, where it functions as a strong Xist activator.
Hic Pro An Optimized And Flexible Pipeline For Hi C Data Processing
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Author : Oldenburg Oldenburg Press
language : en
Publisher:
Release Date : 2016-01-29
Hic Pro An Optimized And Flexible Pipeline For Hi C Data Processing written by Oldenburg Oldenburg Press and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-29 with categories.
HiC-Pro is an optimized and flexible pipeline for processing Hi-C data from raw reads to normalized contact maps. HiC-Pro maps reads, detects valid ligation products, performs quality controls and generates intra- and inter-chromosomal contact maps. It includes a fast implementation of the iterative correction method and is based on a memory-efficient data format for Hi-C contact maps. In addition, HiC-Pro can use phased genotype data to build allele-specific contact maps. We applied HiC-Pro to different Hi-C datasets, demonstrating its ability to easily process large data in a reasonable time. Source code and documentation are available at http://github.com/nservant/HiC-Pro.
Molecular Biology Of Long Non Coding Rnas
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Author : Ahmad Khalil
language : en
Publisher: Springer
Release Date : 2013-09-20
Molecular Biology Of Long Non Coding Rnas written by Ahmad Khalil and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-09-20 with Medical categories.
Long non-coding RNAs (lnc)RNAs have emerged as a new paradigm in epigenetic regulation of the genome. Thousands of lncRNAs have been identified and observed in a wide range of organisms. Unlike mRNA, lncRNA have no protein-coding capacity. So, while their function is not entirely clear, they may serve as key organizers of protein complexes that allow for higher order regulatory events. Discovering these functions has been the result of intense research done of the last few years, and lncRNA research has had several critical developments during that time. This book will consolidate these ideas and models to better examine the most important issues in lncRNA biology. This will include critical studies that have led to the discovery and annotation of lncRNAs in numerous species, and the molecular mechanisms for a few lncRNA that have begun to emerge.
Molecular Genetic Pathology
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Author : Liang Cheng
language : en
Publisher: Springer
Release Date : 2013-03-05
Molecular Genetic Pathology written by Liang Cheng and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-05 with Medical categories.
Molecular Genetic Pathology, Second Edition presents up-to-date material containing fundamental information relevant to the clinical practice of molecular genetic pathology. Fully updated in each area and expanded to include identification of new infectious agents (H1N1), new diagnostic biomarkers and biomarkers for targeted cancer therapy. This edition is also expanded to include the many new technologies that have become available in the past few years such as microarray (AmpliChip) and high throughput deep sequencing, which will certainly change the clinical practice of molecular genetic pathology. Part I examines the clinical aspects of molecular biology and technology, genomics. Poharmacogenomics and proteomics, while Part II covers the clinically relevant information of medical genetics, hematology, transfusion medicine, oncology, and forensic pathology. Supplemented with many useful figures and presented in a helpful bullet-point format, Molecular Genetic Pathology, Second Edition provides a unique reference for practicing pathologists, oncologists, internists, and medical genetisists. Furthermore, a book with concise overview of the field and highlights of clinical applications will certainly help those trainees, including pathology residents, genetics residents, molecular pathology fellows, internists, hematology/oncology fellows, and medical technologists in preparing for their board examination/certification.
Long Non Coding Rna Biology
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Author : M.R.S. Rao
language : en
Publisher: Springer
Release Date : 2017-08-16
Long Non Coding Rna Biology written by M.R.S. Rao and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-16 with Medical categories.
This contributed volume offers a comprehensive and detailed overview of the various aspects of long non-coding RNAs and discusses their emerging significance. Written by leading experts in the field, it motivates young researchers around the globe, and offers graduate and postgraduate students fascinating insights into genes and their regulation in eukaryotes and higher organisms.
The Sex Chromatin
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Author : Keith L. Moore
language : en
Publisher:
Release Date : 1966
The Sex Chromatin written by Keith L. Moore and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1966 with Sex Chromatin categories.
Microbial Adhesion And Invasion
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Author : Magnus Hook
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Microbial Adhesion And Invasion written by Magnus Hook and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
This book contains the proceedings of the symposium on Microbial Adhesion and Invasion. The meeting was the fifth in a series of symposia initiated and sponsored by the Department of Biochemistry, University of Alabama at Birmingham. We gratefully acknowledge the generous financial support of the following institutions and companies. -Department of Biochemistry, University of Alabama at Birmingham, Birmingham, Alabama, USA - National Institutes of Health, Bethesda, Maryland, USA -Alfa Laval International, AB, Tumba, Sweden -Procter and Gamble, Cincinnati, Ohio, USA -Amgen Inc., Thousand Oaks, California, USA -Johnson and Johnson, New Brunswick, New Jersey, USA We would like to express our appreciation to Agneta Hook, Timo Kostiainen, Mary Homonylo McGavin, Martin McGavin, Cindy Patti, Joe Patti and Anna-Marja Saamanen for their time and hard work making this symposium a success; and special thanks to Kay Cooper and Wade Butcher for help with the management of the symposium and editorial assistance with this book.
Targeted Molecular Imaging In Oncology
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Author : E. Edmund Kim
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Targeted Molecular Imaging In Oncology written by E. Edmund Kim and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Medical categories.
This volume is unique in reporting on strategies for the application of molecular targeted imaging agents such as antibodies, peptides, receptors and contrast agents in the biologic grading of tumors, differential diagnosis of tumors, prediction of therapeutic response and monitoring tumor response to treatment. It also includes updated information on the imaging of tumor angiogenesis, hypoxia, apoptosis and gene delivery as well as expression in the understanding and utility of tumor molecular biology for better cancer management.
Immunoneurology
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Author : Michel Chofflon
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Immunoneurology written by Michel Chofflon and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
A considerable amount of information has been gathered in the field of immunoneurology over recent years. This knowledge about modifications in the pathways of neuroimmune diseases has enabled the development of new therapies. In this volume leading experts present the state of the art in the field, covering all aspects from basic science to the development of better therapies.
Human Na Ve Pluripotent Stem Cells
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Author : Peter Rugg-Gunn
language : en
Publisher: Humana
Release Date : 2021-12-07
Human Na Ve Pluripotent Stem Cells written by Peter Rugg-Gunn and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-07 with Science categories.
This volume provides readers with a comprehensive collection of methods to guide them on how to generate, characterize, and use naïve human pluripotent stem cells (hPSCs). The chapters in this book cover topics such as three predominant routes to generate naïve hPSC lines; methods to differentiate naïve hPSCs into specialized cell types; and techniques to characterize naïve hPSCs using key molecular landmarks that benchmark and quality control the cell lines. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Human Naïve Pluripotent Stem Cells: Methods and Protocols is a valuable resource for novice and expert researchers who are looking to learn more or expand their research in this developing field.